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HALO®

IMAGE ANALYSIS PLATFORM

HALO is the gold standard image analysis platform for quantitative tissue analysis in digital pathology.

With unmatched ease-of-use and scalability, powerful analytic capabilities, and the fastest processing speeds available for digital pathology, pharmaceutical, healthcare and research organizations worldwide are using HALO for high-throughput, quantitative tissue analysis in oncology, neuroscience, metabolism, toxicology and more. 

Watch a video of the HALO platform in action here.

HALO®

IMAGE ANALYSIS PLATFORM

HALO is the gold standard image analysis platform for quantitative tissue analysis in digital pathology.

With unmatched ease-of-use and scalability, powerful analytic capabilities, and the fastest processing speeds available for digital pathology, pharmaceutical, healthcare and research organizations worldwide are using HALO for high-throughput, quantitative tissue analysis in oncology, neuroscience, metabolism, toxicology and more.  

Watch a video of the HALO platform in action here.

RELATED RESOURCES

Brochure
Brochure (Simplified Chinese)
Demo Video

RELATED PRODUCTS

HALO image analysis modules
HALO AI deep learning add-on
HALO Link image management
Pharma Services

CONTACT  US

For demo, trial, or quotation:
info@indicalab.com
+1(505) 492 0979

EASY-TO-USE MODULES & ADD-ONS

HALO modules simplify the analysis workflow so there is no need to ‘build’ algorithms from scratch. Modules make HALO easy-to-use and understand which means you can spend less time learning software and more time analyzing data.

HALO add-ons can be used in combination with any of the other analysis modules to improve the analysis workflow. These include tools to help automate tissue segmentation, such as tissue classifier, serial section analysis, and TMA, as well as tools to improve image processing speeds for high-throughput labs, such as analysis cluster.

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EXTENSIVE ANALYTICS

HALO reports morphological and multiplexed expression data on a cell-by-cell basis across entire tissue sections and maintains an interactive link between cell data and cell image. Click on any cell in the image and immediately see analysis outputs for that specific cell. Sorting and filtering capabilities allow the user to mine millions of cells while visually assessing corresponding cell populations. For example, sort cells according to biomarker intensity and immediately locate cells with highest intensity in the image. Just imagine the endless possibilities.

EXTENSIVE ANALYTICS

HALO reports morphological and multiplexed expression data on a cell-by-cell basis across entire tissue sections and maintains an interactive link between cell data and cell image. Click on any cell in the image and immediately see analysis outputs for that specific cell. Sorting and filtering capabilities allow the user to mine millions of cells while visually assessing corresponding cell populations. For example, sort cells according to biomarker intensity and immediately locate cells with highest intensity in the image. Just imagine the endless possibilities.

SCALABLE PLATFORM

HALO’s modular design and flexible licensing allow it to be adapted to any requirement and budget. Start with all the modules or just a few and add more modules as your needs change. Use HALO on a single workstation or ramp up to a server-based license for your entire group. Purchase a permanent license or renew annually.

Discover HALO Modules

Click on the links below to explore our most popular HALO modules & add-ons. Use the category filters or click the 'Load More' button at the bottom of the list to view additional options.

Highplex FL
Quantify expression of an unlimited number of biomarkers in any cellular compartment - membrane, nucleus or cytoplasm.
Highplex FL
Multiplex IHC
Quantify expression of up to five brightfield stains in any cellular compartment - membrane, nucleus or cytoplasm.
Multiplex IHC
FREE TRIAL
Click here to fill out a demo request form. Upload up to three images if you would like to test analysis on your own slides.
Upload Images
Tissue Classifier Add-on
Separate multiple tissue classes across a tissue using a learn-by-example approach. Can be used in conjuction with all other modules (fluorescent and brightfield) to select specific tissue classes for further analysis.
Tissue Classifier Add-on
Spatial Analysis
Plot cells and objects from one or more images and perform nearest neighbor analysis, proximity analysis, and tumor infiltration analysis.
Spatial Analysis
ISH
Quantify spot number, optical density and co-expression of one or two brightfield RNA or DNA probes on a per cell basis. Includes support for brightfield RNAscope® assays.
ISH (RNAScope®)
ISH-IHC
Quantify IHC positivity and spot number, optical density and co-expression of one or two brightfield RNA or DNA probes on a per cell basis. Includes support for brightfield RNAscope® assays.
ISH-IHC (RNAScope®)
FISH-IF
Quantify an unlimited number of fluorescent RNA/DNA probes and IF protein biomarkers on a per cell basis. Includes support for fluorescent RNAscope® assays.
FISH-IF (RNAScope®)
Multiplex FISH
Quantify number, intensity and co-expression of an unlimited number of fluorescently labeled RNA or DNA probes on a per cell basis. Includes support for fluorescent RNAscope ® assays.
Multiplex FISH (RNAScope®)
Tissue Microarray (TMA) Add-on
Module to assist in the segmentation of TMA spots for further analysis.
Tissue Microarray (TMA) Add-on
Area Quantification
Deconvolve up to five colors in brightfield and measure positive area and average optical density for each stain and stain colocalization (where applicable).
Area Quantification
Cytonuclear IHC
Quantify expression of up to four brightfield cytoplasmic/nuclear markers on a per cell basis and bin cells according to intensity (1+, 2+ and 3+).
Cytonuclear IHC
Area Quantification FL
Measure the positive area, average intensity and dye colocalization (where applicable) of an unlimited number of fluorescent dyes.
Area Quantification FL
Cytonuclear FL
Quantify expression of an unlimited number of fluorescently labeled cytoplasmic/nuclear markers on a per cell basis and bin cells according to intensity (1+, 2+ and 3+).
Cytonuclear FL
Membrane IHC
Quantify intensity of brightfield membrane markers on a per cell basis and bin cells according to intensity (0, 1+, 2+, 3+).
Membrane IHC
Membrane FL
Quantify intensity of fluorescently-labeled membrane markers on a per cell basis and bin cells according to intensity (0, 1+, 2+, 3+).
Membrane FL
Object Colocalization
Count one or two objects and measure the object area, diameter, stain intensity, and colocalization (where applicable). Microvessel and amyloid plaque quantification are most common applications.
Object Colocalization
Vacuole
Quantifies vacuole area, diameter, perimeter, and number of vacuoles per region of interest. Measures steatosis in kidney, lipid droplets in adipose tissue, and alveolar area in lung tissue.
Vacuole
Object Colocalization FL
Count one or two fluorescently labeled objects and measures the object area, diameter, stain intensity, and colocalization (where applicable). Microvessel and amyloid plaque quantification are most common applications.
Object Colocalization FL
Muscle Fiber
Quantifies area, diameter, and perimeter of muscle fibers stained with laminin or other fiber membrane stain.
Muscle Fiber
Muscle Fiber FL
Quantifies area, diameter, and perimeter of fluorescently-labelled muscle fibers stained with membrane markers, such as laminin.
Muscle Fiber FL
Branch Structure
Quantify branched objects such as capillaries in brightfield and fluorescence.
Branch Structure
Islet IHC
Count pancreatic islets, quantify number of alpha and beta cells in each islet, and determine area of islets stained with insulin and glucagon or other islet-specific stains
Islet IHC
Islet FL
Count pancreatic islets fluorescently-labeled with up to three dyes, quantify number of dye positive cells per islet and area of dye positivity per islet.
Islet FL
Microglial Activation
Quantify microglial activation based on length and thickness of microglial processes.
Microglial Activation
Amplification & Deletion FISH
Quantify up to two fluorescently-labeled DNA probes to measure amplification or deletion.
Amplification & Deletion FISH
Break Apart Fusion FISH
Meaure gene rearrangements detected using break-apart fusion probes.
Break Apart Fusion FISH
Serial Registration Analysis Add-on
Analyze serially stained tissue sections stained with different markers or a single tissue section which has been stained, stripped and re-stained for multiple markers.
Serial Section Analysis Add-on
Analysis Cluster Add-on
Designed for organization with large volume of slides or users, analysis clusters speed up analysis by facilitating simultaneous processing of multiple images in parallel.
Analysis Cluster Add-on
Axon
Quantify axons in cross sections. Calculate axon area, myelin area, myelin thickness, inner and outer axon diameter, and G-ratio.
Axon

Discover
HALO Modules

Click on the links below to explore our most popular HALO modules & add-ons. Use the category filters or click the 'Load More' button at the bottom of the list to view additional options.

Highplex FL
Quantify expression of an unlimited number of biomarkers in any cellular compartment - membrane, nucleus or cytoplasm.
Highplex FL
Multiplex IHC
Quantify expression of up to five brightfield stains in any cellular compartment - membrane, nucleus or cytoplasm.
Multiplex IHC
FREE TRIAL
Click here to fill out a demo request form. Upload up to three images if you would like to test analysis on your own slides.
Upload Images
Tissue Classifier Add-on
Separate multiple tissue classes across a tissue using a learn-by-example approach. Can be used in conjuction with all other modules (fluorescent and brightfield) to select specific tissue classes for further analysis.
Tissue Classifier Add-on
Spatial Analysis
Plot cells and objects from one or more images and perform nearest neighbor analysis, proximity analysis, and tumor infiltration analysis.
Spatial Analysis
ISH
Quantify spot number, optical density and co-expression of one or two brightfield RNA or DNA probes on a per cell basis. Includes support for brightfield RNAscope® assays.
ISH (RNAScope®)
ISH-IHC
Quantify IHC positivity and spot number, optical density and co-expression of one or two brightfield RNA or DNA probes on a per cell basis. Includes support for brightfield RNAscope® assays.
ISH-IHC (RNAScope®)
FISH-IF
Quantify an unlimited number of fluorescent RNA/DNA probes and IF protein biomarkers on a per cell basis. Includes support for fluorescent RNAscope® assays.
FISH-IF (RNAScope®)
Multiplex FISH
Quantify number, intensity and co-expression of an unlimited number of fluorescently labeled RNA or DNA probes on a per cell basis. Includes support for fluorescent RNAscope ® assays.
Multiplex FISH (RNAScope®)
Tissue Microarray (TMA) Add-on
Module to assist in the segmentation of TMA spots for further analysis.
Tissue Microarray (TMA) Add-on
Area Quantification
Deconvolve up to five colors in brightfield and measure positive area and average optical density for each stain and stain colocalization (where applicable).
Area Quantification
Cytonuclear IHC
Quantify expression of up to four brightfield cytoplasmic/nuclear markers on a per cell basis and bin cells according to intensity (1+, 2+ and 3+).
Cytonuclear IHC
Area Quantification FL
Measure the positive area, average intensity and dye colocalization (where applicable) of an unlimited number of fluorescent dyes.
Area Quantification FL
Cytonuclear FL
Quantify expression of an unlimited number of fluorescently labeled cytoplasmic/nuclear markers on a per cell basis and bin cells according to intensity (1+, 2+ and 3+).
Cytonuclear FL
Membrane IHC
Quantify intensity of brightfield membrane markers on a per cell basis and bin cells according to intensity (0, 1+, 2+, 3+).
Membrane IHC
Membrane FL
Quantify intensity of fluorescently-labeled membrane markers on a per cell basis and bin cells according to intensity (0, 1+, 2+, 3+).
Membrane FL
Object Colocalization
Count one or two objects and measure the object area, diameter, stain intensity, and colocalization (where applicable). Microvessel and amyloid plaque quantification are most common applications.
Object Colocalization
Vacuole
Quantifies vacuole area, diameter, perimeter, and number of vacuoles per region of interest. Measures steatosis in kidney, lipid droplets in adipose tissue, and alveolar area in lung tissue.
Vacuole
Object Colocalization FL
Count one or two fluorescently labeled objects and measures the object area, diameter, stain intensity, and colocalization (where applicable). Microvessel and amyloid plaque quantification are most common applications.
Object Colocalization FL
Muscle Fiber
Quantifies area, diameter, and perimeter of muscle fibers stained with laminin or other fiber membrane stain.
Muscle Fiber
Muscle Fiber FL
Quantifies area, diameter, and perimeter of fluorescently-labelled muscle fibers stained with membrane markers, such as laminin.
Muscle Fiber FL
Branch Structure
Quantify branched objects such as capillaries in brightfield and fluorescence.
Branch Structure
Islet IHC
Count pancreatic islets, quantify number of alpha and beta cells in each islet, and determine area of islets stained with insulin and glucagon or other islet-specific stains
Islet IHC
Islet FL
Count pancreatic islets fluorescently-labeled with up to three dyes, quantify number of dye positive cells per islet and area of dye positivity per islet.
Islet FL
Microglial Activation
Quantify microglial activation based on length and thickness of microglial processes.
Microglial Activation
Amplification & Deletion FISH
Quantify up to two fluorescently-labeled DNA probes to measure amplification or deletion.
Amplification & Deletion FISH
Break Apart Fusion FISH
Meaure gene rearrangements detected using break-apart fusion probes.
Break Apart Fusion FISH
Serial Registration Analysis Add-on
Analyze serially stained tissue sections stained with different markers or a single tissue section which has been stained, stripped and re-stained for multiple markers.
Serial Section Analysis Add-on
Analysis Cluster Add-on
Designed for organization with large volume of slides or users, analysis clusters speed up analysis by facilitating simultaneous processing of multiple images in parallel.
Analysis Cluster Add-on
Axon
Quantify axons in cross sections. Calculate axon area, myelin area, myelin thickness, inner and outer axon diameter, and G-ratio.
Axon

Platform Compatibility

HALO is compatible with a broad spectrum of image and digital slide formats.  Yours not on the list? Email us your requirements.

File Formats

Non-proprietary (JPG, TIF)
Nikon (ND2)
3D Histech (MRXS)
Perkin Elmer (QPTIFF, component TIFF)
Olympus (VSI)
Hamamatsu (NDPI, NDPIS)
Aperio (SVS, AFI)
Zeiss (CZI)
Leica (SCN, LIF)
Ventana (BIF)

HALO Application Notes

Follow the links below to explore a few of the most popular HALO applications.

Fluorescence

Analyze Multiplexed Fluorescent Biomarkers in Whole Slide PerkinElmer Vectra® Polaris images fused in HALO

We demonstrate how HALO can create a multispectral 7-plex whole slide image from individual field-of-view image tiles captured from the PerkinElmer Vectra 3 or Polaris platform and analyze these images using our highplex FL module and spatial analysis modules.

Read More

Brightfield

Measure immune cell density and spatial distance to tumor cells within the tumor and invasive margin

Using our multiplex IHC module, we quantify immune cells and tumor cell markers across whole slide images.  The tissue classifier add-on is employed to segment tumor and stroma and the spatial analysis module is used for proximity and invasive margin analysis.  

Read More

Brightfield and Fluorescence

Quantify Single and Multiplexed RNAscope® probes across whole slide tissues

Using our ISH module for brightfield and our FISH module for fluorescence, we demonstrate how to quantify ISH signal from RNAScope® assays on a per cell or per unit area basis and output an overall expression score based on ACD Bio’s recommended scoring guidelines.  

Read More

Read what our customers are publishing

Our customers are making vital discoveries in oncology, neuroscience, and diabetes research.  Check out some of the research our customers are publishing using the HALO Image Analysis Platform and Indica analysis modules.

Immunogradient Indicators for Antitumor Response Assessment by Automated Tumor-Stroma Interface Zone Detection

    Allan Rasmusson, Dovile Zilenaite, Ausrine Nestarenkaite, Renaldas Augulis, Aida Laurinaviciene, Valerijus Ostapenko, Tomas Poskus, and Arvydas Laurinavicius The American Journal of Pathology, Vol. 190, No. 6, June 2020 | DOI: doi.org/10.1016/j.ajpath.2020.01.018 The distribution of tumor-infiltrating lymphocytes (TILs) within the tumor...

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    Prognostic significance of mesothelin expression in colorectal cancer disclosed by area-specific four-point tissue microarrays

      Takehiro Shiraishi, Eiji Shinto, Ines P. Nearchou, Hitoshi Tsuda, Yoshiki Kajiwara, Takahiro Einama, Peter D. Caie, Yoji Kishi & Hideki Ueno Virchows Archiv | February 2020 | DOI: 10.1007/s00428-020-02775-y Mesothelin (MSLN) is a cell surface glycoprotein present in many cancer...

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      Detection of Lung Cancer Lymph Node Metastases from Whole-Slide Histopathologic Images Using a Two-Step Deep Learning Approach

        Hoa Hoang Ngoc Pham, Mitsuru Futakuchi, Andrey Bychkov, Tomoi Furukawa, Kishio Kuroda, Junya Fukuoka The American Journal of Pathology | Volume 189, Issue 12, December 2019 | DOI: 10.5858/arpa.2019-0004-OA The application of deep learning for the detection of lymph node metastases...

        Read More

        A Deep Learning Convolutional Neural Network Can Recognize Common Patterns of Injury in Gastric Pathology

          Martin, D.R., Hanson, J.A., Gullapalli, R.R., Schultz, F.A., Sethi, A. and Clark, D.P. Archives of Pathology & Laboratory Medicine In-Press | Published April 5, 2019 | DOI: 10.5858/arpa.2019-0004-OA Context.— Most deep learning (DL) studies have focused on neoplastic pathology, with...

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          Automated Analysis of Lymphocytic Infiltration, Tumor Budding, and Their Spatial Relationship Improves Prognostic Accuracy in Colorectal Cancer

            Ines P. Nearchou, Kate Lillard, Christos G. Gavriel, Hideki Ueno, David J. Harrison, and Peter D. Caie Cancer Immunology Research| Published March 7, 2019 | DOI 10.1158/2326-6066.CIR-18-0377 Both immune profiling and tumor budding significantly correlate with colorectal cancer patient outcome...

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            Peroxisome Proliferator-Activated Receptor g2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility

              Sam Virtue, Kasparas Petkevicius, Jose Maria Moreno-Navarrete, Benjamin Jenkins, Daniel Hart, Martin Dale, Albert Koulman, Jose Manuel Fernandez-Real, and Antonio Vidal-Puig Cell Reports| Published August 21st, 2018 | DOI https://doi.org/10.1073/pnas.1721418115 One understudied function of white adipose tissue (AT) is its role...

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              FOXM1 contributes to treatment failure in acute myeloid leukemia

                Irum Khan, Marianna Halasi, Anand Patel, Rachael Schultz, Nandini Kalakota, Yi-Hua Chen, Nathan Aardsma, Li Liu, John D. Crispino, Nadim Mahmud, Olga Frankfurt, and Andrei L. Gartel JCI Insight | Published August 9th, 2018 | DOI https://doi.org/10.1172/jci.insight.121583 Acute myeloid leukemia (AML) patients...

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                Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity

                  Sandra Kleiner, Daniel Gomez, Bezawit Megra, Erqian Na, Ramandeep Bhavsar, Katie Cavino, Yurong Xin, Jose Rojas, Giselle Dominguez-Gutierrez, Brian Zambrowicz, Gaelle Carrat, Pauline Chabosseau, Ming Hu, Andrew J. Murphy, George D. Yancopoulos, Guy A. Rutter, and Jesper Gromada PNAS | Published July 23rd, 2018 | DOI https://doi.org/10.1073/pnas.1721418115 SLC30A8 encodes a zinc transporter that is primarily expressed in the pancreatic...

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                  Digital image analysis improves precision of PD‐L1 scoring in cutaneous melanoma

                    Viktor H. Koelzer, Aline Gisler, Jonathan C. Hanhart, Johannes Griss, Stephan N. Wagner, Niels Willi, Gieri Cathomas, Melanie Sachs, Werner Kempf, Daniela S. Thommen, Kirsten D. Mertz Nature Medicine | First published April 16th, 2018 | DOI https://doi.org/10.1111/his.13528 Abstract Aims Immune checkpoint...

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                    A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

                      Daniela S. Thommen, Viktor H. Koelzer, Petra Herzig, Andreas Roller, Marcel Trefny, Sarah Dimeloe, Anna Kiialainen, Jonathan Hanhart, Catherine Schill, Christoph Hess, Spasenija Savic Prince, Mark Wiese, Didier Lardinois, Ping-Chih Ho, Christian Klein, Vaios Karanikas, Kirsten D. Mertz, Ton N....

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                      The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung

                        Fangfang Gao, Nathan Griffin, Sam Faulkner, Christopher W. Rowe, Lily Williams, Severine Roselli, Rick F. Thorne, Aysha Ferdoushi, Phillip Jobling, Marjorie M. Walker & Hubert Hondermarck Scientific Reports | Published May 25th, 2018 | DOI https://doi.org/10.1038/s41598-018-26408-2 Abstract The neurotrophic tyrosine kinase...

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                        Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin-Growth Hormone Circuit

                          Heiko Löhr, Simon Hess, Mafalda M.A. Pereira, Philip Reinoß, Sandra Leibold, Christel Schenkel, Claudia M. Wunderlich, Peter Kloppenburg, Jens C. Brüning, Matthias Hammerschmidt5,'Correspondence information about the author Matthias Hammerschmidt Cell Reports , 2018 DOI: https://doi.org/10.1016/j.celrep.2018.04.018 Abstract Anorexigenic pro-opiomelanocortin (Pomc)/alpha-melanocyte stimulating hormone...

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                          T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma

                            Ingunn M. Stromnes, Ayaka Hulbert, Robert H. Pierce, Philip D. Greenberg and Sunil R. Hingorani Cancer Immunology Research , 2017 DOI: 10.1158/2326-6066.CIR-16-0322 Abstract Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to most therapies, including immune checkpoint blockade. To elucidate mechanisms of immunotherapy resistance, we assessed immune parameters in...

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                            PD-1 Blockade Induces Responses by Inhibiting Adaptive Immune Resistance

                              Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJ, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, West AN, Carmona M, Kivork C, Seja E, Cherry G, Gutierrez AJ, Grogan TR, Mateus C, Tomasic G, Glaspy JA, Emerson...

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                              The R-enantiomer of ketorolac delays mammary tumor development in mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) mice

                                Amanda S. Peretti, Dayna Dominguez, Martha M. Grimes, Helen J. Hathaway, Eric R. Prossnitz, Melanie R. Rivera, Angela Wandinger-Ness, Donna F. Kusewitt, & Laurie G. Hudson The American Journal of Pathology, 2017 https://doi.org/10.1016/j.ajpath.2017.10.018 Abstract Epidemiologic studies report improved breast cancer...

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                                High levels of tumor-associated neutrophils are associated with improved overall survival in patients with stage II colorectal cancer

                                  Ryan S. Berry, Meng-Jun Xiong, Alissa Greenbaum, Parisa Mortaji, Robert A. Nofchissey, Fred Schultz, Cathleen Martinez, Li Luo, Katherine T. Morris, & Joshua A. Hanson PLoS ONE, December 2017 https://doi.org/10.1371/journal.pone.0188799 Abstract Conflicting reports regarding whether high tumor-associated neutrophils (TAN) are...

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                                  Association of HIV Status With Local Immune Response to Anal Squamous Cell Carcinoma

                                    Elizabeth L. Yanik, Genevieve J. Kaunitz, Tricia R. Cottrell, Farah Succaria, Tracee L. McMiller, Maria L. Ascierto, Jessica Esandrio, Haiying Xu, Aleksandra Ogurtsova, Toby Cornish, Evan J. Lipson, Suzanne L. Topalian, Eric A. Engels, & Janis M. Taube JAMA Oncology,...

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                                    Cross-Platform Comparison of Computer-assisted Image Analysis Quantification of In Situ mRNA Hybridization in Investigative Pathology.

                                      Timothy R. Holzer, Jeffrey C. Hanson, Erin M. Wray, Jason A. Bailey, Kim R. Kennedy, Patrick R. Finnegan, Aejaz Nasir, & Kelly M. Credille Applied Immunohistochemistry &  Molecular Morphology, July 2017 doi: 10.1097/PAI.0000000000000542 Abstract Although availability of automated platforms has...

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                                      A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

                                        Donald M. O’Rourke, MacLean P. Nasrallah, Arati Desai, Jan J. Melenhorst, Keith Mansfield, Jennifer J. D. Morrissette, Maria Martinez-Lage, Steven Brem, Eileen Maloney, Angela Shen, Randi Isaacs, Suyash Mohan, Gabriela Plesa, Simon F. Lacey, Jean-Marc Navenot, Zhaohui Zheng, Bruce L....

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                                        Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice

                                          Amanda L. Posgai, Clive H. Wasserfall, Kwang-Chul Kwon, Henry Daniell, Desmond A. Schatz, & Mark A. Atkinson Scientific Reports, February 2017 doi:10.1038/srep42372 Abstract Autoantigen-specific immunological tolerance represents a central objective for prevention of type 1 diabetes (T1D). Previous studies demonstrated...

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                                          Molecular Pathways: Mucins and Drug Delivery in Cancer

                                            Chinthalapally V. Rao, Naveena B. Janakiram, and Altaf Mohammed Clinical Cancer Research, February 2017 DOI: 10.1158/1078-0432.CCR-16-0862 Abstract Over the past few decades, clinical and preclinical studies have clearly demonstrated the role of mucins in tumor development. It is well established...

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                                            Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice

                                              Haruka Okamotoa, Katie Cavinoa, Erqian Naa, Elizabeth Krumma, Sun Y. Kima, Xiping Chenga, Andrew J. Murphya, George D. Yancopoulosa, and Jesper Gromadaa PNAS January 23, 2017, doi:10.1073/pnas.1621069114 Abstract Inactivating mutations in the insulin receptor results in extreme insulin resistance. The resulting...

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                                              Angptl4 does not control hyperglucagonemia or α-cell hyperplasia following glucagon receptor inhibition

                                                Haruka Okamotoa, Katie Cavinoa, Erqian Naa, Elizabeth Krumma, Steven Kima, Panayiotis E. Stevisa, Joyce Harpa, Andrew J. Murphya, George D. Yancopoulosa, and Jesper Gromadaa PNAS January 31, 2017, doi:10.1073/pnas.1620989114  Abstract Genetic disruption or pharmacologic inhibition of glucagon signaling effectively lowers...

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                                                Neutrophils dominate the immune cell composition in non-small cell lung cancer

                                                  Julia Kargl, Stephanie E. Busch, Grace H. Y. Yang, Kyoung-Hee Kim, Mark L. Hanke, Heather E. Metz, Jesse J. Hubbard, Sylvia M. Lee, David K. Madtes, Martin W. McIntosh & A. McGarry Houghton Nature Communications 8, Article number: 14381, February 2017 Abstract...

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                                                  Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain

                                                    Michael V. Morabito, Yann Ravussin, Bridget R. Mueller, Alicja A. Skowronski, Kazuhisa Watanabe, Kylie S. Foo, Samuel X. Lee, Anders Lehmann, Stephan Hjorth, Lori M. Zeltser, Charles A. LeDuc, Rudolph L. Leibel PLOS One, January 20, 2017 Abstract Diet-induced obesity (DIO) resulting...

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                                                    Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

                                                      Vinay Bulusu, Sergey Tumanov, Evdokia Michalopoulou, Niels J. van den Broek, Gillian MacKay, Colin Nixon, Sandeep Dhayade, Zachary T. Schug, Johan Vande Voorde, Karen Blyth, Eyal Gottlieb, Alexei Vazquez, Jurre J. Kamphorst Cell Reports January 2017 Volume 18, Issue 3 ...

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                                                      Differential Cytokine Gene Expression in Granulomas from Lungs and Lymph Nodes of Cattle Experimentally Infected with Aerosolized Mycobacterium bovis

                                                        Mitchell V. Palmer , Tyler C. Thacker ,W. Ray Waters Abstract The hallmark lesion of tuberculosis in humans and animals is the granuloma. The granuloma represents a distinct host cellular immune response composed of epithelioid macrophages, lymphocytes, and multinucleated giant cells,...

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                                                        Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells

                                                          Yurong Xin, Jinrang Kim, Min Ni, Yi Wei, Haruka Okamoto, Joseph Lee, Christina Adler, Katie Cavino, Andrew J. Murphy, George D. Yancopoulos, Hsin Chieh Lin, and Jesper Gromada PNAS March 2016 vol. 113 no. 12 Abstract This study provides an assessment of the Fluidigm C1 platform for RNA sequencing of...

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                                                          Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells

                                                            Mengna Chi, Hamish Evans, Jackson Gilchrist, Jack Mayhew, Alexander Hoffman, Elizabeth Ann Pearsall, Helen Jankowski, Joshua Stephen Brzozowski & Kathryn Anne Skelding Scientific Reports | Published September 8th, 2016 | DOI: 10.1038/srep33132 Calcium/calmodulin-stimulated protein kinase II (CaMKII) is a multi-functional...

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                                                            Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors

                                                              Helena Escuin-Ordinas, Shuoran Li, Michael W. Xie, Lu Sun, Willy Hugo, Rong Rong Huang, Jiang Jiao, Felipe Meira de-Faria, Susan Realegeno, Paige Krystofinski, Ariel Azhdam, Sara Marie D. Komenan, Mohammad Atefi, Begona Comin-Aunduix, Matteo Pellegrini, Alistar J Cochran, Robert Modlin,...

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                                                              Exacerbated Experimental Colitis in TNFAIP8-Deficient Mice

                                                                Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen YH. J Immunol. 2015 Jun 15;194(12):5736-42. The TNF-α-induced protein 8 (TNFAIP8 or TIPE) is a risk factor for cancer and bacterial infection, and...

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                                                                Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer

                                                                  Pundavela J, Roselli S1, Faulkner S, Attia J, Scott RJ, Thorne RF, Forbes JF, Bradshaw RA, Walker MM, Jobling P, Hondermarck H. Mol Oncol. 2015 May 14. pii: S1574-7891(15)00115-5. Infiltration of the tumor microenvironment by nerve fibers is an understudied...

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                                                                  ANGPTL8/betatrophin does not control pancreatic beta cell expansion

                                                                    Gusarova V, Alexa CA, Na E, Stevis PE, Xin Y, Bonner-Weir S, Cohen JC, Hobbs HH, Murphy AJ, Yancopoulos GD, Gromada J. Cell. 2014 Oct 23;159(3):691-6. Recently, it was reported that angiopoietin-like protein 8 (ANGPTL8) was the long-sought "betatrophin" that...

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                                                                    Islet-1 is essential for pancreatic beta cell function

                                                                      Ediger BN, Du A, Liu J, Hunter CS, Walp ER, Schug J, Kaestner KH, Stein R, Stoffers DA, May CL. Diabetes. 2014 Dec;63(12):4206-17. Islet-1 (Isl-1) is essential for the survival and ensuing differentiation of pancreatic endocrine progenitors. Isl-1 remains expressed...

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                                                                      G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

                                                                        Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD. Nature. 2015 Apr 2;520(7545):94-8. The regulated release of anorexigenic α-melanocyte stimulating hormone (α-MSH) and orexigenic Agouti-related...

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                                                                        Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys

                                                                          Okamoto H, Kim J, Aglione J1, Lee J, Cavino K, Na E1, Rafique A, Kim JH, Harp J, Valenzuela DM, Yancopoulos GD, Murphy AJ, Gromada J. Endocrinology. 2015 Aug;156(8):2781-94. Antagonizing glucagon action represents an attractive therapeutic option for reducing hepatic...

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                                                                          The digital quantification of PD1T cells has strong potential to guide the treatment of lung cancer patients with PD-1 inhibitors... The HALO platform strongly facilitated the research and development of this novel predictive indicator for clinical translation

                                                                          - Dr. Viktor Koelzer, Pathologist and SNSF research fellow Institute of Cancer and Genomic Science, University of Birmingham

                                                                          As a CRO specifically offering detailed high precision histopathology IA services, we chose the HALO platform as it enables us to develop tailored image analysis algorithms and generate highly detailed and robust data in a timely manner to address key questions our Clients face when interpreting drug efficacy, safety or biomarker related responses from their histology studies.

                                                                          - John Waller, Phd, Chief Operations Officer, OracleBio Ltd

                                                                          In my opinion the “ease-of-use” with the Halo system is second to none particularly when I think of some of the issues we faced in the past. Even when compared with other current systems Halo is being recognised by major Pharma companies, that run other more expensive mainframe type analysis systems, for the “ease-of-use” aspect...

                                                                          - David Fairley, Managing Director, Histologix

                                                                          Top Notch Training & Support

                                                                          We’ve worked hard to ensure our HALO platform interfaces are the most intuitive in the industry, but we realize that you may still need extra support.  We’ve got you covered! 

                                                                          Unlimited IT support, scientific support & training are included with every license at no additional cost.  With support staff in the US, UK and Japan, you are supported in any time zone.  Need help tuning an algorithm or training for new staff – we are just a call away.   

                                                                          The vast majority of our new customers heard about Indica Labs from an existing customer.  The two primary reasons for referral – our user-friendly technology and excellent support.  We know that you have a choice in image analysis providers and we strive to make sure every customers is 100% satisfied.

                                                                          Top Notch Training & Support

                                                                          We’ve worked hard to ensure our HALO platform interfaces are the most intuitive in the industry, but we realize that you may still need extra support.  We’ve got you covered! 

                                                                          Unlimited IT support, scientific support & training are included with every license at no additional cost.  With support staff in the US, UK and Japan, you are supported in any time zone.  Need help tuning an algorithm or training for new staff – we are just a call away.   

                                                                          The vast majority of our new customers heard about Indica Labs from an existing customer.  The two primary reasons for referral – our user-friendly technology and excellent support.  We know that you have a choice in image analysis providers and we strive to make sure every customers is 100% satisfied.

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                                                                          You can also drop us an email at info@indicalab.com

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