Indica
Backed by cutting edge technology, an uncompromising focus on ease-of-use and dedicated customer service, Indica Labs’ software and services are being used to make vital discoveries in pathology labs and research organizations around the world.
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Muscle Fiber FL Quantification

MUSCLE FIBER FL

 

Product Overview

The Muscle Fiber FL module detects fluorescently-stained muscle fibers and reports the total count as well as the perimeter, area, and diameter of each fiber. The module also detects nuclei (and nuclear position with respect to the fiber) and reports fiber membrane dye intensity and co-localization (where applicable).

Since muscle fiber cross-sections are irregularly shaped, the algorithm uses patent pending image processing techniques to detect each fiber’s minimum diameter and maximum diameter. Finally the module reports the diameter (average/minimum/maximum), the average perimeter length, and the average fiber area for all fibers in the entire section.

As shown in the example image above, the module detects positivity of fibers for each selected channel within the fiber compartment and/or fiber membrane. Additionally, the algorithm provides the option to detect and count nuclei, and identify fibers with centrally located nuclei. A notable increase or decrease in fibers with centrally located nuclei can be indicative of certain myopathic findings.

The Muscle Fiber module integrates seamlessly into the HALO™ platform which is compatible with a number of third party systems and  file formats.

Contact info@indicalab.com for product demonstration and pricing information or upload some images for a free trial.

MUSCLE FIBER FL

The Muscle Fiber FL module detects fluorescently-stained muscle fibers and reports the total count as well as the perimeter, area, and diameter of each fiber. The module also detects nuclei (and nuclear position with respect to the fiber) and reports fiber membrane dye intensity and co-localization (where applicable).

Since muscle fiber cross-sections are irregularly shaped, the algorithm uses patent pending image processing techniques to detect each fiber’s minimum diameter and maximum diameter. Finally the module reports the diameter (average/minimum/maximum), the average perimeter length, and the average fiber area for all fibers in the entire section.

As shown in the example image above, the module detects positivity of fibers for each selected channel within the fiber compartment and/or fiber membrane. Additionally, the algorithm provides the option to detect and count nuclei, and identify fibers with centrally located nuclei. A notable increase or decrease in fibers with centrally located nuclei can be indicative of certain myopathic findings.

HALO is compatible with a broad spectrum of image and digital slide formats.  Yours not on the list? Email us your requirements.

Non-proprietary (JPG, TIF)
Nikon (ND2)
3D Histech (MRXS)
Perkin Elmer (QPTIFF, component TIFF)
Olympus (VSI)
Hamamatsu (NDPI, NDPIS)
Aperio (SVS, AFI)
Zeiss (CZI)
Leica (SCN, LIF)
Philips (Requires Philips IMS)

Use the form below to upload up to three images for us to analyze using HALO.  If the form does not display, please click here.