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Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

In this study, McKinnon et al identify overexpression of α-synuclein leading to catalytic impairment of the 26S proteosome in defined regions of rat brains. Brain tissue was fixed following α-synuclein overexpression for immunofluorescence studies of dopaminergic neurons which were quantified by the HALO image analysis platform. Future research will focus on characterizing the relationship between proteasome impairment and neurodegeneration.

McKinnon C, De Snoo ML, Gondard E, Neudorfer C, Chau H, Ngana SG, O’Hara DM, Brotchie JM , Koprich JB, Lozano AM, Kalia LV, Kalia SK

Acta Neuropathologica Communications | First published 14 February 2020 | DOI https://doi.org/10.1186/s40478-020-0894-0