ACE2 and SARS-CoV-2 Expression in the Normal and COVID-19 Pancreas
Kusmartseva, I., Wu, W., Syed, F. et al. ACE2 and SARS-CoV-2 Expression in the Normal and COVID-19 Pancreas. This article is a preprint and has
Spotlight on Covid-19 Research Publications
Identification of immune checkpoints in COVID-19
Researchers aiming to block excessive lung inflammation in COVID-19 patients found upregulated immune checkpoint biomarkers in patients with a range of COVID-19 symptoms (from paucisymptomatic to acute respiratory distress syndrome). In addition, Carvelli et al found increased expression of C5a, an inflammatory mediator, in serum and the C5aR1 receptor on myeloid cells in COVID-19 patients, which are known to initiate inflammatory responses by recruiting naeutrophils and monocytes to lungs. An In vitro neutrophil migration assay quantified with the CytoNuclear FL Module of HALO software demonstrated that the clinical stage therapeutic monoclonal antibody, avdoralimab, effectively inhibited C5a-induced neutrophil migration. The authors propose use of avdoralimab to limit excessive lung inflammation associated with acute respiratory distress in COVID-19 patients.
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
Hoang, T.N., Pino, M., Boddapati, A.K. et al.. Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques. This article is a
ARDS and Cytokine Storm in SARS-CoV-2 Infected Caribbean Vervets
Blair, R.V., Vaccari, M., Doyle-Meyers, L.A.. et al. ARDS and Cytokine Storm in SARS-CoV-2 Infected Caribbean Vervets. This article is a preprint and has not
Acute Respiratory Distress and Cytokine Storm in Aged, SARS-CoV-2 Infected African Green Monkeys, but not in Rhesus Macaques
Blair, R.V., Vaccari, M., Doyle-Meyers, L.A.. et al. Acute Respiratory Distress and Cytokine Storm in Aged, SARS-CoV-2 Infected African Green Monkeys, but not in Rhesus Macaques. This article is a preprint and has not been certified by peer review. doi: https://doi.org/10.1101/2020.06.18.157933. SARS-CoV-2 induces a wide range of disease severity ranging from asymptomatic infection, to a life-threating illness, particularly in the elderly and persons with comorbid conditions. Among those persons with serious COVID-19 disease, acute respiratory distress syndrome (ARDS) is a common and often fatal presentation. Animal models of SARS-CoV-2 infection that manifest severe disease are needed to investigate the pathogenesis of COVID-19 induced ARDS and evaluate therapeutic strategies.
Neuropathology and Virus in Brain of SARS-CoV-2 Infected Non-Human Primates
Rutkai, I., Mayer, M.G., Hellmers, L.M., et al. Neuropathology and Virus in Brain of SARS-CoV-2 Infected Non-Human Primates. This article is a preprint and has
Lung Expression of Human ACE2 Sensitizes the Mouse to SARS-CoV-2 Infection
Han, K., Blair, R.V., Iwanaga ,N., et al. Lung Expression of Human ACE2 Sensitizes the Mouse to SARS-CoV-2 Infection. Am J Respir Cell Mol Biol.
Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates
Fahlberg, M.D., Blair, R.V., Doyle-Meyers, L.A. et al. Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates. This article is a
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 infection in the lung epithelium
Bryce A. Schuler, A. Christian Habermann, Erin J. Plosa, Chase J. Taylor, Christopher Jetter, Meghan E. Kapp, John T. Benjamin, Peter Gulleman, David S. Nichols,