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HALO® Module

Multiplex IHC

Indica Labs’ Multiplex IHC module separates up to five stains simultaneously within any cellular compartment (nucleus, cytoplasm or membrane) and can be used for a variety of IHC applications. This module is ideally suited for applications in immuno-oncology where multiple markers are required to characterize distinct immune and tumor cell populations within the tissue. Each cell is individually measured for cytoplasmic, nuclear, and/or membrane positivity. The software also reports a variety of other statistics relating size and staining intensity metrics.

Try it out! Click here to initiate your free proof-of-concept HALO® image analysis.

File formats supported by the HALO image analysis platform:

  • Non-proprietary (JPG, TIF, OME.TIFF)
  • Nikon (ND2)
  • 3D Histech (MRXS)
  • Akoya (QPTIFF, component TIFF)
  • Olympus / Evident (VSI)
  • Hamamatsu (NDPI, NDPIS)
  • Aperio (SVS, AFI)
  • Zeiss (CZI)
  • Leica (SCN, LIF)
  • Ventana (BIF)
  • Philips (iSyntax, i2Syntax)
  • KFBIO (KFB, KFBF)
  • DICOM (DCM*)
    *whole-slide images

Depicting the Cellular Architecture of the Tumour Microenvironment by Integrating Hyperplex Immunofluorescence and Automated Image Analysis

Download our scientific poster in collaboration with Lunaphore to learn more about how our Highplex FL module was used in the field.

Qualitative and Quantitative Evaluation of the Tissue Micro-Environment by High-Resolution 17-Plex Immunofluorescence Reveals Distinct Populations​

Download our scientific poster in collaboration with RareCyte to learn more about how our Highplex FL module was used to aid workflows.

Glomeruli Quantification and Characterization Application Note

Don’t let varied stain selections hold back your digital image analysis of kidney sections! With HALO AI you can develop a tissue classifier that accurately detects and segments glomeruli in sections across a range of stains including H&E, trichrome, PAMS, and DAB with hematoxylin.

HALO AI High Impact Publications

Review this selection of high-impact publications for examples of HALO AI applications in fields ranging from metabolism to immuno-oncology and myology.

Depicting TME Cellular Architecture Using Hyperplex IF and Automated Image Analysis

Download our eBook in collaboration with Lunaphore to learn more about how Pharma Services depicted TME cellular architecture using hyperplex IF and automated image analysis.

Qualitative and Quantitative Evaluation of the Tissue Micro-Environment by High-Resolution 17-Plex Immunofluorescence Reveals Distinct Populations

Check out this eBook to see how AI-based nuclear segmentation and tissue classification can streamline cell phenotyping across tissue compartments and samples.

Sequential Same Slide Multiplex IF and H&E Staining for Combined Phenotypic and Morphological Characterization of FFPE Tissue Sections

Read this eBook for an introduction to a sequential staining and image analysis workflow that leverages a terminal H&E stain for the delineation of tissue architectural regions in subsequent HALO image analysis.

Introduction of a Robust Workflow for the Whole-Slide Acquisition and Co-Registration of Multiplex Immunofluorescence Tissue Images for Analysis of a 9-Color, 8-Marker Immunophenotyping Assay

Download our eBook to learn about a HALO workflow for co-registration and cellular analysis of immunofluorescence images from cyclically stained and imaged slides.

Publication Spotlight

The table below includes publications that cite the Multiplex IHC module. 

Your publication not on the list?  Drop us an email to let us know about it!

TitleAuthorsYearJournalApplicationHALO ModulesProduct
Evaluation of Early Markers of Ischemia-reperfusion Injury and Preservation Solutions in a Modified Hindlimb Model of Vascularized Composite AllotransplantationRostami S, Xu M, Datta S, Haykal S2022Transplantation DirectCytonuclear, Multiplex IHCHALO
Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancerZheng S, Zou Y, Tang Y, Yang A, Liang J, Wu L, Tian W, Xiao W, Xie X, Yang L, Xie J, Wei W, Xie X2022OncoImmunologyImmuno-oncologyCytonuclear, Multiplex IHCHALO
Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivationWu H, He P, Ren Y, Xiao S, Wang W, Liu Z, Li H, Wang Z, Zhang D, Cai J, Zhou X, Jiang D, Fei X, Zhao L, Zhang H, Liu Z, Chen R, Li W, Wang C, Zhang S, Qin J, Nasan B, Sun C2022Nature CommunicationsInfectious DiseaseMultiplex IHCHALO
Transcription factor Mesenchyme Homeobox Protein 2 (MEOX2) modulates nociceptor functionKokotovic T, Lenartowicz E, Langeslag M, Ciotu C, Fell C, Scaramuzza A, Fischer M, Kress M, Penninger J, Nagy V2022The FEBS JournalNeruoscienceMultiplex IHCHALO
Collaborative workflow between pathologists and deep learning for evaluation of tumor cellularity in lung adenocarcinomaSakamoto T, Furukawa T, Pham H, Kuroda K, Tabata K, Kshima Y, Okoshi E, Morimoti S, Bychkov A, Fukuoka J2022bioRxivOncologyCytonuclear, Multiplex IHCHALO AI
African-Ancestry Associated Gene Expression Signatures and Pathways in Triple Negative Breast Cancer, a Comparison across Women of African DescentMartini R, Delpe P, Chu T, Arora K, Lord B, Verma A, Chen Y, Gebregzabher, Oppong J, Adjei E, Jibril A, Awuah B, Bekele M, Abebe E, Kyei I, Aitpillah F, Adinku M, Ankomah K, Osei-Bonsu E, Chitale D, Bensenhaver J, Nathanson S, Jackson L, Jiagge E, Petersen L, Proctor E, Gyan K, Gibbs L, Monojlovic Z, Kittles R, White J, Yates C, Manne U, Gardner K, Mongan N, Cheng E, Ginter P, Hoda S, Elemento O, Robine N, Sboner A, Carpten J, Newman L, Davis M2022medRxivOncologyMultiplex IHC, Serial SectionHALO
A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivoKofink C, Trainor N, Mair B, Wrhrle S, Wurm M, Mischerikow N, Bader G, Rumpel K, Gerstberger T, Cui Y, Greb P, Garavel G, Scharnweber M, Fuchs J, Gremel G, Chette P, Hopf S, Budano N, Rinnenthal J, Gmaschitz G, Diers E, McLennan R, Roy M, Whitworth C, Vetma V, Mayer M, Koegl M, Ciulli A, Weinstabl H, Farnaby W2022Biological and Medicinal ChemistryClassifier, Cytonuclear, Multiplex IHCHALO
Pathogenesis of follicular thymic hyperplasia associated with rheumatoid arthritisOhe R, Yang S, Yamashita D, Ichikawa C, Saito A, Kabasawa T, Utsunomiya A, Aung N, Urano Y, Kitaoka T, Suzuki K, Takahara D, Sasaki A, Takakubo Y, Takagi M, Yamakawa M, Futakuchi M2022Pathology InternationalOtherCytonuclear, Multiplex IHCHALO
Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDACBaer J, Zuo C, Kang L, Alarcon de la Lastra A, Bocherding N, Knolhoff B, Bogner S, Zhu Y, Lewis M, Zhang N, Kim K, Fields R, Mills J, Ding L, Randolph G, DeNardo D2022bioRxivFibrosisClassifier, Area Quantification, Cytonuclear, Multiplex IHC, Highplex FL, Figure MakerHALO
Nuclear expression of pSTAT3Tyr705†and pSTAT3Ser727†in the stromal compartment of localized hormone-naÔve prostate cancerMarginean F, Hellsten R, Krzyanowska A, Bjartell A2022Pathology - Research and PracticeOncologyCytonuclear, Multiplex IHC, TMAHALO
An Fc-inert PD-L1◊4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulationMuik A, Altintas I, Gieseke F, Schoedel K, Burm S, Toker A, Salcedo T, Verzijl, Eisel D, Grunwitz C, Kranz L, Vormehr M, Satijn D, Diken M, Kreiter S, Sasser K, Ahmadi T, Tureci O, Breij E, Jure-Kunkel M, Sahin U2022OncoImmunologyImmuno-oncologyArea Quantification, Immune, Multiplex IHCHALO
Tertiary lymphoid structures critical for prognosis in endometrial cancer patients - a TransPORTEC studyHoreweg N, Workel, H, Loiero D, Church D, Vermij L, LÈon-Castillo A, Krog R, de Boer S, Nout R, Powel M, Mileshkin L, MacKay H, Leary A, Singh N, J¸rgenliemk-Schulz I, Creutzberg C, Koelzer V, Nijman H, Bosse T, Bruyn M2022Nature CommunicationsOncologyCytonuclear, Multiplex IHC, TMAHALO, HALO AI
ZEB1 transcription factor promotes immune escape in melanomaPlaschka M, Benboubker V, Grimont M, Berthet J, Tonon L, Lopez J, Le-Bouar M, Balme B, Tondeau G, de la Fouchardiere A, Larue L, Puisieux A, Grinberg-Bleyer Y, Bendriss-Vermare N, Dubois B, Caux C, Dalle S, Caramel J2022Journal for ImmunoTherapy of CancerImmuno-oncologyCytonuclear, Multiplex IHC, Highplex FLHALO
Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplasticaHong Y, Shan S, Gu Y, Huang H, Zhang Q, Han Y, Dong Y, Liu Z, Huang M, Ren T2022Nature CommunicationsOtherCytonuclear, Multiplex IHCHALO
Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in miceOrdonez A, Bullen C, Villabona-Rueda A, Thompson E, Turner M, Merino V, Yan Y, Kim J, Davis S, Komm O, Powell J, D'Alessio F, Yolken R, Jain S, Jones-Brando L2022Communications BiologyInfectious DiseaseArea Quantification, Multiplex IHCHALO
Interspatial Distribution of Tumor and Immune Cells in Correlation with PD-L1 in Molecular Subtypes of Gastric CancersDislich B, Mertz K, Gloor B, Langer R2022CancersImmuno-oncologyMultiplex IHC, Spatial Analysis, Figure MakerHALO
Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaquesAid M, Vidal S, Piedra-Mora C, Ducat S, Chan C, Bondoc S, Colarusso A, Starke C, Nekorchuk M, Busman-Sahay K, Estes J, Martinot A, Barouch D2022PLOS PathogensInfectious DiseaseArea Quantification, Multiplex IHCHALO, HALO AI
Organelle resolved proteomics reveals new chordoma cell surface markers required for proliferation and association with outcomeKhan S, Zuccato J, Ignatchenko V, Singh O, Govindarajan M, Waas M, Gao A, Zadeh G, Kislinger T2022Research SquareOncologyCytonuclear, Multiplex IHCHALO
Immune cell subsets in interface cutaneous immune-related adverse events (cirAEs) associated with anti-PD-1 therapy resemble accute graft vs host disease more than licen planusCruz G, Kaunitz G, Stein J, Sander I, Hollmann T, Cottrell T, Taube J, Sunshine J2022Journal of Cutaneous PathologyImmunologyCytonuclear, Multiplex IHCHALO
Therapeutic impact of BET inhibitor BI 894999 treatment: backtranslation from the clinicTontsch-Grunt U, Traexler P, Baum A, Musa H, Marzin K, Wang S, Trapani F, Engelhardt H, Solca F2022British Journal of CancerOncologyClassifier, Cytonuclear, Multiplex IHCHALO
Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19Chait M, Yilmaz M, Shakil S, Ku A, Dogra P, Connors T, Szabo P, Gray J, Wells S, Kubota M, Matsumoto R, Poon M, Snyder M, Baldwin M, Sims P, Saqi A, Farber D, Weisberg S2022JCI InsightInfectious DiseaseMultiplex IHCHALO
Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell CarcinomaóA Proof of Principle StudyUrsprung S, Woitek R, McLean M, Priest A, Crispin-Ortuzar M, Brodie C, Gill A, Gehrung M, Beer L, Riddick A, Field-Rayner J, Grist J, Deen S, Riemer F, Kaggie J, Zaccagna F, Duarte J, Locke M, Frary A, Aho T, Armitage J, Casey R, Mendichovszky I, Welsh S, Barrett T, Graves M, Eisen T, Mitchell T, Warren A, Brindle K, Sala E, Stewart G, Gallagher F2022CancersOncologyArea Quantification, Cytonuclear, Multiplex IHCHALO
C57BL/6J Mice Are Not Suitable for Modeling Severe SARS-CoV-2 Beta and Gamma Variant InfectionCurrey J, Rabito F, Maness N, Blair R, Rappaport J, Qin X, Kolls J, Srivastava A2022VirusesInfectious DiseaseCytonuclear, Multiplex IHCHALO
Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infectionLee A, Feng E, Chew M, Balint E, Poznanski S, Giles E, Zhang A, Marzok A, Revill S, Vahedi F, Dubey A, Ayaub E, Jimenez-Saiz R, McGrath J, Ritchie T, Jordana M, Jonigk D, Ackermann M, Ask K, Miller M, Richards C, Ashkar A2022PLOS PathogensInfectious DiseaseArea Quantification, Multiplex IHC, TMAHALO
Dietary Pharmacological Zinc and Copper Enhances Voluntary Feed Intake of Nursery PigsDeMille C, Burrough E, Kerr B, Schweer W, Gabler N2022Frontiers in Animal ScienceOtherCytonuclear, Multiplex IHCHALO
Spatial transcriptome of a germinal center plasmablastic burst hints at†MYD88/CD79B†mutants-enriched diffuse large B-cell lymphomasL'Imperio V, Morello G, Vegliante M, Cancila V, Bertolazzi G, Mazzara S, Belmonte B, Mangogna A, Balzarini P, Corral L, Lopez G, Di Napoli A, Facchetti F, Pagni F, Tripodo C2022European Journal of ImmunologyOncologyCytonuclear, Multiplex IHCHALO
Multi-scale integrative analyses identify THBS2+†cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinomaYang H, Sun B, Fan L, Ma W, Xu K, Hall S, Wang Z, Schmid R, Peng R, Marti T, Gao W, Xu J, Yang W, Yao F2022TheranosticsOncologyCytonuclear, Multiplex IHCHALO
Maternal Western-Style Diet Impairs Bone Marrow Development and Drives a Hyperinflammatory Phenotype in Hematopoietic Stem and Progenitor Cells in Fetal Rhesus MacaquesSureshchandra S, Chan C, Robino J, Parmelee L, Nash M, Wesolowski S, Pietras E, Friedman J, Takahashi D, Shen W, Hennebold J, Goldman D, Packwood W, Lindner J,Roberts C, Burwitz B, Messaoudi I, Varlamov O2022bioRxivMetabolismMultiplex IHCHALO
Preclinical evaluation of†FAP?2286 for†fbroblast activation protein targeted radionuclide imaging and†therapyZboralski D, Hoehne A, Bredenbeck A, Schumann A, Nguyen M, Schneider E, Ungewiss J, Paschke M, Haase C, von Hacht J, Kwan T, Lin K, Lenore J, Harding T, Xiao J, Simmons A, Mohan A, Beindorff N, Reineke U, Smerling C, Osterkamp F2022European Journal of Nuclear Medicine and Molecular ImagingOncologyCytonuclear, Multiplex IHCHALO
Integrated†Analysis†Of†Immunotherapy†Treated†Clear†Cell†Renal†Cell†Carcinomas:†An†Exploratory†StudySobottka B, Nienhold R, Nowak M, Hench J, Haeuptle P, Frank A, Sachs M, Kahraman A, Moch H, Koelzer V, Mertz K2022Journal of ImmunotherapyImmuno-oncologyCytonuclear, Multiplex IHC, Figure MakerHALO, HALO AI
A lncRNA signature associated with tumor immune heterogeneity predicts distant metastasis in locoregionally advanced nasopharyngeal carcinomaLiang Y, Zhang Y, Tan X, Qiao H, Liu S, Tang L, Mao Y, Chen L, Li W, Zhou G, Zhao Y, Li J, Li Q, Huang S, Gong S, Zheng Z, Li Z, Sun Y, Jiang W, Ma J, Li Y, Liu N2022Nature CommunicationsImmuno-oncologyClassifier, Multiplex IHC, RegistrationHALO
Prenatal di-(2-ethylhexyl_ phthalate exposure induced myocardial cytotoxicity via the regulation of the NRG1-dependent ErbB2/ErbB4-PI3K/AKT signaling pathway in fetal miceYu D, Zhu D, Wang X, Li B, Li J, Lu P, Ji Y, Wang X2022Ecotoxicology and Environmental SafetyOtherMultiplex IHCHALO
Effects of Extracorporeal Shockwave Therapy on Functional Recovery and Circulating miR-375 and miR-382-5p after Subacute and Chronic Spinal Cord Contusion Injury in RatsAshmwe M, Posa K, Ruhrnossl A, Heinzel J, Heimel P, Mock M, Schadl B, Keibl C, Couillard-Despres S, Redl H, Mittermayr R, Hercher D2022BiomedicinesNeuroscience, OtherClassifier, Multiplex IHCHALO
Spatial meta-transcriptomics reveal associations of intratumor bacteria burden with lung cancer cells showing a distinct oncogenic signatureWong-Rolle A, Dong Q, Zhu Y, Divakar P, Hor J, Kedei N, Wong M, Tillo D, Conner E, Rajan A, Schrump D, Jim C, Germain R, Zhao C2022Journal for ImmunoTherapy of CancerImmuno-oncologyCytonuclear, Multiplex IHCHALO
SOX9+ malignant cells define a poor prognosis subtype of Glioma with tumor-associated macrophage recruitmentYu S, Ma C, Wang H, Yu B, Luan Y, Xia Z2022Research SquareImmuno-oncologyCytonuclear, Multiplex IHCHALO
The combination of gene hyperamplification and PD-L1 expression as a biomarker for the clinical benefit of tislelizumab in gastric/gastroesophageal junction adenocarcinomaLu Z, Yang S, Luo X, Shi Y, Lee J, Deva S, Liu T, Chao Y, Zhang Y, Huang R, Xu Y, Shen Z, Shen L2022Gastric CancerImmuno-oncologyClassifier, Multiplex IHCHALO
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrixKay E, Paterson K, Riero-Domingo C, Sumpton D, Dabritz J, Tardito S, Boldrini C, Hernandez-Fernaud J, Athineos D, Dhayade S, Stepanova E, Gjerga E, Neilson L, Lilla S, Hedley A, Koulouras G, McGregor G, Jamieson C, Johnson R, Park M, Kirschner K, Miller C, Kamphorst J, Loayza-Puch F, Saez-Rodriguez J, Mazzone M, Blyth K, Zagnoni M, Zanivan S2022Nature MetabolismOncology, MetabolismCytonuclear, Multiplex IHC, Highplex FLHALO
Discovery of†a†novel ALK/ROS1/FAK inhibitor, APG-2449, in†preclinical non-small cell lung cancer and†ovarian cancer modelsFang D, Tao R, Wang G, Li Y, Zhang K, Xu C, Zhai G, Wang Q, Wang J, Tang C, Min P, Xiong D, Chen J, Wang S, Yang D, Zhai Y2022BMC CancerOncologyMultiplex IHCHALO
Cell graph neural networks enable the precise prediction of patient survival in gastric cancerWang Y, Wang Y, Hu C, Li M, Fan Y, Otter N, Sam I, Gou H, Hu Y, Kwok T, Zalcberg J, Boussioutas A, Daly R, Montufar G, Lio P, Xu D, Webb G, Song J2022Precision OncologyOncologyMultiplex IHCHALO
Spartalizumab or placebo in combination with dabrafenib and trametinib in patients with†BRAF†V600-mutant melanoma: exploratory biomarker analyses from a randomized phase 3 trial (COMBI-i)Tawbi H, Robert C, Brase J, Gusenleitner D, Gasal E, Garrett J, Savchenko A, Gorgun G, Flaherty K, Ribas A, Dummer R, Schadendorf D, Long G, Nathan P, Ascierto P2022Journal for ImmunoTherapy of CancerOncologyMultiplex IHC, Spatial AnalysisHALO
Approaches to spatially resolving the tumour immune microenvironment of hepatocellular carcinomaMarsh-Wakefield F, Ferguson A, Liu K, Santhakumar C, McCaughan G, Palendira U2022Therapeutic Advances in Medical OncologyReviewMultiplex IHC, Spatial Analysis, Highplex FLHALO
Intact HIV proviruses persist in the brain despite viral suppression with ARTCochrane C, Angelovich T, Byrnes S, Waring E, Guanizo A, Trollope G, Zhou J, Vue J, Senior L, Wanicek E, Eddine J, Gartner M, Jenkins T, Gorry P, Brew B, Lewin S, Estes J, Roche M, Churchill M2022Annals of NeurologyInfectious DiseaseMultiplex IHCHALO
Radioprotective effect of X-ray abdominal FLASH irradiation: Adaptation to oxidative damage and inflammatory response may be benefiting factorsZhu H, Xie D, Yang Y, Huang S, Gao X, Peng Y, Wang B, Wang J, Xiao D, Wu D, Li C, Li C, Qian C, Deng X2022Medical PhysicsOncology, OtherMultiplex IHCHALO
Hyperpolarised†13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancerSushentsev N, McLean M, Warren A, Benjamin A, Brodie C, Frary A, Gill A, Jones J, Kaggie J, Lamb B, Locke M, Miller J, Mills I, Priest A, Robb F, Shah N, Schulte R, Graves M, Gnanapragasam V, Brindle K, Barrett T, Gallacher F2022Nature CommunicationsOncologyISH/FISH, Membrane, Multiplex IHCHALO
DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-based Antibody-Drug Conjugate 2 Targeting B7-H3 Exerts Potent Antitumor Activities in Preclinical ModelsYamato M, Hasegawa J, Maejima T, Hattori C, Kumagai K, Watanabe A, Nishiya Y, Shibutani T, Aida T, Hayakawa I, Nakada T, Abe Y, Agatsuma T2022Molecular Cancer TherapeuticsOncologyMultiplex IHCHALO
Prostate cancer androgen receptor activity dictates efficacy of Bipolar Androgen TherapySena L, Kumar R, Sanin D, Thompson E, Rosen D, Dalrymple S, Antony L, Yang Y, Comes-Alexandre C, Hicks J, Jones T, Bowers K, Eskra J, Meyers J, Gupta A, Skaist A, Yegnasubramanian S, Luo J, Brennen W, Kachhap S, Antonarakis E, De Marzo A, Isaacs J, Markowski M, Denmeade S2022medRxivOncologyClassifier, Cytonuclear, Multiplex IHC, RegistrationHALO
Senescence-Associated Molecules and Tumor-Immune-Interactions as Prognostic Biomarkers in Colorectal CancerKellers F, Fernandez A, Konykiewitz B, Schindeldecker M, Tagscherer K, Heintz A, Jesinghaus M, Roth W, Foersch S2022Frontiers in MedicineOncologyClassifier, Multiplex IHC, Spatial Analysis, Registration, TMAHALO
Tau Pathology in Chronic Traumatic Encephalopathy is Primarily NeuronalButler M, Dixon E, Stein T, Alvarez V, Huber B, Buckland M, McKee A, Cherry J2022Journal of Neuropathology & Experimental NeurologyNeuroscienceMultiplex IHC, Spatial Analysis, Highplex FLHALO, HALO AI
Chemoradiation-induced alteration of programmed death-ligand 1, CD8+ tumor-infiltrating lymphocytes and mucin expression in rectal cancerBaretti M, Zhu Q, Fu W, Meyer J, Wang H, Anders R, Azad N2022OncotargetOncologyMultiplex IHC, Spatial AnalysisHALO
Glycosphingolipids are mediators of cancer plasticity through independent signaling pathwaysCumin C, Huang Y, Rossdam C, Ruoff F, Cespedes S, Liang C, Lombardo F, Coelho R, Rimmer N, Konantz M, Lopez M, Alam S, Schmidt A, Calabrese D, Fedier A, Vlajnic T, Itzstein M, Templin M, Buettner F, Everest-Dass A, Heinzelmann-Schwarz V, Jacob F2022Cell reportsOncologyClassifier, Multiplex IHCHALO
Bright-Field Multiplex Immunohistochemistry Assay for Tumor Microenvironment Evaluation in Melanoma TissuesUgolini F, Pasqualini E, Simi S, Baroni G, Massi D2022CancersOtherMultiplex IHCHALO, HALO Link
Knockdown of ZBTB11 impedes R-loop elimination and increases the sensitivity to cisplatin by inhibiting DDX1 transcription in bladder cancerChen L, Liu Z, Tang H, Zhou Z, Chen J, Ma Z, Deng M, Li X, Wu Y, Zheng L, Zhou L, Zheng X, Liu Z2022Cell ProliferationOncologyMultiplex IHC, Highplex FL, Figure MakerHALO
Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancersXu Y, Wei Z, Feng M, Zhu D, Mei S, Wu Z, Feng Q, Chang W, Ji M, Liu C, Zhu Y, Shen L, Yang F, Chen Y, Feng Y, Xu J, Zhu D2022Cell ReportsOncology, Immuno-oncologyMultiplex IHC, Highplex FLHALO
Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphomaScholler N, Perbost R, Locke F, Jain M, Turcan S, Danan C, Chang E, Neelapu S, Miklos D, Jacobson C, Lekakis L, Lin Y, Ghobadi A, Kim J, Chou J, Plaks V, Wang Z, Xue A, Mattie M, Rossi J, Bot A, Galon J2022Nature MedicineImmuno-oncologyMultiplex IHC, Figure MakerHALO
A Beta-containing bivalent SARS-CoV-2 spike protein vaccine candidate with AS03 elicits durable and broad neutralization of variants including Omicron in macaques and confers protection in hamstersBerry C, Pavot V, Anosova N, Kishko M, Huang D, Tibbitts T, Raillard A, Gautheron S, Cummings S, Bangari D, Kar S, Atyeo C, Deng Y, Alter G, Gutzeit C, Koutsoukos M, Chicz R, Lecouturier V2022Research SquareInfectious DiseaseMultiplex IHCHALO
Immune cells in mesothelioma microenvironment simplistic marker of response to nivolumab plus ipilimumabDisselhorst M, Lubeck Y, van der Noort V, Quispel-Janssen J, Seignette I, Sanders J, Peters D, Hooijberg E, Baas P2022Lung CancerOncologyMultiplex IHC, RegistrationHALO
In situ†mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissuesYoung L, Conroy L, Clarke H, Hawkinson T, Bolton K, Sanders W, Chang J, Webb M, Alilain W, Vander Kooi C, Drake R, Andrews D, Badgett T, Wagner L, Allison D, Sun R, Gentry M2022EMBO Molecular MedicineOncology, MetabolismMultiplex IHCHALO
Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic†Trp53†alterations and†Pten†lossMejia-Hernandez J, Keam S, Saleh R, Muntz F, Fox S, Byrne D, Kogan A, Pang L, Huynh J, Litchfield C, Caramia F, Lozano G, He H, You J, Sandhu S, Williams S, Haupt Y, Haupt S2022Cell Death & DiseaseOncologyMultiplex IHC, Highplex FL, Figure MakerHALO
Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERR? deficiencyDufour C, Xia H, B'chir W, Perry M, Kuzmanov U, Gainullina A, Dejgaard K, Scholtes C, Ouellet C, Zuo D, Sanguin-Gendreau V, Guluzian C, Smith H, Muller W, Audet-Walsh E, Sergushichev A, Emili A, Giguere V2022Communications BiologyOtherMultiplex IHCHALO
Effects of hypoxia-preconditioned HucMSCs on neovascularization and follicle survival in frozen/thawed human ovarian cortex transplanted to immunodeficient miceCheng J, Ruan X, Li Y, Du J, Jin F, Gu M, Zhou Q, Xu X, Yang Y, Wang H, Mueck A2022Stem Cell Research & TherapyOtherMultiplex IHCHALO
STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependentZhang X, Chen Q, He Y, Shi Q, Yin C, Xie Y, Yu H, Bao Y, Tang C, Dong Z2022Research SquareOncologyMultiplex IHCHALO
Integrated pathological analysis to develop a Gal-9 based immune survival stratification to predict the outcome of lung large cell neuroendocrine carcinoma and its usefulness in immunotherapyChe Y, Luo Z, Cao Y, Wang J, Xue Q, Sun N, He J2022International Journal of Biological SciencesOncologyClassifier, Multiplex IHCHALO
Dapagliflozin reduces the vulnerability of rats with pulmonary arterial hypertension-induced right heart failure to ventricular arrhythmia by restoring calcium handlingWu J, Liu T, Shi S, Fan Z, Hiram R, Xiong F, Cui B, Su X, Chang R, Zhang W, Yan M, Tang Y, Huang H, Wu G, Guang C2022Cardiovascular DiabetologyOtherMultiplex IHCHALO
The NALCN channel regulates metastasis and nonmalignant cell disseminationRahrmann E, Shorthouse D, Jassim A, Hu L, Ortiz M, Mahler-Araujo B, Vogel P, Paez-Ribes M, Fatemi A, Hannon G, Iyer R, Blundon J, Lourenco F, Kay J, Nazarian R, Hall B, Zakharenko S, Winton D, Zhu L, Gilbertson R2022Nature GeneticsOncologyISH/FISH, Multiplex IHCHALO
The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory driversTatari N, Khan S, Livingstone J, Zhai K, Mckenna D, Ignatchenko V, Chokshi C, Gwynne W, Singh M, Revill S, Mikolajewicz N, Zhu C, Chan J, Hawkins C, Lu J, Provias J, Ask K, Morrissy S, Brown S, Weiss T, Weller M, Han H, Greenspoon J, Moffat J, Venugopal C, Boutros P2022Acta NeuropathologicaOncologyMultiplex IHC, Figure Maker, TMAHALO
PD-L1 predicts chemotherapy resistance in large-cell neuroendocrine carcinomaChe Y, Luo Z, Cao Y, Sun N, Xue Q, He J2022British Journal of SurgeryOncologyClassifier, Multiplex IHCHALO
Overcoming high level adenosine-mediated immunosuppression by DZD2269, a potent and selective A2aR antagonistBai Y, Zhang X, Zheng J, Liu Z, Yang Z, Zhang X2022Journal of Experimental & Clinical Cancer ResearchOncologyMultiplex IHCHALO
Carbonic anhydrase 14 protects the liver against the cytotoxicity of bile acids in a biliary bicarbonate umbrella-related mannerQian J, Shen Q, Zhang T, Chen J, Chen L, Dong Y, Yan R, Chen Z2022Life SciencesOtherMultiplex IHCHALO
Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibodyMicalizzi D, Che D, Nicholson B, Edd J, Desai N, Lang E, Toner M, Maheswaran S, Ting D, Haber D2022Proceedings of the National Academy of SciencesOncologyMultiplex IHC, Highplex FLHALO
Cystatin C is glucocorticoid-responsive, directs recruitment of Trem2+ macrophages and predicts failure of cancer immunotherapyKleeman S, Demestichas B, Mourikis N, Loiero D, Ferrer M, Bankier S, Riazat-Kesh Y, Lee H, Chantzichristos D, Regan C, Preall J, Sinha S, Rosin N, Yipp B, de Almeida L, Biernaskie J, Dufour A, Tober-Lau P, Ruusalepp A, Bjorkegren J, Ralser M, Kuth F, Demechev V, Heywood T, Gao Q, Johannsson G, Koelzer V, Walker B, Meyer H, Janowitz T2022medRxivImmuno-oncologyMultiplex IHCHALO, HALO AI
Single-incision cochlear implantation and hearing evaluation in piglets and minipigsYildiz E, Gerlitz M, Gadenstaetter A, Landegger L, Nieratschker M, Schum D, Schmied M, Haase A, Kanz F, Kramer A, Glueckert R, Staecker H, Honeder C, Arnoldner C2022Hearing ResearchNeuroscienceMultiplex IHCHALO
The Neo-PLANET phase II trial of neoadjuvant camrelizumab plus concurrent chemoradiotherapy in locally advanced adenocarcinoma of stomach or gastroesophageal junctionTang Z, Wang Y, Liu D, Wang X, Xu C, Yu Y, Cui Y, Tang C, Li Q, Sun J, Zhang Q, Ji Y, Ma G, Li H, Shen Z, Shen K, Zheng R, Hou Z, Liu T, Wang J, Sun Y2022Nature CommunicationsImmuno-oncologyCytonuclear, Multiplex IHCHALO
Assessment of spatial transcriptomics for oncology discoveryLyubetskaya A, Rabe B, Fisher A, Lewin A, Neuhaus I, Brett C, Brett T, Pereira E, Golhar R, Kebede S, Font-Tello A, Mosure K, Wittenberghe N, Mavrakis K, Maclsaac K, Chen B, Drokhlyansky E2022Cell Reports MethodsOncologyCytonuclear, Multiplex IHC, RegistrationHALO, HALO AI
Dynamin-2 deficiency causes age- and sex-dependent neutropenia and myelodysplasia in miceWillis A, Corey S, Murga-Zamalloa C, Karimi S, Khaddour K, Quigley J, Eklund E, Chen Y2022Blood AdvancesOtherCytonuclear, Multiplex IHCHALO
The association of HHLA2 and PD-L1 expression with prognosis and immune microenvironment in hepatocellular carcinomaWang C, Chen S, Yang X, Wu T, Liu L, Yun J2022Research SquareOncologyCytonuclear, Multiplex IHCHALO
Presence of Tim3+ and PD-1+ CD8+ T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and distinct clinicopathological featuresKlapholz M, Drage M, Srivastava A, Anderson A2022The Journal of PathologyOncologyMultiplex IHC, Highplex FLHALO
Evaluating changes in GABAergic and glutamatergic pathways in early life following prenatal stress and postnatal neurosteroid supplementationCrombie G, Palliser H, Shaw J, Hodgson D, Walkder D, Hirst J2022PsychoneuroendocrinologyNeuroscienceMultiplex IHCHALO
Impact of HPV status on immune responses in head and neck squamous cell carcinomaQureshi H, Zhu X, Yang G, Steadele M, Pierce R, Futran N, Lee S, Mendez E, Houghton A2022Oral OncologyOncologyMultiplex IHC, Spatial Analysis, Highplex FLHALO
Murine fecal microbiota transfer models selectively colonize human microbes and reveal transcriptional programs associated with response to neoadjuvant checkpoint inhibitorsShaikh F, Gills J, Mohammad F, White J, Stevens C, Ding H, Fu J, Tam A, Blosser R, Domingue J, Larman T, Chaft J, Spicer J, Reuss J, Naidoo J, Forde P, Ganguly S, Housseau F, Pardoll D, Sears C2022Cancer Immunology, ImmunotherapyImmuno-oncologyMultiplex IHCHALO
Association between mitochondrial and nuclear DNA damages and cellular senescence in the patients with biliary atresia undergoing Kasai portoenterostomy and liver transplantationNakajima Y, Yamazaki Y, Gao X, Hashimoto M, Nio M, Wada M, Fujishima F, Sasano H2022Medical Molecular MorphologyGastroenterologyMultiplex IHCHALO
Bone quality and composition are influenced by egg production, layer line, and estradiol-17ß in laying hensEusemann B, Ulrich R, Sacnhez-Rodriquez E, Benavides-Reyes C, Dominguez-Gasca, Rodriguez-Navarro A, Petow S2022Avian PathologyOtherClassifier, Multiplex IHCHALO
Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancerXiong X, Hasani S, Young L, Rivas D, Skaggs A, Martinez R, Wang C, Weiss H, Gentry M, Sun R, Gao T2022Cell Death & DifferentiationOncologyMultiplex IHCHALO
Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal CancerRajurkar M, Parikh A, Solovyov A, You E, Kulkarni A, Chu C, Xu K, Jaicks C, Taylor M, Wu C, Alexander K, Good C, Szabolcs A, Gerstberger S, Tran A, Xu N, Ebright R, Van Seventer E, Vo K, Tai E, Lu C, Joseph-Chazan J, Raabe M, Nieman L, Desai N, Arora K, Ligorio M, Thapar V, Cohen L, Garden P, Senussi Y, Zheng H, Allen J, Blaszkowsky L, Clark J, Goyal L, Wo J, Ryan D, Cocoran R, Deshpande V, Rivera M, Aryee M, Hong T, Berger S, WAlt D, Burns K, Park P, Greenbaum B, Ting D2022Cancer DiscoveryOncologyArea Quantification, Multiplex IHCHALO
The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcomaZullow H, Sankar A, Ingram D, Guerra D, D'Avino A, Collings C, Lazcano R, Wang W, Liang Y, Qi J, Lazar A, Kadoch C2022Molecular CellOncologyMultiplex IHCHALO
Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cellsCrist S, Nemkov T, Dumpit R, Dai J, Tapscott S, True L, Swarbrick A, Sullivan L, Nelson P, Hansen K, Ghajar C2022Nature Cell BiologyMyologyMultiplex IHC, RegistrationHALO
In vitro cell cultures of Brunner's glands from male mouse to study GLP-1 receptor functionVoetmann L, Underwood C, Rolin B, Hansen A, Kirk R, Pyke C, Knudsen L, Frederiksen K2022Methods in Cell PhysiologyGastroenterologyMultiplex IHCHALO
Reduced SARS-CoV-2 disease outcomes in Syrian hamsters receiving immune sera: Quantitative image analysis in pathologic assessmentsPieda-Mora C, Robinson S, Tostanoski L, Dayao D, Chandrashekar A, Bauer K, Wrijil L, Ducat S, Hayes T, Yu J, Bondzie E, McMahan K, Sellers D, Giffin V, Hope D, Nampanya F, Mercado N, Kar S, Andersen H, Tzipori S, Barouch D, Martinot A2022Veterinary PathologyInfectious Disease, OtherClassifier, Multiplex IHCHALO
Aberrant inflammation in rat pregnancy leads to cardiometabolic alterations in their offspring and intrauterine growth restriction in the F2 generationUshida T, Cotechini T, Protopapas N, Atallah A, Collyer C, Toews A, Maconald-Goodfellow S, Tse M, Winn L, Pang S, Adams M, Othman M, Kotani T, Kajiyama H, Graham C2022Journal of Developmental Origins of Health and DiseaseMetabolism, OtherMultiplex IHCHALO
High-strength biodegradable zinc alloy implants with antibacterial and osteogenic properties for the treatment of MRSA-induced rat osteomyelitisJia B, Zhang Z, Zhuang Y, Yang H, Han Y, Wu Q, Jia X, Yin Y, Qu X, Zheng Y, Dai K2022BiomaterialsBiomaterialsMultiplex IHCHALO
Escherichia coli-specific CXCL13-producing TFH are associated with clinical efficacy of neoadjuvant PD-1 blockade against muscle-invasive bladder cancerGoubet A, Lordello L, Silva C, Peguillet I, Gazzano M, Mbogning-Fonkou M, Thelemaque C, Lebacle C, Thibault C, Audenet F, Pignot G, Gravis G, Helissey C, Campbedel L, Roupret M, Xylinas E, Ouzaid I, Dubuisson A, Mazzenga M, Flament C, Ly P, Marty V, Signolle N, Sauvat A, Sbarrato T, Filahi M, Davin C, Haddad G, Khalil J, Bleriot C, Danlos F, Dunsmore G, Mulder K, Silvin A, Raoult T, Archambaud B, Belhechmi S, Boneca I, Cayet N, Moya-Nilges M, Mallet A, Daillere R, Rouleau E, Radulescu C, Allory Y, Fieschi J, Rouanne M, Ginhoux F, Le Teuff G, Derosa L, Marabelle A, Van Dorp J, Van Dijk N, van der Heijden M, Besse B, Andre F, Merad M, Kroemer G, Scoazec J, Zitvogel L, Loriot Y2022Cancer DiscoveryOncologyMultiplex IHC, Spatial AnalysisHALO
Integrative Analysis of Bioinformatics and Machine Learning Algorithms Identifies a Novel Diagnostic Model Based on Costimulatory Molecule for Predicting Immune Microenvironment Status in Lung AdenocarcinomaZhai W, Duan F, Wang Y, Wang J, Zhao Z, Lin Y, Rao B, Chen S, Zheng L, Long H2022The American Journal of PathologyOncologyClassifier, Multiplex IHCHALO
Localization of macrophage subtypes and neutrophils in the prostate tumor microenvironment and their association with prostate cancer racial disparitiesMaynard J, Godwin T, Lu J, Vidal I, Lotan T, De Marzo A, Joshu C, Sfanos K2022The ProstateOncologyISH/FISH, Multiplex IHCHALO
Upfront FOLFOXIRI plus bevacizumab with or without atezolizumab in the treatment of patients with metastatic colorectal cancer (AtezoTRIBE): a multicentre, open-label, randomised, controlled, phase 2 trialAntoniotti C, Rossini D, Pietrantonio F, Catteau A, Salvatore L, Lonardi S, Boquet I, Tamberi S, Marmorino F, Moretto R, Ambrosini M, Tamburini E, Tortora G, Passardi A, Bergamo F, Kassambara A, Sbarrato T, Morano F, Ritorto G, Borelli B, Boccaccino A, Conca V, Giordano M, Ugolini C, Fieschi J, Papadopulos A, Massoue C, Aprile G, Antonyzzo L, Gelsomino F, Martinelli E, Pella N, Masi G, Fontanini G, Boni L, Galon J, Cremolini C2022The Lancet OncologyOncologyMultiplex IHC, Spatial AnalysisHALO
NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancerSalome B, Sfakianos J, Ranti D, Daza J, Bieber C, Charap A, Hammer C, Banchereau R, Farkas A, Ruan D, Izadmehr S, Geanon D, Kelly G, Real R, Lee B, Beaumont K, Shroff S, Wang Y, Wang Y, Thin T, Garcia-Barros M, Hegewisch-Solloa E, Mace E, Wang L, O'Donnell T, Chowell D, Fernandez-Rodriguez R, Skobe M, Taylor N, Kim-Schulze S, Sebra R, Palmer D, Clancy-Thompson E, Hammond S, Kamphorst A, Malmberg K, Marcenaro E, Romero P, Brody R, Viard M, Yuki Y, Martin M, Carrington M, Mehrazin R, Wilund P, Mellman I, Mariathasan S, Zhu J, Galsky M, Bhardwaj N, Horowitz A2022Cancer CellOncology, Immuno-oncologyClassifier, Multiplex IHCHALO, HALO AI
Ghrelin May Inhibit Inflammatory Response and Apoptosis During Ischemia-Reperfusion InjuryFukunaga N, Ribeiro R, Bissoondath V, Billia F, Rao V2022Transplantation ProceedingsOtherMultiplex IHCHALO
Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicantsJardi F, Kelly C, Teague C, Fowler-Williams H, Sevin D, Rodrigues D, Jo H, Ferreira S, Herpers B, Van Heerden M, de Kok T, Pin C, Lynch A, Duckworth C, De Jonghe S, Lammens L, Pritchard D2022Archives of ToxicologyToxicologyMultiplex IHCHALO
Defactinib, pembrolizumab, and gemcitabine in patients with advanced treatment refractory pancreatic cancer: A phase I, dose escalation, and expansion studyWang-Gillam A, Lim K, McWilliams R, Suresh R, Lockhart A, Brown A, Breden M, Belle J, Herndon J, Bogner S, Pedersen K, Tan B, Boice N, Acharya A, Abdiannia M, Gao F, Yoon H, Zhu M, Trikalinos N, Ratner L, Aranha O, Hawkins W, Herzog B, DeNardo D2022Clinical Cancer ResearchImmuno-oncologyMultiplex IHC, Spatial AnalysisHALO
Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorptionLi M, Yang D, Yan H, Tang Z, Jiang D, Zhang J, Chi Z, Nie W, Zhen W, Yu W, Chen S, Wang Z, Yu Q, Zhang X, Yang F, Fan S, Lin X, Wang D2022Developmental CellOtherArea Quantification, Multiplex IHCHALO
Th1-involved immune infiltrates improve neoadjuvant chemoradiotherapy response of esophageal squamous cell carcinomaYuan J, Weng Z, Tan Z, Luo K, Zhong J, Xie X, Qu C, Lin X, Yang H, Wen J, Fu J2022Cancer LettersImmuno-oncologyMultiplex IHC, Spatial AnalysisHALO
Oct4 promoted proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in colon cancer cells by activating the SCF/c-Kit signaling pathwayBu X, Liu Y, Wang L, Yan Z, Xin G, Su W2022Cell CycleOncologyMultiplex IHCHALO
The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signalingZhang B, Liu Q, Wen W, Gao H, Wei W, Tang A, Qin B, Lyu H, Meng X, Li K, Jin H, Yu F, Pan Q Lin J, Lee M2022Cell DiscoveryOncologyMultiplex IHC, TMAHALO
Identification and validation of DPY30 as a prognostic biomarker and tumor immune microenvironment infiltration characterization in esophageal cancerMei P, Xiao H, Guo Q, Meng W, Wang M, Huang Q, Liao Y2022Oncology LettersOncologyMultiplex IHCHALO
Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infectionVaca G, Meyer M, Cadete A, Hsiao C, Golding A, Jeon A, Jacquinet E, Azcue E, Guan C, Sanchez-Felix X, Pietzsch C, Mire C, Hyde M, Comeaux M, Williams J, Sung J, Carfi A, Edwards D, Bukreyev A, Bahl K2023bioRxivInfectious DiseaseMultiplex IHCHALO
Prognostic Value of CD8+ Lymphocytes in Hepatocellular Carcinoma and Perineoplastic Parenchyma Assessed by Interface Density Profiles in Liver Resection SamplesStulpinas R, Zilenaite-Petrulaitiene D, Rasmusson A, Gulla A, Grigonyte A, Strupas K, Laurinavicius A2023CancersOncologyMultiplex IHC, HALO AIHALO, HALO AI
In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinomaTaniguchi S, Matsui T, Kimura K, Funaki S, Miyamoto Y, Uchida Y, Sudo T, Kikuta J, Hara T, Motooka D, Liu Y-C, Okuzaki D, Morii E, Emoto N, Shintani Y, Ishii M2023Nature CommunicationsImmuno-oncologyMultiplex IHCHALO
Pretreatment with 3-methyladenine ameliorated Pseudomonas aeruginosa-induced acute pneumonia by inhibiting cell death of neutrophils in a mouse infection modelYue L, Qi J, Yuan J, Wang X, Wang Y, Shan B, Ke H, Li H, Luan N, Liu C2023International Journal of Medical MicrobiologyInfectious DiseaseMultiplex IHCHALO
Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitorsChen F, Byrd A, Liu J, Flight R, DuCote T, Naughton K, Song X, Edgin A, Lukyanchuk A, Dixon D, Gosser C, Esoe D-P, Jayswal R, Orkin S, Moseley H, Wang C, Brainson C2023Nature CommunicationsOncologyMultiplex IHC, HALO AIHALO, HALO AI
Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistanceThatikonda V, Lu H, Jurado S, Kostyrko K, Bristow C, Bosch K, Feng N, Gao S, Gerlach D, Gmachi M, Lieb S, Jeschko A, Machado A, Marszalek E, Mahendra M, Jaeger P, Sorokin A, Strauss S, Trapani F, Kopetz S, Vellano C, Petronczki M, Kraut N, Heffernan T, Marszalek J, Pearson M, Waizenegger I, Hofmann M2023bioRxivOncologyISH/FISH, Multiplex IHC, Highplex FL, Figure MakerHALO
APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitorsZong C, Zhang Z, Gao L, He J, Wang Y, Li Q, Liu X, Yang J, Chen D, Huang R, Zheng G, Jin X, Wei W, Jia R, Shen J2023Research SquareOncologyMultiplex IHCHALO
Nucleolin mediates SARS-CoV-2 replication and viral-induced apoptosis of host cellsMerino V, Yan Y, Ordonez A, Bullen C, Lee A, Saeki H, Ray K, Huang T, Jain S, Pomper M2023Antiviral ResearchInfectious DiseaseArea Quantification, Multiplex IHCHALO
CD8+ Cell Density Gradient across the Tumor Epithelium–Stromal Interface of Non-Muscle Invasive Papillary Urothelial Carcinoma Predicts Recurrence-Free Survival after BCG ImmunotherapyDrachneris J, Rasmusson A, Morkunas M, Fabijonavicius M, Cekauskas A, Jankevicius F, Laurinavicius A2023CancersImmuno-oncologyMultiplex IHC, Spatial Analysis, HALO AIHALO
IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activationChao H, Zheng L, Hsu P, He J, Wu R, Xu S, Zeng R, Zhou Y, Ma H, Liu H, Tang Q2023JCI InsightFibrosisMultiplex IHCHALO
Oncolytic BHV-1 Is Sufficient to Induce Immunogenic Cell Death and Synergizes with Low-Dose Chemotherapy to Dampen Immunosuppressive T Regulatory CellsDavola M, Cormier O, Vito A, El-Sayes N, Collins S, Salem O, Revill S, Ask K, Wan Y, Mossman K2023CancersOncologyMultiplex IHCHALO
Synergistic therapeutic combination with a CAF inhibitor enhances CAR-NK-mediated cytotoxicity via reduction of CAF-released IL-6Lee Y, Go G, Koh E, Yoon H, Seo M, Hong S, Jeong J, Kim J, Cho D, Kim T, Kim S, Jun E, Jang M2023Journal for ImmunoTherapy of CancerImmuno-oncologyArea Quantification, Multiplex IHCHALO
Pan-tumor T-lymphocyte detection using deep neural networks: Recommendations for transfer learning in immunohistochemistryWilm F, Ihling C, Méhes G, Terracciano L, Puget C, Klopfleisch R, Schüffler P, Aubreville M, Maier A, Mrowiec T, Breininger K2023Journal of Pathology InformaticsOncologyMultiplex IHCHALO, HALO AI
Radiation-induced persistent DNA damage response and late toxicity in cardiac tissueShigemori K, Jiang Y, Martin J, Hawkins M, Ryan A, Parkes E2023bioRxivOtherMultiplex IHCHALO, HALO AI
Single-cell analysis reveals changes in BCG vaccine-injected mice modeling tuberculous meningitis brain infectionZhang X, Zhao Z, Wu Q, Wang L, Li L, Wang M, Ren Y, Pan L, Tang H, Li F2023Cell ReportsInfectious DiseaseMultiplex IHC, Highplex FLHALO
Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancerBrahim S, Negulescu A, Geneste C, Schott T, Lin S, Morel L, Rama N, Gadot N, Treilleux I, Mehlen P, Meurette O2023Cell Death & DiseaseOncologyMultiplex IHCHALO
Electroacupuncture Zusanli (ST36) Relieves Somatic Pain in Colitis Rats by Inhibiting Dorsal Root Ganglion Sympathetic-Sensory Coupling and Neurogenic InflammationWang Y, Zhu H, Lv X, Ren X, Peng Y, Qu J, Shen X, Sun R, Xiao M, Zhang H, Chen Z, Cong P2023Neural PlasticityNeuroscienceMultiplex IHCHALO
Myeloid-specific deletion of activating transcription factor 6 alpha increases CD11b+ macrophage subpopulations and aggravates lung fibrosisMekhael O, Revill S, Hayat A, Cass S, MacDonald K, Vierhout M, Ayoub A, Reihani A, Padwal M, Imani J, Ayaub E, Yousof T, Dvorkin-Gheva A, Rullo A, Hirota J, Richards C, Bridgewater D, Stämpfli M, Hambly N, Naqvi A, Kolb M, Ask K2023Immunology and Cell BiologyImmunology, FibrosisClassifier, Area Quantification, FISH, Multiplex IHCHALO
Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasionJeong Y, Knutsdottir H, Shojaeian F, Lerner M, Wissler M, Henriet E, Ng T, Datta S, Navarro-Serer B, Chianchiano P, Kinny-Koster B, Zimmerman J, Stein-O'Brien G, Gaida M, Eshleman J, Lin M, Fertig E, Ewald A, Bader J, Wood L2023The Journal of Clinical InvestigationOncologyMultiplex IHCHALO
Free fatty acids induce coronary microvascular dysfunction via inhibition of the AMPK/KLF2/eNOS signaling pathwayZhang Y, Zhao J, Ren C, Hu B, Ding R, He Z, Liang C2023International Journal of Molecular MedicineOtherMultiplex IHCHALO
Loss of Peroxiredoxin IV Protects Mice from Azoxymethane/Dextran Sulfate Sodium-Induced Colorectal Cancer DevelopmentThapa P, Jiang H, Ding N, Hao Y, Alshahrani A, Lee E, Fujii J, Wei Q2023AntioxidantsOncologyMultiplex IHC, Highplex FLHALO
Cellular mechanisms of heterogeneity in NF2-mutant schwannomaChiasson-MacKenzie C, Vitte J, Liu C, Wright E, Flynn E, Stott S, Giovannini M, McClatchey A2023Nature CommunicationsOncologyClassifier, Multiplex IHC, Spatial Analysis, FISH-IFHALO
Immune and pathologic responses in patients with localized prostate cancer who received daratumumab (anti-CD38) or edicotinib (CSF-1R inhibitor) Siddiqui B, Chapin B, Jindal S, Duan F, Basu S, Yadav S, Gu A, Espejo A, Kinder M, Pettaway C, Ward J, Tidwell R, Troncoso P, Corn P, Logothetis C, Knoblauch R, Hutnick N, Gottardis M, Drake C, Sharma P, Subudhi S2023Journal for ImmunoTherapy of CancerImmuno-oncologyMultiplex IHC, Figure MakerHALO
YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cellsBai Y, Gotz C, Chincarini G, Zhao Z, Slaney C, Boath J, Furic L, Angel C, Jane S, Phillips W, Stacker S, Farah C, Darido C2023Nature CommunicationsOncologyClassifier, Multiplex IHCHALO
HX009, a novel BsAb dual targeting PD1 x CD47, demonstrates potent anti-lymphoma activity in preclinical modelsKe H, Zhang F, Wang J, Xiong L, An X, Tu X, Chen C, Wang Y, Mao B, Guo S, Ju C, He X, Sun R, Zhang L, O'Connor O, Li Q2023Scientific ReportsImmuno-oncologyMultiplex IHCHALO
Prognostic value of tumor immune microenvironment factors in patients with stage I lung adenocarcinomaXue Q, Wang Y, Zheng Q, Chen L, Lin Y, Jin Y, Shen X, Li Y2023American Journal of Cancer ResearchOncologyClassifier, Multiplex IHC, Highplex FLHALO
An Immune-Related Gene Expression Signature Predicts Benefit from Adding Atezolizumab to FOLFOXIRI plus Bevacizumab in Metastatic Colorectal CancerAntoniotti C, Boccaccino A, Seitz R, Giordano M, Catteau A, Rossini D, Pietrantonio F, Salvatore L, McGregor K, Bergamo F, Conca V, Leonetti S, Morano F, Papiani G, Tamburini E, Bensi M, Murgioni S, Ross D, Passardi A, Boquet I, Nielsen T, Galon J, Varga M, Schweitzer B, and Cremolini C2023Clinical Cancer ResearchImmuno-oncologyMultiplex IHC, Spatial AnalysisHALO
Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancerWang F, Long J, Li L, Wu Z, Da T, Wang X, Huang C, Jiang Y, Yao X, Ma H, Lian Z, Zhao Z, Cao J2023Science AdvancesOncologyMultiplex IHC, Spatial Analysis, Highplex FLHALO
Dissecting tumor lymphocyte infiltration to predict benefit from immune-checkpoint inhibitors in metastatic colorectal cancer: lessons from the AtezoTRIBE studyMoretto R, Rossini D, Catteau A, Antoniotti C, Giordano M, Boccaccino A, Ugolini C, Proietti A, Conca V, Kassambara A, Pietrantonio F, Salvatore L, Lonardi S, Tamberi S, Tamburini E, Poma A, Fieschi J, Fontanini G, Masi G, Galon J, Cremolini C2023Journal for ImmunoTherapy of CancerImmuno-oncologyMultiplex IHC, Spatial AnalysisHALO
Transcriptional-translational conflict is a barrier to cellular transformation and cancer progressionJana S, Brahma S, Arora S, Wladyka C, Hoang P, Blinka S, Hough R, Horn J, Liu Y, Wang L, Depeille P, Smith E, Montgomery R, Lee J, Haffner M, Vakar-Lopez F, Grivas P, Wright J, Lam H, Black P, Roose J, Ryazanov A, Subramaniam A, Henikoff S, and Hsieh A2023Cancer CellOncologyMultiplex IHC, Highplex FLHALO
Phase I/II sequencing study of azacitidine, epacadostat, and pembrolizumab in advanced solid tumorsLuke J, Fakih M, Schneider C, Chiorean E, Bendell J, Kristeleit R, Kurzrock R, Blagden S, Brana I, Goff L, O'Hayer K, Geschwindt R, Smith M, Zhou F, Naing A2023British Journal of CancerImmuno-oncologyMultiplex IHCHALO
Targeting DRP1 mediated mitochondrial metabolism as a novel treatment strategy for triple negative breast cancer (TNBC)Wang Y, Harada-Shoji N, Kitamura N, Yamazaki Y, Ebata A, Amari M, Watanabe M, Miyashita M, Tada H, Abe T, Suzuki T, Gonda K, Ishida T2023Research SquareOncologyMultiplex IHCHALO
Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosisConroy L, Clarke H, Allison D, Valenca S, Sun Q, Hawkinson T, Young L, Ferreira J, Hammonds A, Dunne J, McDonald R, Absher K, Dong B, Bruntz R, Markussen K, Juras J, Alilain W, Liu J, Gentry M, Angel P, Waters C, Sun R2023Nature CommunicationsFibrosisMultiplex IHC, Highplex FLHALO
Induction of cancer neoantigens facilitates development of clinically relevant models for the study of pancreatic cancer immunobiologyPanni U, Chen M, Zhang F, Cullinan D, Li L, James C, Zhang X, Rogers S, Alarcon A, Baer JM, Zhang D, Gao F, Miller CA, Gong Q, Lim KH, DeNardo DG, Goedegebuure SP, Gillanders WE, and Hawkins WG2023Cancer Immunology, ImmunotherapyImmuno-oncologyMultiplex IHCHALO
Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trialNassiri F, Patil V, Yefet L, Singh O, Liu J, Dang R, Yamaguchi T, Daras M, Cloughesy T, Colman H, Kumthekar P, Chen C, Aiken R, Groves M, Ong S, Ramakrishna R, Vogelbaum M, Khagi S, Kaley T, Melear J, Peereboom D, Rodriguez A, Yankelevich M, Nair S, Puduvalli V, Aldape K, Gao A, López-Janeiro Á, de Andrea C, Alonso M, Boutros P, Robbins J, Mason W, Sonabend A, Stupp R, Fueyo J, Gomez-Manzano C, Lang F, Zadeh G2023Nature MedicineImmuno-oncologyMultiplex IHCHALO
Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E-based Antibody-Drug Conjugate for treatment of Nectin-4-expressing Cancers Zhou W, Fang P, Yu D, Ren H, You M, Yin L, Mei F, Zhu H, Wang Z, Xu H, Cao Y, Sun X, Xu X, Bi J, Wang J, Ma L, Wang X, Chen L, Zhang Y, Cen X, Zhu X, Lou L, Liu D, Tan X, Yang J, Meng T, Shen J2023Molecular Cancer TherapeuticsOncologyMultiplex IHCHALO
Tumor-derived semaphorin 4A improves PD-1–blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferationNAITO Y, KOYAMA S, MASUHIRO K, HIRAI T, UENAMI T, INOUE T, OSA A, MACHIYAMA H, WATANABE G, SAX N, VILLA J, KINUGASA-KATAYAMA Y, NOJIMA S, YAGA M, HOSONO Y, OKUZAKI D, SATOH S, TSUDA T, NAKANISHI Y, SUGA Y, MORITA T, FUKUSHIMA K, NISHIDE M, SHIROYAMA T, MIYAKE K, IWAHORI K, HIRATA H, NAGATOMO I, YANO Y, TAMIYA M, KUMAGAI T, TAKEMOTO N, INOHARA H, YAMASAKI S, YAMASHITA K, AOSHI T, AKBAY E, HOSEN N, SHINTANI Y, TAKAMATSU H, MORI M, TAKEDA Y, KUMANOGOH A2023Science AdvancesImmuno-oncologyMultiplex IHC, Highplex FLHALO
SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties Warren M, Matissek S, Rausch M, Panduro M, Hall R, Dulak A, Brennan D, Das Yekkirala S, Koseoglu S, Masia R, Yang Y, Reddy N, Prenovitz R, Strand J, Zaidi T, Devereaux E, Jacoberger Foissac C, Stagg J, Lee B, Holland P, Palombella V, Lake A2023ImmunoHorizonsImmuno-oncologyClassifier, Area Quantification, Multiplex IHCHALO
Immunoscore immune checkpoint using spatial quantitative analysis of CD8 and PD-L1 markers is predictive of the efficacy of anti- PD1/PD-L1 immunotherapy in non-small cell lung cancerGhiringhelli F, Bibeau F, Greillier L, Fumet J, Ilie A, Monville F, Laugé C, Catteau A, Boquet I, Majdi A, Morgand E, Oulkhouir Y, Brandone N, Adam J, Sbarrato T, Kassambara A, Fieschi J, Garcia S, Lepage A, Tomasini P, Galon J2023EBioMedicineImmuno-oncologyMultiplex IHC, Spatial AnalysisHALO
An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicityCheng L, Zhu M, Gao Y, Liu W, Yin W, Zhou P, Zhu Z, Niu L, Zeng X, Zhang D, Fang Q, Wang F, Zhao Q, Zhang Y, Shen G2023Cellular and Molecular Biology LettersImmuno-oncologyMultiplex IHC, Highplex FLHALO
Type III interferon inhibits bladder cancer progression by reprogramming macrophage-mediated phagocytosis and orchestrating effective immune responsesWang B, Zhou B, Chen J, Sun X, Yang W, Yang T, Yu H, Chen P, Chen K, Huang X, Fan X, He W, Huang J, Lin T2023Research SquareImmuno-oncologyMultiplex IHCHALO, HALO AI
Detection of virus in colorectal cancer and the tumor immune microenvironment in EBV-associated colorectal cancerLv D, Zuo Y, Bibi A, Meng T, Xu Y2023Research SquareOncology, Infectious DiseaseMultiplex IHCHALO
Effects of a long-acting secretin peptide analog alone and in combination with a GLP-1R agonist in a diet-induced obesity mouse modelLoeffler M, Klepac K, Baljuls A, Hamilton B, Mayer-Wrangowski S, Haebel P, Zimmermann T2023Molecular MetabolismMetabolismMultiplex IHCHALO
Endosomal Escape Vehicle Platform Enhances the Delivery of Oligonucleotides in Preclinical Models of Neuromuscular DisordersLi X, Kheirabadi M, Dougherty P, Kamer K, Shen X, Estrella N, Peddigari S, Pathak A, Blake S, Sizensky E, del Genio C, Gaur A, Dhanabal M, Girgenrath M, Sethuraman N, Qian Z2023Molecular Therapy: Nucleic AcidNeuroscienceMultiplex IHCHALO
Endocrine therapy synergizes with SMAC mimetics to potentiate antigen presentation and tumor regression in hormone receptor-positive breast cancer Hermida-Prado F, Xie Y, Sherman S, Nagy Z, Russo D, Akhshi T, Chu Z, Feit A, Campisi M, Chen M, Nardone A, Guarducci C, Lim K, Font-Tello A, Lee I, García-Pedrero J, Canadas I, Agudo J, Huang Y, Sella T, Jin Q, Tayob N, Mittendorf E, Tolaney S, Qiu X, Long H, Symmans W, Lin J, Santagata S, Bedrosian I, Yardley D, Mayer I, Richardson E, Oliveira G, Wu C, Schuster E, Dowsett M, Welm A, Barbie D, Metzger O, Jeselsohn R2023Cancer ResearchOncologyMultiplex IHCHALO
Unbiased differential proteomic profiling between cancerassociated fibroblasts and cancer cell linesLau R, Yu L, Roumeliotis T, Stewart A, Pickard L, Riisanes R, Gurel B, de Bono J, Choudhary J, Banerji U2023Journal of ProteomicsOncologyMultiplex IHCHALO
Absence of sympathetic innervation hampers the generation of tertiary lymphoid structures upon acute lung inflammationRiffard C, Letaïef L, Azar S, Casrouge A, Brunet I, Teillaud JL, Dieu-Nosjean MC2023Research SquareImmunologyMultiplex IHCHALO, HALO AI
GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferationShinzawa K, Matsumoto S, Sada R, Harada A, Saitoh K, Kato K, Ikeda S, Hirayama A, Yokoi K, Tanemura A, Nimura K, Ikawa M, Soga T, Kikuchi A2023OncogeneOncologyMultiplex IHCHALO
Intratumoral Heterogeneity of Ki67 Proliferation Index Outperforms Conventional Prognostic Factors in Hormone Receptor-Positive Breast CancerZilenaite-Petrulaitiene D, Rasmusson A, Besusparis J, Valkiuniene R, Augulis R, Laurinaviciene A, Plancoulaine B, Petkevicius L, Laurinavicius A2023Research SquareOncologyMultiplex IHC, Figure MakerHALO, HALO AI
Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer Quan Y, He J, Zou Q, Zhang L, Sun Q, Huang H, Li W, Xie K, Wie F2023Journal for ImmunoTherapy of CancerImmuno-oncologyClassifier, Multiplex IHC, Highplex FLHALO
Neoadjuvant palbociclib plus either giredestrant or anastrozole in oestrogen receptor-positive, HER2-negative, early breast cancer (coopERA Breast Cancer): an open-label, randomised, controlled, phase 2 studyHurvitz SA, Bardia A, Quiroga V, Park YH, Blancas I, Alonso-Romero JL, Vasiliev A, Adamchuk H, Salgado M, Yardley DA, Berzoy O, Zamora-Auñón P, Chan D, Spera G, Xue C, Ferreira E, Badovinac Crnjevic T, Pérez-Moreno PD, López-Valverde V, Steinseifer J, Fernando TM, Moore HM, Fasching PA, on behalf of the coopERA Breast Cancer study group2023The Lancet OncologyOncologyMultiplex IHCHALO
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancerBhin J, Yemelyanenko J, Chao X, Klarenbeek S, Opdam M, Malka Y, Hoekman L, Kruger D, Bleijerveld O, Brambillasca CS, Sprengers J, Siteur B, Annunziato S, van Haren MJ, Martin NI, van de Ven M, Peters D, Agami R, Linn SC, Boven E, Altelaar M, Jonkers J, Zingg D, Wessels LFA2023Journal of Experimental MedicineOncologyMultiplex IHCHALO
Pan-Cancer Analysis Revealed ITM2A as a Predictive Biomarker of Prognosis and Immunotherapy for Kidney Renal Clear Cell CarcinomaZhang H, Fang J, Ruan R, Yu J, Wang S2023Research SquareOncologyMultiplex IHCHALO
Pathologist-Trained Machine Learning Classifiers Developed to Quantitate Celiac Disease Features Differentiate Endoscopic Biopsies According to Modified Marsh Score and Dietary Intervention ResponseGruver A, Lu H, Zhao X, Fulford A, Soper M, Ballard D, Hanson J, Schade A, His E, Gottlieb K. Credille K2023Research SquareGastroenterologyMultiplex IHCHALO, HALO AI
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in miceLi L, Guo C, Yu Y, Tie L, Lu G, Liu F, Han X, Ji L, Zou X2023Cell & BioscienceMetabolismArea Quantification, Multiplex IHCHALO
Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding areaKawamura I, Ohe R, Suzuki K, Kabasawa T, Kitoaka T, Takahara D, Kono M, Uchiyama N, Musha H, Futakuchi M, Motoi F2023Research SquareImmuno-oncologyMultiplex IHC, Spatial AnalysisHALO
Evaluation of the efficacy of Abelmoschus manihot (L.) on diabetic nephropathy by analyzing biomarkers in the glomeruli and proximal and distal convoluted tubules of the kidneysYu H, Wang M, Yu J, Tang H, Xu Q, Cheng N, Luo X, Wang Y, Ge H, Qiang L, Tang W, Gu H2023Frontiers in PharmacologyGastroenterologyMultiplex IHCHALO
Immune response after pig-to-human kidney xenotransplantation: a multimodal phenotyping studyLoupy A, Goutaudier V, Giarraputo A, Mezine F, Morgand E, Robin B, Khalil K, Mehta S, Keating B, Dandro A, Certain A, Tharaux PL, Narula N, Tissier R, Giraud S, Hauet T, Pass HI, Sannier A, Wu M, Griesemer A, Ayares D, Tatapudi V, Stern J, Lefaucheur C, Bruneval P, Mangiola M, Montgomery RA2023The LancetImmunologyMultiplex IHCHALO, HALO AI
A novel 4-1BB/HER2 bispecific antibody shows potent antitumor activities by increasing and activating tumor-infiltrating T cellsShen A, Liu W, Wang H, Zeng X, Wang M, Zhang D, Zhao Q, Fang Q, Wang F, Cheng L, Shen G, Li Y2023American Journal of Cancer ResearchImmuno-oncologyMultiplex IHCHALO
Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical modelsHopcroft L, Wigmore EM, Williamson SC, Ros S, Eberlein C, Moss JI, Urosevic J, Carnevalli LS, Talbot S, Bradshaw L, Blaker C, Gunda S, Owenson V, Hoffmann S, Sutton D, Jones S, Goodwin RJAG, Willis BS, Rooney C, DeBruin E, Barry ST2023npj Breast CancerOncologyMultiplex IHCHALO, HALO AI
Macrophage reprogramming—rather than depletion —is efficacious in a specific subset of colorectal tumor modelsMohamed N, Amirkhah R, Lavaud X, Gilroy K, Bartolini R, Mulholland E, Garg A, Pennel K, Jackstadt R, Ridgway R, Nixon C, Hatthakarnku P, Campbell A, Leedham S, Edwards J, Dunne P, Barry S, Graham G, Sansom O2023Research SquareImmuno-oncologyMultiplex IHC, Highplex FLHALO
Early Detection of Genotoxic Hepatocarcinogens in Rats Using γH2AX and Ki-67: Prediction by Machine LearningMichiba A, Gi M, Yokohira M, Sakurai E, Teramoto A, Kiriyama Y, Yamada S, Wanibuchi H, Tsukamoto T2023Toxicological SciencesOncologyMultiplex IHC, Highplex FLHALO
Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancerCassier PA, Navaridas R, Bellina M, Rama N, Ducarouge B, Hernandez-Vargas H, Delord JP, Lengrand J, Paradisi A, Fattet L, Garin G, Gheit H, Dalban C, Pastushenko I, Neves D, Jelin R, Gadot N, Braissand N, Léon S, Degletagne C, Matias-Guiu X, Devouassoux-Shisheboran M, Mery-Lamarche EM, Allard J, Zindy E, Decaestecker C, Salmon I, Perol D, Dolcet X, Ray-Coquard I, Blanpain C, Bernet A, Mehlen P2023NatureOncologyMultiplex IHCHALO
Feasibility and Impact of Immunohistochemistry-based Molecular Subtyping for Muscle-invasive Bladder Cancer in Patients Treated with Radiation-based TherapyHesswani C, Jackson CL, Marcq G, Hardy C, Kool R, Mansure JJ, Brimo F, Berman DM, Kassouf W2023European Urology Open ScienceOncologyMultiplex IHCHALO
A TIAM1- TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cellsGinn L, Maltas J, Baker MJ, Chaturvedi A, Wilson L, Guilbert R, Amaral FMR, Priest L, Mole H, Blackhall F, Diamantopoulou Z, Somervaille TCP, Hurlstone A, Mallairi A2023Proceedings of the National Academy of SciencesOncologyMultiplex IHCHALO
Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stabilityBenabdallah NS, Dalal V, Scott RW, Marcous F, Sotiriou A, Kommoss FKF, Pejkovska A, Gaspar L, Wagner L, Sánchez-Rivera FJ, Ta M, Thornton S, Nielsen TO, Underhill TM, Banito A2023Nature Structural & Molecular BiologyOncologyMultiplex IHC, TMAHALO, HALO AI
Effects and Mechanisms of the Subtypes of Apolipoprotein E to the Immune State and Prognosis of hepatocellular carcinoma patientsGao B, Zhou P, Wang L, Wang Z, Yi Y, Zhou J, Fan J, Qiu S, Xu Y2023Research SquareImmuno-oncologyMultiplex IHC, Highplex FLHALO
HER2-Selective and Reversible Tyrosine Kinase Inhibitor Tucatinib Potentiates the Activity of T-DM1 in Preclinical Models of HER2-positive Breast Cancer Olson D, Taylor J, Willis K, Hensley K, Allred S, Zaval M, Farr L, Thurman R, Jain N, Hein R, Ulrich M, Peterson S, Kulukian A2023Cancer Research CommunicationsOncologyClassifier, Multiplex IHCHALO
Icariside II potentiates the anti-PD-1 antitumor effect by reducing chemotactic infiltration of myeloid-derived suppressor cells into the tumor microenvironment via ROS-mediated inactivation of the SRC/ERK/STAT3 signaling pathwaysKong Q, Ma M, Zhang L, Liu S, He S, Wu J, Liu B, Dong J2023PhytomedicineImmuno-oncologyMultiplex IHCHALO
Establishment of reference intervals of endometrial immune cells during the mid-luteal phaseYu S, Huang C, Lian R, Diao L, Zhang X, Cai S, Wei H, Chen C, Li Y, Zeng Y2023Journal of Reproductive ImmunologyImmunologyClassifier, Multiplex IHCHALO
Anticoagulants Enhance Molecular and Cellular Immunotherapy of Cancer by Improving Tumor Microcirculation Structure and Function and Redistributing Tumor InfiltratesWei F, Su Y, Quan Y, Li X, Zou Q, Zhang L, Li S, Jiang M, Lin G, Liang P, He J, Xie K2023Clinical Cancer ResearchImmuno-oncologyClassifier, Multiplex IHC, Spatial Analysis, Highplex FLHALO
Apolipoprotein A-IV of diabetic-foot patients upregulates tumor necrosis factor α expression in microfluidic arterial modelsJi J, Zhao X, Huang J, Wu X, Xie F, Li L, Wang T, Mi S2023Experimental Biology and MedicineOtherMultiplex IHCHALO
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progressionQiu S, Zhong X, Meng X, Li S, Qian X, Lu H, Cai J, Zhang Y, Wang M, Ye Z, Zhang H, Gao P2023Cell ResearchOncologyMultiplex IHCHALO
Spatial mapping reveals granuloma diversity and histopathological superstructure in human tuberculosisSawyer A, Patrick E, Edwards J, Wilmott J, Fielder T, Yang Q, Barber D, Ernst J, Britton W, Palendira U, Chen X, Feng C2023Journal of Experimental MedicineImmunologyMultiplex IHC, Spatial Analysis, Highplex FLHALO
Targeting the IL1β Pathway for Cancer Immunotherapy Remodels the Tumor Microenvironment and Enhances Antitumor Immune ResponsesDiwanji R, O'Brien N, Choi J, Nguyen B, Laszewski T, Grauel A, Yan Z, Xu X, Wu J, Ruddy D, Piquet M, Pelletier M, Savchenko A, Charette L, Rodrik-Outmezguine V, Baum J, Millholland J, Wong C, Martin A, Dranoff G, Pruteanu-Malinici I, Cremasco V, Sabatos-Peyton C, Jayaraman P2023Cancer Immunology ResearchImmuno-oncologyMultiplex IHCHALO
Spinal Cord Stimulation Increases Chemoefficacy and Prevents Paclitaxel-Induced Pain via CX3CL1Sivanesan E, Sanchez K, Zhang C, He S, Linderoth B, Stephens K, Raja S, Guan Y2023Neuromodulation: Technology at the Neural InterfaceOncologyMultiplex IHCHALO
DNA Damage-Induced, S-Phase Specific Phosphorylation of Orc6 is Critical for the Maintenance of Genome StabilityLin Y, Liu D, Chakraborty A, Macias V, Brister E, Sonalkar J, Shen L, Mitra J, Ha T, Kajdacsy-Balla A, Prasanth K, Prasanth S2023Molecular and cellular biologyOtherMultiplex IHCHALO, HALO AI
Using artificial intelligence to identify tumor microenvironment heterogeneity in non-small cell lung cancersDuCote T, Naughton K, Skaggs E, Bocklage T, Allison D, Brainson C2023Laboratory InvestigationOncologyMultiplex IHCHALO, HALO AI
Whole-Slide Imaging, Mutual Information Registration for Multiplex Immunohistochemistry and ImmunofluorescenceDoyle J, Green B, Eminizer M, Jimenez-Sanchez D, Lu S, Engle E, Xu H, Ogurtsova A, Lai J, Soto-Diaz S, Roskes J, Deutsch J, Taube J, Sunshine J, Szalay A2023Laboratory InvestigationOtherMultiplex IHC, RegistrationHALO
Inhibiting membrane rupture with NINJ1 antibodies limits tissue injuryKayagaki N, Stowe I, Alegre K, Deshpande I, Wu S, Lin Z, Kornfeld O, Lee B, Zhang J, Liu J, Suto E, Lee W, Schneider K, Lin W, Seshasayee D, Bhangale T, Chalouni C, Johnson M, Joshi P, Mossemann J, Zhao S, Ali D, Goldenberg N, Sayed B, Steinberg B, Newton K, Webster J, Kelly R, Dixit V2023NatureOtherMultiplex IHCHALO, HALO AI
Nicotinamide N-methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancerPinto Couto J, Vulin M, Jehanno C, Coissieux M, Hamelin B, Schmidt A, Ivanek R, Sethi A, Bräutigam K, Frei A, Hager C, Manivannan M, Gómez-Miragaya J, Obradović M, Varga Z, Koelzer V, Mertz K, Bentires-Alj M2023The EMBO JournalOncologyArea Quantification, Multiplex IHCHALO, HALO AI
The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatmentLv J, Wei Y, Yin J, Chen Y, Zhou G, Wei C, Liang X, Zhang Y, Zhang C, He S, He Q, Huang Z, Guan J, Shen J, Li X, Li J, Li W, Tang L, Mao Y, Guo R, Sun R, Zheng Y, Zhou W, Xiong K, Wang S, Jin X, Liu N, Li G, Kuang D, Sun Y, Ma J2023Nature MedicineOncologyMultiplex IHC, Highplex FLHALO
Immune profiling and RNA-seq uncover the cause of partial unexplained recurrent implantation failureFan X, Zhao Q, Li Y, Chen Z, Liao J, Chen H, Meng F, Lu G, Lin G, Gong F2023International ImmunopharmacologyImmunologyClassifier, Multiplex IHCHALO
Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progressionMacke A, Pachikov A, Divita T, Morris M, LaGrange C, Holzapfel M, Kubyshkin A, Zyablitskaya E, Makalish T, Eremenko S, Qiu H, Riethoven J, Hemstreet G, Petrosyan A2023Molecular Cancer ResearchOncologyClassifier, Area Quantification, Multiplex IHC, TMAHALO
Comparing the peri-implantation endometrial T-bet/GATA3 ratio between control fertile women and patients with recurrent miscarriage: establishment and application of a reference range Get access ArrowYu S, Diao L, Lian R, Chen C, Huang C, Li X, Li Y, Zeng Y2023Human ReproductionOtherClassifier, Multiplex IHCHALO
Jing-Fang powder ethyl acetate extracts attenuate atopic dermatitis by modulating T-cell activityZhao G, Tong Y, Xu J, Zhu W, Zeng J, Liu R, Luan F, Zeng N2023Molecular ImmunologyImmunology, DermatologyMultiplex IHCHALO
LY6E is a pan-coronavirus restriction factor in the respiratory tractMar K, Wells A, Van Dyke M, Lopez A, Eitson J, Fan W, Hanners N, Evers B, Shelton J, Schoggins J2023Nature MicrobiologyInfectious DiseaseMultiplex IHCHALO
Spatial Proximity and Relative Distribution of Tumor-Infiltrating Lymphocytes and Macrophages Predict Survival in MelanomaDe Logu F, Ugolini F, Iannone L F, Simi S, Maio V, de Giorgi V, di Giacomo A M, Miracco C, Cossu A, Palmieri G, Mandalà M, Massi D2023Laboratory InvestigationOncologyMultiplex IHC, Spatial AnalysisHALO, HALO Link
Concurrent targeting of HDAC and PI3K to overcome phenotypic heterogeneity of castration-resistant and neuroendocrine prostate cancersZhang A, Lau N, Wong A, Brown L, Coleman I, Sarkar N, Li D, DeLucia D, Labrecque M, Nguyen H, Conner J, Dumpit R, True L, Lin D, Corey E, Alumkal J, Nelson P, Morrissey C, Lee J2023Cancer Research CommunicationsOncologyMultiplex IHC, Figure MakerHALO
Deep radiomics-based fusion model for prediction of bevacizumab treatment response and outcome in patients with colorectal cancer liver metastases: a multicentre cohort studyZhou S, Sun D, Mao W, Liu Y, Cen W, Ye L, Liang F, Xu J, Shi H, Ji Y, Wang L, Chang W2023eClinicalMedicineOncologyClassifier, Multiplex IHCHALO
Inhibition of mitochondrial fission activates glycogen synthesis to support cell survival in colon cancerHasani S, Young LEA, Van Nort W, Banerjee M, Rivas DR, Kim J, Xiong X, Sun RC, Gentry MS, Sesaki H, Gao T2023Cell Death & DiseaseOncologyMultiplex IHCHALO
Histological spatial analysis on the induction of PD-L1+ macrophages by CD8+ T cells at the marginal microenvironment of triple-negative breast cancerSuzuki K, Ohe R, Kabasawa T, Kitaoka T, Kawai M, Motoi F, Futakuchi M2023Breast CancerOncologyMultiplex IHC, Spatial AnalysisHALO
Positive regulatory loop of platelet-derived growth factor DD-induced STAT3 activation is associated with poor prognosis in advanced urothelial carcinomaAndo K, Kurashina R, Motoi N, Iizuka T, Inoue M, Maruyama R, Mitani K, Takenobu H, Haruta M, Onuki R, Matsuoka Y, Kamijo T, Kageyama Y2023Biochemical and Biophysical Research CommunicationsOncologyMultiplex IHC, TMAHALO
Effect of microbial muramidase supplementation in diets formulated with different fiber profiles for broiler chickens raised under various coccidiosis management programsBortoluzzi C, Perez-Calvo E, Olsen P B, van der Vaart S, van Eerden E, Schmeisser J, Eising I, Segobola P, Sorbara J-O B2023Poultry ScienceInfectious DiseaseMultiplex IHCHALO
Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non-small cell lung cancerTerada Y, Isaka M, Ono A, Kawata T, Serizawa M, Mori K, Muramatsu K, Tone K, Kenmotsu H, Ohshima K, Urakami K, Nagashima T, Kusuhara M, Akiyama Y, Sugino T, Takahashi T, Ohde Y2023Cancer ReportsOncologyMultiplex IHCHALO
Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancersBiswas S, Mandal G, Anadon C M, Chaurio R A, Lopez-Bailon L U, Nagy M Z, Mine J A, Hanggi K, Sprenger K B, Innamarato P, Harro C M, Powers J J, Johnson J, Fang B, Eysha M, Nan X, Li R, Perez B A, Curiel T J, Yu X, Rodriguez P C, Conejo-Garcia J R2023ImmunityOncologyMultiplex IHCHALO
Comprehensive analysis reveals potential therapeutic targets and an integrated risk stratification model for solitary fibrous tumorsZhang R, Yang Y, Hu C, Huang M, Cen W, Ling D, Long Y, Yang X-H, Xu B, Peng J, Wang S, Zhu W, Wei M, Yang J, Xu Y, Zhang X, Ma J, Wang F, Zhang H, Ma P, Zhu X, Song G, Sun L-Y, Wang D-S, Wang F-H, Li Y-H, Santagata S, Li Q, Feng Y-F, Du Z2023Nature CommunicationsOncologyMultiplex IHCHALO
Effects of total flavones of Abelmoschus manihot (L.) on the treatment of diabetic nephropathy via the activation of solute carriers in renal tubular epithelial cellsYu H, Tang H, Wang M, Xu Q, Yu J, Ge H, Qiang L, Tang W, Gu HF2023Biomedicine & PharmacotherapyOtherMultiplex IHC, Figure MakerHALO
GRP78-CAR T cell effector function against solid and brain tumors is controlled by GRP78 expression on T cellsIbanez J, Hebbar N, Thanekar U, Yi Z, Houke H, Ward M, Nevitt C, Tian L, Mack SC, Sheppard H, Chiang J, Velasquez MP, Krenciute G2023Cell Reports MedicineImmuno-oncologyMultiplex IHCHALO
mRNA Vaccine Trafficking and Resulting Protein Expression After Intramuscular AdministrationHassett KJ, Rajilic IL, Bahl K, White R, Cowens K, Jacquinet E, Burke KE2023Molecular Therapy: Nucleic AcidOtherISH, Multiplex IHCHALO
Parishin treatment alleviates cardiac aging in naturally aged miceZhou S, Zhao X, Wu L, Yan R, Sun L, Zhang Q, Gong C, Liu Y, Xiang L, Li S, Wang P, Yang Y, Ren W, Jiang J, Yang Y2023HeliyonOtherArea Quantification, Multiplex IHCHALO
Expression and Correlation of Complement C3 and C4 in Serum and Maternal-Fetal Interface in Patients with Unexplained Recurrent Spontaneous Abortion: A Prospective Cohort StudyZhou Z, Xie H, Liu M, Li R, Jiang W, Zheng Y, Lv Q2023Clinical and Experimental Obstetrics & GynecologyOtherMultiplex IHCHALO
The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancerTaifour T, Attalla SS, Zuo D, Gu Y, Sanguin-Gendreau V, Proud H, Solymoss E, Bui T, Kuasne H, Papavasiliou V, Lee CG, Kamle S, Siegel PM, Elias JA, Park M, Muller WJ2023ImmunityImmuno-oncologyClassifier, Multiplex IHC, Spatial Analysis, Highplex FLHALO
Intratumoral aluminum hydroxide–anchored IL-12 drives potent antitumor activity by remodeling the tumor microenvironmentBattula S, Papastoitsis G, Kaufman HL, Wittrup KD, Schmidt MM2023JCI InsightOncologyMultiplex IHCHALO
CD15 Is a Risk Predictor and a Novel Target in Clear Cell Renal Cell CarcinomaStenzela PJ, Schindeldeckera MS, Seidmanna L, Herpel E, Hohenfellnere M, Hatiboglue G, Foerscha S, Porubskya S, Macher-Goeppingera S, Rotha W, Tagscherer KE2023PathobiologyOncologyMultiplex IHC, TMAHALO
Fusion-negative rhabdomyosarcoma 3D organoids to predict effective drug combinations: A proof-ofconcept on cell death inducersSavary C, Luciana L, Huchede´ P, Tourbez A, Coquet C, Broustal M, Gonzalez AL, Deligne C, Diot T, Naret O, Costa M, Meynard N, Barbet V, Muller K, Tonon L, Gadot N, Degletagne C, Attignon V, Le´on S, Vanbelle C, Bomane A, Rochet I, Mournetas V, Oliveira L, Rinaudo P, Bergeron C, Dutour A, Cordier-Bussat M, Roch A, Brandenberg N, El Zein S, Watson S, Orbach D, Delattre O, Dijoud F, Corradini N, Picard C, Maucort-Boulch D, Le Grand M, Pasquier E, Blay JY, Castets M, and Broutier L.2023Cell Reports MedicineOncologyMultiplex IHCHALO
RFX6 facilitates aerobic glycolysis‐mediated growth and metastasis of hepatocellular carcinoma through targeting PGAM1Qiu Z, Wang C, Huang P, Yuan Y, Shi Y, Lin Z, Huang Z, Zuo D, Qiu J, He W, Shen J, Niu Y, Yuan Y, Li B2023Clinical and Translational MedicineOncologyArea Quantification, Multiplex IHCHALO
Immune microenvironment of basal cell carcinoma and tumor regression following combined PD-1/LAG-3 blockadeDeutsch JS, Lai J, Schenk KM, Soni A, Will EM, Engle LL, Xu H, Ogurtsova A, Madan V, Chong JK, Wang D, Green BF, Nguyen P, Schollenberger MD, Lipson EJ, Taube JM2023Journal for ImmunoTherapy of CancerImmuno-oncologyMultiplex IHCHALO
Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinomaSun Y, Wu P, Zhang Z, Wang Z, Zhou K, Song M, Ji Y, Zang F, Lou L, Rao K, Wang P, Gu Y, Gu J, Lu B, Chen L, Pan X, Zhao X, Peng L, Liu D, Chen X, Wu K, Lin P, Wu L, Su Y, Du M, Hou Y, Yang X, Qiu S, Shi Y, Sun H, Zhou J, Huang X, Peng D, Zhang L, Fan J2023Cancer CellOncologyClassifier, Multiplex IHC, Spatial Analysis, Highplex FLHALO
Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non–small cell lung cancerHerzog B, Baer J, Borcherding N, Kingston N, Belle J, Knolhoff B, Hogg G, Ahmad F, Kang L, Petrone J, Lin C, Govindan R, Denardo D2023Science Translational MedicineOncologyClassifier, Multiplex IHCHALO
Cholesterol efflux drives the generation of immunosuppressive macrophages to promote the progression of human hepatocellular carcinomaLi Z, Wang Y, Xing R, Zeng H, Yu X, Zhang Y, Xu J, Zheng L2023Cancer Immunology ResearchImmuno-oncologyMultiplex IHC, Highplex FLHALO
Phase 1 Dose Escalation and Expansion Study of Golidocitinib, a Highly Selective JAK1 Inhibitor, in Relapsed or Refractory Peripheral T Cell LymphomasSong Y, Yoon D, Yang H, Cao J, Ji D, Koh Y, Jing H, Eom H, Kwak J, Lee W, Lee J, Shin H, Jin J, Wang M, Yang Q, Kim W, Zhu J2023Annals of OncologyImmuno-oncologyMultiplex IHCHALO
SMAD4 and KCNQ3 alterations are associated with lymph node metastases in oesophageal adenocarcinomaFoley K, Shorthouse D, Rahrmann E, Zhuang L, Devonshire G, Gilbertson R, OCCAMS consortium, Fitzgerald R, Hall B2023Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseOncologyMultiplex IHCHALO
Reanalysis of single-cell data reveals macrophage subsets associated with the immunotherapy response and prognosis of patients with endometrial cancerWu Q, Jiang G, Sun Y, Li B2023Experimental Cell ResearchImmuno-oncologyMultiplex IHCHALO
Telomere dysfunction in Tert knockout mice delays BrafV600E-induced melanoma developmentZhang J, Zhang F, Porter KI, Dakup PP, Wang S, Robertson GP, Gaddameedhi S, Zhu J2023International Journal of CancerOncologyMultiplex IHCHALO
Modified Bushen Yiqi formula enhances antitumor immunity by reducing the chemotactic recruitment of M2-TAMs and PMN-MDSCs in Lewis lung cancer-bearing miceKong Q, Zhu H, Gong W, Deng X, Liu B, Dong J2023Journal of EthnopharmacologyImmuno-oncologyMultiplex IHC, Highplex FLHALO
Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDACBaer JM, Zuo C, Kang LI, Alarcon de la Lastra A, Borcherding NC, Knolhoff BL, Bogner SJ, Zhu Y, Yang L, Laurent J, Lewis MA, Zhang N, Kim KW, Fields RC, Yokoyama WM, Mills JC, Ding L, Randolph GJ, DeNardo DG2023Nature ImmunologyImmunologyMultiplex IHCHALO
Tumor microenvironment-mediated immune profiles and efficacy of anti-PD-L1 antibody plus chemotherapy stratified by DLL3 expression in small-cell lung cancerShirasawa M, Yoshida T, Shiraishi K, Goto N, Yagishita S, Imabayashi T, Matsumoto Y, Masuda K, Shinno Y, Okuma Y, Goto Y, Horinouchi H, Yotsukura M, Yoshida Y, Nakagawa K, Naoki K, Tsuchida T, Hamamoto R, Yamamoto N, Motoi N, Kohno T, Watanabe SI, Ohe Y2023British Journal of CancerImmuno-oncologyMultiplex IHCHALO
Targeting the metabolic enzyme PGAM2 overcomes enzalutamide resistance in castration-resistant prostate cancer by inhibiting BCL2 signalingLi Z, Ning K, Zhao D, Zhou Z, Zhao J, Long X, Yang Z, Chen D, Cai X, Hong L, Zhang L, Zhou F, Wang J, Li Y2023Cancer ResearchOncologyMultiplex IHCHALO
A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injuryZhao X, Zeng W, Xu H, Sun Z, Hu Y, Peng B, McBride JD, Duan J, Deng J, Zhang B, Kim SJ, Zoll B, Saito T, Sasaguri H, Saido TC, Ballatore C, Yao H, Wang Z, Trojanowski JQ, Brunden KR, Lee VMY, He Z2023Science Translational MedicineneuroscienceArea Quantification, Object Colocalization, Multiplex IHCHALO
Enlarged tumour-draining lymph node with immune-activated profile predict favourable survival in non-metastatic colorectal cancerGuan X, Cheng P, Wei R, Li J, Jiao S, Zhao Z, Chen H, Liu Z, Jiang Z, Zheng Z, Zou S, Wang X2023British Journal of CancerOncologyMultiplex IHCHALO
Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cellsLinder S, Bernasocchi T, Martínez-Pastor B, Sullivan K, Galbraith M, Lewis C, Ferrer C, Boon R, Silveira G, Cho H, Vidoudez C, Shroff S, Oliveira-Costa J, Ross K, Massri R, Matoba Y, Kim E, Rueda B, Stott S, Gottlieb E, Espinosa J, Mostoslavsky R2023Nature MetabolismOncology, MetabolismMultiplex IHC, RegistrationHALO
Intrauterine perfusion of dexamethasone improves pregnancy outcomes in recurrent reproductive failure patients with elevated uterine natural killer cells. A retrospective cohort studyZhang F, Wang Z, Lian R, Diao L, Li Y, Wu Y, Yin T, Huang C2023American Journal of Reproductive ImmunologyOtherMultiplex IHCHALO
Protein Disulfide Isomerase A2 Is Correlated with Immune Infiltrates and Is a Novel Prognostic Biomarker in Glioma PatientsMa Z, Liu Y, Zou N, Huang Z, Wang M, Li T, Zhou J, Chen L2023Current Medical ScienceOncologyMultiplex IHCHALO
Gastric tubular adenocarcinoma with diffuse neutrophils infiltrating: characteristics and probable treatment strategyWang B, Zhu Y, Wang S, Li Z, Wang L, Rao W, Cheng N, Chen R, Ying J, Xue L2023Gastric CancerOncologyMultiplex IHC, Spatial Analysis, RegistrationHALO
Modified Bushen Yiqi Formula mitigates pulmonary inflammation and airway remodeling by inhibiting neutrophils chemotaxis and IL17 signaling pathway in rats with COPDKong Q, Wang B, Zhong Y, Chen W, Sun J, Liu B, Dong J2023Journal of EthnopharmacologyMultiplex IHCHALO
Lymphoid tissues contribute to plasma viral clonotypes early after antiretroviral therapy interruption in SIV-infected rhesus macaquesSolis-Leal A, Boby N, Mallick S, Cheng Y, Wu F, de la Torre G, Dufour J, Alvarez X, Shivanna V, Liu Y, Fennessey C M, Lifson J D, Li Q, Keele B F, and Ling B2023Science Translational MedicineInfectious DiseaseMultiplex IHCHALO
CD15 Is a Risk Predictor and a Novel Target in Clear Cell Renal Cell CarcinomaStenzela PJ, Schindeldeckera MS, Seidmanna L, Herpel E, Hohenfellnere M, Hatiboglue G, Foerscha S, Porubskya S, Macher-Goeppingera S, Rotha W, Tagscherer KE2023PathobiologyOncologyMultiplex IHC, TMAHALO
Fusion-negative rhabdomyosarcoma 3D organoids to predict effective drug combinations: A proof-ofconcept on cell death inducersSavary C, Luciana L, Huchede´ P, Tourbez A, Coquet C, Broustal M, Gonzalez AL, Deligne C, Diot T, Naret O, Costa M, Meynard N, Barbet V, Muller K, Tonon L, Gadot N, Degletagne C, Attignon V, Le´on S, Vanbelle C, Bomane A, Rochet I, Mournetas V, Oliveira L, Rinaudo P, Bergeron C, Dutour A, Cordier-Bussat M, Roch A, Brandenberg N, El Zein S, Watson S, Orbach D, Delattre O, Dijoud F, Corradini N, Picard C, Maucort-Boulch D, Le Grand M, Pasquier E, Blay JY, Castets M, and Broutier L.2023Cell Reports MedicineOncologyMultiplex IHCHALO
RFX6 facilitates aerobic glycolysis‐mediated growth and metastasis of hepatocellular carcinoma through targeting PGAM1Qiu Z, Wang C, Huang P, Yuan Y, Shi Y, Lin Z, Huang Z, Zuo D, Qiu J, He W, Shen J, Niu Y, Yuan Y, Li B2023Clinical and Translational MedicineOncologyArea Quantification, Multiplex IHCHALO
Immune microenvironment of basal cell carcinoma and tumor regression following combined PD-1/LAG-3 blockadeDeutsch JS, Lai J, Schenk KM, Soni A, Will EM, Engle LL, Xu H, Ogurtsova A, Madan V, Chong JK, Wang D, Green BF, Nguyen P, Schollenberger MD, Lipson EJ, Taube JM2023Journal for ImmunoTherapy of CancerImmuno-oncologyMultiplex IHCHALO
Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinomaSun Y, Wu P, Zhang Z, Wang Z, Zhou K, Song M, Ji Y, Zang F, Lou L, Rao K, Wang P, Gu Y, Gu J, Lu B, Chen L, Pan X, Zhao X, Peng L, Liu D, Chen X, Wu K, Lin P, Wu L, Su Y, Du M, Hou Y, Yang X, Qiu S, Shi Y, Sun H, Zhou J, Huang X, Peng D, Zhang L, Fan J2023Cancer CellOncologyClassifier, Multiplex IHC, Spatial Analysis, Highplex FLHALO
Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non–small cell lung cancerHerzog B, Baer J, Borcherding N, Kingston N, Belle J, Knolhoff B, Hogg G, Ahmad F, Kang L, Petrone J, Lin C, Govindan R, Denardo D2023Science Translational MedicineOncologyClassifier, Multiplex IHCHALO
Cholesterol efflux drives the generation of immunosuppressive macrophages to promote the progression of human hepatocellular carcinomaLi Z, Wang Y, Xing R, Zeng H, Yu X, Zhang Y, Xu J, Zheng L2023Cancer Immunology ResearchImmuno-oncologyMultiplex IHC, Highplex FLHALO
Phase 1 Dose Escalation and Expansion Study of Golidocitinib, a Highly Selective JAK1 Inhibitor, in Relapsed or Refractory Peripheral T Cell LymphomasSong Y, Yoon D, Yang H, Cao J, Ji D, Koh Y, Jing H, Eom H, Kwak J, Lee W, Lee J, Shin H, Jin J, Wang M, Yang Q, Kim W, Zhu J2023Annals of OncologyImmuno-oncologyMultiplex IHCHALO
SMAD4 and KCNQ3 alterations are associated with lymph node metastases in oesophageal adenocarcinomaFoley K, Shorthouse D, Rahrmann E, Zhuang L, Devonshire G, Gilbertson R, OCCAMS consortium, Fitzgerald R, Hall B2023Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseOncologyMultiplex IHCHALO
Reanalysis of single-cell data reveals macrophage subsets associated with the immunotherapy response and prognosis of patients with endometrial cancerWu Q, Jiang G, Sun Y, Li B2023Experimental Cell ResearchImmuno-oncologyMultiplex IHCHALO
Telomere dysfunction in Tert knockout mice delays BrafV600E-induced melanoma developmentZhang J, Zhang F, Porter KI, Dakup PP, Wang S, Robertson GP, Gaddameedhi S, Zhu J2023International Journal of CancerOncologyMultiplex IHCHALO
Modified Bushen Yiqi formula enhances antitumor immunity by reducing the chemotactic recruitment of M2-TAMs and PMN-MDSCs in Lewis lung cancer-bearing miceKong Q, Zhu H, Gong W, Deng X, Liu B, Dong J2023Journal of EthnopharmacologyImmuno-oncologyMultiplex IHC, Highplex FLHALO
Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDACBaer JM, Zuo C, Kang LI, Alarcon de la Lastra A, Borcherding NC, Knolhoff BL, Bogner SJ, Zhu Y, Yang L, Laurent J, Lewis MA, Zhang N, Kim KW, Fields RC, Yokoyama WM, Mills JC, Ding L, Randolph GJ, DeNardo DG2023Nature ImmunologyImmunologyMultiplex IHCHALO
Tumor microenvironment-mediated immune profiles and efficacy of anti-PD-L1 antibody plus chemotherapy stratified by DLL3 expression in small-cell lung cancerShirasawa M, Yoshida T, Shiraishi K, Goto N, Yagishita S, Imabayashi T, Matsumoto Y, Masuda K, Shinno Y, Okuma Y, Goto Y, Horinouchi H, Yotsukura M, Yoshida Y, Nakagawa K, Naoki K, Tsuchida T, Hamamoto R, Yamamoto N, Motoi N, Kohno T, Watanabe SI, Ohe Y2023British Journal of CancerImmuno-oncologyMultiplex IHCHALO
Targeting the metabolic enzyme PGAM2 overcomes enzalutamide resistance in castration-resistant prostate cancer by inhibiting BCL2 signalingLi Z, Ning K, Zhao D, Zhou Z, Zhao J, Long X, Yang Z, Chen D, Cai X, Hong L, Zhang L, Zhou F, Wang J, Li Y2023Cancer ResearchOncologyMultiplex IHCHALO
A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injuryZhao X, Zeng W, Xu H, Sun Z, Hu Y, Peng B, McBride JD, Duan J, Deng J, Zhang B, Kim SJ, Zoll B, Saito T, Sasaguri H, Saido TC, Ballatore C, Yao H, Wang Z, Trojanowski JQ, Brunden KR, Lee VMY, He Z2023Science Translational MedicineneuroscienceArea Quantification, Object Colocalization, Multiplex IHCHALO
Enlarged tumour-draining lymph node with immune-activated profile predict favourable survival in non-metastatic colorectal cancerGuan X, Cheng P, Wei R, Li J, Jiao S, Zhao Z, Chen H, Liu Z, Jiang Z, Zheng Z, Zou S, Wang X2023British Journal of CancerOncologyMultiplex IHCHALO
Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cellsLinder S, Bernasocchi T, Martínez-Pastor B, Sullivan K, Galbraith M, Lewis C, Ferrer C, Boon R, Silveira G, Cho H, Vidoudez C, Shroff S, Oliveira-Costa J, Ross K, Massri R, Matoba Y, Kim E, Rueda B, Stott S, Gottlieb E, Espinosa J, Mostoslavsky R2023Nature MetabolismOncology, MetabolismMultiplex IHC, RegistrationHALO
Intrauterine perfusion of dexamethasone improves pregnancy outcomes in recurrent reproductive failure patients with elevated uterine natural killer cells. A retrospective cohort studyZhang F, Wang Z, Lian R, Diao L, Li Y, Wu Y, Yin T, Huang C2023American Journal of Reproductive ImmunologyOtherMultiplex IHCHALO
Protein Disulfide Isomerase A2 Is Correlated with Immune Infiltrates and Is a Novel Prognostic Biomarker in Glioma PatientsMa Z, Liu Y, Zou N, Huang Z, Wang M, Li T, Zhou J, Chen L2023Current Medical ScienceOncologyMultiplex IHCHALO
Gastric tubular adenocarcinoma with diffuse neutrophils infiltrating: characteristics and probable treatment strategyWang B, Zhu Y, Wang S, Li Z, Wang L, Rao W, Cheng N, Chen R, Ying J, Xue L2023Gastric CancerOncologyMultiplex IHC, Spatial Analysis, RegistrationHALO
Modified Bushen Yiqi Formula mitigates pulmonary inflammation and airway remodeling by inhibiting neutrophils chemotaxis and IL17 signaling pathway in rats with COPDKong Q, Wang B, Zhong Y, Chen W, Sun J, Liu B, Dong J2023Journal of EthnopharmacologyMultiplex IHCHALO
Lymphoid tissues contribute to plasma viral clonotypes early after antiretroviral therapy interruption in SIV-infected rhesus macaquesSolis-Leal A, Boby N, Mallick S, Cheng Y, Wu F, de la Torre G, Dufour J, Alvarez X, Shivanna V, Liu Y, Fennessey C M, Lifson J D, Li Q, Keele B F, and Ling B2023Science Translational MedicineInfectious DiseaseMultiplex IHCHALO

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Highplex FL

Quantify expression of an unlimited number of biomarkers in any cellular compartment - membrane, nucleus or cytoplasm.

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Tissue Classifier Add-On

Separate multiple tissue classes across a tissue using a learn-by-example approach. Can be used in conjunction with all other modules (fluorescent and brightfield) to select specific tissue classes for further analysis.

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Spatial Analysis

Plot cells and objects from one or more images and perform nearest neighbor analysis, proximity analysis, and tumor infiltration analysis.

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