Cytonuclear IHC
Cytonuclear IHC
Product Overview
The Cytonuclear IHC module measures cell-by-cell IHC positivity for single or multi stain applications. Each cell is measured for cytoplasmic or nuclear positivity of every individual stain as well as the colocalization of different marker combinations. Positive cells are binned and assigned an intensity score (0, 1+, 2+, and 3+) based on stain optical density. The module also reports a variety of other metrics relating to cell/nuclear size and stain intensity. Optionally, the tool can output the complete table of cell data including individual cell sizes and optical density measurements for each stain in each cellular compartment. This module has the option to define specific cell phenotypes according to marker positivity, allowing users to define and count specific cell populations based off of defined positivity and negativity rules.
In the first example shown above, the module is configured to output an intensity markup for a single IHC marker (DAB). Cells below the positivity threshold for the DAB marker are blue and cells above the positivity threshold are scoring according to optical density thresholds set in the module, weak positive (1+) in yellow, moderate positive (2+) in orange and strong positive (3+) in red.
In the second example, the module is used to analyze a dual-stain IHC and a co-expression mark-up is generated. Cells positive for the red cytoplasmic marker only are red, cells positive for the brown cytoplasmic marker are green and dual positive cells are cyan.
The Cytonuclear IHC module integrates seamlessly into the HALO® platform which is compatible with a number of third party systems and file formats.
Contact info@indicalab.com for product demonstration and pricing information or upload some images for a free trial.
Cytonuclear IHC
The Cytonuclear IHC module measures cell-by-cell IHC positivity for single or multi stain applications. Each cell is measured for cytoplasmic or nuclear positivity of every individual stain as well as the colocalization of different marker combinations. Positive cells are binned and assigned an intensity score (0, 1+, 2+, and 3+) based on stain optical density. The module also reports a variety of other metrics relating to cell/nuclear size and stain intensity. Optionally, the tool can output the complete table of cell data including individual cell sizes and optical density measurements for each stain in each cellular compartment. This module has the option to define specific cell phenotypes according to marker positivity, allowing users to define and count specific cell populations based off of defined positivity and negativity rules.
In the first example shown above, the module is configured to output an intensity markup for a single IHC marker (DAB). Cells below the positivity threshold for the DAB marker are blue and cells above the positivity threshold are scoring according to optical density thresholds set in the module, weak positive (1+) in yellow, moderate positive (2+) in orange and strong positive (3+) in red.
In the second example, the module is used to analyze a dual-stain IHC and a co-expression mark-up is generated. Cells positive for the red cytoplasmic marker only are red, cells positive for the brown cytoplasmic marker are green and dual positive cells are cyan.
Here are a few publications that cite use of the Cytonuclear IHC or FL modules. Your publication not on the list? Drop us an email to let us know about it!
| Title | Authors | Year | Journal | Application | HALO Modules | |
|---|---|---|---|---|---|---|
| Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator study | Acs B, Pelekanou V, Bai Y, Martinez-Morilla S, Toki M, Leung SCY, Nielsen TO, Rimm DL | 2017 | Laboratory Invesigations | Oncology | Classifier, Cytonuclear | |
| Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis | Allen CT, Lee S, Norberg SM, Kovalovsky D, Ye H, Clavijo PE, Hu-Lieskovan S, Schlegel R, Schlom J, Strauss J, Gulley JL, Trepel J, Hinrichs CS | 2019 | Journal for ImmunoTherapy of Cancer | Oncology, Immuno-oncology | Cytonuclear | |
| Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells | Andre ́P, Denis C, Soulas C, Bourbon-Caillet C, Lopez J, Arnoux T, Bléry M, Bonnafous C, Gauthier L, Morel A, Rossi B, Remark R, Breso V, Bonnet E, Habif G, Guia S, Lalanne AI, Hoffmann C, Lantz O, Fayette J, Boyer-Chammard A, Zerbib R, Dodion P, Ghadially H, Jure-Kunkel M, Morel Y, Herbst R, Narni-Mancinelli E, Cohen RB, Vivier E | 2018 | Cell | Oncology, Immuno-oncology | Area Quantification, Cytonuclear | |
| The R-enantiomer of ketorolac delays mammary tumor development in mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) mice | AS Peretti, D Dominguez, MM Grimes, HJ Hathaway, ER Prossnitz, MR Rivera, A Wandinger-Ness, D Kusewitt, LG Hudson | 2017 | The American Journal of Pathology | Oncology | Classifier, Area Quantification, Cytonuclear | |
| The clinical impact of tumour-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: A cohort study | Berntsson J, Svensson MC, Leandersson K, Nodin B, Micke P, Larsson AH, Eberhard J, Jirstrom K | 2017 | International Journal of Cancer | Oncology, Immuno-oncology | Cytonuclear | |
| Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation | Bulusu V, Tumanov S, Michalopoulou E, van den Broek NJ, MacKay G, Nixon C, Dhayade S, Schug ZT, Voorde JV, Blyth K, Gottlieb E, Vazquez A, Kamphorst JJ | 2017 | Cell Reports | Oncology, Metabolism | Cytonuclear | |
| Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes | Burnett LC, Hubner G, LeDuc C, Morabito MV, Carli JFM, Leibel RL | 2017 | Human Moledular Genetics | Metabolism | Cytonuclear | |
| Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and potential for glucagon-producing neuroendocrine tumors | Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC | 2013 | Diabetes | Oncology, Metabolism | Cytonuclear | |
| Control of mitochondrial function and cell growth by the atypical cadherin Fat1 | Cao LL, Riascos-Bernal DF, Chinnasamy P, Dunaway CM, Hou R, Pujato MA, O'Rourke BP, Miskolci V, Guo L, Hodgson L, Fiser A, Sibinga NES | 2016 | Nature | Metabolism | Cytonuclear | |
| Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis | Carvelli J, Demaria O, Vely F, Batista L, Benmansour NC, Fares J, Carpentier S, Thibult M-L, Morel A, Andre P, Represa A, Piperoglou C, Cordier PY, Le Dault E, Guervilly C, Simone P, Gainnier M, Morel Y, Ebbo M, Schleinitz N, Vivier E | 2020 | Nature | Immunology | Cytonuclear | |
| Identification of the SUMO E3 ligase PIAS1 as a potential survival biomarker in breast cancer | Chanda A, Chan A, Deng L, Kornaga EN, Enwere EK, Morris DG, Bonni S | 2017 | PLOS One | Oncology | Classifier, Cytonuclear | |
| Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells | Chi M, Evans, Gilchrist J, Mayhew J, Hoffman A, Pearsall EA, Jankowski H, Brzozowski JS, Skelding KA | 2016 | Scientific Reports | Oncology | Cytonuclear | |
| Impact of Preanalytical Factors During Histology Processing on Section Suitability for Digital Image Analysis | Chlipala EA, Butters M, Brous M, Fortin JS, Archuletta R, Copeland K, Bolon B | 2020 | Toxicologic Pathology | Toxicology | Area Quantification, Cytonuclear | |
| Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes | Cinti F, Bouchi R, Kim-Muller JY, Ohmura Y, Sandoval PR, Masini M, Marselli L, Suleiman M, Ratner LE, Marchetti P, Accili D | 2016 | The Journal of Clinical Endocrinology & Metabolism | Metabolism | Cytonuclear | |
| RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer | Cruz C, Castroviejo-Bermejo M, Gutiérrez-Enríquez S, Llop-Guevara A, Ibrahim YH, Gris-Oliver A, Bonache S, Morancho B, Bruna A, Rueda OM, Lai Z, Polanska UM, Jones GN,Kristel P, de Bustos L, Guzman M, Rodriguez O, Grueso J, Montalban G, Caratú G, Mancuso F, Fasani R, Jiménez J, Howat WJ, Dougherty B, Vivancos A, Nuciforo P, Serres-Créixams X, Rubio IT, Oaknin A, Cadogan O, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Arribas J, Jonkers J, Díez O, O’Connor MJ, Balmaña J, SerraV | 2018 | Annals of Oncology | Oncology | Classifier, Cytonuclear | |
| Tumor vessel normalization, immuno-stimulatory reprogramming, and improved survival in glioblastoma with combined inhibition of PD-1, angiopoietin-2, and VEGF | Di Tacchio M, Macas J, Weissenberger J, Sommer K, Bähr O, Steinbach JP, Senft C, Seifert V, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Scheel AH, Büttner R, Grauer OM, Schittenhelm J, Tabatabai G, Harter PN, Guenther S, Devraj K, Plate KH, Reiss Y | 2020 | Cancer Immunology Research | Oncology, Immuno-oncology | Classifier, Cytonuclear | |
| Spatial distribution of EGFR and KRAS mutation frequencies correlates with histological growth patterns of lung adenocarcinomas | Dietz S, Harms A, Endris V, Eichhorn, Kriegsmann M, Longuespée R, Stenzinger A, Sültmann H, Warth A, and Kazdal D | 2017 | International Journal of Cancer | Oncology | Cytonuclear | |
| Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis | do Valle Duraes F, Lafont A, Biebel M, Martin K, Darribat K, Cuttat R, Waldt A, Naumann U, Wieczorek G, Gaulis S, Pfister S, Mertz KD, Li J, Roma G, Warncke M | 2020 | JCI Insight | Immunology | Area Quantification, Cytonuclear | |
| The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models | Durant ST, Zheng L, Wang Y, Chen K, Zhang L, Zhang T, Yang Z, Riches L, Trinidad AG, Fok JHL, Hunt T, Pike KG, Wilson J, Smith A, Colclough N, Reddy VP, Sykes A, Janefeldt A, Johnström P, Varnäs K, Takano A, Ling S, Orme J, Stott J, Roberts C, Barrett I, Jones G, Roudier M, Pierce A, Allen J, Kahn J, Sule A, Karlin J, Cronin A, Chapman M, Valerie K, Illingworth R, Pass M | 2018 | Science Advances | Oncology, Neuroscience | Classifier, Cytonuclear | |
| Islet-1 is essential for pancreatic β-cell function | Ediger BN, Du A, Liu J, Hunter CS, Walp ER, Schug J, Kaestner KH, Stein R, Stoffers DA, May CL | 2014 | Diabetes | Metabolism | Cytonuclear | |
| Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade | Eichten A, Su J, Adler AP, Zhang L, Ioffe E, Parveen AA, Yancopoulos GD, Rudge J, Lowy I, Lin HC, MacDonald D, Daly C, Duan X, Thurston G | 2016 | Cancer Research | Oncology, Immuno-oncology | Cytonuclear, Object Colocalization | |
| The prevalence and prognostic significance of estrogen receptor beta expression in non-small cell lung cancer | Enwere EK, Dean ML, Li H, D'Silva A, Bebb DG | 2020 | Translational Lung Cancer Research | Oncology | Cytonuclear, TMA | |
| High response rate to PD-1 blockade in desmoplastic melanomas | Eroglu Z, Zaretsky JM, Hu-Lieskovan H, Kim DW, Algazi A, Johnson DB, Liniker E, Kong B, Munhoz R, Rapisuwon S, Gherardini PF, Chmielowski B, Wang X, Shintaku IP, Wei C, Sosman JA, Joseph RW, Postow MA, Carlino MS, Hwu W-J, Scolyer RA, Messina J, Cochran AJ, Long GV, Ribas A | 2018 | Nature | Oncology, Immuno-oncology | Cytonuclear | |
| Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors | Escuin-Ordinas H, Li S, Xie MW, Sun L, Hugo W, Huang RR, Jiao J, Meira de-Faria F, Realegeno S, Krystofinski P, Azhdam A, Komenan SMD, Atefi M, Comin-Anduix B, Pellegrini M, Cochran AJ, Modlin RL, HerschmanHR, Lo RS, McBride WH, Segura T, Ribas A | 2016 | Nature Communications | Wound Healing | Cytonuclear | |
| Early Stage HER2-Positive Breast Cancers Not Achieving a pCR From Neoadjuvant Trastuzumab- or Pertuzumab-Based Regimens Have an Immunosuppressive Phenotype | Force J, Howie LJ, Abbot SE, Bentley R, Marcom PK, Kimmick G, Westbrook K, Sammons SL, Parks M, Topping DL, Emerson R, Broadwater G, Hyslop T, Blackwell KL, Nair SK | 2018 | Clinical Breast Cancer | Oncology, Immuno-oncology | Cytonuclear | |
| Characterization of the exocrine pancreas in the male Zucker diabetic fatty rat model of type 2 diabetes mellitus following 3 months of treatment with sitagliptin | Forest T, Holder D, Smith A, Cunningham C, Yao X, Dey M, Frederick C, Prahalada S | 2014 | Endocrinology | Metabolism | Cytonuclear | |
| Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity | Freiburghaus C, Emruli VK, Johansson A, Eskelund CW, Grønbæk K, Olsson R, Ek F, Jerkeman M, Ek S | 2018 | BMC Cancer | Oncology | Classifier, Cytonuclear | |
| IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel disease | Friedrich M, Pohin M, Jackson MA, Korsunsky I, Bullers S, Rue-Albrecht K, Christoforidou Z, Sathananthan D, Ravindran R, Peres RS, Sharpe H, Wei K, Watts GFM, Mann EH, Geremia A, Thomas T, Attar M, Oxford IBD Cohort Investigators, Roche Fibroblast Network Consortium, McCuaig S, Thomas L, Collantes E, Uhlig HH, Sansom S, Easton A, Raychaudhuri S, Travis SP, Powrie FM | 2021 | bioRxiv | Immunology | Cytonuclear | |
| The PDE10A inhibitor MP-10 and haloperidol produce distinct gene expression profiles in the striatum and influence cataleptic behavior in rodents | Gentzel RC, Toolan D, Roberts R, Koser AJ, Kandebo M, Hershey J, Renger JJ, Uslaner J, Smith SM | 2015 | Neuropharmacology | Neuroscience | Cytonuclear | |
| Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer | Ghaffari A, Hoskin V, Turashvili G, Varma S, Mewburn J, Mullins G, Greer PA, Kiefer F, Day AG, Madarnas Y, SenGupta S, Elliott BE | 2019 | Breast Cancer Research | Oncology | Classifier, Cytonuclear | |
| Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units | Giorgetti E, Panesar M, Zhang Y, Joller S, Ronco M, Obrecht M, Lambert C, Accart N, Beckmann N, Doelemeyer A, Perrot L, Fruh I, Mueller M, Pierrel E, Summermatter S, Bidinosti M, Shimshek DR, Brachat S, Nash M | 2019 | Cell Reports | Neuroscience | Classifier, Cytonuclear | |
| The novel ATM inhbitior (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan montherapy | Greene J, Nguyen A, Bagby SM, Jones GN, Tai WM, Quackenbush KS, Schreiber A, Messersmith WA, Devaraj KM, Blatchford P, Eckhardt SG, Cadogan EB, Hughes GD, Smith A, Pitts TM, Arcaroli JJ | 2018 | Oncotarget | Oncology | Classifier, Area Quantification, Cytonuclear | |
| Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations | Guntermann C, Piaia A, Hamel M-L, Theil D, Rubic-Schneider T, del Rio-Espinola A, Dong L, Billich A, Kaupmann K, Dawson J, Hoegenauer K, Orain D, Hintermann S, Stringer R, Pate DD, Doelemeyer A, Deurinck M, and Schümann J | 2017 | JCI Insight | Oncology, Immuno-oncology | Area Quantification, Cytonuclear | |
| Digital image analysis agrees with visual estimates of bone marrow trephine biopsy cellularity | Hagiya AS, Etman A, Siddiqi IN, Cen S, Matcuk Jr GR, Brynes RK, Salama ME | 2017 | International Journal of Laboratory Hematology | Oncology | Cytonuclear | |
| A Phase II Trial of Dovitinib in BCD-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Over-Expression: Hoosier Cancer Research Network Trial HCRN 12-157 | Hahn NH, Bivalacqua TJ, Ross AE, Netto GJ, Baras AS, Park JC, Chapman C, Masterson TA, Koch MO, Bihrle R, Foster RS, Gardner TA, Cheng L, Jones DR, Kyle McElyea K, Sandusky GE, Breen T, Liu Z, Albany C, Moore ML, Loman RA, Reed A, Turner SA, de Abreu FB, Gallagher TL, Tsongalis GJ, Plimack ER, Greenberg RE, Geynisman DM | 2016 | Clinical Cancer Research | Oncology | Classifier, Cytonuclear | |
| Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis | Halbrook CJ, Wen H-J, Ruggeri JM, Takuchi KK, Zhang Y, di Magliano MP, Crawford HC | 2016 | Cellular and Molecular Gastroenterology and Hepatology | Immunology, Gastroenterology | Cytonuclear | |
| Cystic fibrosis–related diabetes is caused by islet loss and inflammation | Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC | 2018 | JHI Insights | Immunology, Metabolism, Fibrosis | Cytonuclear | |
| Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer | Hedge S, Krisnawan VE, Herzog BH, Zuo C, Breden MA, Knolhoff BL, Hogg GD, Tang JP, Baer JM, Mpoy C, Lee KB, Alexander KA, Rogers BE, Murphy KM, Hawkins WG, Fields RC, DeSelm CJ, Schwarz JK, DeNardo DG | 2020 | Cancer Cell | Oncology, Immuno-oncology | Area Quantification, Cytonuclear, Immune | |
| Highly Fermentable Fiber Alters Fecal Microbiota and Mitigates Swine Dysentery Induced by Brachyspira hyodysenteriae | Helm ET, Gabler NK, Burrough ER | 2021 | Animals | Infectious Disease | Cytonuclear | |
| LLRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice | Henderson MX, Sengupta M, McGeary I, Zhang B, Olufemi MF, Brown H, Trojanowski JQ, Lee VMY | 2019 | Acta Neuropathologica Communications | Neuroscience | Area Quantification, Cytonuclear | |
| Attenuation of diet-induced hypotalamic inflammation following bariatric surgery in female mice | Herrick MK, Favela KM, Simerly RB, Abumrad NN, Bingham NC | 2018 | Molecular Medicine | Immunology, Neuroscience | Cytonuclear | |
| Tumor Characteristics Associated with Benefit from Pembrolizumab in Advanced Non-Small Cell Lung Cancer | Hu-Lieskovan S, Lisberg A, Zaretsky JM, Grogan TR, Rizvi H, Wells DK, Carroll J, Cummings A, Madrigal J, Jones B, Gukasyan J, Shintaku IP, Slamon D, Dubinett S, Goldman JW, Elashoff D, Hellmann MD, Ribas A, Garon EB | 2019 | Clinical Cancer Research | Immuno-oncology | Cytonuclear | |
| Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase | Hudson LG, Gillette JM, Kang H, Rivera MR, Wandinger-Ness A | 2018 | Cancers | Review | Classifier, Cytonuclear, Figure Maker | |
| pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry | Jones GN, Rooney C, Griffin N, Roudier M, Young LA, Garcia-Trinidad A, Hughes GD, Whiteaker JR, Wilson Z, Odedra R, Zhao L, Ivey RG, Howat WJ, Harrington EA, Carrett JC, Ramos-Montoya A, Lau A, Paulovich AG, Cadogan EB, Pierce AJ | 2018 | British Journal of Cancer | Oncology | Classifier, Cytonuclear | |
| Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies | Kala S, Dunk C, Acosta S, Serghides L | 2020 | Human Reproduction | Infectious Disease | Cytonuclear | |
| Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies | Karpowicz RJ, Haney CM, Mihaila TS, Sandler RM, Petersson EJ, and Lee VM-Y | 2017 | Journal of Biological Chemistry | Neuroscience | Area Quantification, Cytonuclear | |
| Three-dimensional culture models mimic colon cancer heterogeneity induced by different microenvironments | Kawai S, Yamazaki M, Shibuya K, Yamazaki M, Fujji E, Nakano K, Suzuki M | 2020 | Scientific Reports | Oncology | Cytonuclear | |
| Prevalence of somatic mitochondrial mutations and spatial distribution of mitochondria in non-small cell lung cancer | Kazdal D, Harms A, Endris V, Penzel R, Oliveira C, Kriegsmann M, Longuespee R, Winter H, Schneider MA, Muley T, Pfarr N, Weichert W, Stenzinger A,Warth A | 2017 | British Journal of Cancer | Oncology | Cytonuclear | |
| Vascular endothelial ERp72 is involved in the inflammatory response in a rat model of skeletal muscle injury | Khalaf NB, Al-Mehatab D, Fathallah DM | 2021 | Medicine Reports | Immunology | Cytonuclear | |
| Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice | Kim J, Okamoto H, Huang ZJ, Anguiano G, Chen S, Liu Q, Cavino K, Xin Y, Na E, Hamid R, Lee J, Zambrowicz B, Unger R, Murphy AJ, Xu Y, Yancopoulos GD, Li W, Gromada J | 2017 | Cell Metabolism | Metabolism | Cytonuclear | |
| Alterations of the MEK/ERK, BMP, and Wnt/β-catenin pathways detected in the blood of individuals with lymphatic malformations | Kim T, Tafoya E, Chelliah MP, Lekwuttikarn R, Li J, Sarin KY, Teng J | 2019 | PLOS One | Other | Cytonuclear | |
| Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity | Kleinera S, Gomeza D, Megraa B, Naa E, Bhavsara R, Cavinoa K, Xina Y, Rojasa J, Dominguez-Gutierreza G, Zambrowicza B, Carratb G, Chabosseaub P, Hub M, Murphya AJ, Yancopoulosa GD, Rutterb GA, Gromadaa J | 2018 | Proceedings of the National Academy of Sciences | Metabolism | Cytonuclear | |
| Phenotyping of tumor-associated macrophages in colorectal cancer: impact on single cell invasion (tumor budding) and clinicopathological outcome | Koelzer VH, Canonica K, Dawson H, Sokol L, Karamitopoulou-Diamantis E, Lugli A, Zlobec I | 2015 | OncoImmunology | Oncology, Immuno-oncology, Gastroenterology | Cytonuclear | |
| Digital analysis and epigenetic regulation of the signature of rejection in colorectal cancer | Koelzer VH, Sokol L, Zahnd S, Christe L, Dawson H, Berger MD, Inderbitzin D, Zlobec I, Lugli A | 2017 | OncoImmunology | Oncology | Cytonuclear | |
| Digital image analysis of Ki67 proliferation index in breast cancer using virtual dual staining on whole tissue sections: clinical validation and inter‑platform agreement | Koopman T, Buikema HJ, Hollema H, de Bock GH, van der Vegt B | 2018 | Breast Cancer Research and Treatment | Oncology | Classifier, Cytonuclear | |
| Fasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism | Krstic J, Reinisch I, Schindlmaier K, Galhuber M, Berger N, Kupper N, Moyschewitz E, Auer M, Michenthaler H, Nössing C, Depaoli MR, Ramadani-Muja J, Stryeck S, Pichler M, Rinner B, Deutsch AJA, Reinisch A, Madl T, Chiozzi RZ, Heck AJR, Huch M, Malli R, Prokesch A | 2021 | bioRxiv | Oncology | Classifier, Cytonuclear | |
| Ex-vivo delivery of monoclonal antibody (Rituximab) to treat human donor lungs prior to transplantation | Ku TJY, Ribeiero RVP, Ferreira VH, Galasso M, Keshavjee S, Kumar D, Cypel M, Humar A | 2020 | EBioMedicine | Other | Classifier, Cytonuclear | |
| Bimodality of intratumor Ki67 expression is an independent prognostic factor of overall survival in patients with invasive breast carcinoma | Laurinavicius A, Plancoulaine B, Rasmusson A, Besusparis J, Augulis R, Meskauskas R, Herlin P, Laurinaviciene A, Muftah AAA, Miligy I, Aleskandarany M, Rakha EA, Green AR, Ellis IO | 2016 | Virchows Archiv | Oncology | Classifier, Cytonuclear | |
| An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes | Levet S, Medina J, Joanou J, Demolder A, Queruel N, Réant K, Normand M, Seffals M, Dimier J, Germi R, Piofczyk T, Portoukalian J, Touraine J-L, Perron H | 2017 | JCI Insight | Immunology, Metabolism | Classifier, Cytonuclear | |
| Differential roles of RET isoforms in medullary and papillary thyroid carcinomas | Lian EY, Maritan SM, Cockburn JG, Kasaian K, Crupi MJF, Hurlbut D, Jones SJM, Wiseman SM, Mulligan LM | 2017 | Endocrine-Related Cancer | Oncology | Cytonuclear | |
| Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates | Liu M, Li N, Qu C, Gao Y, Wu L, Hu LG | 2021 | Communications Biology | Metabolism | Area Quantification, Cytonuclear | |
| Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene | Katsumata Y, Fardo DW, Bachstetter AD, Artiushin SC, Wang W-X, Wei A, Brzezinski LJ, Nelson BG, Huang Q, Abner EL, Anderson S, Patel I, Shaw BC, Price DA, Niedowicz DM, Wilcock DW, Jicha GA, Neltner JH, Van Eldik LJ, Estus S, Nelson PT | 2019 | Journal of Neuropathology & Experimental Neurology | Neuroscience | Area Quantification, Cytonuclear | |
| Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression | Lizardo MM, Morrow JJ, Miller TE, Hong ES, Ren L, Mendoza A, Halsey CH, Scacheri PC, Helman LJ, Khanna C | 2016 | Neoplasia | Oncology | Cytonuclear | |
| Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival | Logsdon DP, Fenil S, Fabrizio C, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML | 2018 | Scientific Reports | Oncology | Classifier, Cytonuclear | |
| Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a PomcSomatostatin-Growth Hormone Circuit | Lohr H, Hess S, Pereira MMA, Reino P, Leibold S, Schenkel C, Wunderlich CM, Kloppenburg P, Bruning JC, Hammerschmidt M | 2018 | Cell Reports | Neuroscience, Metabolism | Cytonuclear | |
| Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity | Luna E, Decker SC, Riddle DM, Caputo A, Zhang B, Cole T, Caswell C, Xie SX, Lee VMY, Luk KC | 2018 | Acta Neuopathologica | Neuroscience | Area Quantification, Cytonuclear | |
| Modulating the therapeutic response of tumours to dietary serine and glycine starvation | Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH | 2017 | Nature | Oncology | Cytonuclear | |
| Ex vivo tissue slice culture system to measure drug-response rates of hepatic metastatic colorectal cancer | Martin SZ, Wagner DC, Hörner N, Horst D, Lang H, Tagscherer KE, Roth W | 2019 | BMC Cancer | Oncology | Classifier, Cytonuclear | |
| Prognostic value of tumor-inltrating immune cells in primary colorectal cancer and metastases | Martin SZ, Tagscherer KE, Deckert S, Horst D, Moehler M, Lang H, Roth W | 2020 | *Pre-Print | Immuno-oncology | Classifier, Cytonuclear | |
| Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models | Matsuki M, Hoshi T, Yamamoto Y, Ikemori-Kawada M, Minoshima Y, Funahashi Y, Matsui J | 2018 | Cancer Medicine | Oncology | Cytonuclear | |
| Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner | Mgrditchiana T, Arakeliana T, Paggettia J, Nomana MZ, Virya E, Moussaya E, Van Moera K, Kreisb S, Guerinc C, Buartd S, Roberte C, Borgf C, Vielhg P, Chouaibd S, Berchema G, Janji B | 2017 | Proceedings of the National Academy of Sciences | Oncology, Immuno-oncology | Cytonuclear | |
| Weight Pertubation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain | Morabito MV, Ravussin Y, Mueller BR, Skowronski AA, Watanabe K, Foo KS, Lee SX, Lehmann A, Hjorth S, ZeltserLM, LeDuc CA, Leibel RL | 2017 | PLOS One | Metabolism | Cytonuclear | |
| A Dual Blocker of Endothelin A/B Receptors Mitigates Hypertension but not Renal Dysfunction in a Rat Model of Chronic Kidney Disease and Sleep Apnea | Morales-Loredo H, Jones DT, Barrera A, Mendiola P, Garcia J, Pace CE, Murphy M, Kanagy NL, Gonzalez Bosc LV | 2019 | Renal Pathology | Metabolism | Classifier, Cytonuclear, Figure Maker | |
| Tasquinimod modulates tumor-infiltrating myeloid cells and improves the antitumor immune response to PD-L1 blockade in bladder cancer | Nakhlé J, Pierron V, Bauchet A-L, Plas P, Thiongane A, Meyer-Losic F, Schmidlin F | 2016 | OncoImmunology | Oncology, Immuno-oncology | Cytonuclear | |
| Altered dopaminergic regulation of the dorsal striatum is able to induce tic-like movements in juvenile rats | Nespoli E, Rizzo F, Boeckers T, Schulze U, Hengerer B | 2018 | PLOS One | Neuroscience | Cytonuclear | |
| A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma | O’Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, MorrissetteJJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot J-M, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV | 2017 | Science Translational Medicine | Oncology, Immuno-oncology | Cytonuclear, Multiplex IHC | |
| Role of IL-15 Signaling in the Pathogenesis of Simian Immunodeficiency Virus Infection in Rhesus Macaques | Okoye AA, DeGottardi MQ, FukazawaY, Vaidya M, Abana CO, Konfe AL, Fachko DN, Duell DM, He Li H, Lum R, Gao L, Park BS, Skalsky RL, Lewis AD, Axthelm MK, Lifson JD, Wong SW, Picker LJ | 2019 | The Journal of Immunology | Infectious Disease | Cytonuclear, Figure Maker | |
| Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment | Olsson A, Nakhle J, Sundstedt A, Plas P, Bauchet AL, Pierron V, Bruetschy L, Deronic A, Tomgren M, Liberg D, Schmidlin F, Leanderson T | 2015 | Journal for ImmunoTherapy of Cancer | Oncology, Immuno-oncology | Cytonuclear | |
| Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist | Parisi G, Saco JD, Salazar FB, Tsoi J, Krystofinski P, Puig-Saus C, Zhang R, Zhou J, Cheung-Lau GC, Garcia AJ, Grasso CS, Tavaré R, Hu-Lieskovan S, Mackay S, Zalevsky J, Bernatchez C, Diab A, Wu AM , Comin-Anduix B, Charych D, Ribas A | 2020 | Nature Communications | Oncology, Immuno-oncology | Cytonuclear | |
| Mechanical regulation of glycolysis via cytoskeleton architecture | Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G | 2020 | Nature | Oncology | Classifier, Cytonuclear, TMA | |
| Imaging Mass Spectrometry and Proteome Analysis of Marek's Disease Virus-Induced Tumors | Pauker VI, Bertzbach LD, Hohmann A, Kheimar A, Teifke JP, Mettenleiter TC, Karger A, Kaufe BB | 2019 | mSpere | Oncology | Cytonuclear | |
| Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human | Pognan F, Mahl JA, Papoutsi M, David Ledieu D, Raccuglia M, Theil D, Voytek SB, Devine PJ, Kubek‑Luck K, Claudio N, Cordier A, Heier A, Kolly C, Hartmann A, Chibout S-D, Bouchard P, Trendelenburg C | 2018 | Archives of Toxicology | Toxicology | Classifier, Cytonuclear | |
| TNF-? Contributes to Lymphoid Tissue Disorganization and Germinal Center B Cell Suppression during Intracellular Bacterial Infection | Popescu M, Cabrera-Martinez B, Winslow GM | 2019 | The Journal of Immunology | Immunology | Cytonuclear | |
| Changes in epidermal morphology associated with dandruff | Pople JE, Bhogal RK, Moore AE, Jenkins G | 2019 | International Journal of Cosmetic Science | Dermatology | Cytonuclear, Layer Thickness | |
| Automated Computational Detection, Quantitation, and Mapping of Mitosis in Whole‚ÄëSlide Images for Clinically Actionable Surgical Pathology Decision Support | Puri M, Hoover S, Hewitt S, Wei B-R, Adissu H, Halsey C, Beck J, Bradley C, Cramer S, Durham A, Esplin D, Frank C, Lyle L, McGill L, Sanchez M, Schaffer P, Traslavina R, Buza E, Yang H, Lee M, Dwyer J, Simpson R | 2019 | Journal of Pathology Informatics | Oncology | Cytonuclear | |
| Lamin‑B1 is a senescence‑associated biomarker in clear‑cell renal cell carcinoma | Radspieler M, Schindeldecker M, Stenzel P, Försc S, Tagscherer K, Herpel E, Hohenfellner M, Hatiboglu G, Roth W, Macher‑Goeppinger S | 2019 | Oncology Letters | Oncology | Cytonuclear | |
| Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa | Reyes-Uribe L, Wu W, Gelincik O, Bommi PV, Francisco-Cruz A, Solis LM, Lynch PM, Lim R, Stoffel EM, Kanth P, Samadder NJ, Mork ME, Taggart MW, Milne GL, Marnett LJ, Vornik L, Liu DD, Revuelta M, Chang K, You YN, Kopelovich L, Wistuba II, Lee JJ, Sei S, Shoemaker RH, Szabo E, Richmond E, Umar A, Perloff M, Brown PH, Lipkin SM, Vilar E | 2020 | Gut | Oncology | Classifier, Cytonuclear | |
| Intermittent Hypoxia Exacerbates Increased Blood Pressure in Rats with Chronic Kidney Disease | Riggs J, Pace C, Ward HH, Gonzalez Bosc L, Rios L, Barrera A, Kanagy NL | 2018 | American Jornal of Physiology-Renal Physiology | Metabolism | Classifier, Cytonuclear | |
| Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling | Robinson BD, Vlachostergios PJ, Bhinder B, Liu W, Li K, Moss TJ, Bareja R, Park K, Tavassoli P, Cyrta J, Tagawa ST, Nanus DM, Beltran H, Molina AM, Khani F, Miguel Mosquera J, Xylinas E, Shariat SF, Scherr DS, Rubin MA, Lerner SP, Matin SF, Elemento O, Faltas BM | 2019 | Nature Communications | Oncology, Immuno-oncology | Cytonuclear | |
| p53 is associated with high-risk and pinpoints TP53 missense mutations in mantle cell lymphoma | Rodrigues JM, Hassan M, Freiburghaus C, Eskelund CW, Geisler C, Raty R, Kolstad A, Sundstrom C, Glimelius I, Gronbaek K, Kwiecinska A, Porwit A, Jerkeman M, Ek S | 2020 | British Journal of Haematology | Oncology | Classifier, Cytonuclear | |
| The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a β-hydroxybutyrate paradox | Rodrigues LM, Uribe-Lewis S, Madhu B, Honess DJ, Stubbs M, Griffiths JR | 2017 | Cancer & Metabolism | Oncology, Metabolism | Area Quantification, Cytonuclear | |
| RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome | Rooney N, Mason SM, McDonald L, Däbritz HM, Campbell KJ, Hedley A, Howard S, Athineos D, Nixon C, Clark W, Leach JDG, Samsom OJ, Edwards J, Cameron ER, Blyth K | 2020 | Cancer Research | Oncology | Cytonuclear | |
| High levels of tumor-associated neutrophils are associated with improved overall survival in patients with stage II colorectal cancer | RS Berry, M-J Xiong, A Greenbaum, P Mortaji, RA Nofchissey, F Schultz, C Martinez, L Luo, KT Morris, JA Hanson | 2017 | PLOS One | Oncology, Immuno-oncology | Cytonuclear | |
| Pathological tau strains from human brains recapitulate the diversity of tauopathies in non-transgenic mouse brain | S Narasimhan, JL Guo, L Changolkar, A Stieber, JD McBride, LV Silva, Z He, B Zhang, RJ Gathagan, JQ Trojanowski, VMY Lee | 2017 | Journal of Neuroscience | Neuroscience | Cytonuclear | |
| Analytical Performance of an Immunoprofiling Assay Based on RNA Models | Schillebeeckx I, Armstrong JR, Forys JT, Hiken J, Earls J, Flanagan KC, Cui T, Glasscock JI, Messina DN, Duncavage EJ | 2020 | The Journal of Molecular Diagnostics | Immunology | Cytonuclear | |
| Primary resistance to PD-1 blockade mediated by JAK1/2 mutations | Shin DS, Zaretsky JM, Escuin-Ordinas H, Garcia-Diaz A, Hu-Lieskovan S, Kalbasi A, Grasso CS, Hugo W, Sandoval S, Torrejon DY, Palaskas N, Rodriguez GA, Parisi G, Azhdam A, Chmielowski B, Cherry G, Seja E, Berent-Maoz B, Shintaku IP, Le DT, Pardol DM, Diaz LA, Tumeh PC, Graeber TG, Lo RS, Comin-Anduix B, Ribas A | 2016 | Cancer Discovery | Oncology, Immuno-oncology | Cytonuclear | |
| Prognostic significance of mesothelin expression in colorectal cancer disclosed by area-specific four-point tissue microarrays | Shiraishi T, Shinto E, Nearchou IP, Tsuda H, Kajiwara Y, Einama T, Caie PD, Kishi Y, Ueno H | 2020 | Vichows Archiv | Oncology | Cytonuclear, HALO AI, TMA | |
| Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survival | Singhal SK, Byun JS, Park S, Yan T, Yancey R, Caban A, Hernandez SG, Hewitt SM, Boisvert H, Hennek S, Bobrow M, Ahmed SU, White J, Yates C, Aukerman A, Vanguri R, Bareja R, Lenci R, Farré PL, De Siervi A, Nápoles AM, Vohra N, Gardner K | 2021 | Communications Biology | Oncology | Cytonuclear, TMA | |
| KS-Detect-Validation of Solar Thermal PCR for the Diagnosis of Kaposi's Sarcoma Using Pseudo-Biopsy Samples | Snodgrass R, Gardner A, Jiang L, Fu C, Cesarman E, Erickson D | 2016 | PLOS ONE | Oncology | Cytonuclear | |
| Prognostic and Predictive Value of Tumor-infiltrating Leukocytes and of Immune Checkpoint Molecules PD1 and PDL1 in Clear Cell Renal Cell Carcinoma | Stenzel PJ, Schindeldecker M, Teagscherer KE, Foersch S, Herpel E, Hohenfellner M, Hatiboglu G, Alt J, Thomas C, Haferkamp A, Roth W, Macher-Goeppinger S | 2020 | Translational Oncology | Oncology, Immuno-oncology | Classifier, Cytonuclear, TMA | |
| IL‐36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis | Su Z, Paulsboe S, Wetter J, Salte K, Kannan A, Mathew S, Horowitz A, Gerstein C, Namovic M, Todorović V, Seagal J, Edelmayer RM, Viner M, Rinaldi L, Zhou L, Leys L, Huang S, Wang L, Sadhukhan R, Honore P, McGaraughty S, Scott VE | 2019 | Experimental Dermatology | Dermatology | Area Quantification, Cytonuclear | |
| Development of antibody-siRNA conjugate targeted to cardiac and skeletal muscles | Sugo T, Terada M, Oikawa T, Miyata K, Nishimura S, Kenjo E, Ogasawara-Shimizu M, Makita Y, Imaichi S, Murata S, Kentaro Otaka, Kikuchi K, Teratani M, Masuda Y, Kamei T, Takagahara S, Ikeda S, Ohtaki T, Matsumoto H | 2016 | The Journal of Controlled Release | Myology | Cytonuclear, Muscle Fiber | |
| Exacerbated experimental colitis in TNFAIP8-deficient mice | Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen YH | 2015 | The Journal of Immunology | Gastroenterology | Cytonuclear | |
| Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity | Timper K, Paeger L, Sánchez-Lasheras C, Varela L, Jais A, Nolte H, Vogt MC, Hausen AC, Heilinger C, Evers N, Pospisilik JA, Penninger JM, Taylor EB, Horvath TL, Kloppenburg P, Brüning JC | 2018 | Cell Repots | Neuroscience, Metabolism | Cytonuclear | |
| PD-1 blockade induces responses by inhibiting adaptive immune resistance | Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJM, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, West AN, Carmona M, Kivork C, Seja E, Cherry G, Gutierrez A, Grogan TR, Mateus C, Tomasic G, Glaspy JA, Emerson RO, Robins H, Pierce RH, Elas | 2014 | Nature | Oncology, Immuno-oncology | Cytonuclear | |
| O 6-Methylguanine DNA Methyltransferase and Glucose Transporter 2 in Foregut and Hindgut Gastrointestinal Neuroendocrine Neoplasms | Watanbe H, Yamazaki Y, Fujishima F, Izxumi K, Imamura M, Hijioka S, Toriyama K, Yatabe Y, Kudo A, Motoi F, Unno M, Sasano H | 2020 | BMC Cancer | Oncology | Cytonuclear | |
| The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques | Webb GM, Molden J, Bushman-Sahay K, Abdulhaqq S, Wu HL, Weber WC, Bateman KB, Reed JS, Northrup M, Maier N,Tanaka S, Gao L, Davey B, Carpenter BL, Axthelm MK, Stanton JJ, Smedley J, Greene JM, Safrit JT, Estes JD, Skinner PJ, Sacha JB | 2020 | PLOS Pathogens | Infectious Disease | Cytonuclear, ISH/FISH | |
| IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype | Wiggins KA, Parry AJ, Cassidy LD, Humphry M, Webster SJ, Goodall JC, Narita M, Clarke MCH | 2019 | Aging Cell | Immunology | Cytonuclear | |
| SLFN11 informs on standard of care and novel treatments in a wide range of cancer models | Winkler C, Armenia J, Jones GN, Tobalina L, Sale MJ, Petreus T, Baird T, Serra V, Wang AT, Lau A, Garnett MJ, Jaaks P, Coker EA, Pierce AJ, O'Connor MJ, Leo E | 2020 | British Journal of Cancer | Oncology | Classifier, Cytonuclear | |
| A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy | Wisdom AJ, Mowery YM, Hong CS, Qin X, Zhang D, Himes JE, Chen L, Fradin H, Muise ES, Xu ES, Carpenter DJ, Kent CL, Smythe KS, Williams N, Luo L, Ma Y, Owzar K, Bradley T, Kirsch DG | 2020 | bioRxiv | Oncology, Immuno-oncology | Cytonuclear | |
| Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells | Xin Y, Kim J, Ni M, Wei Y, Okamoto H, Lee J, Adler C, Cavino K, Murphy AJ, Yancopoulos GD, Lin HC, Gromada J | 2016 | Proceedings of the National Academy of Sciences | Metabolism | Cytonuclear | |
| Combination therapy reverses hyperglycemia in NOD mice with established type 1 diabetes | Xue S, Posgai A, Wasserfall C, Myhr C, Campbell-Thompson M, Mathews CE, Brusko T, Rabinovitch A, Savinov A, Battaglia M, Schatz D, Haller M, Atkinson MA | 2015 | Diabetes | Metabolism | Cytonuclear | |
| Comparison of the methods for measuring the Ki-67 labeling index in adrenocortical carcinoma: manual versus digital image analysis | Yamazaki Y, Nakamura Y, Shibahara Y, Konosu-Fukaya S, Sato N, Kubota-Nakayama F, Oki Y, Baba S, Midorikawa S, Morimoto R, Satoh F, Sasano | 2016 | Human Pathology | Oncology | Cytonuclear | |
| Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma | Yamazaki Y, Omata K, Tezuka Y, Ono Y, Morimoto R, Adachi Y, Ise K, Nakamura Y, Gomez-Sanchez CE, Shibahara Y, Kitamoto T, Nishikawa T, Ito S, Satoh F, Sasano H | 2018 | Hypertension | Oncology | Area Quantification, Cytonuclear | |
| Association of HIV Status With Local Immune Response to Anal Squamous Cell Carcinoma: Implications for Immunotherapy | Yanik EL, Kaunitz GJ, Cottrell TR, Succaria F, McMiller TL, Ascierto ML, Esandrio J, Xu H, Ogurtsova A, Cornish T, Lipson EJ, Topalian SL, Engels EA, Taube JM | 2017 | JAMA Oncology | Oncology, Immuno-oncology | Cytonuclear | |
| MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression | Yasuda Y, Ozasa H, Kim YH, Yamazoe M, Ajimizu H, Funazo TY, Nomizo T, Tsuji T, Yoshida H, Sakamori Y, Najajima N, Menju T, Yoshizawa A, Date H, Hirai T | 2020 | Cell Death & Disease | Oncology, Immuno-oncology | Cytonuclear | |
| Rabbit monoclonal E‐cadherin antibody: A cost‐effective alternative to mouse monoclonal antibody in distinguishing ductal carcinoma in situ from lobular carcinoma in situ | Baum JE, Croyle JA, Brodsky VB, Liu Y, Shin SJ | 2019 | The Breast Journal | Oncology | Cytonuclear | |
| MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinoma | Berggren KL, Cruz SR, Hixon MD, Cowan AT, Keysar SB, Craig S, James J, Barry M, Ozbun MA, Jimeno A, McCance DJ, Beswick EJ, Gan GN | 2019 | Oncogene | Oncology | Cytonuclear | |
| Genetic mutations underlying phenotypic plasticity in basosquamous carcinoma | Chiang A, Tan CZ, Kuonen F, Hodgkinson LM, Chiang F, Cho RJ, South AP, Tang Jean Y, Chang ALS, Rieger KE, Oro AE, Sarin KY | 2019 | Journal of Investigative Dermatology | Oncology | Cytonuclear | |
| The crosstalk between aldosterone and calcium metabolism in primary aldosteronism: A possible calcium metabolism-associated aberrant “neoplastic” steroidogenesis in adrenals | Gao X, Yamazaki Y, Tezuka Y, Onodera Y, Ogata H, Omata K, Morimoto R, Nakamura Y, Satoh F, Sasano H | 2019 | The Journal of Steroid Biochemistry and Molecular Biology | Oncology, Metabolism | Cytonuclear | |
| Farnesoid X Receptor Agonism, AcetylCoenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model | Gapp B, Jourdain M, Bringer P, Kueng B, Weber D, Osmont A, Zurbruegg S, Knehr J, Falchetto R, Roma G, Dietrich W, Valdez R, Beckmann N, Nigsch F, Sanyal AJ, Ksiazek I | 2019 | Hepatology Communications | Metabolism | Cytonuclear | |
| Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration | Yousef A, Robinson JL, Irwin DJ, Byrne MD, Kwong LK, Lee EB, Xu Y, Xie SX, Rennert L, Suh ER, Van Deerlin VM, Grossman M, Lee VM-Y, Trojanowski JQ | 2017 | Acta Neuropathologica Communications | Area Quantification, Cytonuclear | ||
| Variability in Platelet-Derived Growth Factor Receptor Alpha Antibody Specificity May Impact Clinical Utility of Immunohistochemistry Assays | Holzer TR, Reising LO, Credille KM, Schade AE, Oakley | 2016 | Journal of Histochemistry & Cytochemistry | Oncology | Cytonuclear, ISH/FISH | |
| Oral tenofovir disoproxil fumarate/emtricitabine for HIV pre-exposure prophylaxis increases expression of type I/III interferon-stimulated factors in the gastrointestinal tract but not in the blood | Hughes SM, Levy CN, Calienes F, Stekler JD, Pandey U, Vojtech L, Berard AR, Birse K, Noel-Romas L, Richardson B, Golden J, Cartwright M, Collier AC, Stevens CE, Curlin ME, Holtz TH, Mugo N, Irungu E, Katabira E, Muwonge T, Lama JR, Baeten JM, Burgener A, Lingappa JR, McElrath MJ, Mackelprang R, McGowan I, Cranston RD, Cameron MJ, Hladik F | 2019 | bioRxiv | Infectious Disease | Cytonuclear | |
| Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion | Jiang H, Liu X, Knolhoff BL, Hegde S, Lee KB, Jiang H, Fields RC, Pachter JA, Lim K-H, DeNardo DG | 2019 | Gut | Oncology | Cytonuclear, ISH/FISH | |
| The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma | Yu H, Wang H, Dong W, Cao Z-Y, Li R, Yang C, Cong W-M, Dong H, Jin G-Z | 2020 | Peer J | Oncology | Cytonuclear | |
| Hot Spot and Whole-Tumor Enumeration of CD8(+) Tumor-Infiltrating Lymphocytes Utilizing Digital Image Analysis Is Prognostic in Triple-Negative Breast Cancer | McIntire PJ, Irshaid L, Liu Y, Chen Z, Menken F, Nowak E, Shin SJ, Ginter PS | 2018 | Clinical Breast Cancer | Oncology, Immuno-oncology | Cytonuclear, Figure Maker | |
| Hotspot enumeration of CD8+ tumor infiltrating lymphocyte using digital image analysis in triple negative breast Cancer yields consistent results | McIntire PJ, Zhong E, Patel A, Khani F, D'Alfonso T, Chen Z, Shin SJ, Ginter PS | 2019 | Human Pathology | Oncology | Cytonuclear | |
| Female-biased embryonic death from inflammation induced by genomic instability | McNairn AJ, Chuang C-H, Bloom JC, Wallace MD, Schimenti JC | 2019 | Nature | Immunology | Cytonuclear | |
| Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma | Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, Torrejon DY, Abril-Rodriguez G, Sandoval S, Barthly L, Saco J, Homet Moreno BH, Mezzadra R, Chmielowski B, Ruchalski K, Shintaku IP, Sanchez PJ, Puig-Saus C, Cherry G, Seja E, Kong X, Pang J, Berent-Maoz B, Comin-Anduix B, Graeber TG, Tumeh PC, Schumacher TNM, Lo RS, Ribas A | 2016 | The New England Journal of Medicine | Oncology, Immuno-oncology | Cytonuclear | |
| Imaging CAR T cell therapy with PSMA-targeted positron emission tomography | Minn I, Huss DJ, Ahn H-H, Chinn TM, Park A, Jones J, Brummet M, Rowe SP, Sysa-Shah P, Du Y, Levitsky HI, Pomper MG | 2019 | Science Advances | Oncology | Cytonuclear | |
| Accelerated wound healing by injectable star poly(ethylene)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs | Zhu X, Yin L, Theisen M, Zhuo J, Siddiqui S, Levy B, Presnyak V, Frassetto A, Milton J, Salerno T, Benenato KE, Milano J, Lynn A, Sabnis S, Burke K, Besin G, Lukacs CM, Guey LT, Finn PF, Martini PGV | 2018 | Journal of Controlled Release | Biomaterials, Wound Healing | Cytonuclear | |
| Prohibitin is a prognostic marker of relapse and therapeutic target to block chemotherapy resistance in Wilms tumor | Ortiz MV, Ahmed S, Burns M, Henssen AG, Hollmann TJ, MacArthur I, Gunasekera S, Gaewsky L, Bradwin G, Ryan J, Letai A, He Y, Naranjo A, Chi Y-Y, LaQuaglia M, Heaton T, Cifani P, Dome JS, Gadd S, Perlman E, Mullen E, Steen H, Kentsis A | 2019 | JCI Insight | Oncology | Cytonuclear | |
| Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers | Scheper W, Kelderman S, Fanchi LF, Linnemann C, Bendle G, de Rooij MAJ, Hirt C, Mezzadra R, Slagter M, Dijkstra K, Kluin RJC, Snaebjornsson P, Milne K, Nelson BH, Zijlmans H, Kenter G, Voest EE, Haanen JBAG, Schumacher TN | 2018 | Nature Medicine | Oncology, Immuno-oncology | Cytonuclear | |
| The use of automated Ki67 analysis to predict Oncotype DX risk-of-recurrence categories in early-stage breast cancer | Thakur SS, Li H, Chan AMY, Tudor R, Bigras G, Morris D, Enwere EK | 2018 | PLOS ONE | Oncology | Cytonuclear, Figure Maker, Partitions (tiles, margins) | |
| GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity | Untereiner A, Abdo S, Bhattacharjee A, Gohil H, Pourasgari F, Ibeh N, Lai M, Batchuluun B, Wong A, Khuu N, Liu Y, Rijjal DA, Winegarden N, Virtanen C, Orser BA, Cabrera O, Varga G, Rocheleau J, Dai FF, Wheeler MB | 2018 | The FASEB Journal | Metabolism | Cytonuclear | |
| Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function | Williams CM, Calderon JH, Hock E, Jimenez Y, Barringer K, Carbonaro M, Molina-Portela MP, Thurston G, Li Z, Daly C | 2021 | The FASEB Journal | Metabolism | Cytonuclear | |
| Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours | Gampala S, Shah F, Zhang C, Rhodes SD, Babb O, Grimard M, Wireman RS, Rad E, Calver B, Bai R-Y, Staedtke V, Hulsey EL, Saadatzadeh MR, Pollok KE, Tong Y, Smith AE, Clapp DW, Tee AR, Kelley MR, Fishel ML | 2021 | British Journal of Cancer | Oncology | Area Quantification, Cytonuclear | |
| First in class dual MDM2/MDMX inhibitor ALRN-6924 enhances antitumor efficacy of chemotherapy in TP53 wild-type hormone receptor-positive breast cancer models | Pairawan S, Zhao M, Yuca E, Annis A, Evans K, Sutton D, Carvajal L, Ren J-G, Santiago S, Guerlavais, Akcakanat A, Tapia C, Yang F, Bose PSC, Zheng X, Dumbrava EI, Aivado M, Meric-Bernstam F | 2021 | Breast Cancer Research | Oncology | Cytonuclear | |
| Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinoma | Kazdal D, Rempel E, Oliveira C, Allgäuer M, Harms A, Singer K, Kohlwes E, Ormanns S, Fink L, Kriegsmann J, Leichsenring M, Kriegsmann K, Stögbauer F, Tavernar L, Leichsenring J, Volckmar A-L, Longuespée R, Winter H, Eichhorn M, Heußel CP, Herth F, Christopoulos P, Reck M, Muley T, Weichert W, Budczies J, Thomas M, Peters S, Warth A, Schirmacher P, Stenzinger A, Kriegsmann M | 2021 | Translational Lung Cancer Research | Oncology | Classifier, Cytonuclear | |
| Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells | Dahou H, Minati M-A, Jacquemin P, Assi M | 2021 | antioxidants | Oncology | Cytonuclear | |
| In vivo endothelialization and neointimal hyperplasia assessment after rabbit carotid endarterectomy with bovine pericardium | Chen Y, Feng Y, Wang T, Zhang X, Zhang M, Bai X, Li L, Yang K, Ma Y, Zhang Z, Jiao L | 2021 | Annals of Translational Medicine | Myology | Cytonuclear | |
| Tumor morphology and location associate with immune cell composition in pleomorphic sarcoma | Wustrack RL, Shao E, Sheridan J, Zimel M, Cho S-J, Horvai AE, Luong D, Kwek SS, Fong L, Okimoto RA | 2021 | Cancer Immunology, Immunotherapy | Immuno-oncology | Cytonuclear | |
| Cellular Senescence in Human Aldosterone-Producing Adrenocortical Cells and Related Disorders | Pieroni J, Yamazaki Y, Gao X, Tezuka Y, Ogata H, Omata K, Ono Y, Morimoto R, Nakamura Y, Satoh F, Sasano H | 2021 | Biomedicines | Metabolism | Cytonuclear | |
| Toluidine blue staining of murine mast cells and quantitation by a novel, automated image analysis method using whole slide skin images | Raja N, Naikodi S, Govindarajan A, Palanisamy K | 2021 | Journal of Histotechnology | Immunology | Cytonuclear | |
| Human Type II Taste Cells Express ACE2 and are Infected by SARS-CoV-2 | Doyle M, Ashley Appleton A, Q Liu, Yao Q, Mazucanti C, Egan J | 2021 | American Journal of Pathology | Cytonuclear | ||
| Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells | Vito A, Salem O, El-Sayes N, MacFawn I, Portillo A, Milne K, Harrington D, Ashkar A, Wan Y, Workenhe S, Nelson B, Bruno T, Mossman K | 2021 | Communications Biology | Immuno-oncology | Cytonuclear | |
| Repeated porphyrin lipoprotein-based photodynamic therapy controls distant disease in mouse mesothelioma via the abscopal effect | Lou J, Aragaki M, Bernards N, Kinoshita T, Mo J Motooka Y, Ishiwata T, Gregor A, Chee T, Chen Z, Chen J, Kaga K, Wakasa S, Zheng G, Yasufuku K | 2021 | Nanophotonics | Oncology | Cytonuclear | |
| Mobilization of CD8+ T cells via CXCR4 blockade facilitates PD-1 checkpoint therapy in human pancreatic cancer | Seo YD, Jiang X, Sullivan KM, Jalikis FG, Smythe KS, Abbasi A, Vignali M, Park JO, Daniel SK, Pollack SM, Kim TS, Yeung R, Crispe IN, Pierce RH, Robins H, Pillarisetty VG | 2019 | Clinical Cancer Research | Immuno-oncology | Cytonuclear | |
| Temporal Analysis of Amylase Expression in Control, Autoantibody Positive, and Type 1 Diabetes Pancreatic Tissues | Kusmartseva I, Beery M, Hiller H, Padilla M, Selman S, Posgai A, Nick HS, Campbell-Thompson M, Schatz DA, Haller MJ, Wasserfall CH, Atkinson MA | 2019 | Diabetes | Metabolism | Cytonuclear | |
| Prognostic features of the tumour microenvironment in oesophageal adenocarcinoma | McShane R, Arya S, Stewart A, Caie P, Bates M | 2021 | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | Immuno-oncology, Review | Cytonuclear | |
| Mammalian Retinal Cell Quantification | Muthuswamy A, Chen H, Hu Y, Turner OC, Aina OH | 2020 | Toxicologic Pathology | Other | Cytonuclear | |
| Phosphorylation of connexin 43 at MAPK, PKC or CK1 sites each distinctly alter the kinetics of epidermal wound repair | Lastwika JK, Dunn CA, Solan JL, Lampe PD | 2019 | Journal of Cell Science | Dermatology | Cytonuclear | |
| Using immuno-PET imaging to monitor kinetics of T cell-mediated inflammation and treatment efficiency in a humanized mouse model for GvHD | Pektor S, Schlöder J, Klasen B, Bausbacher N, Wagner D-C, Schreckenberger W, Grabbe S, Jonuleit H, Miederer M | 2019 | European Journal of Nuclear Medicine and Molecular Imaging | Immunology | Cytonuclear | |
| High CD8+ tumour infiltrating lymphocyte density associates with unfavourable prognosis in oesophageal adenocarcinoma following poor response to neo?adjuvant chemoradiotherapy | Koemans WJ, van Dieren JM, van den Berg J, Meijer G, Snaebjornsson P, Chalabi M, Lecot F, Riedl R, Krijgsman O, Hofland I, Broeks A, Voncken FEM, Peppelenbosch MP, Sosef MN, van Sandick JW, Kodach LL | 2021 | Histopathology | Immuno-oncology | Cytonuclear | |
| Ki-67 Proliferation Index Assessment in Gastroenteropancreatic Neuroendocrine Tumors by Digital Image Analysis With Stringent Case and Hotspot Level Concordance Requirements | Boukhar SA, Gosse MD, Bellizzi AM, Rajan A | 2021 | American Journal of Clinical Pathology | Oncology | Cytonuclear | |
| Simultaneous targeting of TGF-b/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion | Lan Y, Moustaga M, Knoll M, Xu C, Furkel J, Lazorchak A, Yeung T, Hasheminasab S, Jenkins M, Meister S, Yu H, Schlegel J, Marelli B, Tang Z, Qin G, Klein C, Qi J, Zhou C, Locke G, Krunic D, Derner M, Schwager C, Fontana R, Kriegsmann K, Jiang F, Rein K, Kriegsmann M, Debus J, Lo K, Abdollahi A | 2021 | Cancer Cell | Oncology | Cytonuclear | |
| IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies | Friedrich M, Pohin M, Jackson M, Korsunsky I, Bullers S, Rue-Albrecht K, Christoforidou Z, Sathananthan D, Thomas T, Ravindran R, Tandon R, Peres R, Sharpe H, Wei K, Watts G, Mann E, Geremia A, Attar M, Oxford IBD Cohort Investigators, Roche Fibroblast Network Consortium, McCuaig S, Thomas L, Collantes E, Uhlig H, Sansom S, Easton A, Raychaudhuri S, Travis S, Powrie F | 2021 | Nature Medicine | Gastroenterology | Cytonuclear | |
| Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma | Campbell M, Matin S, Tam A, Sheth R, Ahrar K, Tidwell R, Rao P, Karam J, Wood C, Tannir N, Jonasch E, Gao J, Zurita A, Shah A, Jindal S, Duan F, Basu S, Chen H, Espejo A, Allison J, Yadav S, Sharma P | 2021 | Nature Communications | Oncology | Cytonuclear | |
| Small molecule inhibitors of ?-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans | Chen K, Menezes K, Rodgers J, )'Hara D, Tran N, Fujisawa K, Ishikura S, Khodaei S, Chau H, Cranston A, Kapadia M, Pawar G, Ping S, Krizus A, Lacoste A, Spangler S, Visanji N, Marras C, Majbour N, El-Agnaf O, Lozano A, Culotti, Suo S, Ryu W, Kalia S, Kalia L | 2021 | Molecular Neurodegeneration | Neuroscience | Cytonuclear | |
| Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity | Prinzing B, Zebley C, Petersen C, Fan Y, Anido A, Yi Z, Nguyen P, Houke H, Bell M, Haydar D, Brown C, Boi S, Alli S, Crawford J, Riberdy J, Park J, Zhou S, Velasquez M, DeRenzo C, Lazzarotto C, Tsai S, Vogel P, Pruett-Miller S, Langfitt D, Gottschalk S, Youngblood B, Krenciute G | 2021 | Science Translational Medicine | Immuno-oncology | Cytonuclear | |
| A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy | Wisdom AJ, Mowery YM, Hong CS, Qin X, Zhang D, Himes JE, Chen L, Fradin H, Muise ES, Xu ES, Carpenter DJ, Kent CL, Smythe KS, Williams N, Luo L, Ma Y, Owzar K, Bradley T, Kirsch DG | 2020 | Nature Communications | Oncology, Immuno-oncology | Cytonuclear | |
| Integrated human pseudoislet system and microfluidic platform demonstrate differences in GPCR signaling in islet cells | Walker JT, Haliyur R, Nelson HA, Ishahak M, Poffenberger G, Aramandla R, Reihsmann C, Luchsinger JR, Saunders DC, Wang P, Garcia-Ocana A, Bottino R, Agarwal A, Powers AC, Brissove M | 2019 | bioRxiv | Gastroenterology | Cytonuclear | |
| Temporospatial Development of Neuropathologic Findings in a Canine Model of Mucopolysaccharidosis IIIB | Harm TA, Hostetter SJ, Nenninger AS, Valentine BN, Ellinwood NM, Smith JD | 2020 | Veterinary Pathology | Immunology, Neruoscience | Area Quantification, Cytonuclear | |
| Tumor Platinum Concentrations and Pathological Responses Following Cisplatin-Containing Chemotherapy in Gastric Cancer Patients | Cao Y, Chang Q, Cabanero M, Zhang W, Hafezi-Bakhtiari S, Hedley D, Darling G, Quereshy F, Jang R, Elimova E, Knox J, Ornatsky O, Serra S, Chen E | 2019 | Journal of Gastrointestinal Cancer | Oncology | Area Quantification, Cytonuclear | |
| Transcriptomic Analysis of Healthy and Atopic Dermatitis Samples Reveals the Role of IL-37 in Human Skin | Zhou J, Gemperline D, Turner M, Oldach J, Molignano J, Sims J, Stayrook K | 2021 | ImmunoHorizons | Dermatology | Area Quantification, Cytonuclear | |
| Interleukin-33 activates group 2 innate lymphoid cell expansion and modulates endometriosis | Miller J, Lingegowda H, Symons L, Bougie O, Young S, Lessey B, Koti M, Tayade C | 2021 | JCI Insight | Other | Area Quantification, Cytonuclear | |
| FK506-binding protein 13 expression is upregulated in interstitial lung disease and correlated with clinical severity: a potentially protective role | Tat V, Ayaub EA, Ayoub A, Vierhout M, Naiel S, Padwal MK, Abed S, Mekhael O, Tandon K, Revill SD, Yousof T, Bellaye PS, Kolb PS, Dvorkin-Gheva A, Naqvi A, Cutz JC , Hambly N, Kato J, Vaughan M, Moss J, Kolb MRJ, Ask K | 2019 | American Journal of Respiratory Cell and Molecular Biology | Immunology, Fibrosis | Area Quantification, Cytonuclear | |
| A minimal standardized human bone marrow microphysiological system to assess resident cell behavior during normal and pathological processes | Voeltzel T, Fossard G, Degaud M, Geistlich K, Gadot N, Jeanpierre S, Mikaelian I, Brevet M, Anginot A, Le Bousse-Kerdiles M, Trichet V, Lefort S, Maguer-Satta V | 2021 | Biomaterials Science | Biomaterials | Area Quantification, Cytonuclear | |
| HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells | Wang Y, Lifschitz L, Gellatly K, Vinton CL, Busman-Sahay K, McCauley S, Vangala P, Kim K, Derr, Jaiswall S, Kucukural A, McDonel P, Hunt PW, Greenough T, Houghton J, Somsouk M, Estes JD, Brenchley JM, Garber M, Deeks SG, Luban J | 2020 | Nature Immunology | Immunology, Infectious Disease | Area Quantification, Cytonuclear, ISH/FISH | |
| Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression | Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies S, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Linden D, Bidault G, Petsalaki E, Griffin J, Oakley F, Allison M, Vidal-Puig | 2021 | Molecular Metabolism | Metabolism | Area Quantification, Cytonuclear, Multiplex IHC | |
| Inter-organ transmission of hepatocellular senescence induces multi-organ dysfunction through the TGF? signalling pathway | Kiourtis C, Terradas-Terradas M, Gee L, Hsieh Y, Nixon C, Clark W, Shaw R, Hanson P, Sumpton D, Mackay G, May S, Muller M, Najumudeen A, Campbell A, Barry S, Morris C, LeBeau F, Sansom O, Kirschner K, Oakley F, Bird T | 2021 | Research Square | Other | Area Quantification, Cytonuclear, Multiplex IHC | |
| Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa | Reyes-Uribe L, Wu Wenhui, Gelincik O, Bommi P, Francisco-Cruz A, Solis L, Lynch P, Lim R, Stoffel E, Kanth P, Samadder N, Mork M, Taggart M, Milne G, Marnett L, Vornik L, Liu D, Revuelta M, Chang K, You Y, Kipelovich L, Wistuba I, Lee J, Sei S, Shoemaker R, Szabo E, Richmond E, Umar A, Perloff M, Brown P, Lipkin S, Vilar E | 2020 | The BMJ | Oncology, Gastroenterology | Classifier, Cytonuclear | |
| Quantitative digital image analysis of tumor-infiltrating lymphocytes in HER2-positive breast cancer | Abe N, Matsumoto H, Takamatsu R, Tamaki K, Takigami N, Uehara K, Kamada Y, Tamaki N, Motonari T, Unesoko M, Nakada N, Zaha N, Zaha H, Yoshimi N | 2019 | Vichows Archiv | Oncology | Classifier, Cytonuclear | |
| SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer | Winkler C, King M, Berthe J, Ferraioli D, Garuti A, Grillo F, Rodriguez-Canales J, Ferrando L, Chopin N, Ray-Coquard I, Delpuech O, Bedognetti D, Ballestrero A, Leo E, Zoppoli G | 2021 | JCI Insight | Oncology | Classifier, Cytonuclear | |
| AG-205 Upregulates Enzymes Involved in Cholesterol Biosynthesis and Steroidogenesis in Human Endometrial Cells Independently of PGRMC1 and Related MAPR Proteins | Thieffry C, Van Wynendaele M, Aynaci A, Maja M, Dupuis C, Loriot A, Marbaix E, Henriet P | 2021 | Biomolecules | Other | Cytonuclear, Highplex FL | |
| An endogenous opioid circuit determines state-dependent appetitive behavior | Castro D, Oswell C, Zhang E, Pedersen C, Piantadosi S, Rossi M, Hunker A, Guglin A, Moron J, Zweifel L, Stuber G, Bruchas M | 2021 | bioRxiv | Neuroscience | Cytonuclear, Highplex FL | |
| Maternal platelets pass interstices of trophoblast columns and are not activated by HLA-G in early human pregnancy | Guettler J, Forstner D, Cvirn G, Maninger S, Brugger B Nonn O, Kupper N, Pritz E, Wernitznig S, Dohr G, Hutter H, Juch H, Isermann B, Kohli S, Gauster M | 2021 | Journal of Reproductive Immunology | Other | Cytonuclear, Highplex FL | |
| Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers | Newman J, Gavard A, Lieb S, Ravichandran M, Hauer K, Werni P, Geist L, Bottcher J, Engen J, Rumpel K, Samwer M, Petronczki, Gileadi O | 2021 | Life Science Alliance | Oncology | Cytonuclear, Highplex FL | |
| MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression | Knight J, Alexandrou C, Skalka G, Vlahov N, Pennel K, Officer L, Teodosio A, Kanellos G, Gay D, May-Wilson S, Smith E, Najumudeen A, Gilroy K, Ridgway R, Flanagan D, Smith R, McDonald L, MacKay C, Cheasty A, McArthur K, Stanway E, Leach J, Jackstadt R, Waldron J, Campbell A, Vlachogiannis G, Valeri N, Haigis K, Sonenberg N, Proud C, Jones N, Swarbrick M, McKinnon H, Faller W, LeQuense J, Edwards J, Willis A, Bushell M, Sansom O | 2021 | Cancer Discovery | Oncology | Cytonuclear, Highplex FL | |
| CD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis | Geng J, Chen R, Yang F, Lin P, Zhu Y, Fu X, Wang K, Feng Z, Wu J, Zhang H, Li Q, Chen Z, Zhu P | 2021 | Cellular and Molecular Immunology | Immuno-oncology | Cytonuclear, Highplex FL | |
| EHF is essential for epidermal and colonic epithelial homeostasis and suppresses Apc-initiated colonic tumorigenesis | Reehorst C, Nightingale R, Luk I, Jenkins L, Koentgen F, Williams D, Darido C, Tan F, Anderton H, Chopin M, Schoffer K, Eissmann M, Buchert M, Mouradov D, Sieber O, Ernst M, Dhillon A, Maridason J | 2021 | Development | Oncology | Cytonuclear, Highplex FL | |
| Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a tuberculosis/simian immunodeficiency virus coinfection model | Sharan R, Ganatra S, Bucsan A, Cole J, Singh D, Alvarez X, Gough M, Alvarez C, Blakley A, Ferdin J, Thippeshappa R, Singh B, Escobedo R, Shivanna V, Dick E, Hall-Ursone S, Khader S, Mehra S, Rengarajan J, Kaushal D | 2021 | The Journal of Clinical Investigation | Infectious Disease | Cytonuclear, Highplex FL | |
| CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption | Harper J, Gordon S, Chan CN, Wang H, Lindemuth E, Galardi C, Falcinelli SD, Raines SLM, Read JL, Nguyen K, McGary CS, Nekorchuk M, Busman-Sahay K, Schawalder J, King C, Pino M, Micci L, Cervasi B, Jean S, Sanderson A, Johns B, Koblansky AA, Amrine-Madsen H, Lifson J, Margolis DM, Silvestri G, Bar KJ, Favre D, Estes JD, Paiardini | 2020 | Nature Medicine | Immunology, Infectious Disease | Cytonuclear, ISH/FISH | |
| Three subtypes of lung cancer fibroblasts definedistinct therapeutic paradigms | Hu H, Peotrowska Z, Hare P, Chen H, Mulvey H, Mayfield A, Noeen S, Kattermann K, Greenberg M, Williams A, Riley A, Wilson J, Mao Y, Huang R, Banwait M, Ho J, Crowther G, Hariri L, Sequist L, Benes C, Niederst M, Engelman J | 2021 | Cancer Cell | Oncology | Cytonuclear, ISH/FISH | |
| p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4 | Humpton T, Hall H, Kiourtis C, Nixon C, Clark W, Hedley A, Shaw R, Bird T, Blyth K, Vousden K | 2021 | Cell Death & Differentiation | Metabolism | Cytonuclear, Multiplex IHC | |
| Combined CTLA-4 and PD-L1 blockade in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer is associated with increased myeloid and neutrophil immune subsets in the bone microenvironment | Subudhi S, Siddiqui B, Aparicio A, Yadav S, Basu S, Chen H, Jindal S, Tidwell R, Varma A, Logothetis C, Allison J, Corn P, Sharma P | 2021 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Cytonuclear, Multiplex IHC | |
| Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody | Katano I, Hanazawa A, Otsuka I, Yamaguchi T, Mochizuki M, Kawai K, Ito R, Goto M, Kagawa T, Takahashi T | 2021 | Scientific Reports | Oncology | Cytonuclear, Multiplex IHC | |
| A comparability study of natural and deglycosylated PD-L1 levels in lung cancer: evidence from immunohistochemical analysis | Mei J, Xu J, Yang X, Gu D, Zhou W, Wang H, Liu C | 2021 | Molecular Cancer | Oncology | Cytonuclear, Multiplex IHC | |
| A faithful in vivo model of human macrophages in metastatic melanoma | Voillet V, Berger T, McKenna K, Paulson K, Smythe K, Hunter D, Valente W, Weaver S, Campbell J, Kim T, Byrd D, Bielas J, Pierce R, Chapuis A, Gottardo R, Rongvaux | 2021 | bioRxiv | Cytonuclear, Multiplex IHC | ||
| E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK–CBL–CIN85 axis | Ahmed S, Buetow L, Gabrielsen M, Lilla S, Sibbet G, Sumpton D, Zanivan S, Hedley A, Clark W, Huang D | 2021 | Oncogene | Oncology | Cytonuclear, Multiplex IHC | |
| CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation | Le A, Yelland T, Paul N, Fort L, Nikolaou S, Ismail S, Machesky L | 2021 | Journal of Cell Biology | Other | Cytonuclear, Multiplex IHC | |
| In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics | Xu H, O'Reilly M, Gibbons G, Changolkar L, McBride J, Riddle D, Zhang B, Stieber A, Nirschl J, Kim S, Hoxha K, Brunden K, Schellenberg G, Trojanowski J, Lee V | 2021 | Acta Neuropathologica | Neruoscience | Cytonuclear, Multiplex IHC | |
| CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition | Gallo D, Young J, Fourtounis J, Martino G, Alvarez-Quilon A, Bernier C, Duffy N, Papp R, Roulston A, Stocco R, Szychowski J, Veloso A, Alam H, Baruah P, Fortin A, Bowlan J, Chaudhary N, Desjardins J, Dietrich E, Fournier S, Fugere-Desjardins C, de Rugy T, Leclaire M, Liu B, Melo H, Nicolas O, Singhania A, Szilard R, Tkac J, Yin S, Morris S, Zinda M, Marshall C, Duocher D | 2021 | bioRxiv | Other | Cytonuclear, Multiplex IHC | |
| Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity | Qiao Y, Qiu Y, Ding J, Luo N, Wang H, Ling X, Sun J, Wu Z, Wang Y, Liu Y, Guo F, Sun T, Shen W, Zhang M, Wu D, Chen B, Xu W, Wang X | 2021 | Nature Communications | Immuno-oncology | Cytonuclear, Multiplex IHC | |
| Pixelwise H-score: a novel digital image analysis-based metric to quantify membrane biomarker expression from immunohistochemistry images | Ram S, Vizcarra P, Whalen P, Deng S, Painter C, Jackson-Fisher A, Pirie-Shepherd S, Xia X, Powell E | 2021 | PLOS One | Other | Cytonuclear, Multiplex IHC | |
| LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis | Wei W, Wang N, Deng M, Dong P, Liu J, Xiang Z, Li X, Li Z, Liu Z, Peng Y, Li Z, Jiang L, Yao K, Ye Y, Lu W, Zhang Z, Zhou F, Liu Z, Xie D, Yu C | 2021 | Redox Biology | Metabolism | Cytonuclear, Multiplex IHC | |
| Hedgehog-signalling in papillary fibroblasts is essential for hair follicle regeneration during wound healing | Frech S, Forsthuber A, Korosec A, Lipp K, Kozumov V, Lichtenberger B | 2021 | Journal of Investigative Dermatology | Dermatology | Cytonuclear, Multiplex IHC | |
| Evaluation of Early Markers of Ischemia-reperfusion Injury and Preservation Solutions in a Modified Hindlimb Model of Vascularized Composite Allotransplantation | Rostami S, Xu M, Datta S, Haykal S | 2022 | Transplantation Direct | Cytonuclear, Multiplex IHC | ||
| B7-1 and programmed cell death-ligand 1 in primary and lymph node metastasis lesions of non-small cell lung carcinoma | Yamada T, Miki Y, Suzuki M, Kondoh O, Saito-Koyama R, Ono K, Okada Y, Sasano H | 2021 | Cancer Medicine | Oncology | Cytonuclear, Multiplex IHC | |
| Discoidin Domain Receptor 1 (DDR1) is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma | Ruggeri JM, Franco-Barraza J, Sohail A, Zhang Y, Long D, di Magliano MP, Cukierman E, Fridman R, Crawford HC | 2020 | The American Journal of Pathology | Oncology, Immunology | Cytonuclear, Multiplex IHC, Highplex FL | |
| CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma | Geng J, Chen L, Yuan Y, Wang K, Wang Y, Qin C, Wu G, Chen R, Zhang Z, Wei D, Du P, Zhang J, Lin P, Zhang K, Deng Y, Xu K, Liu J, Sun X, Guo T, Yang X, Wu J, Jiang J, Li L, Zhang K, Wang Z, Zhang J, Yan Q, Zhu H, Zheng Z, Miao J, Fu X, Yang F, Chen X, Tang H, Zhang Y, Shi Y, Zhu Y, Pei Z, Huo F, Liang X, Wang Y, Wang Q, Xie W, Li Y, Shi M, Bian H, Zhu P, Chen Z | 2021 | Signal Transduction and Targeted Therapy | Infectious Disease | Cytonuclear, Multiplex IHC, Highplex FL | |
| Cross-linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFN?/CXCL10-dependent peripheral T cell recruitment in humanized murine model | Cremasco F, Menietti E, Speziale D, Sam J, Sammicheli S, Richard M, Varol A, Klein C, Umana P, Bacac M, Colombetti S, Perro M | 2021 | PLOS ONE | Oncology | Cytonuclear, Multiplex IHC, Highplex FL | |
| Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis | Czauderna C, Poplawski A, O'Roourke C, Castven D, Pérez-Aguilar B, Becker D, Heilmann-Heimbach S, Odenthal M, Amer W, Schmiel M, Drebber U, Binder H, Ridder D, Schindeldecker M, Straub B, Galle P, Andersen J, Thorgeirsson S, Park Y, Marquardt J | 2021 | JCI Insight | Oncology | Cytonuclear, TMA | |
| PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma | Smeester BA, Slipek NJ, Pomeroy EJ, Laoharawee K, Osum SH, Larsson AT, Williams KB, Stratton N, Yamamoto K, Peterson JJ, Rathe SK, Mills LJ, Hudson WA, Crosby MR, Wang M, Rahramann EP, Moriarity SB, Largaespada DA | 2020 | Bone | Oncology | Cytonuclear, TMA | |
| Diagnostic and prognostic implications of a three-antibody molecular subtyping algorithm for non-muscle invasive bladder cancer | Jackson C, Chen L, Hardy C, Ren K, Visram K, Bratti V, Johnstone J, Sjödahl G, Siemens D, Gooding R, Berman D | 2021 | The Journal of Pathology: Clinical Research | Oncology | Cytonuclear, TMA | |
| Comprehensive clinicopathologic study of alpha fetoprotein-expression in a large cohort of patients with hepatocellular carcinoma | Ridder D, Weinmann A, Schindeldecker M, Urbansky L, Berndt K, Gerber T, Lang H, Lotz J, Lackner K, Roth W, Straub B | 2021 | International Journal of Cancer | Oncology | Cytonuclear, TMA | |
| STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia | Morozzi G, Rothen J, Toussaint G, De Lange K, Westritschnig K, Doelemeyer A, Ueberschlag V, Kahle P, Lambert C, Obrecht M, Beckmann N, Ritter V, Panesar M, Stauffer D, Garnier I, Mueller M, Guerini D, Keller C, Knehr J, Roma G, Bidinosti M, Brachat S, Morvan F, Forano M | 2021 | iScience | Neuroscience | Cytonuclear, HALO AI | |
| Tissue-resident FOLR2+ macrophages associate with tumor-infiltrating CD8+ T cells and with increased survival of breast cancer patients | Ramos, R, Missolo-Koussou Y, Gerber-Ferder Y, Bromley C, Bugatti M, Nunez N, Tosello J, Richer W, Denizeau J, Sedlik C, Caudana P, Kotsias F, Niborski L, Viel S, Bohec M, Lameiras S, Baulande S, Lesage L, Nicolas A, Mesure D, Vincent-Salomon A, Reyal F, Dutertre C, Ginhoux F, Vimeux L, Donnadieu E, Buttard B, Galon J, Zelenay S, Vermi W, Guermonprez P, Piaggio E, Helft J | 2021 | bioRxiv | Immuno-oncology | Cytonuclear, Highplex FL, TMA | |
| The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration | Puigdellivol M, Milde S, Vilalta A, Cockram T, Allendorf D, Lee J, Dundee J, Pampuscenko K, Borutaite V, Nuthall H, Brelstaff J, Spillantini G, Brown G | 2021 | Cell Reports | Neuroscience | Area Quantification, Cytonuclear, Multiplex IHC | |
| Cannabinoid control of gingival immune activation in chronically SIV-infected rhesus macaques involves modulation of the indoleamine-2,3-dioxygenase-1 pathway and salivary microbiome | McDew-White M, Lee E, Alvarez X, Sestak K, Ling B, Byrareddy S, Okeoma C, Mohan M | 2022 | EBioMedicine | Infectious Disease | Area Quantification, Cytonuclear, Highplex FL | |
| Tumor cell-derived exosomes deliver TIE2 protein to macrophages to promote angiogenesis in cervical cancer | Du S, Qian J, Tan S, Li W, Liu P, Zhao J, Zeng Y, Xu L, Wang Z, Cai J | 2022 | Cancer Letters | Oncology | Area Quantification, Cytonuclear, Spatial Analysis, Highplex FL | |
| e The Association of Cholesterol Uptake and Synthesis with Histology and Genotype in Cortisol-Producing Adenoma (CPA) | Motomura N, Yamazaki Y, Koga D, Harashima S, Gao X, Tezuka Y, Omata K, Ono Y, Morimoto R, Satoh F, Nakamura Y, Kwon G, Choi M, Ito A, Sasano H | 2022 | International Journal of Molecular Sciences | Area Quantification, Cytonuclear, Membrane | ||
| spatialTIME and iTIME: R package and Shiny application for visualization and analysis of immunofluorescence data | Creed J, Wilson C, Soupir A, Colin-Leitzinger C, Kimmel G, Ospina O, Chakiryan N, Markowitz J, Peres L, Coghill A, Fridley B | 2021 | Bioinformatics | Other | Classifier, Cytonuclear, Highplex FL | |
| Understanding the impact of chemotherapy on the immune landscape of high-grade serous ovarian cancer | Vanguri R, Benhamida J, Young J, Li Y, Zivanovic O, Chi D, Snyder A, Hollmann T, Mager K | 2022 | Gynecologic Oncology Reports | Oncology | Classifier, Cytonuclear, Highplex FL | |
| IgA-dominated humoral immune responses govern patients' outcome in endometrial cancer | Mandal G, Biswas S, Anadon C, Yu X, Gatenbee C, Prabhakaran S, Payne K, Chaurio R, Martin A, Innamarato P, Moran C, Powers J, Harro C, Mine J, Sprenger K, Rigolizzo K, Wang X, Curiel T, Rodriguez P, Anderson A, Saglam O, Conejo-Garcia J | 2021 | Cancer Research | Immuno-oncology | Classifier, Cytonuclear, Highplex FL | |
| A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo | Kofink C, Trainor N, Mair B, Wrhrle S, Wurm M, Mischerikow N, Bader G, Rumpel K, Gerstberger T, Cui Y, Greb P, Garavel G, Scharnweber M, Fuchs J, Gremel G, Chette P, Hopf S, Budano N, Rinnenthal J, Gmaschitz G, Diers E, McLennan R, Roy M, Whitworth C, Vetma V, Mayer M, Koegl M, Ciulli A, Weinstabl H, Farnaby W | 2022 | Biological and Medicinal Chemistry | Classifier, Cytonuclear, Multiplex IHC | ||
| Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDAC | Baer J, Zuo C, Kang L, Alarcon de la Lastra A, Bocherding N, Knolhoff B, Bogner S, Zhu Y, Lewis M, Zhang N, Kim K, Fields R, Mills J, Ding L, Randolph G, DeNardo D | 2022 | bioRxiv | Fibrosis | Classifier, Area Quantification, Cytonuclear, Multiplex IHC, Highplex FL, Figure Maker | |
| Anti-CAIX BB? CAR4/8 T Cells Exhibit Superior Efficacy in a Clear Cell Renal Cell Carcinoma (ccRCC) Mouse Model | Wang Y, Buck A, Grimaud M, Culhane A, Kodangattil S, Razimbaud C, Bonal D, Nguyen Q, Zhu Z, Wei K, O'Donnell M, Huang Y, Signoretti S, Choueiri T, Freeman G, Zhu Q, Marasco | 2021 | Molecular Therapy: Oncolytics | Oncology | Cytonuclear, Multiplex IHC | |
| Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression | Cheung P, Yang J, Fang R, Borgers A, Krengel K, Stoffel A, Althoff K, Yip C, Siu E, Ng L, Lang K, Cham L, Engel D, Soun C, Cima I, Scheffler B, Striefler J, Sinn M, Bahra M, Pelzer U, Oettle H, Markus P, Smeets E, Aarntzen E, Savvatakis K, Liffers S, Lueong S, Neander C, Bazarna A, Zhang X, Paschen A, Crawford H, Chan A, Cheung S, Siveke J | 2022 | Nature Communications | Oncology | Cytonuclear, Spatial Analysis, Highplex FL | |
| Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer | Zheng S, Zou Y, Tang Y, Yang A, Liang J, Wu L, Tian W, Xiao W, Xie X, Yang L, Xie J, Wei W, Xie X | 2022 | OncoImmunology | Immuno-oncology | Cytonuclear, Multiplex IHC | |
| The Tumor Immune Landscape and Architecture of Tertiary Lymphoid Structures in Urothelial Cancer | van Dijk N, Gil-Himenez A, Silina K, van Montfoort M, Einerhand S, Jonkman L, Voskuilen C, Peters D, Sanders J, Lubeck Y, Broeks A, Hooijberg E, Vis D, van den Broek M, Wessels L, van Rhijn B, van der Heijden M | 2021 | Frontiers in Immunology | Immuno-oncology | Cytonuclear, Spatial Analysis, Highplex FL | |
| Collaborative workflow between pathologists and deep learning for evaluation of tumor cellularity in lung adenocarcinoma | Sakamoto T, Furukawa T, Pham H, Kuroda K, Tabata K, Kshima Y, Okoshi E, Morimoti S, Bychkov A, Fukuoka J | 2022 | bioRxiv | Oncology | Cytonuclear, Multiplex IHC | |
| New Fully Automated Preparation of High Apparent Molar Activity 68Ga-FAPI-46 on a Trasis AiO Platform | Da Pieve C, Braga M, Turton D, Valla F, Cakmak P, Plate K, Kramer-Marek G | 2022 | Molecules | Other | Cytonuclear, Highplex FL | |
| Retrospective analysis of the efficacy of adjuvant cytokine-induced killer cell immunotherapy combined with chemotherapy in colorectal cancer patients after surgery | Li X, Zhou H, Huang W, Wang X, Meng M, Hou Z, Liao L, Tang W, Xie Y, Wang R, Yu H, Wang L, Zhu H, Wang W, Tan J, Li R | 2022 | Clinical & Translational Immunology | Oncology | Cytonuclear, Highplex FL | |
| Intratumoural spatial distribution of S100B?+?folliculostellate cells is associated with proliferation and expression of FSH and ER? in gonadotroph tumours | Ilie M, Vasiljevic A, Chanal M, Gadot N, Chinezu L, Jouanneau E, Hennino A, Raverot G, Bertolino P | 2022 | Acta Neuropathologica Communications | Oncology | Cytonuclear, Spatial Analysis | |
| Glioblastoma exosomes influence glial cell hyaluronic acid deposition to promote invasiveness< | Koessinger D, Novo D, Koessinger A, Zerbst D, Moore M, Mitchell L, Neilson M, Stevenson K, Chalmers A, Birch J, Norman J | 2022 | bioRxiv | Cytonuclear | ||
| Pathogenesis of follicular thymic hyperplasia associated with rheumatoid arthritis | Ohe R, Yang S, Yamashita D, Ichikawa C, Saito A, Kabasawa T, Utsunomiya A, Aung N, Urano Y, Kitaoka T, Suzuki K, Takahara D, Sasaki A, Takakubo Y, Takagi M, Yamakawa M, Futakuchi M | 2022 | Pathology International | Other | Cytonuclear, Multiplex IHC | |
| Nuclear expression of pSTAT3Tyr705 and pSTAT3Ser727 in the stromal compartment of localized hormone-naïve prostate cancer | Marginean F, Hellsten R, Krzyanowska A, Bjartell A | 2022 | Pathology - Research and Practice | Oncology | Cytonuclear, Multiplex IHC, TMA | |
| Tertiary lymphoid structures critical for prognosis in endometrial cancer patients - a TransPORTEC study | Horeweg N, Workel, H, Loiero D, Church D, Vermij L, Léon-Castillo A, Krog R, de Boer S, Nout R, Powel M, Mileshkin L, MacKay H, Leary A, Singh N, Jürgenliemk-Schulz I, Creutzberg C, Koelzer V, Nijman H, Bosse T, Bruyn M | 2022 | Nature Communications | Oncology | Cytonuclear, Multiplex IHC, TMA | |
| Genomic and single-cell landscape reveals novel drivers and therapeutic vulnerabilities of transformed cutaneous T-cell lymphoma | Song X, Chang S, Seminario-Vidal L, de Mingo Pulido A, Tordesillas L, Song X, Reed R, Harkins A, Whiddon S, Nguyen J, Segura C, Zhang C, Yoder S, Sayegh Z, Zhao Y, Messina J, Harro C, Zhang X, Conejo-Garcia J, Berglund A, Sokol L, Zhang J, Rodriguez P, Mule J, Futreal A, Tsai K, Chen P | 2022 | Cancer Discovery | Oncology | Cytonuclear, Highplex FL, TMA | |
| Tumor immune cell clustering and its association with survival in African American women with ovarian cancer | Wilson C, Soupir A, Thapa R, Creed J, Nguyen J, Segura C, Gerke T, Schildkraut J, Peres L, Fridley B | 2022 | PLOS Computational Biology | Cytonuclear, Highplex FL | ||
| Immunologic Gene Signature Analysis Correlates Myeloid Cells and M2 Macrophages with Time to Trabectedin Failure in Sarcoma Patients | Schroder B, Zhang Y, Smythe K, Desai P, Thomas A, Viveiros P, Alexiev B, Obeidin F, Chen E, Cranmer L, Wagner M, Jones R, Campbell J, Pierce R, He Q, Pollack S | 2022 | Cancers | Oncology | Cytonuclear, Highplex FL | |
| ZEB1 transcription factor promotes immune escape in melanoma | Plaschka M, Benboubker V, Grimont M, Berthet J, Tonon L, Lopez J, Le-Bouar M, Balme B, Tondeau G, de la Fouchardiere A, Larue L, Puisieux A, Grinberg-Bleyer Y, Bendriss-Vermare N, Dubois B, Caux C, Dalle S, Caramel J | 2022 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Cytonuclear, Multiplex IHC, Highplex FL | |
| Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica | Hong Y, Shan S, Gu Y, Huang H, Zhang Q, Han Y, Dong Y, Liu Z, Huang M, Ren T | 2022 | Nature Communications | Other | Cytonuclear, Multiplex IHC | |
| Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion | Veprik A, Denwood G, Liu D, Bakar R, Morfin V, McHugh K, Tebeka N, Vetterli L, Yonova-Doing E, Gribble F, Reimann F, Hoehn K, Hemsley P, Ahnfelt-Ronne J, Rorsman P, Zhang Q, Wet H, Cantley J | 2022 | Communications Biology | Metabolism | Cytonuclear, Highplex FL | |
| Construction of immune related prognostic model for pancreatic ductal adenocarcinoma based on single cell RNA-seq analysis | Chen K, Wang Q, Liu X, Wang F, Ma Y, Zhang S, Shao Z, Yang Y, Tian X | 2022 | Research Square | Oncology | Cytonuclear, Highplex FL | |
| Extracellular matrix proteins regulate NK cell function in peripheral tissues | Bunting M, Vyas M, Requesens M, Langenbucher A, Schiferle E, Manguso R, Lawrence M, Demehri S | 2022 | Science Advances | Dermatology | Cytonuclear, Highplex FL | |
| Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19 | Paul T, Ledderose S, Bartsch H, Sun N, Soliman S, Markl B, Ruf V, Herms J, Stern M, Keppler O, Delbridge C, Muller S, Piontek G, Kimoto Y, Schreiber F, Williams T, Neumann J, Knosel T, Schulz H, Spallek R, Graw M, Kirchner T, Walch A, Rudelius M | 2022 | Nature Communications | Infectious Disease | Cytonuclear, Highplex FL | |
| Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma—A Proof of Principle Study | Ursprung S, Woitek R, McLean M, Priest A, Crispin-Ortuzar M, Brodie C, Gill A, Gehrung M, Beer L, Riddick A, Field-Rayner J, Grist J, Deen S, Riemer F, Kaggie J, Zaccagna F, Duarte J, Locke M, Frary A, Aho T, Armitage J, Casey R, Mendichovszky I, Welsh S, Barrett T, Graves M, Eisen T, Mitchell T, Warren A, Brindle K, Sala E, Stewart G, Gallagher F | 2022 | Cancers | Oncology | Area Quantification, Cytonuclear, Multiplex IHC | |
| Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis | Chen Z, Zheng L, Chen Y, Liu X, Kawakami M, Mustachi L, Roszik J, Ferry-Galow K, Parchment R, Liu X, Andresson T, Duncan G, Kurie J, Rodriguez-Canales J, Liu X, Dmitrovsky E | 2022 | Cancer Biology & Therapy | Oncology | Classifier, Cytonuclear | |
| Therapeutic impact of BET inhibitor BI 894999 treatment: backtranslation from the clinic | Tontsch-Grunt U, Traexler P, Baum A, Musa H, Marzin K, Wang S, Trapani F, Engelhardt H, Solca F | 2022 | British Journal of Cancer | Oncology | Classifier, Cytonuclear, Multiplex IHC | |
| Improved cognitive impairments by silencing DMP1 via enhancing the proliferation of neural progenitor cell in Alzheimer-like mice | Zhao H, Wei J, Du Y, Chen P, Liu X, Liu H | 2022 | Aging Cell | Neuroscience | Cytonuclear, Highplex FL | |
| Peritumoral TIGIT+CD20+ B cell infiltration indicates poor prognosis but favorable adjuvant chemotherapeutic response in gastric cancer | Liu H, Wu J, Xu X, Wang H, Zhang C, Yin S, He Y | 2022 | International Immunopharmacology | Oncology | Cytonuclear, Spatial Analysis, Highplex FL | |
| Subpopulations of cancer-associated fibroblasts link the prognosis and metabolic features of pancreatic ductal adenocarcinoma | Hu B, Wu C, Mao H, Gu H, Dong H, Yan J, Qi Z, Yuan L, Dong Q, Long J | 2022 | Annals of Translational Medicine | Oncology | Cytonuclear, Highplex FL | |
| Organelle resolved proteomics reveals new chordoma cell surface markers required for proliferation and association with outcome | Khan S, Zuccato J, Ignatchenko V, Singh O, Govindarajan M, Waas M, Gao A, Zadeh G, Kislinger T | 2022 | Research Square | Oncology | Cytonuclear, Multiplex IHC | |
| Immune cell subsets in interface cutaneous immune-related adverse events (cirAEs) associated with anti-PD-1 therapy resemble accute graft vs host disease more than licen planus | Cruz G, Kaunitz G, Stein J, Sander I, Hollmann T, Cottrell T, Taube J, Sunshine J | 2022 | Journal of Cutaneous Pathology | Immunology | Cytonuclear, Multiplex IHC | |
| SPOP promotes cervical cancer progress by inducing PD-1 move away from PD-L1 in spatial localization | Wu J, Wu Y, Guo Q, Chen S, Wang S, Zhu J, Wu X, Ju X | 2022 | Research Square | Oncology | Cytonuclear, Spatial Analysis, Highplex FL, TMA | |
| C57BL/6J Mice Are Not Suitable for Modeling Severe SARS-CoV-2 Beta and Gamma Variant Infection | Currey J, Rabito F, Maness N, Blair R, Rappaport J, Qin X, Kolls J, Srivastava A | 2022 | Viruses | Infectious Disease | Cytonuclear, Multiplex IHC | |
| Dietary Pharmacological Zinc and Copper Enhances Voluntary Feed Intake of Nursery Pigs | DeMille C, Burrough E, Kerr B, Schweer W, Gabler N | 2022 | Frontiers in Animal Science | Other | Cytonuclear, Multiplex IHC | |
| Spatial transcriptome of a germinal center plasmablastic burst hints at MYD88/CD79B mutants-enriched diffuse large B-cell lymphomas | L'Imperio V, Morello G, Vegliante M, Cancila V, Bertolazzi G, Mazzara S, Belmonte B, Mangogna A, Balzarini P, Corral L, Lopez G, Di Napoli A, Facchetti F, Pagni F, Tripodo C | 2022 | European Journal of Immunology | Oncology | Cytonuclear, Multiplex IHC | |
| Multi-scale integrative analyses identify THBS2+ cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma | Yang H, Sun B, Fan L, Ma W, Xu K, Hall S, Wang Z, Schmid R, Peng R, Marti T, Gao W, Xu J, Yang W, Yao F | 2022 | Theranostics | Oncology | Cytonuclear, Multiplex IHC | |
| Pilot Trial of Arginine Deprivation Plus Nivolumab and Ipilimumab in Patients with Metastatic Uveal Melanoma | Kraehenbuehl L, Holland A, Armstrong E, O'Shea S, Mangarin L, Chekalil S, Johnston A, Bomalaski J, Erinjeri J, Barker C, Francis J, Wolchok J, Merghoub T, Shoushtari A | 2022 | Cancers | Oncology | Cytonuclear, Highplex FL | |
| Preclinical evaluation of FAP?2286 for fbroblast activation protein targeted radionuclide imaging and therapy | Zboralski D, Hoehne A, Bredenbeck A, Schumann A, Nguyen M, Schneider E, Ungewiss J, Paschke M, Haase C, von Hacht J, Kwan T, Lin K, Lenore J, Harding T, Xiao J, Simmons A, Mohan A, Beindorff N, Reineke U, Smerling C, Osterkamp F | 2022 | European Journal of Nuclear Medicine and Molecular Imaging | Oncology | Cytonuclear, Multiplex IHC | |
| Prognostic Integrated Image-Based Immune and Molecular Profiling in Early-Stage Endometrial Cancer | Horeweg N, de Bruyn M, Nout R, Stelloo E, Kedzierska K, Leon-Castillo A, Plat A, Mertz K, Osse M, Jurgenliemk-Schulz I, Lutgens L, Jobsen J, van der Steen-Banasik E, Smit V, Creutzberg C, Bosse T, Nijman H, Koelzer V, Church D | 2020 | Cancer Immunology Research | Oncology | Cytonuclear, Multiplex IHC, TMA | |
| Comparing Deep Learning and Immunohistochemistry in Determining the Site of Origin for Well-Differentiated Neuroendocrine Tumors | Redemann J, Schultz F, Martinez C, Harrell M, Clark D, Martin D, Hanson J | 2020 | Journal of Pathology Informatics | Oncology | Cytonuclear, TMA | |
| Randomized Controlled Trial of the Gastrin/CCK2 Receptor Antagonist Netazepide in Patients with Barrett's Esophagus | Abrams J, Del Portillo A, Hills C, Compres G, Friedman R, Cheng B, Poneros J, Lightdale C, Del La Rue R, di Pietro M, Fitzgerald R, Sepulveda A, Wang T | 2021 | Cancer Prevention Research | Cytonuclear, Multiplex IHC | ||
| 3’UTR-directed, kinase proximal mRNA decay inhibits C/EBP? phosphorylation/activation to suppress senescence in tumor cells | Salotti J, Karim B, Misra S, Hu L, Basu S, Martin N, Luke B, Saylor K, Andresson T, Scheiblin D, Lockett S, Tessarollo L, Johnson P | 2022 | bioRxiv | Oncology | Classifier, Cytonuclear | |
| Integrated Analysis Of Immunotherapy Treated Clear Cell Renal Cell Carcinomas: An Exploratory Study | Sobottka B, Nienhold R, Nowak M, Hench J, Haeuptle P, Frank A, Sachs M, Kahraman A, Moch H, Koelzer V, Mertz K | 2022 | Journal of Immunotherapy | Immuno-oncology | Cytonuclear, Multiplex IHC, Figure Maker | |
| Restoring Pro-healing/remodeling- associated M2a/c Macrophages using ON101 Accelerates Diabetic Wound Healing | Lin C, Chen C, Huang W, Chen Y, Chen S, Chou H, Hung C, Chen W, Lu C, Nian S, Chen S, Chang H, Chang V, Liu L, Kuo M, Chang S | 2022 | JID Innovations | Other | Area Quantification, Cytonuclear | |
| CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation | Boieri M, Malishkevich A, Guennoun R, Marchese E, Kroon S, Trerice K, Awad M, Park J, Iyer S, Kreuzer J, Haas W, Rivera M, Demehri S | 2022 | Journal of Experimental Medicine | Immuno-oncolgy | Cytonuclear, Highplex FL | |
| Prognostic image-based quantification of CD8CD103 T cell subsets in high-grade serous ovarian cancer patients | Paijens S, Vledder A, Loiero D, Duiker E, Bart J, Hendriks A, Jalving M, Workel H, Hollema H, Werner N, Plat A, Wisman G, Yigit R, Arts H, Kruse A, de Lange N, Koelzer V, Bruyn M, Nijman H | 2021 | OncoImmunology | Immuno-oncology | Cytonuclear, Multiplex IHC, TMA | |
| Higher proportions of CD39+ tumorresident cytotoxic T cells predict recurrence-free survival in patients with stage III melanoma treated with adjuvant immunotherapy | Attrill G, Owen C, Ahmed T, Vergara I, Colebatch A, Conway J, Nahar K, Thompson J, da Silva I, Carlino M, Menzies A, Lo S, Palendira U, Scolyer R, Long G, Wilmott J | 2022 | Journal of Immuno Therapy of Cancer | Immuno-oncology | Cytonuclear, Spatial Analysis, Highplex FL | |
| Baseline and post-treatment biomarkers of resistance to anti-PD-1 therapy in acral and mucosal melanoma: an observational study | Shui I, Liu X, Zhao Q, Kim S, Sun Y, Yearley J, Choudhury T, Webber A, Krepler C, Cristescu R, Lee J | 2022 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Cytonuclear, Highplex FL | |
| Spatial meta-transcriptomics reveal associations of intratumor bacteria burden with lung cancer cells showing a distinct oncogenic signature | Wong-Rolle A, Dong Q, Zhu Y, Divakar P, Hor J, Kedei N, Wong M, Tillo D, Conner E, Rajan A, Schrump D, Jim C, Germain R, Zhao C | 2022 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Cytonuclear, Multiplex IHC | |
| SOX9+ malignant cells define a poor prognosis subtype of Glioma with tumor-associated macrophage recruitment | Yu S, Ma C, Wang H, Yu B, Luan Y, Xia Z | 2022 | Research Square | Immuno-oncology | Cytonuclear, Multiplex IHC | |
| Combined Blockade of GARP:TGF-β1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP+ Blood Vessels in Mouse MC38 Tumors | Bertrand C, Van Meerbeeck P, de Streel G, Vaherto-Bleeckx N, Benhaddi F, Rouaud L, Noel A, Coulie P, van Baren N, Lucas S | 2022 | Frontiers of Immunology | Immuno-oncology | Cytonuclear, Object Colocalization | |
| Multiplexed immunofluorescence analysis of CAFmarkers, EZH2 and FOXM1 in Gastric Tissue: Associations with Clinicopathological Parameters and Clinical Outcomes | Sun H, Wang X, Wang X, Tan C, Weng W, Zhang M, Ni S, Wang L, Huang D, Sheng W, Xu M | 2022 | Research Square | Oncology | Cytonuclear, Highplex FL | |
| Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix | Kay E, Paterson K, Riero-Domingo C, Sumpton D, Dabritz J, Tardito S, Boldrini C, Hernandez-Fernaud J, Athineos D, Dhayade S, Stepanova E, Gjerga E, Neilson L, Lilla S, Hedley A, Koulouras G, McGregor G, Jamieson C, Johnson R, Park M, Kirschner K, Miller C, Kamphorst J, Loayza-Puch F, Saez-Rodriguez J, Mazzone M, Blyth K, Zagnoni M, Zanivan S | 2022 | Nature Metabolism | Oncology, Metabolism | Cytonuclear, Multiplex IHC, Highplex FL | |
| Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa | Reyes-Uribe L, Wu W, Gelincik O, Bommi PV, Francisco-Cruz A, Solis LM, Lynch PM, Lim R, Stoffel EM, Kanth P, Samadder NJ, Mork ME, Taggart MW, Milne GL, Marnett LJ, Vornik L, Liu DD, Revuelta M, Chang K, You YN, Kopelovich L, Wistuba II, Lee JJ, Sei S, Shoemaker RH, Szabo E, Richmond E, Umar A, Perloff M, Brown PH, Lipkin SM, Vilar E | 2020 | Gut | Oncology | Classifier, Cytonuclear | |
| Prostate cancer androgen receptor activity dictates efficacy of Bipolar Androgen Therapy | Sena L, Kumar R, Sanin D, Thompson E, Rosen D, Dalrymple S, Antony L, Yang Y, Comes-Alexandre C, Hicks J, Jones T, Bowers K, Eskra J, Meyers J, Gupta A, Skaist A, Yegnasubramanian S, Luo J, Brennen W, Kachhap S, Antonarakis E, De Marzo A, Isaacs J, Markowski M, Denmeade S | 2022 | medRxiv | Oncology | Classifier, Cytonuclear, Multiplex IHC, Registration | |
| A survey on artificial intelligence in histopathology image analysis | Abdelsamea M, Zidan U, Senousy Z, Gaber M, Rakha E, Ilyas M | 2022 | WIREs Data Mining and Knowledge Discovery | Review | Classifier, Cytonuclear, Figure Maker, TMA | |
| Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer | Kumar R, Mendonca J, Owoyemi O, Boyapati K, Thomas N, Kanacharoen S, Coffey M, Topiwala D, Homes C, Ozbek B, Jones T, Rosen M, Dong L, Wiens S, Brennen W, Isaacs J, Marzo A, Markowski M, Antonarakis E, Qian D, Pienta K, Pardoll D, Carducci M, Denmeade S, Kachhap S | 2021 | Cancer Research | Oncology | Cytonuclear | |
| USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer | Shi D, Wu X, Jian Y, Wang J, Huang C, Mo S, Li Y, Li F, Zhang C, Zhang D, Zhang H, Huang H, Chen X, Wang Y, Lin C, Liu G, Song L, Liao W | 2022 | Nature Communications | Oncology, Dermatology | Cytonuclear, Highplex FL | |
| Single Cell RNA-Seq Identifies Immune-Related Prognostic Model and Key Signature-SPP1 in Pancreatic Ductal Adenocarcinoma | Chen K, Wang Q, Liu X, Wang F, Ma Y, Zhang S, Shao Z, Yang Y, Tian X | 2022 | Genes | Oncology | Cytonuclear, Highplex FL | |
| Positron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo | Dzien P, Mackintosh A, Malviya G, Johnson E, Soloviev D, Brown G, Uribe A, Nixon C, Lyons S, Maddocks O, Blyth K, Lewis D | 2022 | Research Square | Metabolism | Cytonuclear | |
| Single-cell RNA-seq transcriptomic landscape of human and mouse islets and pathological alterations of diabetes | Chen K, Zhang J, Huang Y, Tian X, Yang Y, Dong A | 2022 | iScience | Metabolism | Cytonuclear, Highplex FL | |
| Comparative analysis of the immune response to RFA and cryoablation in a colon cancer mouse model | Mauda-Havakuk M, Hawken N, Owen J, Mikhail A, Saxena A, Karim B, Wakim P, Pritchard W, Karanian J, Wood B | 2022 | Scientific Reports | Oncology | Cytonuclear | |
| Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody | Weaver J, Stack E, Bugge J, Hu C, McGrath L, Mueller A, Wong M, Klebanov B, Rahman T, Kaufman R, Fregeau C, Spaulding V, Priess M, Legendre K, Jaffe S, Upadhyay D, Singh A, Xu C, Krukenberg K, Zhang Y, Ezzyat Y, Axe D, Kuhne M, Meehl M, Shaffer D, Weist B, Wiederschain D, Depis F, Gostissa M | 2022 | Oncoimmunology | Immuno-oncology | Cytonuclear | |
| Single-cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases | Sun H, Li L, Lao I, Li X, Xu B, Cao Y, Jin W | 2022 | Clinical and Translational Medicine | Oncology | Cytonuclear, Highplex FL | |
| Dynamin-2 deficiency causes age- and sex-dependent neutropenia and myelodysplasia in mice | Willis A, Corey S, Murga-Zamalloa C, Karimi S, Khaddour K, Quigley J, Eklund E, Chen Y | 2022 | Blood Advances | Other | Cytonuclear, Multiplex IHC | |
| Tumor-immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas | Soeratram T, Creemers A, Meijer S, deBoer O, Vos W, Hooijer G, van Berge Henegouwen M, Hulshof M, Bergman J, Lei M, Bijlsma M, Ylstra B, van Grieken N, van Laarhoven H | 2021 | The Journal of Pathology | Immuno-oncology | Cytonuclear | |
| The association of HHLA2 and PD-L1 expression with prognosis and immune microenvironment in hepatocellular carcinoma | Wang C, Chen S, Yang X, Wu T, Liu L, Yun J | 2022 | Research Square | Oncology | Cytonuclear, Multiplex IHC | |
| T-cell mediated targeted delivery of anti-PD-L1 nanobody overcomes poor antibody penetration and improves PD-L1 blocking at the tumor site | Pierre-Florent P, Bombart R, Desimpel P, Naulaerts S, Thouvenel L, Collet J, Van den Eynde B, Zhu J | 2022 | Cancer Immunology Research | Immuno-oncology | Area Quantification, Cytonuclear | |
| Histopathologic differences in granulomas of Mycobacterium bovis bacille Calmette Guérin (BCG) vaccinated and non-vaccinated cattle with bovine tuberculosis | Kanipe C, Boggiatto P, Putz E, Palmer M | 2022 | Frontiers in Microbiology | Immunology, Infectious Disease | Cytonuclear | |
| The Neo-PLANET phase II trial of neoadjuvant camrelizumab plus concurrent chemoradiotherapy in locally advanced adenocarcinoma of stomach or gastroesophageal junction | Tang Z, Wang Y, Liu D, Wang X, Xu C, Yu Y, Cui Y, Tang C, Li Q, Sun J, Zhang Q, Ji Y, Ma G, Li H, Shen Z, Shen K, Zheng R, Hou Z, Liu T, Wang J, Sun Y | 2022 | Nature Communications | Immuno-oncology | Cytonuclear, Multiplex IHC | |
| Assessment of spatial transcriptomics for oncology discovery | Lyubetskaya A, Rabe B, Fisher A, Lewin A, Neuhaus I, Brett C, Brett T, Pereira E, Golhar R, Kebede S, Font-Tello A, Mosure K, Wittenberghe N, Mavrakis K, Maclsaac K, Chen B, Drokhlyansky E | 2022 | Cell Reports Methods | Oncology | Cytonuclear, Multiplex IHC, Registration | |
| Impacts of neoadjuvant chemoradiotherapy on the immune landscape of esophageal squamous cell carcinoma | Wen J, Fang S, Hu Y, Xi M, Weng Z, Pan C, Luo K, Ling Y, Lai R, Xie X, Lin X, Lin T, Chen J, Liu Q, Fu J, Yang H | 2022 | EBioMedicine | Immuno-oncology | Cytonuclear, Highplex FL | |
| Visualization of calcium channel blockers in human adrenal tissues and their possible effects on steroidogenesis in the patients with primary aldosteronism (PA) | Motomura N, Yamazaki Y, Gao X, Tezuka Y, Omata K, Ono Y, Morimoto R, Satoh F, Nakamura Y, Shim J, Choi M, Ito A, Sasano H | 2022 | The Journal of Steroid Biochemistry and Molecular Biology | Metabolism | Cytonuclear | |
| Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs | Wang A, Ribeiro R, Ali A, Brambate E, Abdelnour-Berchtold E, Michaelsen V, Zhang Y, Rahfeld P, Moon H, Gokhale H, Gazzalle A, Pal P, Liu M, Waddell T, Cserti-Gadewich C, Tinckam K, Kizhakkedathu J, West L, Keshavjee S, Withers S, Cypel M | 2022 | Science Translational Medicine | Other | Area Quantification, Cytonuclear | |
| Epithelial-to-mesenchymal transition promotes immune escape by inducing CD70 in non-small cell lung cancer | Ortiz-Cuaran S, Swalduz A, Foy J, Marteau S, Morel A, Fauvet F, De Souza G, Michon L, Boussageon M, Gadot N, Godefroy M, Leon S, Tortereau A, Mourksi N, Leonce C, Albraret M, Dongre A, Vanbervliet B, Robert M, Tonon L, Pommier R, Hofman V, Attignon V, Boyault S, Audoynaud C, Auclair J, Boquet F, Wang Q, Menetrier-Caux C, Perol M, Caux C, Hofman P, Lantuejoul S, Puisieux A, Saintgny P | 2022 | European Journal of Cancer | Oncology | Cytonuclear | |
| The Multi-Kinase Inhibitor Lucitanib Enhances the Antitumor Activity of Coinhibitory and Costimulatory Immune Pathway Modulators in Syngeneic Models | Robillard L, Liao M, Nguyen M, Harding T, Simmons A, Dusek R | 2022 | Journal of Immunotherapy | Immuno-oncology | Cytonuclear | |
| ProNGF Expression and Targeting in Glioblastoma Multiforme | Marsland M, Dowdell A, Faulkner S, Jobling P, Rush R, Gedye C, Lynam J, Griffin C, Baker M, Marsland J, Jiang C, Hondermarck H | 2023 | International Journal of Molecular Sciences | Oncology | Cytonuclear | HALO |
| Altered MANF Expression in Pancreatic Acinar and Ductal Cells in Chronic Alcoholic Pancreatitis: A Cross-Sectional Study | Caldwell N, Li H, Bellizzi A, Luo J | 2023 | Biomedicines | Gastroenterology | Area Quantification, Cytonuclear | HALO |
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