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PATHOLOGY

ILLUMINATED

PATHOLOGY

solution for digital pathology

With the

HALO® IMAGE ANALYSIS

gold standard analysis sol-
-ution for digital pathology.

EXPLORE HALO

PLATFORM

, the gold standard analysis

platform, the

ANALYSIS

HALO® IMAGE

With the

Anatomic Pathology
Workflow Software

STREAMLINE YOUR WORKFLOWS WITH HALO AP

Future-proof your lab with
HALO AP Anatomic Pathology
Workflow Software

Implement Remote Sign-Out with
HALO AP

BRIDGE THE GAP

Looking for a new partner to assist with biomarker studies?

in your image analysis pipeline.

INQUIRE NOW >

From biomarker discovery to translational studies
and clinical trials. keep your time-sensitive image
analysis projects moving forward at any phase.

We can help you

THE POWER OF ARTIFICIAL INTELLIGENCE
IN THE HANDS OF THE PATHOLOGIST

LEARN ABOUT HALO AI

EXPLORE HALO LINK

Backed by cutting edge technology, an uncompromising focus on ease-of-use and dedicated customer service, Indica Labs’ software and services are being used to make vital discoveries in pathology labs and research organizations around the world. Discover how our solutions can help you.

ILLUMINATED

PATHOLOGY

EXPLORE HALO

ILLUMINATED

PATHOLOGY

WITH HALO IMAGE ANALYSIS, THE
FLAGSHIP PLATFORM FOR PATHOLOGY.

WITH HALO IMAGE ANALYSIS, THE FLAGSHIP PLATFORM
FOR QUANTITATIVE TISSUE INFORMATICS.

STREAMLINE YOUR WORKFLOWS
WITH HALO AP

IMPLEMENT REMOTE SIGN-OUT
WITH HALO AP

Future-proof your lab with
HALO AP Anatomic Pathology
Workflow Software

BRIDGE THE GAP

Looking for a new partner to assist with biomarker studies?

in your image analysis pipeline.

INQUIRE NOW >

We can help you

THE POWER OF ARTIFICIAL INTELLIGENCE
IN THE HANDS OF THE PATHOLOGIST

LEARN ABOUT HALO AI

HALO® Image Analysis

With uncompromising ease-of-use and flexibility, the HALO IMAGE ANALYSIS PLATFORM can adapt to any image analysis application.

HALO AI™ Deep Learning

HALO AI, the first of its kind intuitive interface for deep learning in digital pathology, is putting the power of AI in the hands of the pathologist.

HALO Link™ Image Management

Share images and analysis data with remote collaborators using HALO LINK, our browser-based image management system.

Pharma Services

If you are overwhelmed with your image analysis workload or need help with more complex analysis, our PHARMA SERVICES team can help.

HALO AP® Clinical Workflow

The HALO AP platform brings case-centric automation, collaboration and quantification to your Anatomic Pathology lab.

Explore our Integrated Platforms

Click play to learn how all of our HALO products fit together to offer an end-to-end Digital Pathology workflow from bench to bedside!

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Application Notes & White Papers

Follow the links below to explore a few of our most popular applications.

HALO Application Note

Measure immune cell density and spatial distance to tumor cells within the tumor and invasive margin

Using our multiplex IHC module, we quantify immune cells and tumor cell markers across whole slide images. The tissue classifier add-on is employed to segment tumor and stroma and the spatial analysis module is used for proximity and invasive margin analysis.

HALO Application Note

Quantify Single and Multiplexed RNAscope® probes across whole slide tissues

Using our ISH module for brightfield and our FISH module for fluorescence, we demonstrate how to quantify ISH signal from RNAScope® assays on a per cell or per unit area basis and output an overall expression score based on ACD Bio’s recommended scoring guidelines.

HALO AI White Paper

Moving deep learning out of the computer lab and into the hands of the pathologist with HALO AI™

If you’ve been to any digital pathology meetings recently you have heard artificial intelligence or deep learning mentioned at least once. In this white paper, we will introduce some of the basics about this emerging technology and explain how HALO AI™ is making artificial intelligence accessible to the pathology community.

Read what our customers are publishing

Our customers are making vital discoveries in oncology, neuroscience, infectious disease, and diabetes research. Check out some of the research our customers are publishing using the HALO Image Analysis Platform and Indica analysis modules.

PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding

Alexander Jaisl, et al, Neuron, 2020
To advance the molecular understanding of obesity, Jais and colleagues set out to identify neuronal populations in mice that respond to being fed a calorie dense, highly palatable food. They identified prepronociceptin (PNOC)-expressing neurons in the hypothalamus that are activated upon acute high fat diet feeding and promote overconsumption. In this publication, HALO image analysis software was used for quantification of transgene expression in mouse neuronal tissue.…
Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers

Myriam Chalabi, et al, Nature Medicine, 2020
Immunotherapy is known to be effective in late-stage, mismatch repair (MMR) deficient colorectal cancers but not in MMR proficient cancer. This study reports the early results from the NICHE clinical trial that is evaluating treatment of early stage, nonmetastatic preoperative colon cancer with a CTLA-4 inhibitor and a PD-1 inhibitor. Chalabi and colleagues report that the treatment was well tolerated and that a major pathological response was…
Transmission of tauopathy strains is independent of their isoform composition

Zhuohao He, et al, Nature Communications, 2020
The accumulation of aggregated tao proteins in neurons is a hallmark of several neurodegenerative diseases, including Alzheimer’s disease. A challenge in the study of tauopathies has been the lack of an appropriate model system. He and colleagues demonstrate here a new mouse model for human tauopathies where the expression of tao isoforms is similar to that in human adult brains. The Area Quantification Module of HALO played a…
Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

Julien Carvelli, et al, Nature, 2020
Researchers aiming to block excessive lung inflammation in COVID-19 patients found upregulated immune checkpoint biomarkers in patients with a range of COVID-19 symptoms (from paucisymptomatic to acute respiratory distress syndrome). In addition, Carvelli et al found increased expression of C5a, an inflammatory mediator, in serum and the C5aR1 receptor on myeloid cells in COVID-19 patients, which are known to initiate inflammatory responses by recruiting neutrophils and monocytes to…
Intratumoral interleukin-12 mRNA therapy promotes TH1 transformation of the tumor microenvironment

Susannah L Hewitt, et al, Clinical Cancer Research, 2020
In patients with advanced stage lung disease, it is beneficial to evaluate candidacy for immunotherapy without invasive biopsy testing. Lou et al performed a concordance study to evaluate formalin fixed cell blocks compared to lung tumor resections using a PD-L1 22C3 IHC pharmDx™ assay and found strong concordance between pathologists and HALO image analysis software. Future research will focus on clinical validation by assessing the clinical benefit…
Implementation of PD-L1 22C3 IHC pharmDxTM in Cell Block Preparations of Lung Cancer: Concordance with Surgical Resections and Technical Validation of CytoLyt® Prefixation

Si Kei Lou, et al, Acta Cytologica, 2020
In patients with advanced stage lung disease, it is beneficial to evaluate candidacy for immunotherapy without invasive biopsy testing. Lou et al performed a concordance study to evaluate formalin fixed cell blocks compared to lung tumor resections using a PD-L1 22C3 IHC pharmDx™ assay and found strong concordance between pathologists and HALO image analysis software. Future research will focus on clinical validation by assessing the clinical benefit from…

Spotlight on Covid-19 Research

Follow the links below to learn how our customers are using HALO, HALO AI and HALO Link to advance our understanding of the novel coronavirus.

Covid-19 Collaborations

Indica Labs works with NIH to launch a global COVID-19 digital pathology repository

Indica Labs announce the launch of the online COVID Digital Pathology Repository (COVID-DPR), a virtual collection of high resolution microscopic COVID-related human tissue images hosted at the National Institutes of Health.

Covid-19 Publications

Cutting edge investigations into Covid-19 published by HALO and HALO AI customers

Read about the exciting research being performed by our HALO and HALO AI customers to elucidate the biological mechanisms of novel coronavirus infection and Covid-19 disease progression.

Covid-19 Presentations

Digital Pathology in the New Normal: Leveraging HALO to Investigate a Global Pandemic

This workshop will present some insight on how HALO and HALO AI has been used by researchers at three different global institutions to study and characterize the novel coronavirus.

CUSTOMER REVIEWS

Read independent SelectScience reviews on HALO® and learn how these customers are using Indica Labs’ solutions to streamline their workflows.

Read full reviews or write your own

Halo is the simply the best whole-slide analysis software available.

"Halo is simply the best whole-slide analysis software available. We have a large core facility, scanning over 15,000 brightfield and 2,000 fluorescence slides per year (plus many confocal microscopes, etc.). For whole-slide analysis, we formerly used Genie (from Aperio), and InForm (from Perkin Elmer), and we have collaborators using Definiens (no longer available) and Visiopharm. But now we have over 50 users per month working on Halo and the other platforms have been virtually shut down. Halo is very easy to get up and running - within a 2 hour session we can get a new user started with their own classification and cell counting application. Most users run a batch analysis overnight and collect and review their results in the morning. The team at Indica Labs are quick to respond when we have a challenging analysis project - they will WebEx in and help optimize the parameters. They have the experience (and courage) to tell us if the staining is just not suitable or a more complex classifier is required."

James Jonkman

University Health Network, Advanced Optical Microscopy Facility

Excellent tool, fast, user friendly, powerful

"I am almost completely satisfied with the HALO image analysis platform. The main areas of improvement would be in cell segmentation using membrane markers and in data analysis after datafication of the slide. My principle bottleneck is in creating actionable insight from the multiple reported parameters. I think that Indica's experience with AI and multiplex data generation positions you well to exploit the current need in the marketplace. One more thing - phenotyping manually by thresholding with no morphology/cell size, neighbor information is good but if I had a magic wand, then phenotyping would be a full suite of tools with spatial, multimarker, and morphological features that could be weighted from 0 to 1 in a machine learning classifier model."

Michael Surace

AstraZeneca

For the Pathologist HALO is by far the best digital image analysis platform available

"As a Pathologist specializing in digital image analysis, I have had the opportunity to use several different digital image analysis platforms. Indica Labs' HALO is by far the most accurate, versatile and user friendly digital image analysis platform that I have used. Literally within 10-15 minutes of "tuning" one of their "out of the box" detection algorithms, I can perform image analysis for most simple immunohistochemical markers. The workflow is simple, with sacanned images being imported directly into HALO with or without annotations for analysis. This even allows for remote use when working off site. The customer support is AMAZING and I routinely get same day or next day help from the technical support reps. HALO is a must have for any pathologist or scientist involved in quantifying immunohistochemical stains. In addition the HALO AI module is extremely easy to use. Within 20 minutes I was able to set up AI detection of tumor vs. normal tissue, as well as tumor epithelium vs. stroma. HALO provides everything one needs for quantification of IHC for clinical and pre-clinical studies (of course with supervision of a pathologist). Best of all: it is fun, like a video game for Pathologists!"

Philip Martin

AstraZeneca

Stellar support team and next level research capabilities

"The HALO Image Analysis Platform is a complete game changer in research. Being able to analyze our digitalized tissue slides and TMA slides in order to extract cell counts & cell types based on Immunohistochemistry (IHC) & In situ hybridization (ISH; CISH & FISH) staining allows us to better & more reliably determine the effectiveness of drugs as well as further understand diseases & disease progression. Getting good at using HALO takes training, practice and WebEx assistance from Indica Labs, but once you're up an running, there's no stopping the possibilities. Pairing up this revolutionary technology with a stellar service from the Indica Labs support team that has provided us guidance, usage ideas as well as listening to the customers requests with regards to the regular software updates, makes this platform near unbeatable."

Spencer Revill

Molecular Phenotyping & Imaging Core (MPIC) Facility

We use HALO & HALO-Link daily to coordinate studies for our analysts and pathologists

"HALO is a whole-slide image analysis platform that is designed to work how pathologists classify & score images using a microscope. It uses a set of tools that are very familiar to anyone who has used any type of image viewing/editing program at home. It can be learned in a day to analyze brightfield & fluorescent whole slide images and TMAs. There are sophisticated tools to analyze tissues labeled by chromogenic and fluorescent IHC, RNAScope, FISH & ISH. HALO may be installed on stand-alone workstations or cloud services such as AWS. File sharing through HALO-Link lets user access studies through a simple web-interface sharing a common database. HALO AI allows any user to developing sophisticated AI based tissue classification without the need for external programs or expensive computing hardware."

Timothy Baradet

Bristol-Myers Squibb

Amazing software and service.

"Indica labs is of great support when using Halo. Their customer service is really great. Halo is a very user friendly software, but the technical support is also what makes it the best digital pathology software on the market. they are always open to any suggestion and the response time is usually very short."

Camille Britton-Rivet

Immunocore

Highly recommend

"I work mostly with multiplex immunohistochemistry images evaluating the tumor microenvironment with a focus on tumor infiltration and cell-cell interactions. I've used several image analysis softwares over the years, but I continue to use HALO because it is easy to use yet very powerful. I started using HALO back when Indica Labs was a much smaller company and before they launched HALO Link (which I also like). Although they've grown substantially, they continue to try to provide great customer service and are always working to improve their product. No technology is perfect, but they appear to be passionate about getting past the hurdles of image analysis and to expand the functionality of the software while keeping the learning curve reasonable

Kimberly Smythe

Fred Hutch CRC

LATEST NEWS

Catch up on the latest press releases, event announcements and other news from Indica Labs.

Leveraging the collaborative image management platform, HALO Link, for multi-site image analysis collaborations

by Valery Rodriguez
Events, News, Past Webinars
November 12, 2021

03 December 2021 | In this webinar you will learn how the Pharma Services team at Indica Labs uses HALO Link to collaborate with customers, to launch and display image analysis re...
Read More
Bench-to-Bedside Transition of Novel HALO® Assays into Clinical Trials with HALO AP®

by Valery Rodriguez
Events, HALO AP, News, Past Webinars
November 12, 2021

10 December 2021 | In this 1-hour webinar, featured speakers will demonstrate end-to-end how to develop a quantitative assay in HALO and transition it into clinical trials using ...
Read More
Using digital pathology to determine the role of tumor-infiltrating B cells in clinical outcome of patients with melanoma

by Valery Rodriguez
Events, News, Past Webinars
November 12, 2021

15 December 2021 | This webinar will share an analysis of biomarkers using pre-treatment melanoma samples from the dabrafenib plus trametinib arm of the randomized, Phase III COMB...
Read More
2021 Masterclass: HALO AI Deep Dive on the Validation Workflow

by Valery Rodriguez
Events, News, Past Webinars
November 13, 2021

16 December 2021 | In this Masterclass webinar we will delve into one of the latest AI tools, the AI validation workflow (available as of the HALO v3.3 release). This tool can be ...
Read More

Explore our Integrated Platforms

Application Notes & White Papers

HALO Application Note

Measure immune cell density and spatial distance to tumor cells within the tumor and invasive margin

HALO Application Note

Quantify Single and Multiplexed RNAscope® probes across whole slide tissues

HALO AI White Paper

Moving deep learning out of the computer lab and into the hands of the pathologist with HALO AI™

Read what our customers are publishing

Spotlight on Covid-19 Research

Covid-19 Collaborations

Indica Labs works with NIH to launch a global COVID-19 digital pathology repository

Covid-19 Publications

Cutting edge investigations into Covid-19 published by HALO and HALO AI customers

Covid-19 Presentations

Digital Pathology in the New Normal: Leveraging HALO to Investigate a Global Pandemic

CUSTOMER REVIEWS

Halo is the simply the best whole-slide analysis software available.

James Jonkman

Excellent tool, fast, user friendly, powerful

Michael Surace

For the Pathologist HALO is by far the best digital image analysis platform available

Philip Martin

Stellar support team and next level research capabilities

Spencer Revill

We use HALO & HALO-Link daily to coordinate studies for our analysts and pathologists

Timothy Baradet

Amazing software and service.

Camille Britton-Rivet

Highly recommend

Kimberly Smythe

LATEST NEWS

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