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Spotlight on Covid-19 Research Publications

Indica Labs / Spotlight on Covid-19 Research Publications

Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

Hoang, T.N., Pino, M., Boddapati, A.K. et al.. Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques. This article is a preprint and has not been certified by peer review, doi: https://doi.org/10.1101/2020.09.16.300277 Effective therapeutics aimed at mitigating COVID-19 symptoms are urgently needed. SARS-CoV-2 induced hypercytokinemia and systemic inflammation are associated with disease severity. Baricitinib, a clinically approved JAK1/2 inhibitor with potent anti-inflammatory properties is currently being investigated in COVID-19 human clinical trials. Recent reports suggest that baricitinib...

ARDS and Cytokine Storm in SARS-CoV-2 Infected Caribbean Vervets

Blair, R.V., Vaccari, M., Doyle-Meyers, L.A.. et al. ARDS and Cytokine Storm in SARS-CoV-2 Infected Caribbean Vervets. This article is a preprint and has not been certified by peer review. doi: https://doi.org/10.1101/2020.06.18.157933 SARS-CoV-2 induces a wide range of disease severity ranging from asymptomatic infection, to a life-threating illness, particularly in the elderly and persons with comorbid conditions. Up to now, SARS-CoV-2 has infected more than five million and led to more than 300,000 deaths worldwide. Among those persons with serious COVID-19...

Acute Respiratory Distress and Cytokine Storm in Aged, SARS-CoV-2 Infected African Green Monkeys, but not in Rhesus Macaques

Blair, R.V., Vaccari, M., Doyle-Meyers, L.A.. et al. Acute Respiratory Distress and Cytokine Storm in Aged, SARS-CoV-2 Infected African Green Monkeys, but not in Rhesus Macaques. This article is a preprint and has not been certified by peer review.  doi: https://doi.org/10.1101/2020.06.18.157933. SARS-CoV-2 induces a wide range of disease severity ranging from asymptomatic infection, to a life-threating illness, particularly in the elderly and persons with comorbid conditions. Among those persons with serious COVID-19 disease, acute respiratory distress syndrome (ARDS) is a...

Neuropathology and Virus in Brain of SARS-CoV-2 Infected Non-Human Primates

Rutkai, I., Mayer, M.G., Hellmers, L.M., et al. Neuropathology and Virus in Brain of SARS-CoV-2 Infected Non-Human Primates. This article is a preprint and has not been certified by peer review. DOI: 10.21203/rs.3.rs-59871/v1 Neurological manifestations are a significant complication of coronavirus infection disease-19 (COVID-19). Understanding how COVID-19 contributes to neurological disease is needed for appropriate treatment of infected patients, as well as in initiating relevant follow-up care after recovery. Investigation of autopsied brain tissue has been key to advancing our understanding...

Identification of immune checkpoints in COVID-19

Carvelli, J., Demaria, O., Vély, F., et al. Identification of immune checkpoints in COVID-19. Please note that this article has not completed peer review. doi: 10.21203/rs.3.rs-27340/v1 Coronavirus disease 2019 (COVID-19) is a new pandemic acute respiratory disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)11-3. We provide here a longitudinal analysis of immune responses, including immune cell phenotyping and assessments of the soluble factors present in the blood and broncho-alveolar lavage fluid (BALF) of patients at various stages of COVID-19 severity: paucisymptomatic,...

Lung Expression of Human ACE2 Sensitizes the Mouse to SARS-CoV-2 Infection

Han, K., Blair, R.V., Iwanaga ,N., et al. Lung Expression of Human ACE2 Sensitizes the Mouse to SARS-CoV-2 Infection. Am J Respir Cell Mol Biol. 2020 Sep 29. Preclinical mouse models that recapitulate some characteristics of COVID-19 will facilitate focused study of pathogenesis and virus-host responses. Human angiotensin converting enzyme (hACE2) serves as an entry receptor for SARS-CoV-2 to infect people via binding to spike proteins. Herein we report development and characterization of a rapidly deployable COVID-19 mouse model. C57BL/6J (B6)...

Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

Tostanoski, L.H., Wegmann, F., Martinot, A.J. et al. Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters. Nat Med (2020). Coronavirus disease 2019 (COVID-19) in humans is often a clinically mild illness, but some individuals develop severe pneumonia, respiratory failure and death1,2,3,4. Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in hamsters5,6,7 and nonhuman primates8,9,10 have generally reported mild clinical disease, and preclinical SARS-CoV-2 vaccine studies have demonstrated reduction of viral replication in the upper and lower respiratory tracts in...

Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates

Fahlberg, M.D., Blair, R.V., Doyle-Meyers, L.A. et al. Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates.  This article is a preprint and has not been certified by peer review. doi: https://doi.org/10.1101/2020.07.21.213777.  We investigated the immune events following SARS-COV-2 infection, from the acute inflammatory state up to four weeks post infection, in non-human primates (NHP) with heterogeneous pulmonary pathology. The acute phase was characterized by a rapid migration of CD16+ monocytes from the blood and concomitant increase...

ACE2 and SARS-CoV-2 Expression in the Normal and COVID-19 Pancreas

Kusmartseva, I., Wu, W., Syed, F. et al. ACE2 and SARS-CoV-2 Expression in the Normal and COVID-19 Pancreas. This article is a preprint and has not been certified by peer review.  doi: https://doi.org/10.1101/2020.08.31.270736 Diabetes is associated with increased mortality from Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Given literature suggesting a potential association between SARS-CoV-2 infection and diabetes induction, we examined pancreatic expression of the key molecule for SARS-CoV-2 infection of cells, angiotensin-converting enzyme-2 (ACE2). Specifically, we analyzed five public scRNAseq pancreas...

Two distinct immunopathological profiles in autopsy lungs of COVID-19

Nienhold, R., Ciani, Y., Koelzer, V.H. et al. Two distinct immunopathological profiles in autopsy lungs of COVID-19. Nat Commun 11, 5086 (2020). Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. Immune mediated damage has been proposed as a pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Here we show transcriptomic, histologic and cellular profiles of post mortem...

Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 infection in the lung epithelium

Bryce A. Schuler, A. Christian Habermann, Erin J. Plosa, Chase J. Taylor, Christopher Jetter, Meghan E. Kapp, John T. Benjamin, Peter Gulleman, David S. Nichols, Lior Z. Braunstein, Alice Hackett, View ORCID ProfileMichael Koval, Susan H. Guttentag, Timothy S. Blackwell, Vanderbilt COVID-19 Consortium Cohort, Steven A. Webber, Nicholas E. Banovich, View ORCID ProfileJonathan A. Kropski, Jennifer M. S. Sucre, HCA Lung Biological Network bioRxiv | Posted August 03, 2020 | This article is a preprint and has not been certified by...