Before Markup

HALO® Module

Highplex FL

Indica Labs’ Highplex FL module allows for simultaneous analysis of an unlimited number of fluorescent markers in any cellular compartment – nucleus, cytoplasm, and/or membrane.  With the option to define specific cell phenotypes according to marker positivity, this module is ideally suited for applications in immuno-oncology where multiple markers are required to characterize distinct immune and tumor cell populations within the tissue.  It can be used in conjunction with most fluorescent whole-slide image formats, multispectral floating-point tiff images and whole-slide qptiff images from the Akoya PhenoImager (Phenoptics), PhenoCycler (CODEX®), Vectra® 3, and Polaris™ platforms, as well as imagery obtained using novel highplexing and ultra-highplexing technologies from Lunaphore (OME.TIFF images from the COMET™ Platform), Ultivue (FixVUE™, FlexVUE™, U-Vue® Panels and InSituPlex® Technology), Standard BioTools (Hyperion™ Imaging System) and IONpath (MIBI™ Platform).

File formats supported by the HALO image analysis platform:

  • Non-proprietary (JPG, TIF, OME.TIFF)
  • Nikon (ND2)
  • 3D Histech (MRXS)
  • Akoya (QPTIFF, component TIFF)
  • Olympus / Evident (VSI)
  • Hamamatsu (NDPI, NDPIS)
  • Aperio (SVS, AFI)
  • Zeiss (CZI)
  • Leica (SCN, LIF)
  • Ventana (BIF)
  • Philips (iSyntax, i2Syntax)
  • KFBIO (KFB, KFBF)
  • DICOM (DCM*)
    *whole-slide images

Spatial Characterization of the TME with Cell DIVE Multiplexed Imaging and HALO Image Analysis

Check out our collaborative poster with Cell Signaling Technology and Leica Microsystems to learn about a combined workflow for spatial analysis of the TME.

Clustering Workflow for Advanced Cell Phenotyping of Hyperplex IF Images

Download our collaborative poster with Lunaphore to learn about a clustering workflow that uses unsupervised learning for COMET™ images.

Characterizing the TME using IMC and HALO® Image Analysis

See in this app note how automated analysis of highly multiplexed IMC images using HALO and HALO AI yields rich cellular and spatial data from a streamlined workflow.

Lunaphore COMET Hyperplex IF and HALO® Image Analysis of the TME

Download our collaborative poster with Lunaphore to see how HALO and HALO AI, alongside the Lunaphore COMET instrument, enable a high throughput workflow for phenotypic and spatial analysis of cells in the tumor microenvironment.

Fusion of Spectrally Unmixed Image Tiles into Whole Slide TIFs and HALO Image Analysis

In this application note, we describe how HALO can convert spectrally unmixed image tiles into whole slide images for analysis of the tumor microenvironment.

Characterizing the TME using IMC and HALO® Image Analysis

See in this app note how automated analysis of highly multiplexed IMC images using HALO and HALO AI yields rich cellular and spatial data from a streamlined workflow.

Lunaphore COMET Hyperplex IF and HALO® Image Analysis eBook

Our collaborative eBook with Lunaphore shows how HALO and HALO AI, alongside the Lunaphore COMET instrument, enable a high-throughput workflow for phenotypic and spatial analysis of cells in the tumor microenvironment.

Qualitative and Quantitative Evaluation of the TME eBook

Check out this eBook to see how AI-based nuclear segmentation and tissue classification can streamline cell phenotyping across tissue compartments and samples.

Sequential Same Slide mIF and H&E eBook

Reveal more data on a single slide with this workflow for sequential same slide multiplex IF and H&E staining and imaging using HALO and HALO AI.

mIF Co-Registration and Cellular Analysis eBook

Learn how HALO offers a streamlined workflow for co-registration and cellular analysis of immunofluorescence images from cyclically stained and imaged slides.

Publication Spotlight

The table below includes publications that cite the Highplex FL module. 

Your publication not on the list?  Drop us an email to let us know about it!

Title Authors Year Journal Application HALO Modules Product
Cannabinoid control of gingival immune activation in chronically SIV-infected rhesus macaques involves modulation of the indoleamine-2,3-dioxygenase-1 pathway and salivary microbiome McDew-White M, Lee E, Alvarez X, Sestak K, Ling B, Byrareddy S, Okeoma C, Mohan M 2022 EBioMedicine Infectious Disease Area Quantification, Cytonuclear, Highplex FL HALO
ACE2-IgG1 fusions with improved in vitro and in vivo activity against SARS-CoV-2 Iwanaga N, Cooper L, Rong L, Maness N, Beddingfield B, Qin Z, Crabtree J, Tripp R, Yang H, Blair R, Jangra S, Garcia-Sastre A, Schotsaert M, Chandra S, Robinson J, Srivastava A, Rabito F, Qin X, Kolls J 2022 iScience Infectious Disease Highplex FL HALO AI
Tumor MHC Class I Expression Associates with Intralesional Interleukin-2 Response in Melanoma Pourmaleki M, Jones C, Ariyan C, Zeng Z, Pirun M, Navarrete D, Li Y, Zhang M, Nandakumar S, Campos C, Nadeem S, Klimstra D, Temple-Oberle C, Brenn T, Kipson E, Schenk K, Stein J, Taube J, White M, Traweek R, Wargo J, Kirkwood J, Gasmi B, Goff S, Corwin A, McDonough E, Ginty F, Callahan M, Schietinger A, Socci N, Mellinghoff I, Hollmann T 2022 Cancer Research Immunology Immuno-oncology Highplex FL HALO
Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression Cheung P, Yang J, Fang R, Borgers A, Krengel K, Stoffel A, Althoff K, Yip C, Siu E, Ng L, Lang K, Cham L, Engel D, Soun C, Cima I, Scheffler B, Striefler J, Sinn M, Bahra M, Pelzer U, Oettle H, Markus P, Smeets E, Aarntzen E, Savvatakis K, Liffers S, Lueong S, Neander C, Bazarna A, Zhang X, Paschen A, Crawford H, Chan A, Cheung S, Siveke J 2022 Nature Communications Oncology Cytonuclear, Spatial Analysis, Highplex FL HALO
Tumor cell-derived exosomes deliver TIE2 protein to macrophages to promote angiogenesis in cervical cancer Du S, Qian J, Tan S, Li W, Liu P, Zhao J, Zeng Y, Xu L, Wang Z, Cai J 2022 Cancer Letters Oncology Area Quantification, Cytonuclear, Spatial Analysis, Highplex FL HALO
Understanding the impact of chemotherapy on the immune landscape of high-grade serous ovarian cancer Vanguri R, Benhamida J, Young J, Li Y, Zivanovic O, Chi D, Snyder A, Hollmann T, Mager K 2022 Gynecologic Oncology Reports Oncology Classifier, Cytonuclear, Highplex FL HALO
New Fully Automated Preparation of High Apparent Molar Activity 68Ga-FAPI-46 on a Trasis AiO Platform Da Pieve C, Braga M, Turton D, Valla F, Cakmak P, Plate K, Kramer-Marek G 2022 Molecules Other Cytonuclear, Highplex FL HALO
Retrospective analysis of the efficacy of adjuvant cytokine-induced killer cell immunotherapy combined with chemotherapy in colorectal cancer patients after surgery Li X, Zhou H, Huang W, Wang X, Meng M, Hou Z, Liao L, Tang W, Xie Y, Wang R, Yu H, Wang L, Zhu H, Wang W, Tan J, Li R 2022 Clinical & Translational Immunology Oncology Cytonuclear, Highplex FL HALO
Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDAC Baer J, Zuo C, Kang L, Alarcon de la Lastra A, Bocherding N, Knolhoff B, Bogner S, Zhu Y, Lewis M, Zhang N, Kim K, Fields R, Mills J, Ding L, Randolph G, DeNardo D 2022 bioRxiv Fibrosis Classifier, Area Quantification, Cytonuclear, Multiplex IHC, Highplex FL, Figure Maker HALO
Genomic and single-cell landscape reveals novel drivers and therapeutic vulnerabilities of transformed cutaneous T-cell lymphoma Song X, Chang S, Seminario-Vidal L, de Mingo Pulido A, Tordesillas L, Song X, Reed R, Harkins A, Whiddon S, Nguyen J, Segura C, Zhang C, Yoder S, Sayegh Z, Zhao Y, Messina J, Harro C, Zhang X, Conejo-Garcia J, Berglund A, Sokol L, Zhang J, Rodriguez P, Mule J, Futreal A, Tsai K, Chen P 2022 Cancer Discovery Oncology Cytonuclear, Highplex FL, TMA HALO
Tumor immune cell clustering and its association with survival in African American women with ovarian cancer Wilson C, Soupir A, Thapa R, Creed J, Nguyen J, Segura C, Gerke T, Schildkraut J, Peres L, Fridley B 2022 PLOS Computational Biology Cytonuclear, Highplex FL HALO
Immunologic Gene Signature Analysis Correlates Myeloid Cells and M2 Macrophages with Time to Trabectedin Failure in Sarcoma Patients Schroder B, Zhang Y, Smythe K, Desai P, Thomas A, Viveiros P, Alexiev B, Obeidin F, Chen E, Cranmer L, Wagner M, Jones R, Campbell J, Pierce R, He Q, Pollack S 2022 Cancers Oncology Cytonuclear, Highplex FL HALO
Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression Carossino M, Kenney D, O'Connell A, Montarnaro P, Tseng A, Gertje H, Grosz K, Ericsson M, Huber B, Kurnick S, Subramaniam S, Kirkland T, Walker J, Francis K, Klose A, Paragas N, Bosmann M, Saeed M, Balasuriya U, Douam F, Crossland N 2022 Viruses Infectious Disease Classifier, Area Quantification, Highplex FL HALO
Multi-modal molecular imaging maps the correlation between tumor microenvironments and nanomedicine distribution Strittmatter N, Moss J, Race A, Sutton D, Canales J, Ling S, Wong E, Wilson J, Smith A, Howes C, Bunch J, Barry S, Goodwin R, Ashford M 2022 Theranostics Immuno-oncology Highplex FL HALO, HALO AI
An anti-PD-1ñGITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy Chan S, Belmar N, Ho S, Rogers B, Stickler M, Graham M, Lee E, Tran N, Zhang D, Gupta P, Sho M, MacDonough T, Woolley A, Kim H, Zhang H, Liu W, Zheng P, Dezso Z, Halliwill K, Ceccarelli M, Rhodes S, Thakur A, Forsyth C, Xiong M, Tan S, Iyer R, Lake M, Digiammarino E, Zhou L, Bigelow L, Longenecker K, Judge R, Liu C, Trumble M, Remis J, Fox M, Cairns B, Akamatsu Y, Hollenbaugh D, Farding F, Alvarez H 2022 Nature Cancer Immuno-oncology Area Quantification, Cytonuclear, Highplex FL HALO
ZEB1 transcription factor promotes immune escape in melanoma Plaschka M, Benboubker V, Grimont M, Berthet J, Tonon L, Lopez J, Le-Bouar M, Balme B, Tondeau G, de la Fouchardiere A, Larue L, Puisieux A, Grinberg-Bleyer Y, Bendriss-Vermare N, Dubois B, Caux C, Dalle S, Caramel J 2022 Journal for ImmunoTherapy of Cancer Immuno-oncology Cytonuclear, Multiplex IHC, Highplex FL HALO
Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion Veprik A, Denwood G, Liu D, Bakar R, Morfin V, McHugh K, Tebeka N, Vetterli L, Yonova-Doing E, Gribble F, Reimann F, Hoehn K, Hemsley P, Ahnfelt-Ronne J, Rorsman P, Zhang Q, Wet H, Cantley J 2022 Communications Biology Metabolism Cytonuclear, Highplex FL HALO
Extracellular matrix proteins regulate NK cell function in peripheral tissues Bunting M, Vyas M, Requesens M, Langenbucher A, Schiferle E, Manguso R, Lawrence M, Demehri S 2022 Science Advances Dermatology Cytonuclear, Highplex FL HALO
Multiplex Immunohistochemical Phenotyping of T Cells in Primary Prostate Cancer Ozbek B, Ertunc O, Erickson A, Vidal I, Gomes-Alexandre C, Guner G, Hicks J, Jones T, Taube J, Sfanos K, Yegnasubramanian S, DeMarzo A 2022 The Prostate Immuno-oncology Classifier, Cytonuclear, Highplex FL, Serial Section, Registration, Figure Maker, TMA HALO
Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19 Paul T, Ledderose S, Bartsch H, Sun N, Soliman S, Markl B, Ruf V, Herms J, Stern M, Keppler O, Delbridge C, Muller S, Piontek G, Kimoto Y, Schreiber F, Williams T, Neumann J, Knosel T, Schulz H, Spallek R, Graw M, Kirchner T, Walch A, Rudelius M 2022 Nature Communications Infectious Disease Cytonuclear, Highplex FL HALO
Spatially mapping the immune landscape of melanoma using imaging mass cytometry Moldoveanu D, Ramsay L, Lajoie M, Anderson-Trocme L, Lingrand M, Berry D, Perus L, Wei Y, Moraes C, Alkallas R, Rajkumar S, Zuo D, Dankner M, Xu E, Bertos N, Najafabadi H, Gravel S, Costantino S, Richer M, Lund A, Del Rincon S, Spatz A, Miller W, Jamal R, Lapointe R, Mes-Masson A, Turcotte S, Petrecca K, Dumitra S, Meguerditchian A, Richardson K, Tremblay F, Wang B, Chergui M, Guiot M, Watters K, Stagg J, Quail D, Mihalcioiu C, Meterissian S, Watson I 2022 Science Immunology Oncology Highplex FL HALO
Improved cognitive impairments by silencing DMP1 via enhancing the proliferation of neural progenitor cell in Alzheimer-like mice Zhao H, Wei J, Du Y, Chen P, Liu X, Liu H 2022 Aging Cell Neuroscience Cytonuclear, Highplex FL HALO
Peritumoral TIGIT+CD20+†B cell infiltration indicates poor prognosis but favorable adjuvant chemotherapeutic response in gastric cancer Liu H, Wu J, Xu X, Wang H, Zhang C, Yin S, He Y 2022 International Immunopharmacology Oncology Cytonuclear, Spatial Analysis, Highplex FL HALO
Subpopulations of cancer-associated fibroblasts link the prognosis and metabolic features of pancreatic ductal adenocarcinoma Hu B, Wu C, Mao H, Gu H, Dong H, Yan J, Qi Z, Yuan L, Dong Q, Long J 2022 Annals of Translational Medicine Oncology Cytonuclear, Highplex FL HALO
Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection Kenney D, O'Connell A, Turcinovic J, Montanaro P, Hekman R, Tamura T, Berneshawi A, Cafiero T, Abdullatif S, Blum B, Goldstein S, Heller B, Gertje H, Bullitt E, Trachtenberg A, Chavez E, Nono E, Morrison C, Tseng A, Sheikh A, Kurnick S, Grosz K, Bosmann M, Ericsson M, Huber B, Saeed M, Balazs A, Francis K, Klose A, Paragas N, Campbell J, Connor J, Emili A, Crossland N, Ploss A, Douam F 2022 Cell Reports Infectious Disease Area Quantification, Highplex FL HALO
SPOP promotes cervical cancer progress by inducing PD-1 move away from PD-L1 in spatial localization Wu J, Wu Y, Guo Q, Chen S, Wang S, Zhu J, Wu X, Ju X 2022 Research Square Oncology Cytonuclear, Spatial Analysis, Highplex FL, TMA HALO
Pilot Trial of Arginine Deprivation Plus Nivolumab and Ipilimumab in Patients with Metastatic Uveal Melanoma Kraehenbuehl L, Holland A, Armstrong E, O'Shea S, Mangarin L, Chekalil S, Johnston A, Bomalaski J, Erinjeri J, Barker C, Francis J, Wolchok J, Merghoub T, Shoushtari A 2022 Cancers Oncology Cytonuclear, Highplex FL HALO
Nitric oxide favours tumour-promoting inflammation through mitochondria-dependent and -independent actions on macrophages Drehmer D, Luiz J, Hernandez C, Alves-Filho J, Hussell T, Townsend P, Moncada S 2022 Redox Biology Oncology Highplex FL HALO
CD4+†T helper 2 cells suppress breast cancer by inducing terminal differentiation Boieri M, Malishkevich A, Guennoun R, Marchese E, Kroon S, Trerice K, Awad M, Park J, Iyer S, Kreuzer J, Haas W, Rivera M, Demehri S 2022 Journal of Experimental Medicine Immuno-oncology Cytonuclear, Highplex FL HALO
Higher proportions of CD39+ tumorresident cytotoxic T cells predict recurrence-free survival in patients with stage III melanoma treated with adjuvant immunotherapy Attrill G, Owen C, Ahmed T, Vergara I, Colebatch A, Conway J, Nahar K, Thompson J, da Silva I, Carlino M, Menzies A, Lo S, Palendira U, Scolyer R, Long G, Wilmott J 2022 Journal of Immuno Therapy of Cancer Immuno-oncology Cytonuclear, Spatial Analysis, Highplex FL HALO
Baseline and post-treatment biomarkers of resistance to anti-PD-1 therapy in acral and mucosal melanoma: an observational study Shui I, Liu X, Zhao Q, Kim S, Sun Y, Yearley J, Choudhury T, Webber A, Krepler C, Cristescu R, Lee J 2022 Journal for ImmunoTherapy of Cancer Immuno-oncology Cytonuclear, Highplex FL HALO
Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species Fears A, Beddingfield B, Chirichella N, Slisarenko N, Kileen S, Redmann R, Goff K, Spencer S, Picou B, Golden N, Midkiff C, Bush D, Branco L, Boisen M, Gao H, Montefiori D, Blair R, Doyle-Meyers L, Russel-Lodrigue K, Maness N, Roy C 2022 PLOS Pathogens Infectious Disease Highplex FL HALO
gp96 Expression in Gliomas and Its Association with Tumor Malignancy and T Cell Infiltrating Level Li C, Wang Y, Long L, Zhang P, Zhang Y, Ji N 2022 Hindawi Journal of Oncology Immuno-oncology Spatial Analysis, Highplex FL, Figure Maker HALO
Multiplexed immunofluorescence analysis of CAFmarkers, EZH2 and FOXM1 in Gastric Tissue: Associations with Clinicopathological Parameters and Clinical Outcomes Sun H, Wang X, Wang X, Tan C, Weng W, Zhang M, Ni S, Wang L, Huang D, Sheng W, Xu M 2022 Research Square Oncology Cytonuclear, Highplex FL HALO
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix Kay E, Paterson K, Riero-Domingo C, Sumpton D, Dabritz J, Tardito S, Boldrini C, Hernandez-Fernaud J, Athineos D, Dhayade S, Stepanova E, Gjerga E, Neilson L, Lilla S, Hedley A, Koulouras G, McGregor G, Jamieson C, Johnson R, Park M, Kirschner K, Miller C, Kamphorst J, Loayza-Puch F, Saez-Rodriguez J, Mazzone M, Blyth K, Zagnoni M, Zanivan S 2022 Nature Metabolism Oncology, Metabolism Cytonuclear, Multiplex IHC, Highplex FL HALO
Integrated single-cell analyses decode the developmental landscape of the human fetal spine Yu H, Tang D, Wu H, Li C, Lu Y, He F, Zhang X, Yang Y, Shi W, Hu W, Zeng Z, Dai W, Ou M, Dai Y 2022 iScience Other Highplex FL HALO
Establishing a multiplex imaging panel to study T cell development in the thymus in mouse Allam A, Russell S 2022 STAR Protocols Immunology Highplex FL HALO
Developing T cells form an immunological synapse for passage through the ?-selection checkpoint Allam A, Charnley M, Pham K, Russel S 2022 Journal of Cell Biology Immunology Highplex FL HALO
Endothelial cell death after ionizing radiation does not impair vascular structure in mouse tumor models Kaeppler J, Chen J, Buono M, Vermeer J, Kannan P, Cheng W, Voukantsis D, Thompson J, Hill M, Allen D, Gomes A, Kersemans V, Kinchesh P, Smart S, Buffa F, Nerlov C, Muschel R, Markelc B 2022 EMBO Reports Oncology Spatial Analysis, Highplex FL HALO
Non-canonical EphA2 activation underpins PTEN-mediated metastatic migration and poor clinical outcome in prostate cancer Sachdeva A, Hart C, Kim K, Tawadros T, Oliveira P, Shanks J, Brown M, Clarke N 2022 British Journal of Cancer Oncology Highplex FL HALO
Approaches to spatially resolving the tumour immune microenvironment of hepatocellular carcinoma Marsh-Wakefield F, Ferguson A, Liu K, Santhakumar C, McCaughan G, Palendira U 2022 Therapeutic Advances in Medical Oncology Review Multiplex IHC, Spatial Analysis, Highplex FL HALO
Tau Pathology in Chronic Traumatic Encephalopathy is Primarily Neuronal Butler M, Dixon E, Stein T, Alvarez V, Huber B, Buckland M, McKee A, Cherry J 2022 Journal of Neuropathology & Experimental Neurology Neuroscience Multiplex IHC, Spatial Analysis, Highplex FL HALO, HALO AI
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia Vasquez E, Nasreddin N, Valbuena G, Mulholland E, Belnoue-Davis H, Eggington H, Schenck R, Wouters V, Wirapati P, Gilroy K, Lannagan R, Flanagan D, Nujumudeen A, Omwenga S, McCorry A, Easton A, Koelzer V, East J, Morton D, Trusolino L, Maughan T, Campbell A, Loughrey M, Dunne P, Tsantoulis P, Juels D, Tejpar S, Sansom O, Leedham S 2022 Cell Stem Cell Oncology Highplex FL, Registration HALO
Knockdown of ZBTB11 impedes R-loop elimination and increases the sensitivity to cisplatin by inhibiting DDX1 transcription in bladder cancer Chen L, Liu Z, Tang H, Zhou Z, Chen J, Ma Z, Deng M, Li X, Wu Y, Zheng L, Zhou L, Zheng X, Liu Z 2022 Cell Proliferation Oncology Multiplex IHC, Highplex FL, Figure Maker HALO
LncRNA scaRNA2 bridges DNA end-resection to homologous recombination repair mediated chemoradioresistance Yang Y, Chen Y, Shen H, Liu T, Cao K, Wan Z, Du Z, Wang H, Yu Y, Ma S, Li B, Zhang W, Cai J, Gao F 2022 Research Square Oncology Highplex FL, TMA HALO
Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers Xu Y, Wei Z, Feng M, Zhu D, Mei S, Wu Z, Feng Q, Chang W, Ji M, Liu C, Zhu Y, Shen L, Yang F, Chen Y, Feng Y, Xu J, Zhu D 2022 Cell Reports Oncology, Immuno-oncology Multiplex IHC, Highplex FL HALO
Transcriptional and functional analyses of neoantigen-specific CD4 T cells during a profound response to anti-PD-L1 in metastatic Merkel cell carcinoma Church C, Pulliam T, Longino N, Park S, Smythe K, Makarov V, Riaz N, Jing L, Amezquita R, Campbell J, Gottardo R, Pierce R, Choi J, Chan T, Koelle D, Nghiem P 2022 Journal for ImmunoTherapy of Cancer Oncology, Immuno-oncology Highplex FL HALO
Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic†Trp53†alterations and†Pten†loss Mejia-Hernandez J, Keam S, Saleh R, Muntz F, Fox S, Byrne D, Kogan A, Pang L, Huynh J, Litchfield C, Caramia F, Lozano G, He H, You J, Sandhu S, Williams S, Haupt Y, Haupt S 2022 Cell Death & Disease Oncology Multiplex IHC, Highplex FL, Figure Maker HALO
In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response Sahu A, Kose K, Kraehenbuehl L, Byers C, Holland A, Tembo T, Santella A, Alfonso A, Li M, Cordova M, Gill M, Fox C, Gonzalez S, Kumar P, Wang A, Kurtansky N, Chandrani P, Yin S, Mehta P, Navarrete-Dechent C, Peterson G, King K, Dusza S, Yang N, Liu S, Phillips W, Guitera P, Rossi A, Halpern A, Deng L, Pulitzer M, Marghoob A, Chen C, Merghoub T, Rajadhyaksha M 2022 Nature Communications Immuno-oncology Highplex FL, Figure Maker HALO
In†vivo†G-CSF treatment activates the GR-SOCS1 axis to suppress IFN-? secretion by natural killer cells Zhao X, Peng T, Cao X, Hou Y, Li R, Han T, Fan Z, Zhao M, Chang Y, Chen H, Li C, Huang X 2022 Cell Reports Immunology Highplex FL HALO
Phase I/II clinical trial of a helper peptide vaccine plus PD-1 blockade in PD-1 antibody-naÔve and PD-1 antibody-experienced patients with melanoma (MEL64) Vavolizza R, Petroni G, Mauldin I, Chianese-Bullock K, Olson W, Smith K, Dengel L, Haden K, Grosh W, Kaur V, Varhegyi N, Gaughan E, Slingluff C 2022 Journal for ImmunoTherapy of Cancer Immuno-oncology Highplex FL HALO
Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites Conway J, Rawson R, Lo S, Ahmed T, Veregara I, Gide T, Attrill G, Carlino M, Saw R, Thompson J, Spillane A, Shannon K, Shivalingam B, Menzies A, Wilmott J, Long G, Scolyer R, da Silva I 2022 Journal for ImmunoTherapy of Cancer Oncology Classifier, Spatial Analysis, Highplex FL HALO
Intratumoral administration of CD1c (BDCA-1)+†and CD141 (BDCA-3)+†myeloid dendritic cells in combination with talimogene laherparepvec in immune checkpoint blockade refractory advanced melanoma patients: a phase I clinical trial Schwarze J, Tijtgat J, Awada G, Cras L, Vasaturo A, Bagnall C, Forsyth R, Dufait I, Tuyaerts S, Riet I, Neyns B 2022 Journal for ImmunoTherapy of Cancer Oncology, Immuno-oncology Highplex FL HALO
TIE2-high cervical cancer cells promote tumor angiogenesis by upregulating TIE2 and VEGFR2 in endothelial cells Tan S, Chen Y, Du S, Li W, Liu P, Zhao J, Yang P, Cai J, Gao R, Wang Z 2022 Translational Oncology Oncology Area Quantification, Highplex FL HALO
Proliferative tumor infiltrating lymphocytes abundance within microenvironment impact clinical outcome in cutaneous B-cell lymphomas Menguy S, Prochazkova-Carolotti M, Azzi-Martin L, Ferte T, Bresson-Bepoldin L, Rey C, Vergier B, Merlio J, Beylot-Barry M, Pham-Ledard A 2022 Journal of Investigative Dermatology Immuno-oncology Classifier, Highplex FL HALO
USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer Shi D, Wu X, Jian Y, Wang J, Huang C, Mo S, Li Y, Li F, Zhang C, Zhang D, Zhang H, Huang H, Chen X, Wang Y, Lin C, Liu G, Song L, Liao W 2022 Nature Communications Oncology, Dermatology Cytonuclear, Highplex FL HALO, HALO AI
Single Cell RNA-Seq Identifies Immune-Related Prognostic Model and Key Signature-SPP1 in Pancreatic Ductal Adenocarcinoma Chen K, Wang Q, Liu X, Wang F, Ma Y, Zhang S, Shao Z, Yang Y, Tian X 2022 Genes Oncology Cytonuclear, Highplex FL HALO
Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons Q8 modulate food intake and preference in mice Lewis J, Woodward O, Nuzzaci D, Smith C, Adriaenssens A, Billing L, Brighton C, Phillips B, Tadross J, Kinston S, Ciabatti E, Gottgens B, Tripodi M, Mornigold D, Baker D, Gribble F, Reimann F 2022 Molecular Metabolism Metabolism ISH/FISH, Highplex FL HALO
Attenuation of relapsing fever neuroborreliosis in mice by IL-17A blockade Cheng M, Xu J, Ding K, Liu H 2022 Proceedings of the National Academy of Sciences Infectious Disease Highplex FL HALO
Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system Weigert A, Zheng X, Nenzel A, Turkowski K, Gunther S, Strack E, Sirait-Fischer E, Elwakeel E, Kur I, Nikam V, Valasarajan C, Winter H, Wissgott A, Voswinkel R, Grimminger F, Brune B, Seeger W, Pullamsetti S, Savai R 2022 Nature Communications Oncology Spatial Analysis, Highplex FL HALO
Single-cell RNA-seq transcriptomic landscape of human and mouse islets and pathological alterations of diabetes Chen K, Zhang J, Huang Y, Tian X, Yang Y, Dong A 2022 iScience Metabolism Cytonuclear, Highplex FL HALO
Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody Micalizzi D, Che D, Nicholson B, Edd J, Desai N, Lang E, Toner M, Maheswaran S, Ting D, Haber D 2022 Proceedings of the National Academy of Sciences Oncology Multiplex IHC, Highplex FL HALO
Single-cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases Sun H, Li L, Lao I, Li X, Xu B, Cao Y, Jin W 2022 Clinical and Translational Medicine Oncology Cytonuclear, Highplex FL HALO
Impacts of neoadjuvant chemoradiotherapy on the immune landscape of esophageal squamous cell carcinoma Wen J, Fang S, Hu Y, Xi M, Weng Z, Pan C, Luo K, Ling Y, Lai R, Xie X, Lin X, Lin T, Chen J, Liu Q, Fu J, Yang H 2022 EBioMedicine Immuno-oncology Cytonuclear, Highplex FL HALO
Method To Visualize the Intratumor Distribution and Impact of Gemcitabine in Pancreatic Ductal Adenocarcinoma by Multimodal Imaging Strittmatter N, Richards F, Race A, Ling S, Sutton D, Nilsson A, Wallez Y, Barnes J, Maglennon G, Gopinathan A, Brais R, Wong E, Serra M, Atkinson J, Smith A, Wilson J, Hamm G, Johnson T, Dunlop C, Kaistha B, Bunch J, Sansom O, Takats Z, Andren P, Lau A, Barry S, Goodwin R, Jodrell D 2022 Analytical Chemistry Oncology Classifier, Highplex FL HALO, HALO AI
Xiaoyaosan ethyl acetate fraction alleviates depression-like behaviors in CUMS mice by promoting hippocampal neurogenesis via modulating the IGF-1R_/PI3K/Akt signaling pathway Zeng J, Ji Y, Luan F, Hu J, Rui Y, Liu Y, Rao Z, Liu R, Zeng N 2022 Journal of Experimental & Clinical Cancer Research Neuroscience Highplex FL HALO
SIGLEC15 amplifies immunosuppressive properties of tumor-associated macrophages in pancreatic cancer Li, T, Jin K, Li H, Ye L, Li P, Jiang B, Lin X, Liao Z, Zhang H, Shi S, Lin M, Fei Q, Xiao Z, Xu H, Liu L, Yu X, Wu W 2022 Cancer Letters Immuno-oncology Highplex FL, TMA HALO
Presence of Tim3+ and PD-1+ CD8+ T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and distinct clinicopathological features Klapholz M, Drage M, Srivastava A, Anderson A 2022 The Journal of Pathology Oncology Multiplex IHC, Highplex FL HALO
Impact of HPV status on immune responses in head and neck squamous cell carcinoma Qureshi H, Zhu X, Yang G, Steadele M, Pierce R, Futran N, Lee S, Mendez E, Houghton A 2022 Oral Oncology Oncology Multiplex IHC, Spatial Analysis, Highplex FL HALO
Developing a Nomogram for Preoperative Prediction of Cervical Cancer Lymph Node Metastasis by Multiplex Immunofluorescence Wu J, Guo Q, Zhu J, Wu Y, Liang S Chen S, Wang S, Ju X, Wu X 2022 Authorea Oncology Spatial Analysis, Highplex FL, TMA HALO
PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen Liu M, Wu C, Luo S, Hua Q, Chen H, Weng Y, Xu J, Lin H, Wang L, Li J, Zhu L, Guo Z, Zhuang S, Kang T, Zheng L 2022 Journal of Experimental Medicine Oncology Highplex FL, Registration HALO
Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer Ramos R, Missolo-Koussou Y, Gerber-Ferder Y, Bromley C, Bugatti M, Nunez N, Boari J, Richer W, Menger L, Denizeau J, Sedlik C, Caudana P, Kotsias F, Niborski L, Viel S, Bohec M, Lameiras S, Baulande S, Lesage L, Nicolas A, Meseure D, Vincent-Salomon A, Reyal F, Dutertre C, Ginhoux F, Vimeux L, Donnadieu E, Buttard B, Galon J, Zelenay S, Vermi W, Guermonprez P, Piaggio E, Helft J 2022 Cell Immuno-oncology Classifier, Spatial Analysis, Highplex FL HALO
A Phase 1/2 Trial Combining Avelumab and Trabectedin for Advanced Liposarcoma and Leiomyosarcoma Wagner M, Zhang Y, Cranmer L, Loggers E, Black G, McDonnell S, Maxwell S, Johnson R, Moore R, Hermida de Viveriros P, Aicher L, Smythe K, He Q, Jones R, Pollack S 2022 Clinical Cancer Research Oncology Highplex FL HALO
Anatomic and functional mapping of human uterine innervation Pinsard M, Mouchet N, Dion L, Bessede T, Bertrand M, Darai E, Bellaud P, Loget P, Mazaud-Guittot S, Morandi X, Leveque J, Lavoue V, Duraes M, Timoh K 2022 Fertility and Sterility Other Highplex FL HALO
Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function Veatch J, Lee S, Shasha C, Singhi N, Szeto J, Moshiri A, Kim T, Smythe K, Kong P, Fitzgibbon M, Jesernig B, Bhatia S, Tykodi S, Hall E, Byrd D, Thompson J, Pillarisetty V, Duhen T, Houghton A, Newell E, Gottardo R, Riddell S 2022 Cancer Cell Immuno-oncology Spatial Analysis, Highplex FL HALO
A molecular analysis of neural olfactory placode differentiation in human pluripotent stem cells Bricker R, Bhaskar U, Titone R, Carless M, Barberi T 2022 Stem Cells and Development Other Highplex FL, Figure Maker HALO
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis Rossi M, Altea-Manzano P, Demicco M, Doglioni G, Bornes L, Fukano M, Vandekeere A, Cuadros A, Fernandez-Garcia J, Riera-Domingo C, Jauset C, Planque M, Alkan H, Nittner D, Zuo D, Broadfield L, Parik S, Pane A, Rizzollo F, Rinaldi G, Zhang T, Teoh S, Aurora A, Karras P, Vermeire I, Broekaert D, Van Elsen J, Knott M, Orth M, Demeyer S, Eelen G, Dobrolecki L, Bassez A BRussel T, Sotlar K, Lewis M, Bartsch H, Wuhrer M, van Veelen P, Carmeliet J, Cools J, Morrison S, Marine J, Lambrechts D, Mazzone M, Hannon G, Lunt S, Grunewald T, Park M, van Rheenen J, Fendt S 2022 Nature Oncology Highplex FL HALO
Potentiating adoptive cell therapy using synthetic IL-9 receptors Kalbasi A, Siurala M, Su L, Tariveranmoshabad M, Picton L, Ravikumar P, Li P, Lin J, Escuin-Ordinas H, Da T, Kremer S, Sun A, Castelli S, Agarwal S, Scholler J, Song D, Rommel P, Radaelli E, Young R, Leonard W, Ribas A, June C, Gargia K 2022 Nature Immuno-oncology Highplex FL HALO
Tumor cells modulate macrophage phenotype in a novel in vitro co-culture model of the non-small cell lung cancer tumor microenvironment Park J, Chandra R, Cai L, Ganguly D, Li H, Toombs J, Girard L, Brekken R, Minna J 2022 Journal of Thoracic Oncology Immuno-oncology Highplex FL HALO
A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear Cell Renal Cell Carcinoma Rappold P, Vuong L, Leibold J, Chakiryan N, Curry M, Kuo F, Sabio E, Jiang H, Nixon B, Liu M, Berglund A, Silagy A, Mascareno A, Golkaram M, Marker M, Reising A, Savchenko A, Milholland J, Chen Y, Russo P, Coleman J, Reznik E, Manley B, Ostrovnaya I, Makarav V, DiNatale R, Blum K, Ma X, Chowell D, Li M, Solit D, Lowe S, Chan T, Motzer R, Voss M, Hakimi A 2022 Cancer Discovery Oncology Highplex FL HALO
Spatiotemporal expression pattern of Progesterone Receptor Component (PGRMC) 1 in endometrium from patients with or without endometriosis or adenomyosis Thieffry C, Van Wynendaele M, Samain L, Tyteca D, Pierreux C, Marbaix E, Henriet P 2022 The Journal of Steroid Biochemistry and Molecular Biology Other ISH/FISH, Highplex FL HALO, HALO AI
Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells Goff P, Riolobos L, LaFleur B, Spraker M, Seo Y, Smythe K, Campbell J, Pierce R, Zhang Y, He Q, Kim E, Schaub S, Kane G, Mantilla J, Chen E, Ricciotti R, Thompson M, Cranmer L, Wagner M, Loggers E, Jones R, Murphy E, Blumenschein W, McClanahan T, Earls J, Flanagan K, LaFranzo N, Kim T, Pollack S 2022 Clinical Cancer Research Immuno-oncology Highplex FL HALO
Targeted RNA editing in brainstem alleviates respiratory dysfunction in a mouse model of Rett syndrome Sinnamon J, Jacobson M, Yung J, Mandel G 2022 Proceedings of the National Academy of Sciences Neuroscience Highplex FL HALO
Characterization of anti-CD79b/CD3 bispecific antibody, a potential therapy for B cell malignancies Wang J, Li C, He K, Kuang Z, Lu J, Yao Y, He F, Li N, Li L, Fu F, Wu Z, Zhou S, Kang D, Qiu X, Wu M, Liu Y, Cao X, Xu M, Chen B, Wu W, Guo F 2022 Cancer Immunology, Immunotherapy Immuno-oncology Highplex FL HALO
Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis Sabate-Perez A, Romero M, Sanchez-Fernandez-de-Landa P, Carobbio S, Mouratidis M, Sala D, Engel P, Villena J, Virtue S, Vidal-Puig A, Palacin M, Testar X, Zorzano A 2022 Autophagy Metabolism Highplex FL HALO, HALO AI
Epigallocatechin-3-gallate reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis Li H, Qiao C, Zhao L, Jing Q, Xue D, Zhang Y 2022 Journal of Leukocyte Biology Immunology Highplex FL HALO
Notch signaling promotes mature T-cell lymphomagenesis Gao X, Wang C, Abdelrahman S, Kady N, Murga-Zamalloa C, Gann P, Sverdlov M, Wolfe A, Polk A, Brown N, Bailey N, Inamdar K, Casavilca-Zambrano S, Montes J, Barrionuevo C, Taxa L, Reneau J, Siebel C, Maillard I, Wilcox R 2022 Cancer Research Immuno-oncology Highplex FL HALO, HALO AI
Plasma CD27, a surrogate of the intratumoral CD27-CD70 interaction, correlates with immunotherapy resistance in renal cell carcinoma Benhamouda N, Sam I, Epaillard N, Gey A, Phan L, Pham H, Gruel N, Saldmann A, Pineau J, Hasan M, Quiniou V, Nevoret C, Verkarre V, Libri V, Mella S, Granier C, Broudin C, Ravel P, De Guillebon E, Mauge L, Helley D, Jabla B, Chaput N, Albiges L, Katsahian S, Adam J, Mejean A, Adotevi O, Vano Y, Oudard S, Tartour E 2022 Clinical Cancer Research Oncology Spatial Analysis, Highplex FL HALO
Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses Mandula J, Chang S, Mohamed E, Jimenez R, Sierra-Mondragon R, Chang D, Obermayer A, Moran-Segura C, Das S, Vazquez-Martinez J, Prieto K, Chen A, Smalley K, Czerniecki B, Forsyth P, Koya R, Ruffell B, Cubillos-Ruiz J, Munn D, Shaw T, Conejo-Garcia J, Rodriguez P 2022 Cancer Cell Immuno-oncology Highplex FL HALO
CD103 and periplakin are potential biomarkers for response of metastatic melanoma to pembrolizumab Edmonds N, Flores S, Mahmutovic A, Young S, Mauldin I, Slingluff C 2022 Melanoma Research Immuno-oncology Highplex FL HALO
High endothelial venules associated with better prognosis in esophageal squamous cell carcinoma Li H, Tang L, Han X, Zhong L, Gao W, Chen Y, Huang J, Wen Z 2022 Annals of Diagnostic Pathology Oncology Object Colocalization, Spatial Analysis, Highplex FL HALO
Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2 Planchais C, Reyes-Ruiz A, Lacombe R, Zarantonello A, Lecerf M, Revel M, Roumenina L, Atanasov B, Mouquet H, Dimitrov J 2022 Protein Science Infectious Disease Area Quantification, Highplex FL HALO
Novel post-acquisition image processing to attenuate red blood cell autofluorescence for quantitative image analysis Bouffard N, Lee K, DeLance N, Clason T, Chatterjee N, Taatjes D 2022 Histochemistry and Cell Biology Other Highplex FL HALO
Angiogenesis modulation-mediated inhibitory effects of tacrolimus on hypertrophic scar formation Shen Y, Jin R, Liang X, Deng Z, He J, Ding Y, Ding F, Lu L, Liu F, Yang J 2022 Microvascular Research Dermatology Highplex FL HALO
Chronic rhinosinusitis patients display an aberrant immune cell localisation with enhanced S. aureus biofilm metabolic activity and biomass Shaghayegh G, Cooksley C, Bouras G, Panchatcharam B, Idrizi R, Jana M, Ellis S, Psaltis A, Wormald P, Vreugde S 2022 Journal of Allergy and Clinical Immunology Immunology, Infectious Disease Classifier, Spatial Analysis, Highplex FL HALO
Low CD8 T Cell Counts Predict Benefit from Hypoxia-Modifying Therapy in Muscle-Invasive Bladder Cancer Smith V, Mukherjee D, Tsakiroglou A, Baker A, Mistry H, Choudhury A, Hoskin P, Illidge T, West C 2022 Cancers Immuno-oncology Highplex FL, TMA HALO
NUC-7738 regulates _-catenin signalling resulting in reduced proliferation and self-renewal of AML cells Shahid A, Um I, Elshani M, Zhang Y, Harrison D 2022 PLOS One Oncology Highplex FL HALO, HALO AI
Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments Beach C, MacLean D, Majorova D, Melemenidis S, Nambiar D, Kim R, Valbuena G, Guglietta S, Krieg C, Darvish D, Suwa T, Eason A, Domingo E, Moon E, Jiang D, Jiang Y, Koong A, Woodruff T, Graves E, Maughan T, Buczacki S, Stucki M, Le Q-T, Leedham S, Giaccia A, Olcina M 2023 bioRxiv Immuno-oncology Classifier, Area Quantification, Highplex FL HALO
Single-cell RNA sequencing identifies a population of human liver-type ILC1s Kramer B, Nalin A, Ma F, Eickoff S, Lutz P, Leonardelli S, Foeser F, Finnemann C, Hack G, Raabe J, ToVinh M, Ahmad S, Hoffmeister C, Kaiser K, Manekeller S, Branchi V, Bald T, Holzel M, Huneburg R, Nischalke H, Semaan A, Langhans B, Kaczmarek D, Benner B, Lordo M, Kowalski J, Gerhardt A, Timm J, Toma M, Mohr R, Turler A, Charpentier A, van Bremen T, Felmann G, Sattler A, Kotsch K, Abdallah A, Strassburg C, Spengler U, Carson W, Mundy-Bosse B, Pellegrini M, O'Sullivan T, Greud A, Nattermann J 2023 Cell Reports Immunology Highplex FL HALO
Tertiary lymphoid structures in desmoplastic melanoma have increased lymphocyte density, lymphocyte proliferation, and immune cross talk with tumor when compared to non-desmoplastic melanomas Edmonds N, Gradecki S, Katyal P, Lynch K, Stowman A, Gru A, Engelhard V, Slingluff Jr. C, Mauldin I 2023 OncoImmunology Immuno-oncology Highplex FL HALO
Autologous T cell therapy for MAGE-A4+ solid cancers in HLA-A*02+ patients: a phase 1 trial Hong D, Van Tine B, Biswas S, McAlpine C, Johnson M, Olszanski A, Clarke J, Araujo D, Blumenschein G, Kebriaei P, Lin Q, Tipping A, Sanderson J, Wang R, Trivedi T, Annareddy T, Bai J, Rafail S, Sun A, Fernandes L, Navenot J-M, Bushman F, Everett J, Karadeniz D, Broad R, Isabelle M, Naidoo R, Bath N, Betts G, Wolchinsky Z, Batrakou D, Van Winkle E, Elefant E, Ghobadi A, Cashen A, Grand'Maison A, McCarthy P, Fracasso P, Norry E, Williams D, Druta M, Liebner D, Odunsi K, Butler M 2023 Nature Medicine Immuno-oncology ISH/FISH, Spatial Analysis, Highplex FL HALO
A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration Hwang P, Mathur J, Cao Y, Almeida J, Ye J, Morikis V, Cornish D, Clarke M, Stewart S, Pathak A, Longmore G 2023 Developmental Cell Oncology Highplex FL, Registration HALO
Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods Bayer F, Bejarano D, Bartacchi G, Doffin A-C, Gobbini E, Hubert M, Li L, Meiser P, Pedde A-M, Posch W, Rupp L, Schlitzer A, Schmitz M, Schraml B, Uderhardt S, Balladeau-Guilemond J, Wilflingseder D, Zaderer V, Bottcher J 2023 European Journal of Immunology Other Highplex FL HALO
Protocol for investigating tertiary lymphoid structures in human and murine fixed tissue sections using Opal‚Ñ¢-TSA multiplex immunohistochemistry Quigley L, Pang L, Tavancheh E, Ernst M, Behren A, Huynh J, Da Gama Duarte J 2023 STAR Protocols Other Highplex FL HALO
Standardized pathology screening of mature Tertiary Lymphoid Structures in cancers Vanhersecke L, Bougouin A, Crombe A, Brunet M, Sofeu C, Parrens M, Pierron H, Bonhomme B, Lembege N, Rey C, Velasco V, Soubeyran I, Begueret H, Bessede A, Bellera C, Scoazec J-Y, Italiano A, Fridman C, Fridman W, Le Loarer F 2023 Laboratory Investigation Other Highplex FL, Registration HALO
Effects of electroacupuncture on the kisspeptin-gonadotropin-releasing hormone (GnRH) /luteinizing hormone (LH) neural circuit abnormalities and androgen receptor expression of kisspeptin/neurokinin B/dynorphin neurons in PCOS rats. Xu G, Zhao X, Li Z, Hu J, Li X, Li J, Chen Y 2023 Journal of Ovarian Research Other Highplex FL HALO
Fucosylation of HLA-DRB1 regulates CD4+ T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy Lester D, Burton C, Gardner A, Innamarato P, Kodumudi K, Liu Q, Adhikari E, Ming Q, Williamson D, Frederick D, Sharova T, White M, Markowitz J, Cao B, Nguyen J, Johnson J, Beatty M, Mockabee-Macias A, Mercurio M, Watson G, Chen P-L, McCarthy S, MoranSegura C, Messina J, Thomas K, Darville L, Izumi V, Koomen J, Pilon-Thomas S, Ruffell B, Luca V, Haltiwanger R, Wang X, Wargo J, Boland G, Lau E 2023 Nature Cancer Immuno-oncology Highplex FL, Registration HALO
Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy Singh B, Moodley C, Singh D, Escobedo R, Sharan R, Arora G, Ganatra S, Shivanna V, Gonzalez O, Hall-Ursone S, Dick Jr. E, Kaushal D, Alvarez X, Mehra S 2023 JCI Insight Infectious Disease, Fibrosis Area Quantification, Highplex FL HALO
Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance Thatikonda V, Lu H, Jurado S, Kostyrko K, Bristow C, Bosch K, Feng N, Gao S, Gerlach D, Gmachi M, Lieb S, Jeschko A, Machado A, Marszalek E, Mahendra M, Jaeger P, Sorokin A, Strauss S, Trapani F, Kopetz S, Vellano C, Petronczki M, Kraut N, Heffernan T, Marszalek J, Pearson M, Waizenegger I, Hofmann M 2023 bioRxiv Oncology ISH/FISH, Multiplex IHC, Highplex FL, Figure Maker HALO
Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial Tian J, Chen J, Chao S, Pelka K, Giannakis M, Hess J, Burke K, Jorgji V, Sindurakar P, Braverman J, Mehta A, Oka T, Huang M, Lieb D, Spurrell M, Allen J, Abrams T, Clark J, Enzinger A, Enzinger P, Klempner S, McCleary N, Meyerhardt J, Ryan D, Yurgelun M, Kanter K, Van Seventer E, Baiev I, Chi G, Jarnagin J, Bradford W, Wong E, Michel A, Fetter I, Siravegna G, Gemma A, Sharpe A, Demehri S, Leary R, Campbell C, Yilmaz Om Getz G, Parikh A, Hacohen N, Corcoran R 2023 Nature Medicine Oncology Highplex FL HALO
Gold Nanoparticles for Monitoring of Mesenchymal Stem Cell–Loaded Bioresorbable Polymeric Wraps for Arteriovenous Fistulas Barcena A, Perez J, Damasco J, Bernardino M, San Valentin E, Klusman C, Martin B, Cortes A, Canlas G, Heralde III, F, Avritscher R, Fowlkes N, Bouchard R, Cheng J, Huang S, Melancon M 2023 bioRxiv Biomaterials Highplex FL HALO
Discovery of NRG1-VII: a novel myeloid-derived class of NRG1 isoforms Berrocal-Rubio M, Pawer Y, Dinevska M, De Paoli-Iseppi R, Widodo S, Rajab N, De Nardo W, Hallab J, Li A, Mantamadiotis T, Clark M, Wells C 2023 bioRxiv Immunology Highplex FL HALO
Single-cell spatial immune landscapes of primary and metastatic brain tumours Karimi E, Yu M, Maritan S, Perus L, Rezanejad M, Sorin M, Kankner M, Fallah P, Doré S, Zuo D, Fiset B, Kloosterman D, Ramsay L, Wei Y, Lam S, Alsajjan R, Watson I, Urgoiti G, Park M, Randsma D, Senger D, Chan J, Akkari L, Petrecca K, Guiot M-C, Siegel P, Quail D, Walsh L 2023 Nature Immuno-oncology Highplex FL HALO
Multiplex immune profiling reveals the role of serum immune proteomics in predicting response to preoperative chemotherapy of gastric cancer Tang Z, Gu Y, Shi Z, Min L, Zhang Z, Zhou P, Luo R, Wang Ym, Cui Y, Sun Y, Wang X 2023 Cell Reports Medicine Immuno-oncology Highplex FL HALO
Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses Hirz T, Mei S, Sarkar H, Kfoury Y, Wu S, Verhoeven B, Subtelny A, Zlatev D, Wszolek M, Salari K, Murray E, Chen F, Macosko E, Wu C, Scadden D, Dahl D, Baryawno N, Saylor P, Kharchenko P, Sykes D 2023 Nature Communications Immuno-oncology Highplex FL, Figure Maker, HALO AI HALO
Impact of aging on the immunological and microbial landscape of the lung during non-tuberculous mycobacterial infection Cinco I, Rhoades N, Napier E, Davies M, Allison D, Kohama S, Bermudez L, Winthrop K, Fuss C, Spindel E, Messaoudi I 2023 bioRxiv Infectious Disease Highplex FL HALO
Effects of KMT2D mutation and its exon 39 mutation on the immune microenvironment and drug sensitivity in colorectal adenocarcinoma Liu C, Jin Y, Zhang H, Yan J, Guo Y, Bao X, Zhao P 2023 Heliyon Oncology Highplex FL HALO
NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis Ilter D, Drapela S, Schild T, Ward N, Adhikari E, Low V, Asara J, Oskarsson T, Lau E, DeNicola G, McReynolds M, Gomes A 2023 Redox Biology Oncology, Metabolism Classifier, Highplex FL, TMA HALO
Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine model Xin J, Yang T, Wu X, Wu Y, Liu Y, Liu X, Jiang M, Gao W 2023 Communications Biology Gastroenterology Highplex FL HALO
Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression Nandi I, Smith H, Sanguin-Gendreau V, Ji L, Pacis A, Papavasiliou V, Zuo D, Nam S, Attala S, Kim S, Lusson S, Kuasne H, Fortier A, Savage P, Ramirez C, Park M, Katzenellenbogen J, Katzenellenbogen B, Muller W 2023 Journal of Clinical Investigation Oncology Highplex FL HALO
Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner Mahadevan K, McAndrews K, LeBlue V, Yang S, Lyu H, Li B, Sockwell A, Kirtley M, Morse S, Diaz B, Kim M, Feng N, Lopez A, Guerrero P, Sugimoto H, Arian K, Ying H, Barekatain Y, Kelly P, Maitra A, Heffernan T, Kalluri R 2023 bioRxiv Oncology FISH, Highplex FL HALO
PD-1+CD8+ T Cells Proximal to PD-L1+CD68+ Macrophages Are Associated with Poor Prognosis in Pancreatic Ductal Adenocarcinoma Patients Yang X, Wang G, Song Y, Zhuang T, Li Y, Xie Y, Fei X, Zhao Y, Xu D, Hu Y 2023 Cancers Oncology, Immuno-oncology Classifier, Spatial Analysis, Highplex FL, Registration, TMA HALO
Donor Batf3 inhibits murine lung allograft rejection and airway fibrosis Watanabe T, Lam C, Oliver J, Oishi H, Teskey G, Beber S, Boonstra K, Mauricio J, Buhari H, Joe B, Guan Z, Horie M, Keshavjee S, Martinu T, Juvet S 2023 Mucosal Immunity Other, Fibrosis Highplex FL HALO
Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease Saponara E, Penno C, Orsini V, Wang Z, Fischer A, Aebi A, Matadamas-Guzman M, Brun V, Fischer B, Brousseau M, O'Donnell P, Turner J, Meyer A, Bollepalli L, d'Ario G, Roma G, Carbone W, Annunziato S, Obrecht M, Beckmann N, Saravanan C, Osmont A, Tropberger P, Richards S, Genoud C, Ley S, Ksiazek I, Nigsch F, Terracciano L, Schadt H, Bouwmeester T, Tchorz J, Ruffner H 2023 The American Journal of Pathology Gastroenterology Highplex FL HALO
Single-cell analysis reveals changes in BCG vaccine-injected mice modeling tuberculous meningitis brain infection Zhang X, Zhao Z, Wu Q, Wang L, Li L, Wang M, Ren Y, Pan L, Tang H, Li F 2023 Cell Reports Infectious Disease Multiplex IHC, Highplex FL HALO
Spatial multi-omics revealed the impact of tumor ecosystem heterogeneity on immunotherapy efficacy in patients with advanced non-small cell lung cancer treated with bispecific antibody Song X, Xiong A, Wu F, Li X, Wang J, Jiang T, Chen P, Zhang X, Zhao Z, Liu H, Cheng L, Zhao C, Wang Z, Pan C, Cui X, Xu T, Luo H, Zhou C 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Classifier, Highplex FL HALO
Melanotransferrin Functions as a Pro-Oncogenic WNT Agonist: A Yin-Yang Relationship in Melanoma with the WNT Antagonist and Metastasis Suppressor, NDRG1 Paluncic J, Cholam M, Lane D, Skoda J, Park K, Chiang S, Bae D, Scolyer R, Afroz R, Babu G, Wilmott J, Loh K, Jansson P, Dharmasiviam M, Huang M, Zhao X, Kovacevic Z, Richardson D 2023 bioRxiv Oncology Highplex FL HALO
Co-enrichment of CD8-positive T cells and macrophages is associated with clinical benefit of tislelizumab in solid tumors Ye D, Desai J, Shi J, Liu S, Shen W, Liu T, Shi Y, Wang D, Liang L, Yang S, Ma X, Jin W, Zhang P, Huang R, Shen Z, Zhang Y, Wu Y 2023 Biomarker Research Immuno-oncology Spatial Analysis, Highplex FL HALO
Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K+ CD8+T cells in primary Sjögren’s syndrome Xu T, Zhu H, Ma J, Li X, Luo P, Li Y, Lian Z, Gao C 2023 JCI Insight Immunology Highplex FL HALO
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence Gioia U, Tavella S, Martinez-Orellana P, Cicio G, Colliva A, Ceccon M, Cabrini M, Henriques A, Fumagalli V, Paldino A, Presot E, Rajasekharan S, Iacomino N, Pisati F, Matti V, Sepe S, Conte M, Barozzi S, Lavagnino Z, Carletti T, Volpe M, Cavalcante P, Iannacone M, Rampazzo C, Bussani R, Tripodo C, Zacchigna S, Marcello A, di Fagagna F 2023 Nature Cell Biology Infectious Disease ISH/FISH, Highplex FL HALO
TIPE2 Inhibits MGD Inflammation by Regulating Macrophage Polarization Zhao S, Shen Y, Wu S, Shao Y, Shi R, Yan Y, Zhao H 2023 Journal of Personalized Medicine Immunology Area Quantification, Highplex FL HALO
Loss of Peroxiredoxin IV Protects Mice from Azoxymethane/Dextran Sulfate Sodium-Induced Colorectal Cancer Development Thapa P, Jiang H, Ding N, Hao Y, Alshahrani A, Lee E, Fujii J, Wei Q 2023 Antioxidants Oncology Multiplex IHC, Highplex FL HALO
Bi-allelic mutation in SEC16B alters collagen trafficking and increases ER stress El-Gazzar A, Voraberger B, Rauch F, Mairhofer M, Schmidt K, Guillemyn B, Mitulovic G, Reiterer V, Haun M, Mayr M, Mayr J, Kimeswenger S, Drews O, Saraff V, Shaw N, Fratzl-Zelman N, Symoens S, Farhan H, Hogler W 2023 EMBO Molecular Medicine Other Area Quantification, Highplex FL HALO
Tumour Extracellular Vesicles Induce Neutrophil Extracellular Traps To Promote Lymph Node Metastasis Su X, Brassard A, Bartolomucci A, Dhoparee-Dooma I, Qiu Q, Tsering T, Rohanizadeh R, Koufos O, Giannias B, Bourdeau F, Feng L, Leo S, Sangwan V, Tankel J, Quail D, Spicer J, Burnier J, Bailey S, Ferri L, Cools-Lartigue J 2023 bioRxiv Immuno-oncology Area Quantification, Highplex FL HALO
Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques Byrnes S, Busman-Sahay K, Angelovich T, Younger S, Taylor-Brill S, Nekorchuk M, Bondoc S, Dannay R, Terry M, Cochrane C, Jenkins T, Roche M, Deleage C, Bosinger S, Paiardini M, Brew B, Estes J, Churchill M 2023 PLOS Pathogens Infectious Disease Area Quantification, Object Colocalization, ISH, Highplex FL HALO
Development of a deep pathomics score for predicting hepatocellular carcinoma recurrence after liver transplantation Qu W, Tian M, Lu G, Zhou Y, Liu W, Tang Z, Yao Z, Huang R, Zhu G, Jiang X, Tao C, Fang Y, Gao J, Wu X, Chen J, Zhao Q, Yang R, Chu T, Zhou J, Fan J, Yu J, Shi Y 2023 Hepatology International Oncology Spatial Analysis, Highplex FL HALO
Early Identication of High-Risk Patients with HCC Relapse: A Spatial Immune Scoring System Enabled by Articial Intelligence Sun C, Jia G, He P, Goh D, Li F, Wee F, Sun M, Dai T, Lim J, Hao S, Liu L, Yeong J, Tian Z 2023 Research Square Oncology Highplex FL HALO
Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancer Shakfa N, Li D, Conseil G, Lightbody E, Wilson-Sanchez J, Hamade A, Chenard S, Jawa N, Laight B, Afriyie-Asante A, Tyryshkin K, Koebel M, and Koti M 2023 Journal for ImmunoTherapy of Cancer Oncology Highplex FL HALO, HALO Link
Prognostic value of tumor immune microenvironment factors in patients with stage I lung adenocarcinoma Xue Q, Wang Y, Zheng Q, Chen L, Lin Y, Jin Y, Shen X, Li Y 2023 American Journal of Cancer Research Oncology Classifier, Multiplex IHC, Highplex FL HALO
Immune Checkpoint Neuropilins as Novel Biomarkers and Therapeutic Targets for Pancreatic Cancer He L, Zhang X, Lao M, Zhang H, Yang H, Bai X 2023 Cancers Immuno-oncology Highplex FL HALO
Cannabinoid enhancement of lncRNA MMP25-AS1/MMP25 interaction reduces neutrophil infiltration and intestinal epithelial injury in HIV/SIV infection Premadasa L, Lee E, McDew-White M, Alvarez X, Jayakumar S, Ling B, Okeoma C, Byrareddy S, Kulkarni S, and Mohan M 2023 JCI Insight Infectious Disease Area Quantification, Highplex FL HALO
Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer Wang F, Long J, Li L, Wu Z, Da T, Wang X, Huang C, Jiang Y, Yao X, Ma H, Lian Z, Zhao Z, Cao J 2023 Science Advances Oncology Multiplex IHC, Spatial Analysis, Highplex FL HALO
High tumor mutational burden predicts favorable response to anti-PD-(L)1 therapy in patients with solid tumor: a real-world pan-tumor analysis Jung J, Heo Y, Park S 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Spatial Analysis, Highplex FL HALO
Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression Jana S, Brahma S, Arora S, Wladyka C, Hoang P, Blinka S, Hough R, Horn J, Liu Y, Wang L, Depeille P, Smith E, Montgomery R, Lee J, Haffner M, Vakar-Lopez F, Grivas P, Wright J, Lam H, Black P, Roose J, Ryazanov A, Subramaniam A, Henikoff S, and Hsieh A 2023 Cancer Cell Oncology Multiplex IHC, Highplex FL HALO
Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinoma Chakiryan N, Kim Y, Berglund A, Chang A, Kimmel G, Hajiran A, Nguyen J, Moran-Segura C, Saeed-Vafa D, Katende E, Lopez-Blanco N, Chahoud J, Rappold P, Spiess P, Fournier M, Jeong D, Wang L, Teer J, Dhillon J, Kuo F, Hakimi A, Altrock P, Mulé J, Manley B 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Highplex FL HALO
Adrenal cortex size and homeostasis are regulated by gonadal hormones via androgen receptor/β-catenin signaling crosstalk Lyraki R, Grabek A, Tison A, Weerasinghe-Arachchige L, Peitzsch M, Bechman N, Youssef S, de Bruin A, Bakker E, Claessens F, Chaboissier M, Schedl A 2023 Disease Models & Mechanisms Other FISH, Highplex FL HALO
Multi-organ landscape of therapy-resistant melanoma Liu S, Dharanipragada P, Lomeli S, Wang Y, Zhang X, Yang Z, Lim R, Dumitras C, Scumpia P, Dubinett S, Moriceau G, Johnson D, Moschos S, Lo R 2023 Nature Medicine Oncology, Immuno-oncology Highplex FL HALO
Somatic mutation profiling, tumor-infiltrating leukocytes, tertiary lymphoid structures and PD-L1 protein expression in HER2-amplified colorectal cancer Liu X, Kou Z, Zhang H, Dong J, Zhang J, Peng Y, Ma S, Liang L, Meng X, Zhou Y, Yang J 2023 PeerJ Immuno-oncology Highplex FL HALO
Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of glioma Yang X, Ji C, Qi Y, Huang J, Hu L, Zhou Y, Zou L, Xia Y, Tan F, Yao Y, Chen D 2023 Research Square Oncology Highplex FL HALO
Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma  Burger M, Forster M, Romanski A, Straßheimer F, Macas J, Zeiner P, Steidl E, Herkt S, Weber K, Schupp J, Lun J, Strecker M, Wlotzka K, Cakmak P, Opitz C, George R, Mildenberger I, Nowakowska P, Zhang C, Röder J, Müller E, Ihrig K, Langen K, Rieger M, Herrmann E, Bonig H, Harter P, Reiss Y, Hattingen E, Rödel F, Plate K, Tonn T, Senft C, Steinbach J, Wels W 2023 Neuro-Oncology Immuno-oncology Highplex FL HALO
Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis Conroy L, Clarke H, Allison D, Valenca S, Sun Q, Hawkinson T, Young L, Ferreira J, Hammonds A, Dunne J, McDonald R, Absher K, Dong B, Bruntz R, Markussen K, Juras J, Alilain W, Liu J, Gentry M, Angel P, Waters C, Sun R 2023 Nature Communications Fibrosis Multiplex IHC, Highplex FL HALO
Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments Feng Y, Yang T, Zhu J, Li M, Doyle M, Ozcoban V, Bass G, Pizzolla A, Cain L, Weng S, Pasam A, Kocovski N, Huang Y, Keam S, Speed T, Neeson P, Pearson R, Sandhu S, Goode D, Trigos A 2023 Nature Communications Other Highplex FL HALO
High expression ITGA2 affects the expression of MET,PD-L1, CD4 and CD8 with the immune microenvironment in pancreatic cancer patients Jin L, Duan Y, Li Z, Hu J, Shi H, Su Z, Li Z, Du B, Chen Y, Tan Y 2023 Research Square Oncology Highplex FL HALO
Tumor-derived semaphorin 4A improves PD-1–blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation NAITO Y, KOYAMA S, MASUHIRO K, HIRAI T, UENAMI T, INOUE T, OSA A, MACHIYAMA H, WATANABE G, SAX N, VILLA J, KINUGASA-KATAYAMA Y, NOJIMA S, YAGA M, HOSONO Y, OKUZAKI D, SATOH S, TSUDA T, NAKANISHI Y, SUGA Y, MORITA T, FUKUSHIMA K, NISHIDE M, SHIROYAMA T, MIYAKE K, IWAHORI K, HIRATA H, NAGATOMO I, YANO Y, TAMIYA M, KUMAGAI T, TAKEMOTO N, INOHARA H, YAMASAKI S, YAMASHITA K, AOSHI T, AKBAY E, HOSEN N, SHINTANI Y, TAKAMATSU H, MORI M, TAKEDA Y, KUMANOGOH A 2023 Science Advances Immuno-oncology Multiplex IHC, Highplex FL HALO
Sequential pembrolizumab cooperates with platinum/5FU to remodel the tumor immune microenvironment in advanced gastric cancer: A phase II chemoimmunotherapy trial Klempner S, Lee J, Mehta A, An M, Min B, Heo Y, Parikh M, Bi L, Cristescu R, Lee H, Kim T, Lee S, Moon J, Park R, Strickland M, Park W, Kang W, Kim K, Kim S 2023 Research Square Immuno-oncology Classifier, Highplex FL HALO
An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity Cheng L, Zhu M, Gao Y, Liu W, Yin W, Zhou P, Zhu Z, Niu L, Zeng X, Zhang D, Fang Q, Wang F, Zhao Q, Zhang Y, Shen G 2023 Cellular and Molecular Biology Letters Immuno-oncology Multiplex IHC, Highplex FL HALO
Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis Zhang S, Xu Q, Shi L, Li S, Wang W, Wang Q, Lu L, Xiao H, Wang J, Li F, Liang Y, Gong S, Peng H, Zhang Z, Tang G 2023 Signal Transduction and Targeted Therapy Immunology Highplex FL HALO
Activation of IGFBP4 via unconventional mechanism of miRNA attenuates metastasis of intrahepatic cholangiocarcinoma Tao L, Wang Y, Shen Z, Cai J, Zheng J, Xia S, Lin Z, Wan Z, Qi H, Jin R, Wang L, Xu J, Liang X 2023 Hepatology International Oncology Highplex FL HALO
Characterization of intratumoral tertiary lymphoid structures in pancreatic ductal adenocarcinoma: cellular properties and prognostic significance Zou X, Lin X, Cheng H, Chen Y, Wang R, Ma M, Liu Y, Dai Z, Tasiheng Y, Yan Y, Hou Q, Ding F, Chen H, Yu X, Wang X, Liu C 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Highplex FL HALO, HALO AI
Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment Derry J, Burns C, Frazier J, Beirne E, Grenley M, DuFort C, Killingbeck E, Leon M, Williams C, Gregory M, Houlton J, Clayburgh D, Swiecicki P, Huszar D, Berger A, Klinghoffer R 2023 Cellular and Molecular Biology Letters Oncology Highplex FL HALO, HALO AI
A cellular and molecular spatial atlas of dystrophic muscle Stec M, Su Q, Adler C, Zhang L, Golann D, Khan N, Panagis L, Villalta S, Ni M, Wei Y, Walls J, Murphy A, Yancopoulos G, Atwal G, Kleiner S, Halasz G, Sleeman M 2023 Proceedings of the National Academy of Sciences Myology ISH/FISH, Highplex FL HALO
Stem cell-like T cell depletion in the recurrent head and neck cancer immune microenvironment Chen L, Lee N, Sarkar R, Katabi N, Li Y, Morris L, Wong R, Sherman E, Reis-Filho J, Hollmann T, Riaz N 2023 OncoImmunology Immuno-oncology Spatial Analysis, Highplex FL HALO
TSLP/dendritic cell axis promotes CD4+ T cell tolerance to the gut microbiome Messerschmidt J, Azin M, Dempsey K, Demehri S 2023 JCI Insight Immunology Highplex FL HALO
Poor outcome in postpartum breast cancer patients is associated with distinct molecular and immunological features Lefrère H, Moore K, Floris G, Sanders J, Seignette I, Bismeijer T, Peters D, Broeks A, Hooijberg E, Van Calsteren K, Neven P, Warner E, Peccatori F, Loibl S, Maggen C, Han S, Jerzak K, Annibali D, Lambrechts D, de Visser K, Wessels L, Lenaerts L, Amant F 2023 Clinical Cancer Research Oncology Classifier, Highplex FL HALO, HALO AI
Differential expression of CD8 defines phenotypically distinct cytotoxic T cells in cancer and multiple sclerosis Burkard T, Herrero San Juan M, Dreis C, Kiprina A, Namgaladze D, Siebenbrodt K, Luger S, Foerch C, Pfeilschifter J, Weigert A, Radeke H 2023 Clinical and Translational Medicine Oncology, immunology Classifier, Spatial Analysis, Highplex FL, TMA HALO
An intestinal Th17 subset is associated with inflammation in Crohn’s Disease and activated by adherent-invasive Escherichia coli (AIEC) Paroni M, Leccese G, Ranzani V, Moschetti G, Chiara M, Perillo F, Ferri S, Clemente F, Noviello D, Conforti FS, Ferrero S, Karnani B, Bosotti R, Vasco C, Curti S, Crosti MC, Gruarin P, Rossetti G, Conte MP, Vecchi M, Pagani M, Landini P, Facciotti F, Abrignani S, Caprioli F, Geginat J 2023 Journal of Crohn's and Colitis Immunology Highplex FL HALO
Single-cell characterization of pulmonary nodules implicates suppression of immunosurveillance across early stages of lung adenocarcinoma Yanagawa J, Tran L, Salehi-Rad R, Lim R, Dumitras C, Fung E, Wallace W, Prosper A, Fishbein G, Shea C, Hong R, Kahangi B, Deng J, Gower A, Liu B, Campbell J, Mazzilli S, Beane J, Kadara H, Lenburg M, Spira A, Aberle D, Krysan K, Dubinett S 2023 Cancer Research Immuno-oncology Highplex FL HALO
The CD73 is induced by TGF-β1 triggered by nutrient deprivation and highly expressed in dedifferentiated human melanoma Giraulo C, Turiello R, Orlando L, Leonardelli S, Landsberg J, Belvedere R, Rolshoven G, Muller C, Holzel M, Morello S 2023 Biomedicine & Pharmacotherapy Oncology Highplex FL, TMA HALO, HALO AI
Multiplex Immunohistochemistry and Immunofluorescence: A Practical Update for Pathologists Harms P, Frankel T, Moutafi M, Rao A, Rimm D, Taube J, Thomas D, Chang M, Pantanowitz L 2023 Modern Pathology Review Spatial Analysis, Highplex FL HALO
Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer Quan Y, He J, Zou Q, Zhang L, Sun Q, Huang H, Li W, Xie K, Wie F 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Classifier, Multiplex IHC, Highplex FL HALO
Immune checkpoint blockade induces distinct alterations in the microenvironments of primary and metastatic brain tumors Sun L, Kienzler JC, Reynoso JG, Lee A, Shiuan E, Li S, Kim J, Ding L, Monteleone AJ, Owens GC, Phillips JJ, Everson RG, Nathanson D, Cloughesy TF, Li G, Liau LM, Hugo W, Kim W, Prins RM 2023 Journal of Clinical Investigation Immuno-oncology Highplex FL HALO
Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma Picard D, Felsberg J, Langini M, Stachura P, Qin N, Macas J, Reiss Y, Bartl J, Selt F, Sigaud R, Meyer FD, Stefanski A, Stühler K, Roque L, Roque R, Pandyra AA, Brozou T, Knobbe-Thomsen C, Plate KH, Roesch A, Milde T, Reifenberger G, Leprivier G, Faria CC, Remke M 2023 Acta Neuropathologica Oncology Highplex FL HALO
Integration of peripheral blood- and tissue-based biomarkers of response to immune checkpoint blockade in urothelial carcinoma Vanguri RS, Smithy JW, Li Y, Zhuang M, Maher CA, Aleynick N, Peng X, Al-Ahmadie H, Funt SA, Rosenberg JE, Iyer G, Bajorin D, Mathews JC, Nadeem S, Panageas KS, Shen R, Callahan MK, Hollmann TJ 2023 Journal of Pathology Immuno-oncology Highplex FL HALO, HALO AI
A pan-cancer single-cell panorama of human natural killer cells Tang F, Li J, Qi L, Liu D, Bo Y, Qin S, Miao Y, Yu K, Hou W, Li J, Peng J, Tian Z, Zhu L, Peng H, Wang D, Zhang Z 2023 Cell Immuno-oncology Highplex FL HALO
Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-driven inflammation O'Brien VP, Kang Y, Shenoy MK, Finak G, Young WC, Dubrulle J, Koch L, Rodriguez Martinez AE, Williams J, Donato E, Batra SK, Yeung CCS, Grady WM, Koch MA, Gottardo R, Salama NR 2023 Cancer Research Communications Oncology, Infectious Disease Highplex FL HALO
Macrophage reprogramming—rather than depletion —is efficacious in a specific subset of colorectal tumor models Mohamed N, Amirkhah R, Lavaud X, Gilroy K, Bartolini R, Mulholland E, Garg A, Pennel K, Jackstadt R, Ridgway R, Nixon C, Hatthakarnku P, Campbell A, Leedham S, Edwards J, Dunne P, Barry S, Graham G, Sansom O 2023 Research Square Immuno-oncology Multiplex IHC, Highplex FL HALO
Proteogenomic analysis of chemo-refractory highgrade serous ovarian cancer Chowdhury S, Kennedy JJ, Ivey RG, Murillo OD, Hosseini N, Song X, Petralia F, Calinawan A, Savage SR, Berry AB, Reva B, Ozbek U, Krek A, Ma W, Leprevost FdV, Ji J, Yoo S, Lin C, Voytovich UJ, Huang Y, Lee SH, Bergan L, Lorentzen TD, Mesri M, Rodriguez H, Hoofnagle AN, Herbert ZT, Nesvizhskii AI, Zhang B, Whiteaker JR, Fenyo D, McKerrow W, Wang J, Schürer SC, Stathias V, Chen XS, Barcellos-Hoff MH, Starr TK, Winterhoff BJ, Nelson AC, Mok SC, Kaufmann SH, Drescher C, Cieslik M, Wang P, Birrer MJ, Paulovich AG 2023 Cell Oncology Highplex FL HALO, HALO Link
Early Detection of Genotoxic Hepatocarcinogens in Rats Using γH2AX and Ki-67: Prediction by Machine Learning Michiba A, Gi M, Yokohira M, Sakurai E, Teramoto A, Kiriyama Y, Yamada S, Wanibuchi H, Tsukamoto T 2023 Toxicological Sciences Oncology Multiplex IHC, Highplex FL HALO
Regulation of antigen-specific T cell infiltration and spatial architecture in multiple myeloma and premalignancy Robinson MH, Villa NY, Jaye DL, Nooka AK, Duffy A, McCachren SS, Manalo J, Switchenko JM, Barnes S, Potdar S, Azeem MI, Horvat AA, Parihar VC, Gong J, Liang Y, Smith GH, Gupta VA, Boise LH, Kaufman JL, Hofmeister CC, Joseph NS, Lonial S, Dhodapkar KM, Dhodapkar MV 2023 Journal of Clinical Investigation Immuno-oncology Highplex FL HALO
ATR-binding lncRNA ScaRNA2 promotes cancer resistance through facilitating efficient DNA end resection during homologous recombination repair Chen Y, Shen H, Liu T, Cao K, Wan Z, Du Z, Wang H, Yu Y, Ma S, Lu E, Zhang W, Cai J, Gao F, Yang Y 2023 Journal of Experimental & Clinical Cancer Research Oncology Highplex FL, TMA HALO
Combined toxic effects of MWCNTs and ZnO nanoparticle on the liver of common carp Gao X, Huang Y, Ren H, Li Y, Chen J, Xu R 2023 Research Square Toxicology Highplex FL HALO
GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis Yang X, Zhao Y, Wei Q, Zhu X, Wang L, Zhang W, Liu X, Kuai J, Wang F, Wei W 2023 Acta Pharmacologica Sinica B Immunology Highplex FL HALO
Perspectives for immunotherapy of EBV-associated GLELC: A relatively “hot” tumor microenvironment Lei Y, Cao P, Zheng X, Wi J, Cheng M, Liu M 2023 Cancer Medicine Oncology Highplex FL HALO
Remodeling Tumor Immune Microenvironment by Using Polymer-Lipid-Manganese Dioxide Nanoparticles with Radiation Therapy to Boost Immune Response of Castration-Resistant Prostate Cancer Zetrini AE, Lip H, Abbasi AZ, Alradwan I, Ahmed T, He C, Henderson JT, Rauth AM, Wu XY 2023 Research Immuno-oncology, Biomaterials Highplex FL HALO
Effects and Mechanisms of the Subtypes of Apolipoprotein E to the Immune State and Prognosis of hepatocellular carcinoma patients Gao B, Zhou P, Wang L, Wang Z, Yi Y, Zhou J, Fan J, Qiu S, Xu Y 2023 Research Square Immuno-oncology Multiplex IHC, Highplex FL HALO
Single-cell RNA-sequencing reveals heterogeneity and intercellular crosstalk in human tuberculosis lung Wang, H, Wen, Z, Niu, L, Chen, X, Liu, H, Zhang, S, Xu, J, Zhu, Y, Li, H, Chen, H, Shi, L, Wan, L, Li, L, Li, M, Wong, K, Song, Y 2023 Journal of Infection Immunology, Infectious Disease Spatial Analysis, Highplex FL HALO
An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development Wang Z, Wu Z, Wang H, Feng R, Wang G, Li M, Wang S, Chen X, Su Y, Wang J, Zhang W, Bao Y, Lan Z, Song Z, Wang Y, Luo X, Zhao L, Hou A, Tian S, Gao H, Miao W, Liu Y, Wang H, Yin C, Ji Z, Feng M, Liu H, Diao L, Amit I, Chen Y, Zeng Y, Ginhoux F, Wu X, Zhu Y, Li H 2023 Cell Immunology Highplex FL HALO
The prognostic value of CD39 +CD8 + T cells as a potential surrogate marker of tumor-specific T cells in Asian triple-negative breast cancer Meng J, Tira TJY, Joseph CR, Ye J, Lim JCT, Goh D, Yuezhen X, Lim X, Koh VCY, Wee F, Tay TKY, Chan JV, Ng CCY, Iqbal J, Lau MC, Elaine LH, Chong TH, The BT, Dent RA, Tan PH, Sheng JYP 2023 Research Square Immuno-oncology Highplex FL HALO
Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin Ruf B, Bruhns M, Babaei S, Kedei N, Ma L, Revsine M, Benmebarek MR, Ma C, Heinrich B, Subramanyam V, Qi J, Wabitsch S, Green BL, Bauer KC, Myojin Y, Greten LT, McCallen JD, Huang P, Trehan R, Wang X, Nur A, Soika DQM, Pouzolles M, Evans CN, Chari R, Kleiner DE, Telford W, Dadkhah K, Ruchinskas A, Stovroff MK, Kang J, Oza K, Ruchirawat M, Kroemer A, Wang XW, Claassen M, Korangy F, Greten TF 2023 Cell Immuno-oncology Classifier, Spatial Analysis, Highplex FL, Figure Maker HALO
Comprehensive analysis of immune subtypes reveals the prognostic value of cytotoxicity and FAP+ fibroblasts in stomach adenocarcinoma Wang X, Hui S, Tan C, Deng Z, Wang X, Weng W, Zhang M, Ni S, Wang L, Huang D, Wang W, Xu M, Sheng W 2023 Cancer Immunology, Immunotherapy Immuno-oncology Highplex FL HALO
Tumor cell HLA class I expression and pathologic response following neoadjuvant immunotherapy for newly diagnosed head and neck cancer Robbins Y, Friedman J, Redman J, Sievers C, Lassoued W, Gulley J, Allen C 2023 Oral Oncology Immuno-oncology Classifier, Spatial Analysis, Highplex FL HALO
Anticoagulants Enhance Molecular and Cellular Immunotherapy of Cancer by Improving Tumor Microcirculation Structure and Function and Redistributing Tumor Infiltrates Wei F, Su Y, Quan Y, Li X, Zou Q, Zhang L, Li S, Jiang M, Lin G, Liang P, He J, Xie K 2023 Clinical Cancer Research Immuno-oncology Classifier, Multiplex IHC, Spatial Analysis, Highplex FL HALO
Combination IFNβ and membrane-stable CD40L maximize tumor dendritic cell activation and lymph node trafficking to elicit systemic T-cell immunity Zheng H, Yu X, Ibrahim M, Foresman D, Xie M, Johnson J, Boyle T, Ruffell B, Perez B, Antonia S, Ready N, Saltos A, Cantwell M, Beg A 2023 Cancer Immunology Research Immuno-oncology Highplex FL HALO
Key Residue in the Precursor Region of M Protein Contributes to the Neurovirulence and Neuroinvasiveness of the African Lineage of Zika Virus He M, Wang H, Yan X, Lou Y, Song G, Li R, Zhu Z, Zhang R, Qin C, Li X 2023 Journal of Virology Infectious Disease Highplex FL HALO
Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer Bancaro N, Cali B, Troiani M, Elia A, Arzola R, Attanasio G, Lai P, Crespo M, Gurel B, Pereira R, Guo C, Mosole S, Brina D, D'Ambrosio M, Pasquini E, Spataro C, Zagato E, Rinaldi A, Pedotti M, Lascio S, Meani F, Montopoli M, Ferrari M, Gallina A, Varani L, Mestre R, Bolis M, Sommer S, de Bono J, Calcinotto A, Alimonti A 2023 Cancer Cell Oncology Classifier, Highplex FL HALO
Acute Influenza Infection Promotes Lung Tumor Growth by Reprogramming the Tumor Microenvironment Garmendia I, Varthaman A, Marmier S, Angrini M, Matchoua I, Darbois-Delahousse A, Josseaume N, Foy P, Roumenina L, Naouar N, Meylan M, Siberil S, Russick J, Joubert P, Leroy K, Damotte D, Mansuet-Lupo A, Wislez M, Alifano M, Menger L, Garcia-Verdugo I, Sallenave J, Lantz O, Petitprez F, Cremer I 2023 Cancer Immunology Research Oncology, Infectious Disease Highplex FL HALO
Spatial mapping reveals granuloma diversity and histopathological superstructure in human tuberculosis Sawyer A, Patrick E, Edwards J, Wilmott J, Fielder T, Yang Q, Barber D, Ernst J, Britton W, Palendira U, Chen X, Feng C 2023 Journal of Experimental Medicine Immunology Multiplex IHC, Spatial Analysis, Highplex FL HALO
Measurement of ovarian tumor immune profiles by multiplex immunohistochemistry: implications for epidemiologic studies Hathaway C, Conejo-Garcia J, Fridley B, Rosner B, Saeed-Vafa D, Segura C, Nguyen J, Hecht J, Sasamoto N, Terry K, Tworoger S, Townsend M 2023 Cancer Epidemiology, Biomarkers & Prevention Immuno-oncology Highplex FL HALO
New insight on the correlation of immune landscapes with immune markers expression in different risk classification of gastrointestinal stromal tumors Zhang Q, Sun X, Hou Y, Gao X, Shen K, Qin X 2023 Journal of Gastroenterology Immuno-oncology Highplex FL HALO
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants Hirschhorn D, Budhu S, Kraehenbuehl L, Gigoux M, Schröder D, Chow A, Ricca J, Gasmi B, De Henau O, Mangarin L, Li Y, Hamadene L, Flamar A, Choi H, Cortez C, Liu C, Holland A, Schad S, Schulze I, Warner A, Hollmann T, Arora A, Panageas K, Rizzuto G, Duhen R, Weinberg A, Spencer C, Ng D, He X, Albrengues J, Redmond D, Egeblad M, Wolchok J, Merghoub T 2023 Cell Area Quantification, Highplex FL HALO
Plaque Macrophage-Targeting Nanosystems with Cooperative Co-Regulation of ROS and TRAF6 for Stabilization of Atherosclerotic Plaques Yang Q, Jiang H, Wang Y, Leng X, Wang Y, Tong J, Zhou Y, Mo C, Peng J, Gao H 2023 Advanced Functional Materials Biomaterials Highplex FL HALO
Functional specialization of short-lived and long-lived macrophage subsets in human tonsils Alaoui L, Villar J, Leclere R, Le Gallou S, Relouzat F, Michaud H, Tarte K, Teissier N, Favier B, Roussel M, Segura E 2023 Journal of Experimental Medicine Immunology Highplex FL HALO
Hepatic proinflammatory myeloid phenotypes are a hallmark of Ebola virus Kikwit pathogenesis in rhesus monkeys Tseng A, Carossino M, Gertje H, O'Connell A, Gummuluru S, Kolachalama V, Balasuriya U, Connor J, Bennett R, Liu D, Hensley L, Crossland N 2023 Veterinary Pathology Infectious Disease Area Quantification, Highplex FL HALO
Circulating and intratumoral immune determinants of response to atezolizumab plus bevacizumab in patients with variant histology or sarcomatoid renal cell carcinoma Saliby R, Zarif T, Bakouny Z, Shah V, Xie W, Flippot R, Denize T, Kane M, Madsen K, Ficial M, Hirsch L, Wei X, Steinarter J, Harshman L, Vaishampayan U, Severgnini M, McDermott D, Lee G, Xu W, Van Allen E, McGregor B, Signoretti S, Choueiri T, McKay R, Braun D 2023 Cancer Immunology Research Immuno-oncology Highplex FL HALO
The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment Lv J, Wei Y, Yin J, Chen Y, Zhou G, Wei C, Liang X, Zhang Y, Zhang C, He S, He Q, Huang Z, Guan J, Shen J, Li X, Li J, Li W, Tang L, Mao Y, Guo R, Sun R, Zheng Y, Zhou W, Xiong K, Wang S, Jin X, Liu N, Li G, Kuang D, Sun Y, Ma J 2023 Nature Medicine Oncology Multiplex IHC, Highplex FL HALO
Bavituximab decreases immunosuppressive myeloid-derived suppressor cells in newly diagnosed glioblastoma patients Ly K, Richardson L, Liu M, Muzikansky A, Cardona J, Lou K, Beers A, Chang K, Brown J, Ma X, Reardon D, Arrillaga-Romany I, Forst D, Jordan J, Lee E, Dietrich J, Nayak L, Wen P, Chukwueke U, Giobbie-Hurder A, Choi B, Batchelor T, Kalpathy-Cramer J, Curry W, Gerstner E 2023 Clinical Cancer Research Immuno-oncology Highplex FL HALO
Single-cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment Cao G, Yue J, Ruan Y, Han Y, Zhi Y, Lu J, Liu M, Xu X, Wang J, Gu Q, Wen X, Gao J, Zhang Q, Kang J, Wang C, Li F 2023 The EMBO Journal Immuno-oncology Highplex FL HALO
Molecular determinants of clinical outcomes of pembrolizumab in recurrent ovarian cancer: Exploratory analysis of KEYNOTE-100 Ledermann JA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Kobie J, Nebozhyn M, Edmondson M, Sun Y, Cristescu R, Jelinic P, Keefe SM, Matulonis UA 2023 Gynecologic Oncology Immuno-oncology Classifier, Highplex FL HALO
Classification of the tumor immune microenvironment and associations with outcomes in patients with metastatic melanoma treated with immunotherapies Adegoke N, Gide T, Mao Y, Quek C, Patrick E, Carlino M, Lo S, Menzies A, da Silva P, Vergara I, Long G, Scolyer R, Wilmott J 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Classifier, Highplex FL HALO
The PD-1- and LAG-3-targeting bispecific molecule tebotelimab in solid tumors and hematologic cancers: a phase 1 trial Luke J, Patel R, Blumenschein R, Hamilton E, Chmielowski B, Ulahannan S, Connolly R, Santa-Maria C, Wang J, Bahadur S, Weickhardt A, Asch A, Mallesara G, Clingan P, Dlugosz-Danecka M, Tomaszewska-Kiecana M, Pylypenko H, Hamad N, Kindler H, Sumrow B, Kaminker P, Chen F, Zhang X, Shah K, Smith D, De Costa A, Li J, Li H, Sun J, Moore P 2023 Nature Medicine Immuno-oncology Highplex FL HALO
High-plex spatial transcriptomic profiling reveals distinct immune components and the HLA class I/DNMT3A/CD8 modulatory axis in mismatch repair-deficient endometrial cancer Guo J, Tang B, Fu J, Zhu X, Xie W, Wang N, Ding Z, Song Z, Yang Y, Xu G, Xiao X 2023 Cellular Oncology Immuno-oncology Highplex FL, Figure Maker HALO
Carcinogen exposure enhances cancer immunogenicity by blocking the development of an immunosuppressive tumor microenvironment Huang M, Xia Y, Li K, Shao F, Feng Z, Li T, Azin M, Demehri S 2023 The Journal of Clinical Investigation Immuno-oncology Highplex FL HALO
The Expression of the Alpha7 Nicotinic Acetylcholine Receptor and the Effect of Smoking in Curdlan-Administered SKG Mice Kim YE, Lee JH, Lee EJ, Kim DH, Jeong MR, Hong S, Lee CK, Yoo B, Youn J, Chang EJ, Kim YG 2023 Biomedicines Immunology Highplex FL HALO
Targeting pancreatic cancer metabolic dependencies through glutamine antagonism Encarnación-Rosado J, Sohn A S W, Biancur D E, Lin E Y, Osorio-Vasquez V, Rodrick T, González-Baerga D, Zhao E, Yokoyama Y, Simeone D M, Jones D R, Parker S J, Wild R, Kimmelman A C 2023 Nature Cancer Oncology Highplex FL HALO, HALO AI
Tumor‐derived Vimentin as a novel biomarker for distinct subtypes predicting adjuvant chemotherapy resistance and T‐cell‐inflamed phenotype in small cell lung cancer Deng C, Wang Y, Fu F, Li D, Zheng Q, Jin Y, Li Y, Chen H, Zhang Y 2023 MedComm Oncology Highplex FL HALO
A Pilot Study of Neoadjuvant Nivolumab, Ipilimumab, and Intralesional Oncolytic Virotherapy for HER2-negative Breast Cancer Nguyen V, Campbell K, Nowicki T, Elumalai N, Medina E, Baselga-Carretero I, DiNome M, Chang H, Oseguera D, Ribas A, Glaspy J 2023 Cancer Research Communications Immuno-oncology Highplex FL HALO
Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage Kumar ST, Nazarov S, Porta S, Majarjan N, Cendrowska U, Kabani M, Finamore F, Xu Y, Lee VMY, Lashuel HA 2023 Nature Neuroscience Neuroscience Area Quantification, Highplex FL HALO
ACE2-independent SARS-CoV-2 virus entry through cell surface GRP78 on monocytes – evidence from a translational clinical and experimental approach Han B, Lv Y, Moser D, Zhou X, Woehrle T, Han L, Osterman A, Rudelius M, Choukér A, Lei P 2023 EBioMedicine Infectious Disease Highplex FL HALO
A neutrophil extracellular traps-related classification predicts prognosis and response to immunotherapy in colon cancer Feng C, Li Y, Tai Y, Zhang W, Wang H, Lian S, Jin-si-han E, Liu Y, Li X, Chen Q, He M, Lu Z 2023 Scientific Reports Immuno-oncology Spatial Analysis, Highplex FL, Figure Maker, TMA HALO
Reversing immunosuppression in the tumor microenvironment of fibrolamellar carcinoma via PD-1 and IL-10 blockade Daniel S, Sullivan K, Dickerson L, van den Bijgaart R, Utria A, Labadie K, Kenerson H, Jiang X, Smythe K, Campbell J, Pierce R, Kim T, Riehle K, Yeung R, Carter J, Barry K, Pillarisetty V 2023 Research Square Immuno-oncology Highplex FL HALO
Anti-PD-1 immunotherapy with androgen deprivation therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer Hawley J E, Obradovic A Z, Dallos M C, Lim E A, Runcie K, Ager C R, McKiernan J, Anderson C B, Decastro G J, Weintraub J, Virk R, Lowy I, Hu J, Chaimowitz M G, Guo X V, Zhang Y, Haffner M C, Worley J, Stein M N, Califano A 2023 Cancer Cell Immuno-oncology Highplex FL HALO
Epigenetic regulation during cancer transitions across 11 tumour types Terekhanova N V, Karpova A, Liang W W, Strzalkowski A, Chen S, Li Y, Southard-Smith A N, Iglesia M D, Wendl M C, Jayasinghe R G, Liu J, Song Y, Cao S, Houston A, Liu X, Wyczalkowski M A, Lu R J, Caravan W, Shinkle A, Naser Al Deen N, Herndon J M, Mudd J, Ma C, Sarkar H, Sato K, Ibrahim O M, Mo C K, Chasnoff S E, Porta-Pardo E, Held J M, Pachynski R, Schwarz J K, Gillanders W E, Kim A H, Vij R, DiPersio J F, Puram S V, Chheda M G, Fuh K C, DeNardo D G, Fields R C, Chen F, Raphael B J, Ding L 2023 Nature Oncology Highplex FL HALO
Imaging mass cytometry reveals tissue-specific cellular immune phenotypes in the mouse knee following ACL injury South SM, Marlin MC, Mehta-D'souza P, Stephens T, Conner T, Burt KG, Guthridge JM, Scanzello CR, Griffin TM 2023 Osteoarthritis and Cartilage Open Immunology Highplex FL HALO
Digital analysis of the prostate tumor microenvironment with high-order chromogenic multiplexing Rajendran R, Beck RC, Waskasi MM, Kelly BD, Bauer DR 2023 Journal of Pathology Informatics Oncology Highplex FL HALO, HALO AI
Liver cancer stem cell dissemination and metastasis: uncovering the role of NRCAM in hepatocellular carcinoma Zhou L, He L, Liu C, Qiu H, Zheng L, Sample KM, Wu Q, Li J, Xie K, Ampuero J, Li Z, Lv D, Liu M, Romero-Gómez M, Hu Y, Tang H 2023 Journal of Experimental & Clinical Cancer Research Oncology Highplex FL HALO
IFN-γ in ovarian tumor microenvironment upregulates HLA-E expression and predicts a poor prognosis Zheng H, Guan X, Meng X, Tong Y, Wang Y, Xie S, Guo L, Lu R 2023 Journal of Ovarian Research Oncology Highplex FL HALO
Patient-derived exosomes facilitate therapeutic targeting of oncogenic MET in advanced gastric cancer Hyung S, Ko J, Heo YJ, Blum SM, Kim ST, Park SH, Park JO, Kang WK, Lim HY, Klempner SJ, Lee J 2023 Science Advances Oncology Highplex FL HALO
Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice Crossland NA, Beck S, Tan WY, Lo M, Mason JB, Zhang C, Guo W, Crott JW 2023 Gut Microbes Other Area Quantification, Highplex FL HALO
The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer Taifour T, Attalla SS, Zuo D, Gu Y, Sanguin-Gendreau V, Proud H, Solymoss E, Bui T, Kuasne H, Papavasiliou V, Lee CG, Kamle S, Siegel PM, Elias JA, Park M, Muller WJ 2023 Immunity Immuno-oncology Classifier, Multiplex IHC, Spatial Analysis, Highplex FL HALO
A machine learning approach toward automating spatial identification of LAG3+/CD3+ cells in ulcerative colitis Bonnevie ED, Dobrzynski E, Steiner D, Hildebrand D, Monslow J, Singh M, Decman V, Krull DL 2023 Scientific Reports Gastroenterology Highplex FL, Registration HALO, HALO AI
The function role of HIGD1A in nonalcoholic steatohepatitis from chronic hepatitis B Li M, Li J, Wang D, Li T, Ye L, Liang X, Zhang H, Liu Z, Zhang X, Li J, Liu Y, Pan C Q, Dai E 2023 Scandinavian Journal of Gastroenterology Gastroenterology Highplex FL HALO
Tanshinone IIA alleviates early brain injury after subarachnoid hemorrhage in rats by inhibiting the activation of NF-κB/NLRP3 inflammasome Yang F, Ma N, Li S, Chen F, Huang X, Zhao L, Cao L 2023 Biological and Pharmaceutical Bulletin Neuroscience Highplex FL HALO
Rosmarinic acid alleviate CORT-induced depressive-like behavior by promoting neurogenesis and regulating BDNF/TrkB/PI3K signaling axis Zeng J, Xie Z, Chen L, Peng X, Luan F, Hu J, Xie H, Liu R, Zeng N 2023 Biomedicine & Pharmacotherapy Neuroscience Highplex FL HALO
Components of the tumor immune microenvironment based on m-IHC correlate with prognosis and subtype of triple-negative breast cancer Lin L, Li H, Wang X, Wang Z, Su G, Zhou J, Sun S, Ma X, Chen Y, You C, Gu Y 2023 Cancer Medicine Immuno-oncology Classifier, Spatial Analysis, Highplex FL HALO
COVID-19 and influenza infections mediate distinct pulmonary cellular and transcriptomic changes Wang C, Khatun M S, Zhang Z, Allen M J, Chen Z, Ellsworth C R, Currey J M, Dai G, Tian D, Bach K, Yin X-M, Traina-Dorge V, Rappaport J, Maness N J, Blair R V, Kolls J K, Pociask D A, Qin X 2023 Communications Biology Infectious Disease Area Quantification, Highplex FL, Figure Maker HALO, HALO AI
Bioinformatics Prediction and Experimental Validation of the Role of Macrophage Polarization and Ferroptosis in Gestational Diabetes Mellitus Chen C, Yang Z, Qiu Z 2023 Journal of Inflammation Research Immunology Highplex FL HALO
Comprehensive prognostic and immune analysis of a glycosylation related risk model in pancreatic cancer Liu XA, Shi J, Tian L, Xiao B, Zhang K, Zhu Y, Zhang YF, Jiang KR, Zhu Y, Yuan H 2023 BMC Cancer Oncology Highplex FL HALO
Chondrocyte Apoptosis as a Potential Mechanism in Ostrich Limb and Toe Disorders: A Pathological Investigation Xian M, Duan B, Tang L, Zhou H, Wang L, Wang R, Chen Z, Fang J, Huang C, Liu W, Geng Y, OuYang P, Guo H, Deng H, Lai W 2023 Pakistan Veterinary Journal Other Highplex FL HALO
Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched intestinal organoids and tumouroids Harter MF, Recaldin T, Gerard R, Avignon B, Bollen Y, Esposito C, Guja-Jarosz K, Kromer K, Filip A, Aubert J, Schneider A, Bacac M, Bscheider M, Stokar-Regenscheit N, Piscuoglio S, Beumer J, Gjorevski N 2023 Nature Biomedical Engineering Immuno-oncology Spatial Analysis, Highplex FL HALO, HALO AI
Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma Sun Y, Wu P, Zhang Z, Wang Z, Zhou K, Song M, Ji Y, Zang F, Lou L, Rao K, Wang P, Gu Y, Gu J, Lu B, Chen L, Pan X, Zhao X, Peng L, Liu D, Chen X, Wu K, Lin P, Wu L, Su Y, Du M, Hou Y, Yang X, Qiu S, Shi Y, Sun H, Zhou J, Huang X, Peng D, Zhang L, Fan J 2023 Cancer Cell Oncology Classifier, Multiplex IHC, Spatial Analysis, Highplex FL HALO
Cholesterol efflux drives the generation of immunosuppressive macrophages to promote the progression of human hepatocellular carcinoma Li Z, Wang Y, Xing R, Zeng H, Yu X, Zhang Y, Xu J, Zheng L 2023 Cancer Immunology Research Immuno-oncology Multiplex IHC, Highplex FL HALO
Effects of estradiol, progesterone or cAMP on expression of PGRMC1 and progesterone receptor in a xenograft model of human endometrium and in endometrial cell culture Van Wynendaele M, Thieffry C, Samain L, Pierreux C, Tyteca D, Marbaix E, Henriet P 2023 Steroids Other Highplex FL HALO
Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy Zuo Chong, Baer J, Knolhoff B, Belle J, Liu X, De La Lastra A, Fu C, Hogg G, Kingston N, Breden M, Dodhiawala P, Zhou D, Lander V, James C, Ding L, Lim K, Fields R, Hawkins W, Wber J, Zhao G, DeNardo D 2023 Journal of Experimental Medicine Immuno-oncology Highplex FL HALO
Tumor Microenvironment Modifications Induced by Afatinib in Squamous Cell Carcinoma of the Head and Neck: A Window-of-Opportunity Study (EORTC-90111–24111) Beyaert SP, Loriot AE, Huyghe ND, Goebbels RM, Mendola A, Govaerts AS, Fortpied C, Baldin P, Licitra LF, Lalami Y, Clement PM, Machiels JPH, Schmitz S 2023 Clinical Cancer Research Oncology Highplex FL HALO
Complex Urban Atmospheres alters Alveolar Stem Cells Niche Properties and drives Lung Fibrosis Belgacemi R, Baptista BR, Justeau G, Toigo M, Frauenpreis A, Yilmaz R, Der Vartanian A, Cazaunau M, Pangui E, Bergé A, Gratien A, Macias Rodriguez JC, Bellusci S, Derumeaux G, Boczkowski J, Al Alam D, Coll P, Lanone S, Boyer L 2023 American Journal of Physiology - Lung Cellular and Molecular Physiology Fibrosis Classifier, Area Quantification, Highplex FL HALO
Modified Bushen Yiqi formula enhances antitumor immunity by reducing the chemotactic recruitment of M2-TAMs and PMN-MDSCs in Lewis lung cancer-bearing mice Kong Q, Zhu H, Gong W, Deng X, Liu B, Dong J 2023 Journal of Ethnopharmacology Immuno-oncology Multiplex IHC, Highplex FL HALO
TRβ Agonism Induces Tumor Suppression and Enhances Drug Efficacy in Anaplastic Thyroid Cancer in Female Mice Gillis NE, Cozzens LM, Wilson ER, Smith NM, Tomczak JE, Bolf EL, Carr FE 2023 Endocrinology Oncology Highplex FL HALO
Characterization of immunosuppressive myeloid cells in Merkel cell carcinoma: correlation with resistance to PD-1 pathway blockade Tabachnick-Cherny S, Pulliam T, Rodriguez H, Fan X, Hippe D, Jones D, Moshiri A, Smythe K, Kulikauskas R, Zaba L, Paulson K, Nghiem P 2023 Clinical Cancer Research Immuno-oncology Highplex FL HALO
Unlocking the Hidden Depths: Multi-Modal Integration of Imaging Mass Spectrometry-Based and Molecular Imaging Techniques Akbari B, Huber BR, Sherman JH 2023 Critical Reviews in Analytical Chemistry Review Highplex FL HALO, HALO AI, HALO Link, HALO AP
Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance Guo C, Sharp A, Gurel B, Crespo M, Figueiredo I, Jain S, Vogl U, Rekowski J, Rouhifard M, Gallagher L, Yuan W, Carreira S, Chandran K, Paschalis A, Colombo I, Stathis A, Bertan C, Seed G, Goodall J, Raynaud F, Ruddle R, Swales K, Malia J, Bogdan D, Tiu C, Caldwell R, Aversa C, Ferreira A, Neeb A, Tunariu N, Westaby D, Carmichael J, Maza M, Yap C, Matthews R, Badham H, Prout T, Turner A, Parmar M, Tovey H, Riisnaes R, Flohr P, Gil J, Waugh D, Decordova S, Schlag A, Calì B, Alimonti A, de Bono J S 2023 Nature Oncology Spatial Analysis, Highplex FL HALO, HALO AI
The tumor microenvironment state associates with response to HPV therapeutic vaccination in patients with respiratory papillomatosis NORBERG S, BAI K, SIEVERS C, ROBBINS Y, FRIEDMAN J, YANG X, KENYON M, WARD E, SCHLOM J, GULLEY J, LANKFORD A, SEMNANI R, SABZEVARI H, BROUGH D, ALLEN C 2023 Science Translational Medicine Oncology Classifier, Highplex FL HALO, HALO AI
Integrated FET sensing microsystem for specific detection of pancreatic cancer exosomal miRNA10b Yu Y, Liang C, Wan QQ, Jin D, Liu X, Zhang Z, Sun ZY, Zhang GJ 2023 Analytica Chimica Acta Oncology Highplex FL HALO
Construction and Mechanism of IL-15-based Co-Activated Polymeric Micelles for NK Cell Immunotherapy Shao D, Bai T, Zhu B, Guo X, Dong K, Shi J, Huang Q, Kong J 2023 Advanced Healthcare Materials Immuno-oncology Highplex FL HALO
Exocrine pancreas in type 1 and type 2 diabetes: different patterns of fibrosis, metaplasia, angiopathy, and adiposity  Wright J, Eskaros A, Windon A, Bottino R, Jenkins R, Bradley A, Aramandla R, Philips S, Kang H, Saunders D, Brissova M, Powers A 2023 Diabetes Gastroenterology Classifier, Highplex FL HALO
Tissue-specific features of the T cell repertoire after allogeneic hematopoietic cell transplantation in human and mouse DeWolf S, Elhanati Y, Nichols K, Waters N R, Nguyen C L, Slingerland J B, Rodriguez N, Lyudovyk O, Giardina P A, Kousa A I, Andrlová H, Ceglia N, Fei T, Kappagantula R, Li Y, Aleynick N, Baez P, Murali R, Hayashi A, Lee N, Gipson B, Rangesa M, Katsamakis Z, Dai A, Blouin A G, Arcila M, Masilionis I, Chaligné R, Ponce D M, Landau H J, Politikos I, Tamari R, Hanash A M, Jenq R R, Giralt S A, Markey K A, Zhang Y, Perales M-A, Socci N D, Greenbaum B D, Iacobuzio-Donahue C A, Hollmann T J, van den Brink M R M, Peled J U 2023 Science Translational Medicine Immunology Highplex FL HALO
Influence of multi-walled carbon nanotubes on the toxicity of ZnO nanoparticles in the intestinal histopathology, apoptosis, and microbial community of common carp Gao X, Ren H, Huang Y, Li Y, Shen J 2023 Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology Toxicology Highplex FL HALO
Integrative multiomics enhancer activity profiling identifies therapeutic vulnerabilities in cholangiocarcinoma of different etiologies Hong J, Yong C, Heng H, Chan J, Lau M, Chen J, Lee J, Lim A, Li Z, Guan P, Chu P, Boot A, Ng S, Yao X, Wee F, Lim J, Liu W, Wang P, Xiao R, Zeng X, Sun Y, Koh J, Kwek X, Ng C, Klanrit P, Zhang Y, Lai J, Tai D, Pairojkul C, Dima S, Popescu I, Hsieh S, Yu M, Yeong J, Kongpetch S, Jusakul A, Loilome W, Tan P, Tan J, Teh B 2023 Gut Oncology Highplex FL HALO
Neoadjuvant chemotherapy is linked to an amended anti-tumorigenic microenvironment in gastric cancer Huan X, Zou K, Zhang P, Ding H, Luo C, Xiang C, Xu S, Zhuang Y, Wu C, Wang Y, Wu X, Chen C, Zhang J, Yao X, Liu F, Liu S, Wu Z 2023 International Immunopharmacology Immuno-oncology Spatial Analysis, Highplex FL HALO
A novel molecular subtyping based on multi-omics analysis for prognosis predicting in colorectal melanoma: A 16-year prospective multicentric study Liu C, Cheng X, Han K, Hong L, Hao S, Sun X, Xu J, Li B, Jin D, Tian W, Jin Y, Wang Y, Fang W, Bao X, Zhao P, Chen D 2024 Cancer Letters Oncology Highplex FL HALO
Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer Wang J, Wei J, Pu T, Zeng A, Karthikeyan V, Bechtold B, Vo K, Chen J, Lin TP, Chang AP, Corey E, Puhr M, Klocker H, Culig Z, Bland T, Wu BJ 2024 Cell Reports Medicine Oncology Highplex FL HALO
Preclinical evaluation of a novel CAR-T therapy utilizing a scFv antibody highly specific to MAGE-A4p230-239/HLA-A*02:01 complex Wang L, Matsumoto M, Akahori Y, Seo N, Shirakura K, Kato T, Katsumoto Y, Miyahara Y, Shiku H 2024 Molecular Therapy Immuno-oncology Highplex FL HALO
Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis Frei AL, McGuigan A, Sinha RAK, Jabbar F, Gneo L, Tomasevic T, Harkin A, Iveson T, Saunders MP, Oien KA, Maka N, Pezzella F, Campo L, Browne M, Glaire M, Kildal W, Danielsen HE, Hay J, Edwards J, Sansom O, Kelly C, Tomlinson I, Kerr R, Kerr D, Domingo E, consortium T, Church DN, Koelzer VH 2024 The Lancet Oncology Immuno-oncology Area Quantification, Highplex FL, TMA HALO, HALO AI
Early immune remodeling steers clinical response to frontline chemoimmunotherapy in advanced gastric cancer An M, Mehta A, Min BH, Geo YJ, Wright SJ, Parikh M, Bi L, Lee H, Kim TJ, Lee SY, Moon J, Park RJ, Strickland MR, Park WY, Kang WK, Kim KM, Kim ST, Lempner SJ, Lee J 2024 Cancer Discovery Immuno-oncology Classifier, Highplex FL HALO
Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells WANG J, GAI J, ZHANG T, NIU N, QI H, THOMAS II D L, LI K, XIA T, RODRIGUEZ C, PARKINSON R, DURHAM J, MCPHAUL T, NARANG A K, ANDERS R A, OSIPOV A, WANG H, HE J, LAHERU D A, HERMAN J M, LEE V, JAFFEE E M, THOMPSON E D, ZHU Q, ZHENG L 2024 Science Advances Immuno-oncology Spatial Analysis, Highplex FL, Registration HALO
Stromal-derived MAOB promotes prostate cancer growth and progression Pu T, Wang J, Wei J, Zeng A, Zhang J, Chen J, Yin L, Li J, Lin T, Melamed J, Corey E, Gao A, Wu B 2024 Science Advances Oncology Multiplex IHC, Highplex FL HALO
Multiomic molecular characterization of the response to combination immunotherapy in MSS/pMMR metastatic colorectal cancer Takei S, Tanaka Y, Lin Y, Koyama S, Fukuoka S, Hara H, Nakamura Y, Kuboki Y, Kotani D, Kojima T, Bando H, Mishima S, Ueno T, Kojima S, Wakabayashi M, Sakamoto N, Kojima M, Kuwata T, Yoshino T, Nishikawa H, Mano H, Endo I, Shitara K, Kawazoe A 2024 Journal for ImmunoTherapy of Cancer Immuno-oncology Highplex FL HALO
Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer Hirai T, Naito Y, Koyama S, Nakanishi Y, Masuhiro K, Izumi M, Kuge T, Naito M, Mizuno Y, Yamaguchi Y, Kang S, Yaga M, Futami Y, Nojima S, Nishide M, Morita T, Kato Y, Tsuda T, Takemoto N, Kinugasa-Katayama Y, Aoshi T, Villa J K, Yamashita K, Enokida T, Hoshi Y, Matsuura K, Tahara M, Takamatsu H, Takeda Y, Inohara H, Kumanogoh A 2024 JCI Insight Immuno-oncology Highplex FL HALO
Myeloid-Mas Signaling Modulates Pathogenic Crosstalk among MYC+CD63+ Endothelial Cells, MMP12+ Macrophages, and Monocytes in Acetaminophen-Induced Liver Injury Chen S, Lu Z, Zhao Y, Xia L, Liu C, Zuo S, Jin M, Jia H, Li S, Zhang S, Yang B, Wang Z, Li J, Wang F, Yang C 2024 Advanced Science Gastroenterology Highplex FL HALO
Cooperative pro-tumorigenic adaptation to oncogenic RAS through epithelial-to-mesenchymal plasticity De Blander H, Tonon L, Fauvet F, Pommier R M, Lamblot C, Benhassoun R, Angileri F, Gibert B, Rodriguez R, Ouzounova M, Morel A P, Puisieux A 2024 Science Advances Oncology Highplex FL HALO
Impact of metronomic trabectedin combined with low-dose cyclophosphamide on sarcoma microenvironment and correlation with clinical outcome: results from the TARMIC study Sun C-M, Toulmonde M, Spalato-Ceruso M, Peyraud F, Bessede A, Kind M, Cousin S, Buy X, Palussiere J, Bougouin A, Sautès-Fridman C, Fridman H W, Pulido M, Italiano A 2024 Molecular Cancer Oncology Multiplex IHC, Highplex FL HALO
Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis Mennillo E, Kim Y, Lee G, Rusu I, Patel R K, Dorman L C, Flynn E, Li S, Bain J L, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Lotstein M L, Rahim M, Naser M, Bernard-Vazquez F, Eckalbar W, Cho S, Beck K, El-Nachef N, Lewin S, Selvig D R, Terdiman J P, Mahadevan U, Oh D Y, Fragiadakis G K, Pisco A, Combes A J, Kattah M G 2024 Nature Communications Immunology ISH, Spatial Analysis, Highplex FL, TMA HALO, HALO AI
PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma Shu G, Chen M, Liao W, Fu L, Lin M, Gui C, Cen J, Lu J, Chen Z, Wei J, Chen W, Wang Y, Zhu J, Zhao T, Liu X, Jing J, Liu G, Pan Y, Luo J, Zhang J 2024 Cancer Research Oncology Highplex FL HALO, HALO AI
Identification of tyrosine brominated extracellular matrix proteins in normal and fibrotic lung tissues Cruz LC, Habibovic A, Dempsey B, Massafera MP, Janssen-Heininger YM, Lin MJ, Hoffman ET, Weiss DJ, Huang SK, van der Vliet A, Meotti FC 2024 Redox Biology Fibrosis Area Quantification, Highplex FL HALO
Identification of the metaphyseal skeletal stem cell building trabecular bone YANG G, HE Q, GUO X, LI R, LIN J, LANG Y, TAO W, LIU W, LIN H, XING S, QI Y, XIE Z, HAN J, ZHOU B, TENG Y, YANG X 2024 Science Advances Other Highplex FL HALO
Serum amyloid A promotes glycolysis of neutrophils during PD-1 blockade resistance in hepatocellular carcinoma He M, Liu Y, Chen S, Deng H, Feng C, Qiao S, Chen Q, Hu Y, Chen H, Wang X, Jiang X, Xia X, Zhao M, Lyu N 2024 Nature Communications Immuno-oncology Spatial Analysis, Highplex FL HALO
PDGFRa+ ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay Zheng H, An M, Luo Y, Diao X, Zhong W, Pang M, Lin Y, Chen J, Li Y, Kong Y, Zhao Y, Yin Y, Ai L, Huang J, Chen C, Lin T 2024 Cancer Cell Oncology Spatial Analysis, Highplex FL HALO
Multi-omics and imaging mass cytometry characterization of human kidneys to identify pathways and phenotypes associated with impaired kidney function. Asowata E O, Romoli S, Sargeant R, Tan J Y, Hoffmann S, Huang M M, Mahbubani K T, Krause F N, Jachimowicz D, Agren R, Koulman A, Jenkins B, Musial B, Griffin J L, Soderberg M, Ling S, Hansen P B L, Saeb-Parsy K, Woollard K J 2024 Kidney International Other ISH, Spatial Analysis, Highplex FL HALO, HALO AI
An immune cell map of human lung adenocarcinoma development reveals an anti-tumoral role of the Tfh-dependent tertiary lymphoid structure Liu W, You W, Lan Z, Ren Y, Gao S, Li S, Chen W, Huang C, Zeng Y, Xiao N, Wang Z, Xie H, Ma H, Chen Y, Wang G, Chen C, Li H 2024 Cell Reports Medicine Immuno-oncology Multiplex IHC, Highplex FL HALO
Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer (NECTAR): a multi-center phase 2 study Yang Z, Gao J, Zheng J, Han J, Li A, Liu G, Sun Y, Zhang J, Chen G, Xu R, Zhang X, Liu Y, Bai Z, Deng W, He W, Yao H, Zhang Z 2024 Signal Transduction and Targeted Therapy Immuno-oncology Highplex FL HALO

Related HALO Modules

Multiplex IHC

Quantify expression of up to five brightfield stains in any cellular compartment - membrane, nucleus or cytoplasm.

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Tissue Classifier Add-On

Separate multiple tissue classes across a tissue using a learn-by-example approach. Can be used in conjunction with all other modules (fluorescent and brightfield) to select specific tissue classes for further analysis.

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Spatial Analysis

Plot cells and objects from one or more images and perform nearest neighbor analysis, proximity analysis, and tumor infiltration analysis.

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