Indica
Backed by cutting edge technology, an uncompromising focus on ease-of-use and dedicated customer service, Indica Labs’ software and services are being used to make vital discoveries in pathology labs and research organizations around the world.

Tissue Classifier

Tissue Classifier Add-on

 

Product Overview

The Tissue Classifier Add-on utilizes a state-of-the-art machine learning algorithm to identify tissue types based on color, texture, and contextual features.  Utilizing a “learn-by-example” approach, the user highlights a few distinct tissue types and within seconds the software learns to categorize tissue.  The tissue classifier add-on module runs within/ is embedded in the HALO platform and can be used in conjunction with any of our cell-based analysis modules for BF or FL analysis, ultimately minimizing manual outlining of regions of interest.

To learn more, watch this short demonstration below to see how the tissue classifier can be trained to identify tumor regions for subsequent IHC analysis.

The Tissue Classifier Add-on integrates seamlessly into the HALO™ platform which is compatible with a number of file formats.

Contact info@indicalab.com for product demonstration and pricing information or upload some images for a free trial.

Tissue Classifier Add-on

The Tissue Classifier Add-on utilizes a state-of-the-art machine learning algorithm to identify tissue types based on color, texture, and contextual features.  Utilizing a “learn-by-example” approach, the user highlights a few distinct tissue types and within seconds the software learns to categorize tissue.  The tissue classifier add-on module runs within/ is embedded in the HALO platform and can be used in conjunction with any of our cell-based analysis modules for BF or FL analysis, ultimately minimizing manual outlining of regions of interest.

To learn more, watch this short demonstration below to see how the tissue classifier can be trained to identify tumor regions for subsequent IHC analysis.

HALO is compatible with a broad spectrum of image and digital slide formats.  Yours not on the list? Email us your requirements.

Non-proprietary (JPG, TIF)
Nikon (ND2)
3D Histech (MRXS)
Perkin Elmer (QPTIFF, component TIFF)
Olympus (VSI)
Hamamatsu (NDPI, NDPIS)
Aperio (SVS, AFI)
Zeiss (CZI)
Leica (SCN, LIF)
Philips (Requires Philips IMS)

Here are a few publications that cite the use of our HALO Tissue Classifier Add-on. Your publication not on the list?  Drop us an email to let us know about it!

TitleAuthorsYearJournalApplicationHALO Modules
Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator studyAcs B, Pelekanou V, Bai Y, Martinez-Morilla S, Toki M, Leung SCY, Nielsen TO, Rimm DL2017Laboratory InvesigationsOncologyClassifier, Cytonuclear
The R-enantiomer of ketorolac delays mammary tumor development in mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) mice AS Peretti, D Dominguez, MM Grimes, HJ Hathaway, ER Prossnitz, MR Rivera, A Wandinger-Ness, D Kusewitt, LG Hudson2017The American Journal of PathologyOncologyClassifier, Area Quantification, Cytonuclear
Islet amyloidosis in a child with type 1 diabetes Beery ML, Jacobsen LM, Atkinson MA, Butler AE, Campbell-Thompson M2019IsletsMetabolismClassifier
Acute Respiratory Distress in Aged, SARS-CoV-2 Infected African Green Monkeys but not Rhesus MacaquesBlair RV, Vaccari M, Doyle-Meyers LA, Roy CJ, Russell-Lodrigue K, Fahlberg M, Monjure CJ, Beddingfield B, Plante KS, Plante JA, Weaver SC, Qin X, Midkiff CC, Lehmicke G, Golden N, Threeton B, Penney T, Allers C, Barnes MB, Pattison M, Datta PK, Maness NJ, Birnbaum A, Fischer T, Bohm RP, Rappaport J2020The American Journal of PathologyInfectious DiseaseClassifier
Predicting breast cancer response to neoadjuvant chemotherapy based on tumor vascular features in needle biopsies Brocato TA, Brown-Glaberman U, Wang Z, Selwyn RG, Wilson CM, Wyckoff EF, Lomo LC, Saline JL, Hooda-Nehra A, Pasqualini R, Arap W, Brinker CJ, Cristini V2019JCI InsightOncologyClassifier
Identification of the SUMO E3 ligase PIAS1 as a potential survival biomarker in breast cancer Chanda A, Chan A, Deng L, Kornaga EN, Enwere EK, Morris DG, Bonni S2017PLOS OneOncologyClassifier, Cytonuclear
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders Coughlin DG, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig H, Coslett HB, Hamilton R, Siderowf A, Duda JE, Rascovsky K, Lee EB, Lee VM-Y, Grossman M, Trojanowski JQ, Irwin DJ2019Annals of NeurologyNeuroscienceClassifier, Area Quantification,
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer Cruz C, Castroviejo-Bermejo M, Gutiérrez-Enríquez S, Llop-Guevara A, Ibrahim YH, Gris-Oliver A, Bonache S, Morancho B, Bruna A, Rueda OM, Lai Z, Polanska UM, Jones GN,Kristel P, de Bustos L, Guzman M, Rodriguez O, Grueso J, Montalban G, Caratú G, Mancuso F, Fasani R, Jiménez J, Howat WJ, Dougherty B, Vivancos A, Nuciforo P, Serres-Créixams X, Rubio IT, Oaknin A, Cadogan O, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Arribas J, Jonkers J, Díez O, O’Connor MJ, Balmaña J, SerraV2018Annals of OncologyOncologyClassifier, Cytonuclear
Tumor vessel normalization, immuno-stimulatory reprogramming, and improved survival in glioblastoma with combined inhibition of PD-1, angiopoietin-2, and VEGF Di Tacchio M, Macas J, Weissenberger J, Sommer K, Bähr O, Steinbach JP, Senft C, Seifert V, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Scheel AH, Büttner R, Grauer OM, Schittenhelm J, Tabatabai G, Harter PN, Guenther S, Devraj K, Plate KH, Reiss Y2020Cancer Immunology ResearchOncology, Immuno-oncologyClassifier, Cytonuclear
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models Durant ST, Zheng L, Wang Y, Chen K, Zhang L, Zhang T, Yang Z, Riches L, Trinidad AG, Fok JHL, Hunt T, Pike KG, Wilson J, Smith A, Colclough N, Reddy VP, Sykes A, Janefeldt A, Johnström P, Varnäs K, Takano A, Ling S, Orme J, Stott J, Roberts C, Barrett I, Jones G, Roudier M, Pierce A, Allen J, Kahn J, Sule A, Karlin J, Cronin A, Chapman M, Valerie K, Illingworth R, Pass M2018Science AdvancesOncology, NeuroscienceClassifier, Cytonuclear
Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity Freiburghaus C, Emruli VK, Johansson A, Eskelund CW, Grønbæk K, Olsson R, Ek F, Jerkeman M, Ek S2018BMC CancerOncologyClassifier, Cytonuclear
Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer Ghaffari A, Hoskin V, Turashvili G, Varma S, Mewburn J, Mullins G, Greer PA, Kiefer F, Day AG, Madarnas Y, SenGupta S, Elliott BE2019Breast Cancer ResearchOncologyClassifier, Cytonuclear
Magnetic Resonance Imaging as a Biomarker in Rodent Peripheral Nerve Injury Models Reveals an Age-Related Impairment of Nerve Regeneration Giorgetti E, Obrecht M, Ronco M, Panesar M, Lambert C, Accart N, Doelemeyer A, Nash M, Bidinosti M, Beckmann N2019Scientific ReportsNeuroscienceClassifier
Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor UnitsGiorgetti E, Panesar M, Zhang Y, Joller S, Ronco M, Obrecht M, Lambert C, Accart N, Beckmann N, Doelemeyer A, Perrot L, Fruh I, Mueller M, Pierrel E, Summermatter S, Bidinosti M, Shimshek DR, Brachat S, Nash M2019Cell ReportsNeuroscienceClassifier, Cytonuclear
The novel ATM inhbitior (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan montherapy Greene J, Nguyen A, Bagby SM, Jones GN, Tai WM, Quackenbush KS, Schreiber A, Messersmith WA, Devaraj KM, Blatchford P, Eckhardt SG, Cadogan EB, Hughes GD, Smith A, Pitts TM, Arcaroli JJ2018OncotargetOncologyClassifier, Area Quantification, Cytonuclear
MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancerGreer YE, Gilbert SF, Gril B, Narwal R, Brooks DLP, Tice DA, Steeg PS, Lipkowitz2019Breast Cancer ResearchOncologyClassifier
Ultrasensitive automated RNA in situ hybridization for kappa and lambda light chain mRNA detects B-cell clonality in tissue biopsies with performance comparable or superior to flow cytometryGuo L, Wang Z, Anderson CA, Doolittle E, Kernag S, Cotta CV, Ondrejka SL, Ma X-J, Cook JR2018Modern PathologyClassifier
A Phase II Trial of Dovitinib in BCD-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Over-Expression: Hoosier Cancer Research Network Trial HCRN 12-157 Hahn NH, Bivalacqua TJ, Ross AE, Netto GJ, Baras AS, Park JC, Chapman C, Masterson TA, Koch MO, Bihrle R, Foster RS, Gardner TA, Cheng L, Jones DR, Kyle McElyea K, Sandusky GE, Breen T, Liu Z, Albany C, Moore ML, Loman RA, Reed A, Turner SA, de Abreu FB, Gallagher TL, Tsongalis GJ, Plimack ER, Greenberg RE, Geynisman DM2016Clinical Cancer ResearchOncologyClassifier, Cytonuclear
cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma He Y, Zhu W, Shin MH, Gary J, Liu C, Dubois W, Hoover SB, Jiang S, Marrogi E, Mock B, Simpson RM, and Huang J2017Stem Cell ReportsOncologyClassifier
A distinct repertoire of cancer-associated fibroblasts is enriched in cribriform prostate cancerHesterberg AB, Rios BL, Wolf EM, Tubbs C, Wong HY, Schaffer KR, Lotan TL, Giannico GA, Gordetsky JB, Hurley PJ2021Journal of Pathology:Clinical ResearchOncologyClassifier, ISH/FISH
Multiplexed Immunohistochemistry for Molecular and Immune Profiling in Lung Cancer—Just About
Ready for Prime-Time?
Hofman P, Badoual C, Henderson F, Berland L, Hamila M, Long-Mira E, Lassalle S, Roussel H, Hofman V, Tartour E, Ilié M2019CancersOncology, Immuno-oncology, ReviewClassifier, Multiplex IHC
Quantification of histopathological findings using a novel image analysis platformHorai Y, Mizukawa M, Nishina H, Nishikawa S, Ono Y, Takemoto K, Baba N2019Journal of Toxicologic PathologyToxicologyClassifier
Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPaseHudson LG, Gillette JM, Kang H, Rivera MR, Wandinger-Ness A2018CancersReviewClassifier, Cytonuclear, Figure Maker
Molecular and functional heterogeneity of cancer associated fibroblasts in high-grade serous ovarian cancer Hussain A, Voisin V, Poon S, Dmytryshyn J ,Richman C, Meens J, Ho VW, Tang KH, Paterson J, Clarke B, Bernardini M, Bader G, Neel B, Ailles L2019bioRxivOncologyClassifier, Area Quantification
Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21Hussain A, Voisin V, Poon S, Karamboulas C, Bui NHB, Meens J, Dmtryshyn J, Ho VW, Tang KH, Paterson J, Clarke BA, Bernardini MQ, Bader GD, Neel BG,4 Ailles LE2020Journal of Experimental MedicineOncologyClassifier, Area Quantification,
Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatmentHysi E, Fadhel MN, Wang Y, Sebastian JA, Giles A, Czarnota GJ, Exner AA, Kolios MC2020PhotoacousticsOtherClassifier, Area Quantification, Object Colocalization
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistryJones GN, Rooney C, Griffin N, Roudier M, Young LA, Garcia-Trinidad A, Hughes GD, Whiteaker JR, Wilson Z, Odedra R, Zhao L, Ivey RG, Howat WJ, Harrington EA, Carrett JC, Ramos-Montoya A, Lau A, Paulovich AG, Cadogan EB, Pierce AJ2018British Journal of CancerOncologyClassifier, Cytonuclear
Neutrophil content predicts lymphocyte depletion and anti-PD1 treatment failure in NSCLCKargl J, Zhu X, Zhang H, Yang GHY, Friesen TJ, Shipley M, Maeda DY, Zebala JA, McKay-Fleisch J, Meredith G, Mashadi-Hossein A, Baik C, Pierce RH, Redman MW, Thompson JC, Albelda SM, Bolouri H, Houghton AM2019JCI InsightImmuno-oncologyClassifier, Highplex FL
DPP9 enzyme activity controls survival of mouse migratory tongue muscle progenitors and its absence leads to neonatal lethality due to suckling defect Kim T, Tafoya E, Chelliah MP, Lekwuttikarn R, Li J, Sarin KY, Teng J2017Developmental BiologyMyologyClassifier, Area Quantification
Digital image analysis improves precision of PD‐L1 scoring in cutaneous melanoma Koelzer VH, Gisler A, Hanhart JC, Griss J, Wagner SN, Willi N, Cathomas G, Sachs M, Kempf W, Thommen DS, Mertz KD2018HistopathologyOncology, Immuno-oncologyClassifier, Multiplex IHC
Precision immunoprofiling by image analysis and artificial intelligenceKoelzer VH, Sirinukunwattana K, Rittscher J, Mertz KD2019Vichows ArchivReviewClassifier, Multiplex IHC, Spatial Analysis
Machine learning approaches for pathologic diagnosis Komura D, Ishikawa S2019Vichows ArchivReviewClassifier, HALO AI
Digital image analysis of Ki67 proliferation index in breast cancer using virtual dual staining on whole tissue sections: clinical validation and inter‑platform agreement Koopman T, Buikema HJ, Hollema H, de Bock GH, van der Vegt B2018Breast Cancer Research and TreatmentOncologyClassifier, Cytonuclear
Fasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergismKrstic J, Reinisch I, Schindlmaier K, Galhuber M, Berger N, Kupper N, Moyschewitz E, Auer M, Michenthaler H, Nössing C, Depaoli MR, Ramadani-Muja J, Stryeck S, Pichler M, Rinner B, Deutsch AJA, Reinisch A, Madl T, Chiozzi RZ, Heck AJR, Huch M, Malli R, Prokesch A2021bioRxivOncologyClassifier, Cytonuclear
Ex-vivo delivery of monoclonal antibody (Rituximab) to treat human donor lungs prior to transplantationKu TJY, Ribeiero RVP, Ferreira VH, Galasso M, Keshavjee S, Kumar D, Cypel M, Humar A2020EBioMedicineOtherClassifier, Cytonuclear
Bimodality of intratumor Ki67 expression is an independent prognostic factor of overall survival in patients with invasive breast carcinoma Laurinavicius A, Plancoulaine B, Rasmusson A, Besusparis J, Augulis R, Meskauskas R, Herlin P, Laurinaviciene A, Muftah AAA, Miligy I, Aleskandarany M, Rakha EA, Green AR, Ellis IO2016Virchows ArchivOncologyClassifier, Cytonuclear
An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes Levet S, Medina J, Joanou J, Demolder A, Queruel N, Réant K, Normand M, Seffals M, Dimier J, Germi R, Piofczyk T, Portoukalian J, Touraine J-L, Perron H2017JCI InsightImmunology, MetabolismClassifier, Cytonuclear
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival Logsdon DP, Fenil S, Fabrizio C, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML2018Scientific ReportsOncologyClassifier, Cytonuclear
Implementation of PD-L1 22C3 IHC pharmDxTM in Cell Block Preparations of Lung Cancer: Concordance with Surgical Resections and Technical Validation of CytoLyt® PrefixationLou SK, Ko HM, Kinoshita T, MacDonald S, Weiss J, Czarnecka-Kujawa K, Boerner SL, Yasufuku K, Tsao M-S, Schwock J2020Acta CytologicaOncologyClassifier, Membrane
Ex vivo tissue slice culture system to measure drug-response rates of hepatic metastatic colorectal cancerMartin SZ, Wagner DC, Hörner N, Horst D, Lang H, Tagscherer KE, Roth W2019BMC CancerOncologyClassifier, Cytonuclear
Prognostic value of tumor-inltrating immune cells in primary colorectal cancer and metastasesMartin SZ, Tagscherer KE, Deckert S, Horst D, Moehler M, Lang H, Roth W2020*Pre-PrintImmuno-oncologyClassifier, Cytonuclear
MYB-NFIB gene fusions identified in archival adenoid cystic carcinoma tissue employing NanoString analysis: an exploratory study McIntyre JB, Ko JJ, Siever J, Chan AMY, Simpson RHW, Hao D, Lau HY2019Diagnostic PathologyOncologyClassifier, Highplex FL
A Dual Blocker of Endothelin A/B Receptors Mitigates Hypertension but not Renal Dysfunction in a Rat Model of Chronic Kidney Disease and Sleep Apnea Morales-Loredo H, Jones DT, Barrera A, Mendiola P, Garcia J, Pace CE, Murphy M, Kanagy NL, Gonzalez Bosc LV2019Renal PathologyMetabolismClassifier, Cytonuclear, Figure Maker
Spatial immune profiling of the colorectal tumor microenvironment predicts good outcome in stage II patientsNearchou IP, Gwyther BM, Georgiakakis ECT, Gavriel CG, Kajiwara Y, Ueno H, Harrison DJ, Caie PD2020Digital MedicineImmuno-oncologyClassifier, Area Quantification, Spatial Analysis
Immuno-Interface Score to Predict Outcome in
Colorectal Cancer Independent of Microsatellite
Instability Status
Nestarenkaite A, Fadhil W, Ramusson A, Susanti S, Hadjimichael E, Laurinaviciene A, Ilyas M, Laurinavicius A2020CancersImmuno-oncologyClassifier, Multiplex IHC
Locally confined IFNɣ production by CD4+ T cells provides niches for murine cytomegalovirus
4 replication in the salivary gland
Oderbolz J, Zangger N, Zimmerman L, Sandu I, Starruß J, Graw F, Oxenius A2021bioRxivClassifier, Spatial Analysis, Highplex FL
Assessment of associations between clinical and immune microenvironmental factors and tumor mutation burden in resected nonsmall cell lung cancer by applying machine learning to whole-slide imagesOno A, Terada Y, Kawata T, Serizawa M, Isaka M, Kawabata T, Imai T, Mori K, Muramatsu K, Hayashi I, Kenmotsu H, Oshima K, Urakami K, Nagashima T, Kusuhara M, Akiyama Y, Sugino T, Ohde Y, Yamaguchi K, Takahashi T T2020Cancer MedicineClassifier, Multiplex IHC, Serial Section
Histological characterization of aldosterone-producing adrenocortical adenomas with different somatic mutations Ono Y, Yamazaki Y, Omata K, Else T, Tomlins SA, Rhayem Y, Williams TA, Reincke M, Carling T, Monticone S, Mulatero P, Beuschlein F, Ito S, Satoh F, Rainey WE, Sasano H2019The Journal of Clinical Endocrinology & MetabolismOncologyClassifier, Area Quantification
Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancerOsman J, Savari S, Chandrashekar NK, Bellamkonda K, Souglas D, Sjolander A2017OncotargetOncology, ImmunologyClassifier, Area Quantification
Mechanical regulation of glycolysis via cytoskeleton architecturePark JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G2020NatureOncologyClassifier, Cytonuclear, TMA
Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity Petkevicius K, Virtue S, Bidault G, Jenkins B, Cubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie M, Koulman A, Vidal-Puig A2019bioRxivClassifier, Vacuole
Detection of Lung Cancer Lymph Node Metastases from Whole-Slide Histopathologic Images Using a Two-Step Deep Learning ApproachPham HHN, Futakuchi M, Bychkov A, Furukawa T, Kuroda K, Fukuoka J2019The American Journal of PathologyOncologyClassifier, HALO AI
Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human Pognan F, Mahl JA, Papoutsi M, David Ledieu D, Raccuglia M, Theil D, Voytek SB, Devine PJ, Kubek‑Luck K, Claudio N, Cordier A, Heier A, Kolly C, Hartmann A, Chibout S-D, Bouchard P, Trendelenburg C2018Archives of ToxicologyToxicologyClassifier, Cytonuclear
Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosaReyes-Uribe L, Wu W, Gelincik O, Bommi PV, Francisco-Cruz A, Solis LM, Lynch PM, Lim R, Stoffel EM, Kanth P, Samadder NJ, Mork ME, Taggart MW, Milne GL, Marnett LJ, Vornik L, Liu DD, Revuelta M, Chang K, You YN, Kopelovich L, Wistuba II, Lee JJ, Sei S, Shoemaker RH, Szabo E, Richmond E, Umar A, Perloff M, Brown PH, Lipkin SM, Vilar E2020GutOncologyClassifier, Cytonuclear
Intermittent Hypoxia Exacerbates Increased Blood Pressure in Rats with Chronic Kidney Disease Riggs J, Pace C, Ward HH, Gonzalez Bosc L, Rios L, Barrera A, Kanagy NL2018American Jornal of Physiology-Renal PhysiologyMetabolismClassifier, Cytonuclear
p53 is associated with high-risk and pinpoints TP53 missense mutations in mantle cell lymphomaRodrigues JM, Hassan M, Freiburghaus C, Eskelund CW, Geisler C, Raty R, Kolstad A, Sundstrom C, Glimelius I, Gronbaek K, Kwiecinska A, Porwit A, Jerkeman M, Ek S2020British Journal of HaematologyOncologyClassifier, Cytonuclear
Biomarker Evaluation and Toxic Effects of an Acute Oral and Systemic Fumonisin Exposure of Pigs with a Special Focus on Dietary Fumonisin Esterase SupplementationSchertz H, Danicke S, Frahm J, Schatzmayr D, Dohnal I, Bichl G, Schwartz-Zimmerman HE, Colicchia S, Breves G, Teifke JP, Kluess J2018ToxinsToxicologyClassifier
In vivo characterization of a new type of biodegradable starch microsphere for transarterial embolization Sommer CM, Do TD, Schlett CL, Flechsig P, Gockner TL, Kuthning A, Vollherbst DF, Pereira PL, Kauczor HU, Macher-Göppinger S2017Journal of Biomaterials ApplicationsOncologyClassifier
Prognostic and Predictive Value of Tumor-infiltrating Leukocytes and of Immune Checkpoint Molecules PD1 and PDL1 in Clear Cell Renal Cell CarcinomaStenzel PJ, Schindeldecker M, Teagscherer KE, Foersch S, Herpel E, Hohenfellner M, Hatiboglu G, Alt J, Thomas C, Haferkamp A, Roth W, Macher-Goeppinger S2020Translational OncologyOncology, Immuno-oncologyClassifier, Cytonuclear, TMA
A randomized, open-label study of the efficacy and safety of AZD4547 monotherapy versus paclitaxel for the treatment of advanced gastric adenocarcinoma with FGFR2 polysomy or gene amplification Van Cutsem E, Bang Y-J, Mansoor W, Petty RD, Chao Y, Cunningham D, Ferry DR, N. R. Smith NR, Frewer P, Ratnayake J, Stockman PK, Kilgour E, and Landers D2017Annals of OncologyOncologyClassifier, ISH/FISH
Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trialvan Dijk N, Gil-Jimenez A, Silina K, Hendricksen K, Smit LA, de Feijter JM, van Montfoort ML, van Rooijen C, Peters D, Broeks A, van der Poel HG, Bruining A, Lubeck Y, Sikorska K, Boellaard TN, Kvistborg P, Vis DJ, Hooijberg E, Schumacher TN, van den Broek M, Wessels LFA, Blank CU, van Rhijn BW, van der Heijden MS2020Nature MedicineImmuno-oncologyClassifier
SLFN11 informs on standard of care and novel treatments in a wide range of cancer modelsWinkler C, Armenia J, Jones GN, Tobalina L, Sale MJ, Petreus T, Baird T, Serra V, Wang AT, Lau A, Garnett MJ, Jaaks P, Coker EA, Pierce AJ, O'Connor MJ, Leo E2020British Journal of CancerOncologyClassifier, Cytonuclear
Validation and characterisation of prognostically significant PD-L1+ immune cells in HPV+ oropharyngeal squamous cell carcinomaYoung RJ, Bressel M, Porceddu S, Cernelc J, Savas P, Liu H, Urban D, Thai AA, Cooper C, Fua T, Neeson P, Rischin D, Solomon B2019Oral OncologyOncology, Infectious DiseaseClassifier, Highplex FL
A suboptimal maternal diet combined with accelerated postnatal growth results in an altered aging profile in the thymus of male rats Tarry-Adkins JL, Aiken CE, Ashmore TJ, Fernandez-Twinn DS, Chen J-H, Ozanne SE2018The FASEB JournalNeuroscience, MetabolismClassifier, Vacuole
Impact of pre‐therapy glioblastoma multiforme microenvironment on clinical response to autologous CMV‐specific T‐cell therapy Walker DG, Shakya R, Morrison B, Neller MA, Matthews KK, Nicholls J, Smith C, Khanna R2019Clinical & Translational ImmunologyImmuno-oncologyClassifier
CD38 in Advanced Prostate CancersGuo C, Crespo M, Gurel B, Dolling D, Rekowski J, Sharp A, Petremolo A, Sumanasuriya S, Rodrigues DN, Ferreira A, Pereira R, Figueiredo I, Mehra N, Lambros MBK, Neeb A, Gil V, Seed G, Terstappen L, Alimonti A, Drake CG, Yuan W, de Bono JS2021European UrologyOncologyClassifier, Highplex FL
Activated Regulatory T-Cells, Dysfunctional and SenescentT-Cells Hinder the Immunity in Pancreatic CancerSivakumar S, Abu-Shah E, Ahern DJ, Arbe-Barnes EH, Jainarayanan AK, Mangal N, Reddy S, Rendek A, Easton A, Kurz E, Silva M, Soonawalla Z, Heij LR, Bashford-Rogers R, Middleton MR, DUstin ML2021cancersClassifier, Multiplex IHC, Spatial Analysis, Highplex FL
Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinomaKazdal D, Rempel E, Oliveira C, Allgäuer M, Harms A, Singer K, Kohlwes E, Ormanns S, Fink L, Kriegsmann J, Leichsenring M, Kriegsmann K, Stögbauer F, Tavernar L, Leichsenring J, Volckmar A-L, Longuespée R, Winter H, Eichhorn M, Heußel CP, Herth F, Christopoulos P, Reck M, Muley T, Weichert W, Budczies J, Thomas M, Peters S, Warth A, Schirmacher P, Stenzinger A, Kriegsmann M2021Translational Lung Cancer ResearchOncologyClassifier, Cytonuclear
Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cellsNewman AC, Falcone M, Uribe AH, Zhang T, Athineos D, Pietzke M, Vazquez A, Blyth K, Maddocks ODK2021Molecular CellImmuno-oncologyClassifier, ISH/FISH
TNFα secreted by glioma associated macrophages promotes endothelial activation and resistance against anti-angiogenic therapyWei Z, Singh O, Ekinci C, Gill J, Li M, Mamatjan Y, Karimi S, Bunda S, Mansouri S, Aldape K, Zadeh G2021Acta Neuropathologica CommunicationsImmunology, NeuroscienceClassifier, Multiplex IHC
Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formationKim D-K, Bandara G, Cho Y-E, Komarow HD, Donahue DR, Karim B, Baek M-C, Kim HM, Metcalfe DD, Olivera A2021Nature CommunicationsClassifier

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