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Cytonuclear FL

co-expression markup (two markers) co-expression markup (two markers) intensity markup (green marker) intensity markup (green marker)

CYTONUCLEAR FL

 

Product Overview

Cytonuclear FL measures the immunofluorescent positivity of an unlimited number of fluorescent markers in the nucleus or cytoplasm and reports the number of cells that are positive for each marker, the intensity score for each cell (0, 1+, 2+, 3+), and colocalization of different marker combinations. Optionally, the tool can output the complete table of cell data including individual cell sizes and intensity measurements for each dye in each cellular compartment.

In the dual stained mouse pancreas shown above, the cytonuclear FL module is used to 1) identify cells in mouse pancreas positive for one or both biomarkers and 2) score intensity of the nuclear biomarker.

In the first set of images, a co-expression markup is generated where negative cells are marked blue in the nucleus, cells positive for the cytoplasmic biomarker are marked red in the cytoplasm, cells positive for the green biomarker are marked green in the nucleus and dual positive cells are marked both red and green.

In the second set of images, an intensity markup is generated. Here, the nuclear intensity of the green biomarker only is evaluated. Nuclei that are negative for the green biomarker are blue, yellow indicates weak positivity (1+), orange indicates moderate positivity (2+), and red indicates strong positivity (3+).

The Cytonuclear FL module integrates seamlessly into the HALO® platform which is compatible with a number of third party systems and  file formats.

Contact info@indicalab.com for product demonstration and pricing information or upload some images for a free trial.

CYTONUCLEAR FL

Cytonuclear FL measures the immunofluorescent positivity of an unlimited number of fluorescent markers in the nucleus or cytoplasm and reports the number of cells that are positive for each marker, the intensity score for each cell (0, 1+, 2+, 3+), and colocalization of different marker combinations. Optionally, the tool can output the complete table of cell data including individual cell sizes and intensity measurements for each dye in each cellular compartment.

In the dual stained mouse pancreas shown above, the cytonuclear FL module is used to 1) identify cells in mouse pancreas positive for one or both biomarkers and 2) score intensity of the nuclear biomarker.

In the first set of images, a co-expression markup is generated where negative cells are marked blue in the nucleus, cells positive for the cytoplasmic biomarker are marked red in the cytoplasm, cells positive for the green biomarker are marked green in the nucleus and dual positive cells are marked both red and green.

In the second set of images, an intensity markup is generated. Here, the nuclear intensity of the green biomarker only is evaluated. Nuclei that are negative for the green biomarker are blue, yellow indicates weak positivity (1+), orange indicates moderate positivity (2+), and red indicates strong positivity (3+).

HALO is compatible with a broad spectrum of image and digital slide formats.  Yours not on the list? Email us your requirements.

Non-proprietary (JPG, TIF)
Nikon (ND2)
3D Histech (MRXS)
Perkin Elmer (QPTIFF, component TIFF)
Olympus (VSI)
Hamamatsu (NDPI, NDPIS)
Aperio (SVS, AFI)
Zeiss (CZI)
Leica (SCN, LIF)
Philips (Requires Philips IMS)

Here are a few publications that cite use of the Cytonuclear IHC or FL modules.  Your publication not on the list?  Drop us an email to let us know about it!

 

TitleAuthorsYearJournalApplicationHALO Modules
Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator studyAcs B, Pelekanou V, Bai Y, Martinez-Morilla S, Toki M, Leung SCY, Nielsen TO, Rimm DL2017Laboratory InvesigationsOncologyClassifier, Cytonuclear
Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis Allen CT, Lee S, Norberg SM, Kovalovsky D, Ye H, Clavijo PE, Hu-Lieskovan S, Schlegel R, Schlom J, Strauss J, Gulley JL, Trepel J, Hinrichs CS2019Journal for ImmunoTherapy of CancerOncology, Immuno-oncologyCytonuclear
Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK CellsAndre ́P, Denis C, Soulas C, Bourbon-Caillet C, Lopez J, Arnoux T, Bléry M, Bonnafous C, Gauthier L, Morel A, Rossi B, Remark R, Breso V, Bonnet E, Habif G, Guia S, Lalanne AI, Hoffmann C, Lantz O, Fayette J, Boyer-Chammard A, Zerbib R, Dodion P, Ghadially H, Jure-Kunkel M, Morel Y, Herbst R, Narni-Mancinelli E, Cohen RB, Vivier E2018CellOncology, Immuno-oncologyArea Quantification, Cytonuclear
The R-enantiomer of ketorolac delays mammary tumor development in mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) mice AS Peretti, D Dominguez, MM Grimes, HJ Hathaway, ER Prossnitz, MR Rivera, A Wandinger-Ness, D Kusewitt, LG Hudson2017The American Journal of PathologyOncologyClassifier, Area Quantification, Cytonuclear
The clinical impact of tumour-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: A cohort study Berntsson J, Svensson MC, Leandersson K, Nodin B, Micke P, Larsson AH, Eberhard J, Jirstrom K2017International Journal of CancerOncology, Immuno-oncologyCytonuclear
Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation Bulusu V, Tumanov S, Michalopoulou E, van den Broek NJ, MacKay G, Nixon C, Dhayade S, Schug ZT, Voorde JV, Blyth K, Gottlieb E, Vazquez A, Kamphorst JJ2017Cell ReportsOncology, MetabolismCytonuclear
Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes Burnett LC, Hubner G, LeDuc C, Morabito MV, Carli JFM, Leibel RL2017Human Moledular GeneticsMetabolismCytonuclear
Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and potential for glucagon-producing neuroendocrine tumors Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC2013DiabetesOncology, MetabolismCytonuclear
Control of mitochondrial function and cell growth by the atypical cadherin Fat1 Cao LL, Riascos-Bernal DF, Chinnasamy P, Dunaway CM, Hou R, Pujato MA, O'Rourke BP, Miskolci V, Guo L, Hodgson L, Fiser A, Sibinga NES2016NatureMetabolismCytonuclear
Association of COVID-19 inflammation with activation of the C5a–C5aR1 axisCarvelli J, Demaria O, Vely F, Batista L, Benmansour NC, Fares J, Carpentier S, Thibult M-L, Morel A, Andre P, Represa A, Piperoglou C, Cordier PY, Le Dault E, Guervilly C, Simone P, Gainnier M, Morel Y, Ebbo M, Schleinitz N, Vivier E2020NatureImmunologyCytonuclear
Identification of the SUMO E3 ligase PIAS1 as a potential survival biomarker in breast cancer Chanda A, Chan A, Deng L, Kornaga EN, Enwere EK, Morris DG, Bonni S2017PLOS OneOncologyClassifier, Cytonuclear
Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells Chi M, Evans, Gilchrist J, Mayhew J, Hoffman A, Pearsall EA, Jankowski H, Brzozowski JS, Skelding KA2016Scientific ReportsOncologyCytonuclear
Impact of Preanalytical Factors During Histology Processing on Section Suitability for Digital Image AnalysisChlipala EA, Butters M, Brous M, Fortin JS, Archuletta R, Copeland K, Bolon B2020Toxicologic PathologyToxicologyArea Quantification, Cytonuclear
Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes Cinti F, Bouchi R, Kim-Muller JY, Ohmura Y, Sandoval PR, Masini M, Marselli L, Suleiman M, Ratner LE, Marchetti P, Accili D2016The Journal of Clinical Endocrinology & MetabolismMetabolismCytonuclear
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer Cruz C, Castroviejo-Bermejo M, Gutiérrez-Enríquez S, Llop-Guevara A, Ibrahim YH, Gris-Oliver A, Bonache S, Morancho B, Bruna A, Rueda OM, Lai Z, Polanska UM, Jones GN,Kristel P, de Bustos L, Guzman M, Rodriguez O, Grueso J, Montalban G, Caratú G, Mancuso F, Fasani R, Jiménez J, Howat WJ, Dougherty B, Vivancos A, Nuciforo P, Serres-Créixams X, Rubio IT, Oaknin A, Cadogan O, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Arribas J, Jonkers J, Díez O, O’Connor MJ, Balmaña J, SerraV2018Annals of OncologyOncologyClassifier, Cytonuclear
Tumor vessel normalization, immuno-stimulatory reprogramming, and improved survival in glioblastoma with combined inhibition of PD-1, angiopoietin-2, and VEGF Di Tacchio M, Macas J, Weissenberger J, Sommer K, Bähr O, Steinbach JP, Senft C, Seifert V, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Scheel AH, Büttner R, Grauer OM, Schittenhelm J, Tabatabai G, Harter PN, Guenther S, Devraj K, Plate KH, Reiss Y2020Cancer Immunology ResearchOncology, Immuno-oncologyClassifier, Cytonuclear
Spatial distribution of EGFR and KRAS mutation frequencies correlates with histological growth patterns of lung adenocarcinomasDietz S, Harms A, Endris V, Eichhorn, Kriegsmann M, Longuespée R, Stenzinger A, Sültmann H, Warth A, and Kazdal D2017International Journal of CancerOncologyCytonuclear
Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosisdo Valle Duraes F, Lafont A, Biebel M, Martin K, Darribat K, Cuttat R, Waldt A, Naumann U, Wieczorek G, Gaulis S, Pfister S, Mertz KD, Li J, Roma G, Warncke M2020JCI InsightImmunologyArea Quantification, Cytonuclear
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models Durant ST, Zheng L, Wang Y, Chen K, Zhang L, Zhang T, Yang Z, Riches L, Trinidad AG, Fok JHL, Hunt T, Pike KG, Wilson J, Smith A, Colclough N, Reddy VP, Sykes A, Janefeldt A, Johnström P, Varnäs K, Takano A, Ling S, Orme J, Stott J, Roberts C, Barrett I, Jones G, Roudier M, Pierce A, Allen J, Kahn J, Sule A, Karlin J, Cronin A, Chapman M, Valerie K, Illingworth R, Pass M2018Science AdvancesOncology, NeuroscienceClassifier, Cytonuclear
Islet-1 is essential for pancreatic β-cell functionEdiger BN, Du A, Liu J, Hunter CS, Walp ER, Schug J, Kaestner KH, Stein R, Stoffers DA, May CL2014DiabetesMetabolismCytonuclear
Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade Eichten A, Su J, Adler AP, Zhang L, Ioffe E, Parveen AA, Yancopoulos GD, Rudge J, Lowy I, Lin HC, MacDonald D, Daly C, Duan X, Thurston G2016Cancer ResearchOncology, Immuno-oncologyCytonuclear, Object Colocalization
The prevalence and prognostic significance of estrogen receptor beta expression in non-small cell lung cancerEnwere EK, Dean ML, Li H, D'Silva A, Bebb DG2020Translational Lung Cancer ResearchOncologyCytonuclear, TMA
High response rate to PD-1 blockade in desmoplastic melanomas Eroglu Z, Zaretsky JM, Hu-Lieskovan H, Kim DW, Algazi A, Johnson DB, Liniker E, Kong B, Munhoz R, Rapisuwon S, Gherardini PF, Chmielowski B, Wang X, Shintaku IP, Wei C, Sosman JA, Joseph RW, Postow MA, Carlino MS, Hwu W-J, Scolyer RA, Messina J, Cochran AJ, Long GV, Ribas A2018NatureOncology, Immuno-oncologyCytonuclear
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors Escuin-Ordinas H, Li S, Xie MW, Sun L, Hugo W, Huang RR, Jiao J, Meira de-Faria F, Realegeno S, Krystofinski P, Azhdam A, Komenan SMD, Atefi M, Comin-Anduix B, Pellegrini M, Cochran AJ, Modlin RL, HerschmanHR, Lo RS, McBride WH, Segura T, Ribas A2016Nature CommunicationsWound HealingCytonuclear
Early Stage HER2-Positive Breast Cancers Not Achieving a pCR From Neoadjuvant Trastuzumab- or Pertuzumab-Based Regimens Have an Immunosuppressive Phenotype Force J, Howie LJ, Abbot SE, Bentley R, Marcom PK, Kimmick G, Westbrook K, Sammons SL, Parks M, Topping DL, Emerson R, Broadwater G, Hyslop T, Blackwell KL, Nair SK2018Clinical Breast CancerOncology, Immuno-oncologyCytonuclear
Characterization of the exocrine pancreas in the male Zucker diabetic fatty rat model of type 2 diabetes mellitus following 3 months of treatment with sitagliptin Forest T, Holder D, Smith A, Cunningham C, Yao X, Dey M, Frederick C, Prahalada S2014EndocrinologyMetabolismCytonuclear
Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity Freiburghaus C, Emruli VK, Johansson A, Eskelund CW, Grønbæk K, Olsson R, Ek F, Jerkeman M, Ek S2018BMC CancerOncologyClassifier, Cytonuclear
IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel disease Friedrich M, Pohin M, Jackson MA, Korsunsky I, Bullers S, Rue-Albrecht K, Christoforidou Z, Sathananthan D, Ravindran R, Peres RS, Sharpe H, Wei K, Watts GFM, Mann EH, Geremia A, Thomas T, Attar M, Oxford IBD Cohort Investigators, Roche Fibroblast Network Consortium, McCuaig S, Thomas L, Collantes E, Uhlig HH, Sansom S, Easton A, Raychaudhuri S, Travis SP, Powrie FM2021bioRxivImmunologyCytonuclear
The PDE10A inhibitor MP-10 and haloperidol produce distinct gene expression profiles in the striatum and influence cataleptic behavior in rodents Gentzel RC, Toolan D, Roberts R, Koser AJ, Kandebo M, Hershey J, Renger JJ, Uslaner J, Smith SM2015NeuropharmacologyNeuroscienceCytonuclear
Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer Ghaffari A, Hoskin V, Turashvili G, Varma S, Mewburn J, Mullins G, Greer PA, Kiefer F, Day AG, Madarnas Y, SenGupta S, Elliott BE2019Breast Cancer ResearchOncologyClassifier, Cytonuclear
Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor UnitsGiorgetti E, Panesar M, Zhang Y, Joller S, Ronco M, Obrecht M, Lambert C, Accart N, Beckmann N, Doelemeyer A, Perrot L, Fruh I, Mueller M, Pierrel E, Summermatter S, Bidinosti M, Shimshek DR, Brachat S, Nash M2019Cell ReportsNeuroscienceClassifier, Cytonuclear
The novel ATM inhbitior (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan montherapy Greene J, Nguyen A, Bagby SM, Jones GN, Tai WM, Quackenbush KS, Schreiber A, Messersmith WA, Devaraj KM, Blatchford P, Eckhardt SG, Cadogan EB, Hughes GD, Smith A, Pitts TM, Arcaroli JJ2018OncotargetOncologyClassifier, Area Quantification, Cytonuclear
Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations Guntermann C, Piaia A, Hamel M-L, Theil D, Rubic-Schneider T, del Rio-Espinola A, Dong L, Billich A, Kaupmann K, Dawson J, Hoegenauer K, Orain D, Hintermann S, Stringer R, Pate DD, Doelemeyer A, Deurinck M, and Schümann J2017JCI InsightOncology, Immuno-oncologyArea Quantification, Cytonuclear
Digital image analysis agrees with visual estimates of bone marrow trephine biopsy cellularity Hagiya AS, Etman A, Siddiqi IN, Cen S, Matcuk Jr GR, Brynes RK, Salama ME2017International Journal of Laboratory HematologyOncologyCytonuclear
A Phase II Trial of Dovitinib in BCD-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Over-Expression: Hoosier Cancer Research Network Trial HCRN 12-157 Hahn NH, Bivalacqua TJ, Ross AE, Netto GJ, Baras AS, Park JC, Chapman C, Masterson TA, Koch MO, Bihrle R, Foster RS, Gardner TA, Cheng L, Jones DR, Kyle McElyea K, Sandusky GE, Breen T, Liu Z, Albany C, Moore ML, Loman RA, Reed A, Turner SA, de Abreu FB, Gallagher TL, Tsongalis GJ, Plimack ER, Greenberg RE, Geynisman DM2016Clinical Cancer ResearchOncologyClassifier, Cytonuclear
Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis Halbrook CJ, Wen H-J, Ruggeri JM, Takuchi KK, Zhang Y, di Magliano MP, Crawford HC2016Cellular and Molecular Gastroenterology and HepatologyImmunology, GastroenterologyCytonuclear
Cystic fibrosis–related diabetes is caused by islet loss and inflammation Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC2018JHI InsightsImmunology, Metabolism, FibrosisCytonuclear
Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic CancerHedge S, Krisnawan VE, Herzog BH, Zuo C, Breden MA, Knolhoff BL, Hogg GD, Tang JP, Baer JM, Mpoy C, Lee KB, Alexander KA, Rogers BE, Murphy KM, Hawkins WG, Fields RC, DeSelm CJ, Schwarz JK, DeNardo DG2020Cancer CellOncology, Immuno-oncologyArea Quantification, Cytonuclear, Immune
Highly Fermentable Fiber Alters Fecal Microbiota and Mitigates Swine Dysentery Induced by Brachyspira hyodysenteriaeHelm ET, Gabler NK, Burrough ER2021AnimalsInfectious DiseaseCytonuclear
LLRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic miceHenderson MX, Sengupta M, McGeary I, Zhang B, Olufemi MF, Brown H, Trojanowski JQ, Lee VMY2019Acta Neuropathologica CommunicationsNeuroscienceArea Quantification, Cytonuclear
Attenuation of diet-induced hypotalamic inflammation following bariatric surgery in female mice Herrick MK, Favela KM, Simerly RB, Abumrad NN, Bingham NC2018Molecular MedicineImmunology, NeuroscienceCytonuclear
Tumor Characteristics Associated with Benefit from Pembrolizumab in Advanced Non-Small Cell Lung Cancer Hu-Lieskovan S, Lisberg A, Zaretsky JM, Grogan TR, Rizvi H, Wells DK, Carroll J, Cummings A, Madrigal J, Jones B, Gukasyan J, Shintaku IP, Slamon D, Dubinett S, Goldman JW, Elashoff D, Hellmann MD, Ribas A, Garon EB2019Clinical Cancer ResearchImmuno-oncologyCytonuclear
Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPaseHudson LG, Gillette JM, Kang H, Rivera MR, Wandinger-Ness A2018CancersReviewClassifier, Cytonuclear, Figure Maker
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistryJones GN, Rooney C, Griffin N, Roudier M, Young LA, Garcia-Trinidad A, Hughes GD, Whiteaker JR, Wilson Z, Odedra R, Zhao L, Ivey RG, Howat WJ, Harrington EA, Carrett JC, Ramos-Montoya A, Lau A, Paulovich AG, Cadogan EB, Pierce AJ2018British Journal of CancerOncologyClassifier, Cytonuclear
Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnanciesKala S, Dunk C, Acosta S, Serghides L2020Human ReproductionInfectious DiseaseCytonuclear
Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies Karpowicz RJ, Haney CM, Mihaila TS, Sandler RM, Petersson EJ, and Lee VM-Y2017Journal of Biological ChemistryNeuroscienceArea Quantification, Cytonuclear
Three-dimensional culture models mimic colon cancer heterogeneity induced by different microenvironmentsKawai S, Yamazaki M, Shibuya K, Yamazaki M, Fujji E, Nakano K, Suzuki M2020Scientific ReportsOncologyCytonuclear
Prevalence of somatic mitochondrial mutations and spatial distribution of mitochondria in non-small cell lung cancer Kazdal D, Harms A, Endris V, Penzel R, Oliveira C, Kriegsmann M, Longuespee R, Winter H, Schneider MA, Muley T, Pfarr N, Weichert W, Stenzinger A,Warth A2017British Journal of CancerOncologyCytonuclear
Vascular endothelial ERp72 is involved in the inflammatory response in a rat model of skeletal muscle injuryKhalaf NB, Al-Mehatab D, Fathallah DM2021Medicine ReportsImmunologyCytonuclear
Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in MiceKim J, Okamoto H, Huang ZJ, Anguiano G, Chen S, Liu Q, Cavino K, Xin Y, Na E, Hamid R, Lee J, Zambrowicz B, Unger R, Murphy AJ, Xu Y, Yancopoulos GD, Li W, Gromada J2017Cell MetabolismMetabolismCytonuclear
Alterations of the MEK/ERK, BMP, and Wnt/β-catenin pathways detected in the blood of individuals with lymphatic malformations Kim T, Tafoya E, Chelliah MP, Lekwuttikarn R, Li J, Sarin KY, Teng J2019PLOS OneOtherCytonuclear
Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity Kleinera S, Gomeza D, Megraa B, Naa E, Bhavsara R, Cavinoa K, Xina Y, Rojasa J, Dominguez-Gutierreza G, Zambrowicza B, Carratb G, Chabosseaub P, Hub M, Murphya AJ, Yancopoulosa GD, Rutterb GA, Gromadaa J2018Proceedings of the National Academy of SciencesMetabolismCytonuclear
Phenotyping of tumor-associated macrophages in colorectal cancer: impact on single cell invasion (tumor budding) and clinicopathological outcome Koelzer VH, Canonica K, Dawson H, Sokol L, Karamitopoulou-Diamantis E, Lugli A, Zlobec I2015OncoImmunologyOncology, Immuno-oncology, GastroenterologyCytonuclear
Digital analysis and epigenetic regulation of the signature of rejection in colorectal cancer Koelzer VH, Sokol L, Zahnd S, Christe L, Dawson H, Berger MD, Inderbitzin D, Zlobec I, Lugli A2017OncoImmunologyOncologyCytonuclear
Digital image analysis of Ki67 proliferation index in breast cancer using virtual dual staining on whole tissue sections: clinical validation and inter‑platform agreement Koopman T, Buikema HJ, Hollema H, de Bock GH, van der Vegt B2018Breast Cancer Research and TreatmentOncologyClassifier, Cytonuclear
Fasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergismKrstic J, Reinisch I, Schindlmaier K, Galhuber M, Berger N, Kupper N, Moyschewitz E, Auer M, Michenthaler H, Nössing C, Depaoli MR, Ramadani-Muja J, Stryeck S, Pichler M, Rinner B, Deutsch AJA, Reinisch A, Madl T, Chiozzi RZ, Heck AJR, Huch M, Malli R, Prokesch A2021bioRxivOncologyClassifier, Cytonuclear
Ex-vivo delivery of monoclonal antibody (Rituximab) to treat human donor lungs prior to transplantationKu TJY, Ribeiero RVP, Ferreira VH, Galasso M, Keshavjee S, Kumar D, Cypel M, Humar A2020EBioMedicineOtherClassifier, Cytonuclear
Bimodality of intratumor Ki67 expression is an independent prognostic factor of overall survival in patients with invasive breast carcinoma Laurinavicius A, Plancoulaine B, Rasmusson A, Besusparis J, Augulis R, Meskauskas R, Herlin P, Laurinaviciene A, Muftah AAA, Miligy I, Aleskandarany M, Rakha EA, Green AR, Ellis IO2016Virchows ArchivOncologyClassifier, Cytonuclear
An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes Levet S, Medina J, Joanou J, Demolder A, Queruel N, Réant K, Normand M, Seffals M, Dimier J, Germi R, Piofczyk T, Portoukalian J, Touraine J-L, Perron H2017JCI InsightImmunology, MetabolismClassifier, Cytonuclear
Differential roles of RET isoforms in medullary and papillary thyroid carcinomas Lian EY, Maritan SM, Cockburn JG, Kasaian K, Crupi MJF, Hurlbut D, Jones SJM, Wiseman SM, Mulligan LM2017Endocrine-Related CancerOncologyCytonuclear
Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primatesLiu M, Li N, Qu C, Gao Y, Wu L, Hu LG2021Communications BiologyMetabolismArea Quantification, Cytonuclear
Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 GeneKatsumata Y, Fardo DW, Bachstetter AD, Artiushin SC, Wang W-X, Wei A, Brzezinski LJ, Nelson BG, Huang Q, Abner EL, Anderson S, Patel I, Shaw BC, Price DA, Niedowicz DM, Wilcock DW, Jicha GA, Neltner JH, Van Eldik LJ, Estus S, Nelson PT2019Journal of Neuropathology & Experimental NeurologyNeuroscienceArea Quantification, Cytonuclear
Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression Lizardo MM, Morrow JJ, Miller TE, Hong ES, Ren L, Mendoza A, Halsey CH, Scacheri PC, Helman LJ, Khanna C2016NeoplasiaOncologyCytonuclear
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival Logsdon DP, Fenil S, Fabrizio C, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML2018Scientific ReportsOncologyClassifier, Cytonuclear
Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a PomcSomatostatin-Growth Hormone Circuit Lohr H, Hess S, Pereira MMA, Reino P, Leibold S, Schenkel C, Wunderlich CM, Kloppenburg P, Bruning JC, Hammerschmidt M2018Cell ReportsNeuroscience, MetabolismCytonuclear
Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity Luna E, Decker SC, Riddle DM, Caputo A, Zhang B, Cole T, Caswell C, Xie SX, Lee VMY, Luk KC2018Acta NeuopathologicaNeuroscienceArea Quantification, Cytonuclear
Modulating the therapeutic response of tumours to dietary serine and glycine starvation Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH2017NatureOncologyCytonuclear
Ex vivo tissue slice culture system to measure drug-response rates of hepatic metastatic colorectal cancerMartin SZ, Wagner DC, Hörner N, Horst D, Lang H, Tagscherer KE, Roth W2019BMC CancerOncologyClassifier, Cytonuclear
Prognostic value of tumor-inltrating immune cells in primary colorectal cancer and metastasesMartin SZ, Tagscherer KE, Deckert S, Horst D, Moehler M, Lang H, Roth W2020*Pre-PrintImmuno-oncologyClassifier, Cytonuclear
Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models Matsuki M, Hoshi T, Yamamoto Y, Ikemori-Kawada M, Minoshima Y, Funahashi Y, Matsui J2018Cancer MedicineOncologyCytonuclear
Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent mannerMgrditchiana T, Arakeliana T, Paggettia J, Nomana MZ, Virya E, Moussaya E, Van Moera K, Kreisb S, Guerinc C, Buartd S, Roberte C, Borgf C, Vielhg P, Chouaibd S, Berchema G, Janji B2017Proceedings of the National Academy of SciencesOncology, Immuno-oncologyCytonuclear
Weight Pertubation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain Morabito MV, Ravussin Y, Mueller BR, Skowronski AA, Watanabe K, Foo KS, Lee SX, Lehmann A, Hjorth S, ZeltserLM, LeDuc CA, Leibel RL2017PLOS OneMetabolismCytonuclear
A Dual Blocker of Endothelin A/B Receptors Mitigates Hypertension but not Renal Dysfunction in a Rat Model of Chronic Kidney Disease and Sleep Apnea Morales-Loredo H, Jones DT, Barrera A, Mendiola P, Garcia J, Pace CE, Murphy M, Kanagy NL, Gonzalez Bosc LV2019Renal PathologyMetabolismClassifier, Cytonuclear, Figure Maker
Tasquinimod modulates tumor-infiltrating myeloid cells and improves the antitumor immune response to PD-L1 blockade in bladder cancer Nakhlé J, Pierron V, Bauchet A-L, Plas P, Thiongane A, Meyer-Losic F, Schmidlin F2016OncoImmunologyOncology, Immuno-oncologyCytonuclear
Altered dopaminergic regulation of the dorsal striatum is able to induce tic-like movements in juvenile rats Nespoli E, Rizzo F, Boeckers T, Schulze U, Hengerer B2018PLOS OneNeuroscienceCytonuclear
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma O’Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, MorrissetteJJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot J-M, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV2017Science Translational MedicineOncology, Immuno-oncologyCytonuclear, Multiplex IHC
Role of IL-15 Signaling in the Pathogenesis of Simian Immunodeficiency Virus Infection in Rhesus Macaques Okoye AA, DeGottardi MQ, FukazawaY, Vaidya M, Abana CO, Konfe AL, Fachko DN, Duell DM, He Li H, Lum R, Gao L, Park BS, Skalsky RL, Lewis AD, Axthelm MK, Lifson JD, Wong SW, Picker LJ2019The Journal of ImmunologyInfectious DiseaseCytonuclear, Figure Maker
Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment Olsson A, Nakhle J, Sundstedt A, Plas P, Bauchet AL, Pierron V, Bruetschy L, Deronic A, Tomgren M, Liberg D, Schmidlin F, Leanderson T2015Journal for ImmunoTherapy of CancerOncology, Immuno-oncologyCytonuclear
Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonistParisi G, Saco JD, Salazar FB, Tsoi J, Krystofinski P, Puig-Saus C, Zhang R, Zhou J, Cheung-Lau GC, Garcia AJ, Grasso CS, Tavaré R, Hu-Lieskovan S, Mackay S, Zalevsky J, Bernatchez C, Diab A, Wu AM , Comin-Anduix B, Charych D, Ribas A2020Nature CommunicationsOncology, Immuno-oncologyCytonuclear
Mechanical regulation of glycolysis via cytoskeleton architecturePark JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G2020NatureOncologyClassifier, Cytonuclear, TMA
Imaging Mass Spectrometry and Proteome Analysis of Marek's Disease Virus-Induced Tumors Pauker VI, Bertzbach LD, Hohmann A, Kheimar A, Teifke JP, Mettenleiter TC, Karger A, Kaufe BB2019mSpereOncologyCytonuclear
Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human Pognan F, Mahl JA, Papoutsi M, David Ledieu D, Raccuglia M, Theil D, Voytek SB, Devine PJ, Kubek‑Luck K, Claudio N, Cordier A, Heier A, Kolly C, Hartmann A, Chibout S-D, Bouchard P, Trendelenburg C2018Archives of ToxicologyToxicologyClassifier, Cytonuclear
TNF-? Contributes to Lymphoid Tissue Disorganization and Germinal Center B Cell Suppression during Intracellular Bacterial Infection Popescu M, Cabrera-Martinez B, Winslow GM2019The Journal of ImmunologyImmunologyCytonuclear
Changes in epidermal morphology associated with dandruff Pople JE, Bhogal RK, Moore AE, Jenkins G2019International Journal of Cosmetic ScienceDermatologyCytonuclear, Layer Thickness
Automated Computational Detection, Quantitation, and Mapping of Mitosis in Whole‚ÄëSlide Images for Clinically Actionable Surgical Pathology Decision Support Puri M, Hoover S, Hewitt S, Wei B-R, Adissu H, Halsey C, Beck J, Bradley C, Cramer S, Durham A, Esplin D, Frank C, Lyle L, McGill L, Sanchez M, Schaffer P, Traslavina R, Buza E, Yang H, Lee M, Dwyer J, Simpson R2019Journal of Pathology InformaticsOncologyCytonuclear
Lamin‑B1 is a senescence‑associated biomarker in clear‑cell renal cell carcinomaRadspieler M, Schindeldecker M, Stenzel P, Försc S, Tagscherer K, Herpel E, Hohenfellner M, Hatiboglu G, Roth W, Macher‑Goeppinger S2019Oncology LettersOncologyCytonuclear
Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosaReyes-Uribe L, Wu W, Gelincik O, Bommi PV, Francisco-Cruz A, Solis LM, Lynch PM, Lim R, Stoffel EM, Kanth P, Samadder NJ, Mork ME, Taggart MW, Milne GL, Marnett LJ, Vornik L, Liu DD, Revuelta M, Chang K, You YN, Kopelovich L, Wistuba II, Lee JJ, Sei S, Shoemaker RH, Szabo E, Richmond E, Umar A, Perloff M, Brown PH, Lipkin SM, Vilar E2020GutOncologyClassifier, Cytonuclear
Intermittent Hypoxia Exacerbates Increased Blood Pressure in Rats with Chronic Kidney Disease Riggs J, Pace C, Ward HH, Gonzalez Bosc L, Rios L, Barrera A, Kanagy NL2018American Jornal of Physiology-Renal PhysiologyMetabolismClassifier, Cytonuclear
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling Robinson BD, Vlachostergios PJ, Bhinder B, Liu W, Li K, Moss TJ, Bareja R, Park K, Tavassoli P, Cyrta J, Tagawa ST, Nanus DM, Beltran H, Molina AM, Khani F, Miguel Mosquera J, Xylinas E, Shariat SF, Scherr DS, Rubin MA, Lerner SP, Matin SF, Elemento O, Faltas BM2019Nature CommunicationsOncology, Immuno-oncologyCytonuclear
p53 is associated with high-risk and pinpoints TP53 missense mutations in mantle cell lymphomaRodrigues JM, Hassan M, Freiburghaus C, Eskelund CW, Geisler C, Raty R, Kolstad A, Sundstrom C, Glimelius I, Gronbaek K, Kwiecinska A, Porwit A, Jerkeman M, Ek S2020British Journal of HaematologyOncologyClassifier, Cytonuclear
The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a β-hydroxybutyrate paradox Rodrigues LM, Uribe-Lewis S, Madhu B, Honess DJ, Stubbs M, Griffiths JR2017Cancer & MetabolismOncology, MetabolismArea Quantification, Cytonuclear
RUNX1 is a driver of renal cell carcinoma correlating with clinical outcomeRooney N, Mason SM, McDonald L, Däbritz HM, Campbell KJ, Hedley A, Howard S, Athineos D, Nixon C, Clark W, Leach JDG, Samsom OJ, Edwards J, Cameron ER, Blyth K2020Cancer ResearchOncologyCytonuclear
High levels of tumor-associated neutrophils are associated with improved overall survival in patients with stage II colorectal cancer RS Berry, M-J Xiong, A Greenbaum, P Mortaji, RA Nofchissey, F Schultz, C Martinez, L Luo, KT Morris, JA Hanson2017PLOS OneOncology, Immuno-oncologyCytonuclear
Pathological tau strains from human brains recapitulate the diversity of tauopathies in non-transgenic mouse brain S Narasimhan, JL Guo, L Changolkar, A Stieber, JD McBride, LV Silva, Z He, B Zhang, RJ Gathagan, JQ Trojanowski, VMY Lee2017Journal of NeuroscienceNeuroscienceCytonuclear
Analytical Performance of an Immunoprofiling Assay Based on RNA ModelsSchillebeeckx I, Armstrong JR, Forys JT, Hiken J, Earls J, Flanagan KC, Cui T, Glasscock JI, Messina DN, Duncavage EJ2020The Journal of Molecular DiagnosticsImmunologyCytonuclear
Primary resistance to PD-1 blockade mediated by JAK1/2 mutations Shin DS, Zaretsky JM, Escuin-Ordinas H, Garcia-Diaz A, Hu-Lieskovan S, Kalbasi A, Grasso CS, Hugo W, Sandoval S, Torrejon DY, Palaskas N, Rodriguez GA, Parisi G, Azhdam A, Chmielowski B, Cherry G, Seja E, Berent-Maoz B, Shintaku IP, Le DT, Pardol DM, Diaz LA, Tumeh PC, Graeber TG, Lo RS, Comin-Anduix B, Ribas A2016Cancer DiscoveryOncology, Immuno-oncologyCytonuclear
Prognostic significance of mesothelin expression in colorectal cancer disclosed by area-specific four-point tissue microarraysShiraishi T, Shinto E, Nearchou IP, Tsuda H, Kajiwara Y, Einama T, Caie PD, Kishi Y, Ueno H2020Vichows ArchivOncologyCytonuclear, HALO AI, TMA
Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survivalSinghal SK, Byun JS, Park S, Yan T, Yancey R, Caban A, Hernandez SG, Hewitt SM, Boisvert H, Hennek S, Bobrow M, Ahmed SU, White J, Yates C, Aukerman A, Vanguri R, Bareja R, Lenci R, Farré PL, De Siervi A, Nápoles AM, Vohra N, Gardner K2021Communications BiologyOncologyCytonuclear, TMA
KS-Detect-Validation of Solar Thermal PCR for the Diagnosis of Kaposi's Sarcoma Using Pseudo-Biopsy Samples Snodgrass R, Gardner A, Jiang L, Fu C, Cesarman E, Erickson D2016PLOS ONEOncologyCytonuclear
Prognostic and Predictive Value of Tumor-infiltrating Leukocytes and of Immune Checkpoint Molecules PD1 and PDL1 in Clear Cell Renal Cell CarcinomaStenzel PJ, Schindeldecker M, Teagscherer KE, Foersch S, Herpel E, Hohenfellner M, Hatiboglu G, Alt J, Thomas C, Haferkamp A, Roth W, Macher-Goeppinger S2020Translational OncologyOncology, Immuno-oncologyClassifier, Cytonuclear, TMA
IL‐36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis Su Z, Paulsboe S, Wetter J, Salte K, Kannan A, Mathew S, Horowitz A, Gerstein C, Namovic M, Todorović V, Seagal J, Edelmayer RM, Viner M, Rinaldi L, Zhou L, Leys L, Huang S, Wang L, Sadhukhan R, Honore P, McGaraughty S, Scott VE2019Experimental DermatologyDermatologyArea Quantification, Cytonuclear
Development of antibody-siRNA conjugate targeted to cardiac and skeletal muscles Sugo T, Terada M, Oikawa T, Miyata K, Nishimura S, Kenjo E, Ogasawara-Shimizu M, Makita Y, Imaichi S, Murata S, Kentaro Otaka, Kikuchi K, Teratani M, Masuda Y, Kamei T, Takagahara S, Ikeda S, Ohtaki T, Matsumoto H2016The Journal of Controlled ReleaseMyologyCytonuclear, Muscle Fiber
Exacerbated experimental colitis in TNFAIP8-deficient mice Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen YH2015The Journal of ImmunologyGastroenterologyCytonuclear
Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity Timper K, Paeger L, Sánchez-Lasheras C, Varela L, Jais A, Nolte H, Vogt MC, Hausen AC, Heilinger C, Evers N, Pospisilik JA, Penninger JM, Taylor EB, Horvath TL, Kloppenburg P, Brüning JC2018Cell RepotsNeuroscience, MetabolismCytonuclear
PD-1 blockade induces responses by inhibiting adaptive immune resistance Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJM, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, West AN, Carmona M, Kivork C, Seja E, Cherry G, Gutierrez A, Grogan TR, Mateus C, Tomasic G, Glaspy JA, Emerson RO, Robins H, Pierce RH, Elas2014NatureOncology, Immuno-oncologyCytonuclear
O 6-Methylguanine DNA Methyltransferase and Glucose Transporter 2 in Foregut and Hindgut Gastrointestinal Neuroendocrine NeoplasmsWatanbe H, Yamazaki Y, Fujishima F, Izxumi K, Imamura M, Hijioka S, Toriyama K, Yatabe Y, Kudo A, Motoi F, Unno M, Sasano H2020BMC CancerOncologyCytonuclear
The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaquesWebb GM, Molden J, Bushman-Sahay K, Abdulhaqq S, Wu HL, Weber WC, Bateman KB, Reed JS, Northrup M, Maier N,Tanaka S, Gao L, Davey B, Carpenter BL, Axthelm MK, Stanton JJ, Smedley J, Greene JM, Safrit JT, Estes JD, Skinner PJ, Sacha JB2020PLOS PathogensInfectious DiseaseCytonuclear, ISH/FISH
IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype Wiggins KA, Parry AJ, Cassidy LD, Humphry M, Webster SJ, Goodall JC, Narita M, Clarke MCH2019Aging CellImmunologyCytonuclear
SLFN11 informs on standard of care and novel treatments in a wide range of cancer modelsWinkler C, Armenia J, Jones GN, Tobalina L, Sale MJ, Petreus T, Baird T, Serra V, Wang AT, Lau A, Garnett MJ, Jaaks P, Coker EA, Pierce AJ, O'Connor MJ, Leo E2020British Journal of CancerOncologyClassifier, Cytonuclear
A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapyWisdom AJ, Mowery YM, Hong CS, Qin X, Zhang D, Himes JE, Chen L, Fradin H, Muise ES, Xu ES, Carpenter DJ, Kent CL, Smythe KS, Williams N, Luo L, Ma Y, Owzar K, Bradley T, Kirsch DG2020bioRxivOncology, Immuno-oncologyCytonuclear
Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells Xin Y, Kim J, Ni M, Wei Y, Okamoto H, Lee J, Adler C, Cavino K, Murphy AJ, Yancopoulos GD, Lin HC, Gromada J2016Proceedings of the National Academy of SciencesMetabolismCytonuclear
Combination therapy reverses hyperglycemia in NOD mice with established type 1 diabetes Xue S, Posgai A, Wasserfall C, Myhr C, Campbell-Thompson M, Mathews CE, Brusko T, Rabinovitch A, Savinov A, Battaglia M, Schatz D, Haller M, Atkinson MA2015DiabetesMetabolismCytonuclear
Comparison of the methods for measuring the Ki-67 labeling index in adrenocortical carcinoma: manual versus digital image analysis Yamazaki Y, Nakamura Y, Shibahara Y, Konosu-Fukaya S, Sato N, Kubota-Nakayama F, Oki Y, Baba S, Midorikawa S, Morimoto R, Satoh F, Sasano2016Human PathologyOncologyCytonuclear
Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma Yamazaki Y, Omata K, Tezuka Y, Ono Y, Morimoto R, Adachi Y, Ise K, Nakamura Y, Gomez-Sanchez CE, Shibahara Y, Kitamoto T, Nishikawa T, Ito S, Satoh F, Sasano H2018HypertensionOncologyArea Quantification, Cytonuclear
Association of HIV Status With Local Immune Response to Anal Squamous Cell Carcinoma: Implications for Immunotherapy Yanik EL, Kaunitz GJ, Cottrell TR, Succaria F, McMiller TL, Ascierto ML, Esandrio J, Xu H, Ogurtsova A, Cornish T, Lipson EJ, Topalian SL, Engels EA, Taube JM2017JAMA OncologyOncology, Immuno-oncologyCytonuclear
MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expressionYasuda Y, Ozasa H, Kim YH, Yamazoe M, Ajimizu H, Funazo TY, Nomizo T, Tsuji T, Yoshida H, Sakamori Y, Najajima N, Menju T, Yoshizawa A, Date H, Hirai T2020Cell Death & DiseaseOncology, Immuno-oncologyCytonuclear
Rabbit monoclonal E‐cadherin antibody: A cost‐effective alternative to mouse monoclonal antibody in distinguishing ductal carcinoma in situ from lobular carcinoma in situ Baum JE, Croyle JA, Brodsky VB, Liu Y, Shin SJ2019The Breast JournalOncologyCytonuclear
MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinomaBerggren KL, Cruz SR, Hixon MD, Cowan AT, Keysar SB, Craig S, James J, Barry M, Ozbun MA, Jimeno A, McCance DJ, Beswick EJ, Gan GN2019OncogeneOncologyCytonuclear
Genetic mutations underlying phenotypic plasticity in basosquamous carcinoma Chiang A, Tan CZ, Kuonen F, Hodgkinson LM, Chiang F, Cho RJ, South AP, Tang Jean Y, Chang ALS, Rieger KE, Oro AE, Sarin KY2019Journal of Investigative DermatologyOncologyCytonuclear
The crosstalk between aldosterone and calcium metabolism in primary aldosteronism: A possible calcium metabolism-associated aberrant “neoplastic” steroidogenesis in adrenals Gao X, Yamazaki Y, Tezuka Y, Onodera Y, Ogata H, Omata K, Morimoto R, Nakamura Y, Satoh F, Sasano H2019The Journal of Steroid Biochemistry and Molecular BiologyOncology, MetabolismCytonuclear
Farnesoid X Receptor Agonism, AcetylCoenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model Gapp B, Jourdain M, Bringer P, Kueng B, Weber D, Osmont A, Zurbruegg S, Knehr J, Falchetto R, Roma G, Dietrich W, Valdez R, Beckmann N, Nigsch F, Sanyal AJ, Ksiazek I2019Hepatology CommunicationsMetabolismCytonuclear
Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration Yousef A, Robinson JL, Irwin DJ, Byrne MD, Kwong LK, Lee EB, Xu Y, Xie SX, Rennert L, Suh ER, Van Deerlin VM, Grossman M, Lee VM-Y, Trojanowski JQ2017Acta Neuropathologica CommunicationsArea Quantification, Cytonuclear
Variability in Platelet-Derived Growth Factor Receptor Alpha Antibody Specificity May Impact Clinical Utility of Immunohistochemistry AssaysHolzer TR, Reising LO, Credille KM, Schade AE, Oakley2016Journal of Histochemistry & CytochemistryOncologyCytonuclear, ISH/FISH
Oral tenofovir disoproxil fumarate/emtricitabine for HIV pre-exposure prophylaxis increases expression of type I/III interferon-stimulated factors in the gastrointestinal tract but not in the bloodHughes SM, Levy CN, Calienes F, Stekler JD, Pandey U, Vojtech L, Berard AR, Birse K, Noel-Romas L, Richardson B, Golden J, Cartwright M, Collier AC, Stevens CE, Curlin ME, Holtz TH, Mugo N, Irungu E, Katabira E, Muwonge T, Lama JR, Baeten JM, Burgener A, Lingappa JR, McElrath MJ, Mackelprang R, McGowan I, Cranston RD, Cameron MJ, Hladik F2019bioRxivInfectious DiseaseCytonuclear
Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion Jiang H, Liu X, Knolhoff BL, Hegde S, Lee KB, Jiang H, Fields RC, Pachter JA, Lim K-H, DeNardo DG2019GutOncologyCytonuclear, ISH/FISH
The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinomaYu H, Wang H, Dong W, Cao Z-Y, Li R, Yang C, Cong W-M, Dong H, Jin G-Z2020Peer JOncologyCytonuclear
Hot Spot and Whole-Tumor Enumeration of CD8(+) Tumor-Infiltrating Lymphocytes Utilizing Digital Image Analysis Is Prognostic in Triple-Negative Breast Cancer McIntire PJ, Irshaid L, Liu Y, Chen Z, Menken F, Nowak E, Shin SJ, Ginter PS2018Clinical Breast CancerOncology, Immuno-oncologyCytonuclear, Figure Maker
Hotspot enumeration of CD8+ tumor infiltrating lymphocyte using digital image analysis in triple negative breast Cancer yields consistent resultsMcIntire PJ, Zhong E, Patel A, Khani F, D'Alfonso T, Chen Z, Shin SJ, Ginter PS2019Human PathologyOncologyCytonuclear
Female-biased embryonic death from inflammation induced by genomic instability McNairn AJ, Chuang C-H, Bloom JC, Wallace MD, Schimenti JC2019NatureImmunologyCytonuclear
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, Torrejon DY, Abril-Rodriguez G, Sandoval S, Barthly L, Saco J, Homet Moreno BH, Mezzadra R, Chmielowski B, Ruchalski K, Shintaku IP, Sanchez PJ, Puig-Saus C, Cherry G, Seja E, Kong X, Pang J, Berent-Maoz B, Comin-Anduix B, Graeber TG, Tumeh PC, Schumacher TNM, Lo RS, Ribas A2016The New England Journal of MedicineOncology, Immuno-oncologyCytonuclear
Imaging CAR T cell therapy with PSMA-targeted positron emission tomography Minn I, Huss DJ, Ahn H-H, Chinn TM, Park A, Jones J, Brummet M, Rowe SP, Sysa-Shah P, Du Y, Levitsky HI, Pomper MG2019Science AdvancesOncologyCytonuclear
Accelerated wound healing by injectable star poly(ethylene)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs Zhu X, Yin L, Theisen M, Zhuo J, Siddiqui S, Levy B, Presnyak V, Frassetto A, Milton J, Salerno T, Benenato KE, Milano J, Lynn A, Sabnis S, Burke K, Besin G, Lukacs CM, Guey LT, Finn PF, Martini PGV2018Journal of Controlled ReleaseBiomaterials, Wound HealingCytonuclear
Prohibitin is a prognostic marker of relapse and therapeutic target to block chemotherapy resistance in Wilms tumorOrtiz MV, Ahmed S, Burns M, Henssen AG, Hollmann TJ, MacArthur I, Gunasekera S, Gaewsky L, Bradwin G, Ryan J, Letai A, He Y, Naranjo A, Chi Y-Y, LaQuaglia M, Heaton T, Cifani P, Dome JS, Gadd S, Perlman E, Mullen E, Steen H, Kentsis A2019JCI InsightOncologyCytonuclear
Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers Scheper W, Kelderman S, Fanchi LF, Linnemann C, Bendle G, de Rooij MAJ, Hirt C, Mezzadra R, Slagter M, Dijkstra K, Kluin RJC, Snaebjornsson P, Milne K, Nelson BH, Zijlmans H, Kenter G, Voest EE, Haanen JBAG, Schumacher TN2018Nature MedicineOncology, Immuno-oncologyCytonuclear
The use of automated Ki67 analysis to predict Oncotype DX risk-of-recurrence categories in early-stage breast cancerThakur SS, Li H, Chan AMY, Tudor R, Bigras G, Morris D, Enwere EK2018PLOS ONEOncologyCytonuclear, Figure Maker, Partitions (tiles, margins)
GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity Untereiner A, Abdo S, Bhattacharjee A, Gohil H, Pourasgari F, Ibeh N, Lai M, Batchuluun B, Wong A, Khuu N, Liu Y, Rijjal DA, Winegarden N, Virtanen C, Orser BA, Cabrera O, Varga G, Rocheleau J, Dai FF, Wheeler MB2018The FASEB JournalMetabolismCytonuclear
Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic functionWilliams CM, Calderon JH, Hock E, Jimenez Y, Barringer K, Carbonaro M, Molina-Portela MP, Thurston G, Li Z, Daly C2021The FASEB JournalMetabolismCytonuclear
Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumoursGampala S, Shah F, Zhang C, Rhodes SD, Babb O, Grimard M, Wireman RS, Rad E, Calver B, Bai R-Y, Staedtke V, Hulsey EL, Saadatzadeh MR, Pollok KE, Tong Y, Smith AE, Clapp DW, Tee AR, Kelley MR, Fishel ML2021British Journal of CancerOncologyArea Quantification, Cytonuclear
First in class dual MDM2/MDMX inhibitor ALRN-6924 enhances antitumor efficacy of chemotherapy in TP53 wild-type hormone receptor-positive breast cancer modelsPairawan S, Zhao M, Yuca E, Annis A, Evans K, Sutton D, Carvajal L, Ren J-G, Santiago S, Guerlavais, Akcakanat A, Tapia C, Yang F, Bose PSC, Zheng X, Dumbrava EI, Aivado M, Meric-Bernstam F2021Breast Cancer ResearchOncologyCytonuclear
Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinomaKazdal D, Rempel E, Oliveira C, Allgäuer M, Harms A, Singer K, Kohlwes E, Ormanns S, Fink L, Kriegsmann J, Leichsenring M, Kriegsmann K, Stögbauer F, Tavernar L, Leichsenring J, Volckmar A-L, Longuespée R, Winter H, Eichhorn M, Heußel CP, Herth F, Christopoulos P, Reck M, Muley T, Weichert W, Budczies J, Thomas M, Peters S, Warth A, Schirmacher P, Stenzinger A, Kriegsmann M2021Translational Lung Cancer ResearchOncologyClassifier, Cytonuclear
Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer CellsDahou H, Minati M-A, Jacquemin P, Assi M2021antioxidantsOncologyCytonuclear
In vivo endothelialization and neointimal hyperplasia assessment after rabbit carotid endarterectomy with bovine pericardiumChen Y, Feng Y, Wang T, Zhang X, Zhang M, Bai X, Li L, Yang K, Ma Y, Zhang Z, Jiao L2021Annals of Translational MedicineMyologyCytonuclear
Tumor morphology and location associate with immune cell composition in pleomorphic sarcomaWustrack RL, Shao E, Sheridan J, Zimel M, Cho S-J, Horvai AE, Luong D, Kwek SS, Fong L, Okimoto RA2021Cancer Immunology, ImmunotherapyImmuno-oncologyCytonuclear
Cellular Senescence in Human Aldosterone-Producing Adrenocortical Cells and Related DisordersPieroni J, Yamazaki Y, Gao X, Tezuka Y, Ogata H, Omata K, Ono Y, Morimoto R, Nakamura Y, Satoh F, Sasano H2021BiomedicinesMetabolismCytonuclear
Toluidine blue staining of murine mast cells and quantitation by a novel, automated image analysis method using whole slide skin imagesRaja N, Naikodi S, Govindarajan A, Palanisamy K2021Journal of HistotechnologyImmunologyCytonuclear

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