Backed by cutting edge technology, an uncompromising focus on ease-of-use and dedicated customer service, Indica Labs’ software and services are being used to make vital discoveries in pathology labs and research organizations around the world.
IMAGE ANALYSIS PLATFORM
HALO is the gold standard image analysis platform for quantitative tissue analysis in digital pathology.
With unmatched ease-of-use and scalability, powerful analytic capabilities, and the fastest processing speeds available for digital pathology, pharmaceutical, healthcare and research organizations worldwide are using HALO for high-throughput, quantitative tissue analysis in oncology, neuroscience, metabolism, toxicology and more.
Watch a video of the HALO platform in action here.
IMAGE ANALYSIS PLATFORM
HALO is the gold standard image analysis platform for quantitative tissue analysis in digital pathology.
With unmatched ease-of-use and scalability, powerful analytic capabilities, and the fastest processing speeds available for digital pathology, pharmaceutical, healthcare and research organizations worldwide are using HALO for high-throughput, quantitative tissue analysis in oncology, neuroscience, metabolism, toxicology and more.
HALO modules simplify the analysis workflow so there is no need to ‘build’ algorithms from scratch. Modules make HALO easy-to-use and understand which means you can spend less time learning software and more time analyzing data.
HALO add-ons can be used in combination with any of the other analysis modules to improve the analysis workflow. These include tools to help automate tissue segmentation, such as tissue classifier, serial section analysis, and TMA, as well as tools to improve image processing speeds for high-throughput labs, such as analysis cluster.
HALO reports morphological and multiplexed expression data on a cell-by-cell basis across entire tissue sections and maintains an interactive link between cell data and cell image. Click on any cell in the image and immediately see analysis outputs for that specific cell. Sorting and filtering capabilities allow the user to mine millions of cells while visually assessing corresponding cell populations. For example, sort cells according to biomarker intensity and immediately locate cells with highest intensity in the image. Just imagine the endless possibilities.
HALO reports morphological and multiplexed expression data on a cell-by-cell basis across entire tissue sections and maintains an interactive link between cell data and cell image. Click on any cell in the image and immediately see analysis outputs for that specific cell. Sorting and filtering capabilities allow the user to mine millions of cells while visually assessing corresponding cell populations. For example, sort cells according to biomarker intensity and immediately locate cells with highest intensity in the image. Just imagine the endless possibilities.
HALO’s modular design and flexible licensing allow it to be adapted to any requirement and budget. Start with all the modules or just a few and add more modules as your needs change. Use HALO on a single workstation or ramp up to a server-based license for your entire group. Purchase a permanent license or renew annually.
Click on the links below to explore our most popular HALO modules & add-ons. Use the category filters or click the 'Load More' button at the bottom of the list to view additional options.
HALO is compatible with a broad spectrum of image and digital slide formats. Yours not on the list? Email us your requirements.
Non-proprietary (JPG, TIF)
Nikon (ND2)
3D Histech (MRXS)
Perkin Elmer (QPTIFF, component TIFF)
Olympus (VSI)
Hamamatsu (NDPI, NDPIS)
Aperio (SVS, AFI)
Zeiss (CZI)
Leica (SCN, LIF)
Ventana (BIF)
Follow the links below to explore a few of the most popular HALO applications.
We demonstrate how HALO can create a multispectral 7-plex whole slide image from individual field-of-view image tiles captured from the PerkinElmer Vectra 3 or Polaris platform and analyze these images using our highplex FL module and spatial analysis modules.
Using our multiplex IHC module, we quantify immune cells and tumor cell markers across whole slide images. The tissue classifier add-on is employed to segment tumor and stroma and the spatial analysis module is used for proximity and invasive margin analysis.
Using our ISH module for brightfield and our FISH module for fluorescence, we demonstrate how to quantify ISH signal from RNAScope® assays on a per cell or per unit area basis and output an overall expression score based on ACD Bio’s recommended scoring guidelines.
Our customers are making vital discoveries in oncology, neuroscience, and diabetes research. Check out some of the research our customers are publishing using the HALO Image Analysis Platform and Indica analysis modules.
Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD. Nature. 2015 Apr 2;520(7545):94-8. The regulated release of anorexigenic α-melanocyte stimulating hormone (α-MSH) and orexigenic Agouti-related...
Ediger BN, Du A, Liu J, Hunter CS, Walp ER, Schug J, Kaestner KH, Stein R, Stoffers DA, May CL. Diabetes. 2014 Dec;63(12):4206-17. Islet-1 (Isl-1) is essential for the survival and ensuing differentiation of pancreatic endocrine progenitors. Isl-1 remains expressed...
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Helena Escuin-Ordinas, Shuoran Li, Michael W. Xie, Lu Sun, Willy Hugo, Rong Rong Huang, Jiang Jiao, Felipe Meira de-Faria, Susan Realegeno, Paige Krystofinski, Ariel Azhdam, Sara Marie D. Komenan, Mohammad Atefi, Begona Comin-Aunduix, Matteo Pellegrini, Alistar J Cochran, Robert Modlin,...
Mengna Chi, Hamish Evans, Jackson Gilchrist, Jack Mayhew, Alexander Hoffman, Elizabeth Ann Pearsall, Helen Jankowski, Joshua Stephen Brzozowski & Kathryn Anne Skelding Scientific Reports | Published September 8th, 2016 | DOI: 10.1038/srep33132 Calcium/calmodulin-stimulated protein kinase II (CaMKII) is a multi-functional...
Yurong Xin, Jinrang Kim, Min Ni, Yi Wei, Haruka Okamoto, Joseph Lee, Christina Adler, Katie Cavino, Andrew J. Murphy, George D. Yancopoulos, Hsin Chieh Lin, and Jesper Gromada PNAS March 2016 vol. 113 no. 12 Abstract This study provides an assessment of the Fluidigm C1 platform for RNA sequencing of...
Mitchell V. Palmer , Tyler C. Thacker ,W. Ray Waters Abstract The hallmark lesion of tuberculosis in humans and animals is the granuloma. The granuloma represents a distinct host cellular immune response composed of epithelioid macrophages, lymphocytes, and multinucleated giant cells,...
Vinay Bulusu, Sergey Tumanov, Evdokia Michalopoulou, Niels J. van den Broek, Gillian MacKay, Colin Nixon, Sandeep Dhayade, Zachary T. Schug, Johan Vande Voorde, Karen Blyth, Eyal Gottlieb, Alexei Vazquez, Jurre J. Kamphorst Cell Reports January 2017 Volume 18, Issue 3 ...
Julia Kargl, Stephanie E. Busch, Grace H. Y. Yang, Kyoung-Hee Kim, Mark L. Hanke, Heather E. Metz, Jesse J. Hubbard, Sylvia M. Lee, David K. Madtes, Martin W. McIntosh & A. McGarry Houghton Nature Communications 8, Article number: 14381, February 2017 Abstract...
Haruka Okamotoa, Katie Cavinoa, Erqian Naa, Elizabeth Krumma, Steven Kima, Panayiotis E. Stevisa, Joyce Harpa, Andrew J. Murphya, George D. Yancopoulosa, and Jesper Gromadaa PNAS January 31, 2017, doi:10.1073/pnas.1620989114 Abstract Genetic disruption or pharmacologic inhibition of glucagon signaling effectively lowers...
Haruka Okamotoa, Katie Cavinoa, Erqian Naa, Elizabeth Krumma, Sun Y. Kima, Xiping Chenga, Andrew J. Murphya, George D. Yancopoulosa, and Jesper Gromadaa PNAS January 23, 2017, doi:10.1073/pnas.1621069114 Abstract Inactivating mutations in the insulin receptor results in extreme insulin resistance. The resulting...
Chinthalapally V. Rao, Naveena B. Janakiram, and Altaf Mohammed Clinical Cancer Research, February 2017 DOI: 10.1158/1078-0432.CCR-16-0862 Abstract Over the past few decades, clinical and preclinical studies have clearly demonstrated the role of mucins in tumor development. It is well established...
Okamoto H, Kim J, Aglione J1, Lee J, Cavino K, Na E1, Rafique A, Kim JH, Harp J, Valenzuela DM, Yancopoulos GD, Murphy AJ, Gromada J. Endocrinology. 2015 Aug;156(8):2781-94. Antagonizing glucagon action represents an attractive therapeutic option for reducing hepatic...
Pundavela J, Roselli S1, Faulkner S, Attia J, Scott RJ, Thorne RF, Forbes JF, Bradshaw RA, Walker MM, Jobling P, Hondermarck H. Mol Oncol. 2015 May 14. pii: S1574-7891(15)00115-5. Infiltration of the tumor microenvironment by nerve fibers is an understudied...
Michael V. Morabito, Yann Ravussin, Bridget R. Mueller, Alicja A. Skowronski, Kazuhisa Watanabe, Kylie S. Foo, Samuel X. Lee, Anders Lehmann, Stephan Hjorth, Lori M. Zeltser, Charles A. LeDuc, Rudolph L. Leibel PLOS One, January 20, 2017 Abstract Diet-induced obesity (DIO) resulting...
Amanda L. Posgai, Clive H. Wasserfall, Kwang-Chul Kwon, Henry Daniell, Desmond A. Schatz, & Mark A. Atkinson Scientific Reports, February 2017 doi:10.1038/srep42372 Abstract Autoantigen-specific immunological tolerance represents a central objective for prevention of type 1 diabetes (T1D). Previous studies demonstrated...
Donald M. O’Rourke, MacLean P. Nasrallah, Arati Desai, Jan J. Melenhorst, Keith Mansfield, Jennifer J. D. Morrissette, Maria Martinez-Lage, Steven Brem, Eileen Maloney, Angela Shen, Randi Isaacs, Suyash Mohan, Gabriela Plesa, Simon F. Lacey, Jean-Marc Navenot, Zhaohui Zheng, Bruce L....
Timothy R. Holzer, Jeffrey C. Hanson, Erin M. Wray, Jason A. Bailey, Kim R. Kennedy, Patrick R. Finnegan, Aejaz Nasir, & Kelly M. Credille Applied Immunohistochemistry & Molecular Morphology, July 2017 doi: 10.1097/PAI.0000000000000542 Abstract Although availability of automated platforms has...
Elizabeth L. Yanik, Genevieve J. Kaunitz, Tricia R. Cottrell, Farah Succaria, Tracee L. McMiller, Maria L. Ascierto, Jessica Esandrio, Haiying Xu, Aleksandra Ogurtsova, Toby Cornish, Evan J. Lipson, Suzanne L. Topalian, Eric A. Engels, & Janis M. Taube JAMA Oncology,...
Ryan S. Berry, Meng-Jun Xiong, Alissa Greenbaum, Parisa Mortaji, Robert A. Nofchissey, Fred Schultz, Cathleen Martinez, Li Luo, Katherine T. Morris, & Joshua A. Hanson PLoS ONE, December 2017 https://doi.org/10.1371/journal.pone.0188799 Abstract Conflicting reports regarding whether high tumor-associated neutrophils (TAN) are...
Amanda S. Peretti, Dayna Dominguez, Martha M. Grimes, Helen J. Hathaway, Eric R. Prossnitz, Melanie R. Rivera, Angela Wandinger-Ness, Donna F. Kusewitt, & Laurie G. Hudson The American Journal of Pathology, 2017 https://doi.org/10.1016/j.ajpath.2017.10.018 Abstract Epidemiologic studies report improved breast cancer...
Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJ, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, West AN, Carmona M, Kivork C, Seja E, Cherry G, Gutierrez AJ, Grogan TR, Mateus C, Tomasic G, Glaspy JA, Emerson...
Ingunn M. Stromnes, Ayaka Hulbert, Robert H. Pierce, Philip D. Greenberg and Sunil R. Hingorani Cancer Immunology Research , 2017 DOI: 10.1158/2326-6066.CIR-16-0322 Abstract Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to most therapies, including immune checkpoint blockade. To elucidate mechanisms of immunotherapy resistance, we assessed immune parameters in...
Heiko Löhr, Simon Hess, Mafalda M.A. Pereira, Philip Reinoß, Sandra Leibold, Christel Schenkel, Claudia M. Wunderlich, Peter Kloppenburg, Jens C. Brüning, Matthias Hammerschmidt5,'Correspondence information about the author Matthias Hammerschmidt Cell Reports , 2018 DOI: https://doi.org/10.1016/j.celrep.2018.04.018 Abstract Anorexigenic pro-opiomelanocortin (Pomc)/alpha-melanocyte stimulating hormone...
Fangfang Gao, Nathan Griffin, Sam Faulkner, Christopher W. Rowe, Lily Williams, Severine Roselli, Rick F. Thorne, Aysha Ferdoushi, Phillip Jobling, Marjorie M. Walker & Hubert Hondermarck Scientific Reports | Published May 25th, 2018 | DOI https://doi.org/10.1038/s41598-018-26408-2 Abstract The neurotrophic tyrosine kinase...
Daniela S. Thommen, Viktor H. Koelzer, Petra Herzig, Andreas Roller, Marcel Trefny, Sarah Dimeloe, Anna Kiialainen, Jonathan Hanhart, Catherine Schill, Christoph Hess, Spasenija Savic Prince, Mark Wiese, Didier Lardinois, Ping-Chih Ho, Christian Klein, Vaios Karanikas, Kirsten D. Mertz, Ton N....
Viktor H. Koelzer, Aline Gisler, Jonathan C. Hanhart, Johannes Griss, Stephan N. Wagner, Niels Willi, Gieri Cathomas, Melanie Sachs, Werner Kempf, Daniela S. Thommen, Kirsten D. Mertz Nature Medicine | First published April 16th, 2018 | DOI https://doi.org/10.1111/his.13528 Abstract Aims Immune checkpoint...
Sandra Kleiner, Daniel Gomez, Bezawit Megra, Erqian Na, Ramandeep Bhavsar, Katie Cavino, Yurong Xin, Jose Rojas, Giselle Dominguez-Gutierrez, Brian Zambrowicz, Gaelle Carrat, Pauline Chabosseau, Ming Hu, Andrew J. Murphy, George D. Yancopoulos, Guy A. Rutter, and Jesper Gromada PNAS | Published July 23rd, 2018 | DOI https://doi.org/10.1073/pnas.1721418115 SLC30A8 encodes a zinc transporter that is primarily expressed in the pancreatic...
Irum Khan, Marianna Halasi, Anand Patel, Rachael Schultz, Nandini Kalakota, Yi-Hua Chen, Nathan Aardsma, Li Liu, John D. Crispino, Nadim Mahmud, Olga Frankfurt, and Andrei L. Gartel JCI Insight | Published August 9th, 2018 | DOI https://doi.org/10.1172/jci.insight.121583 Acute myeloid leukemia (AML) patients...
Sam Virtue, Kasparas Petkevicius, Jose Maria Moreno-Navarrete, Benjamin Jenkins, Daniel Hart, Martin Dale, Albert Koulman, Jose Manuel Fernandez-Real, and Antonio Vidal-Puig Cell Reports| Published August 21st, 2018 | DOI https://doi.org/10.1073/pnas.1721418115 One understudied function of white adipose tissue (AT) is its role...
Ines P. Nearchou, Kate Lillard, Christos G. Gavriel, Hideki Ueno, David J. Harrison, and Peter D. Caie Cancer Immunology Research| Published March 7, 2019 | DOI 10.1158/2326-6066.CIR-18-0377 Both immune profiling and tumor budding significantly correlate with colorectal cancer patient outcome...
Martin, D.R., Hanson, J.A., Gullapalli, R.R., Schultz, F.A., Sethi, A. and Clark, D.P. Archives of Pathology & Laboratory Medicine In-Press | Published April 5, 2019 | DOI: 10.5858/arpa.2019-0004-OA Context.— Most deep learning (DL) studies have focused on neoplastic pathology, with...
Hoa Hoang Ngoc Pham, Mitsuru Futakuchi, Andrey Bychkov, Tomoi Furukawa, Kishio Kuroda, Junya Fukuoka The American Journal of Pathology | Volume 189, Issue 12, December 2019 | DOI: 10.5858/arpa.2019-0004-OA The application of deep learning for the detection of lymph node metastases...
We’ve worked hard to ensure our HALO platform interfaces are the most intuitive in the industry, but we realize that you may still need extra support. We’ve got you covered!
Unlimited IT support, scientific support & training are included with every license at no additional cost. With support staff in the US, UK and Japan, you are supported in any time zone. Need help tuning an algorithm or training for new staff – we are just a call away.
The vast majority of our new customers heard about Indica Labs from an existing customer. The two primary reasons for referral – our user-friendly technology and excellent support. We know that you have a choice in image analysis providers and we strive to make sure every customers is 100% satisfied.
We’ve worked hard to ensure our HALO platform interfaces are the most intuitive in the industry, but we realize that you may still need extra support. We’ve got you covered!
Unlimited IT support, scientific support & training are included with every license at no additional cost. With support staff in the US, UK and Japan, you are supported in any time zone. Need help tuning an algorithm or training for new staff – we are just a call away.
The vast majority of our new customers heard about Indica Labs from an existing customer. The two primary reasons for referral – our user-friendly technology and excellent support. We know that you have a choice in image analysis providers and we strive to make sure every customers is 100% satisfied.
Fill out the form below to request a recorded or live demo of HALO or any of our other products or services.
You can also drop us an email at info@indicalab.com
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