Before Markup

Highplex FL​ Module

Try It Out

Simultaneously analyze an unlimited number of fluorescent markers in any cellar compartment (nucleus, cytoplasm, and/or membrane) with the HALO® Highplex FL module. This module excels in immuno-oncology applications that demand multiple markers to distinguish between various immune and tumor cell populations within the tissue. Optimize your image analysis with available pre-trained AI-based membrane and/or nuclear segmentation, use threshold assistance features to set data-driven channel positivity thresholds, and define cell types of interest with the streamlined phenotype editor. Once optimized, leverage interactive markups to dynamically explore colocalization and combined cell phenotypes.​

File formats supported by the HALO image analysis platform:

  • Non-proprietary (JPG, TIF, OME.TIFF)
  • Nikon (ND2)
  • 3D Histech (MRXS)
  • Akoya (QPTIFF, component TIFF)
  • Olympus / Evident (VSI)
  • Hamamatsu (NDPI, NDPIS)
  • Aperio (SVS, AFI)
  • Zeiss (CZI)
  • Leica (SCN, LIF)
  • Ventana (BIF)
  • Philips (iSyntax, i2Syntax)
  • KFBIO (KFB, KFBF)
  • DICOM (DCM*)
    *whole-slide images

Spatial Analysis Application Note

Download this application note to learn about the tools provided by the HALO Spatial Analysis module and how they are used to identify proximity and relative spatial distribution of cells and objects.

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High Dimensional Analysis Application Note

In this application note, we walk through the steps and options in the HALO High Dimensional Analysis module workflow and demonstrate how this module enables researchers to interactively explore highly multiplexed datasets and extract biologically meaningful insights.

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Publication Spotlight

The table below includes publications that cite the Highplex FL module. 

Your publication not on the list?  Drop us an email to let us know about it!

TitleAuthorsYearJournalTopicsHALO ModulesProducts
T helper 2 cell–directed immunotherapy eliminates precancerous skin lesionsOka T, Smith S, Son H, Lee T, Oliver-Garcia V, Mortaja M, Trerice K, Isakoff L, Conrad D, Azin M, Raval N, Tabacchi M, Emdad L, Das S, Fisher P, Cornelius L, Demehri S2025The Journal of Clinical InvestigationImmuno-oncologyHighplex FLHALO
Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentationEstephan H, Tailor A, Parker R, Kreamer M, Papandreou I, Campo L, Easton A, Moon EJ, Denko NC, Ternette N, Hammond EM, Giaccia AJ2025The EMBO JournalImmuno-oncologyClassifier, Area Quantification, Spatial Analysis, Highplex FLHALO
PlexinD1 is a driver and a therapeutic target in advanced prostate cancerWei J, Wang J, Guan W, Li J, Pu T, Corey E, Lin TP, Gao AC, Wu BJ2025EMBO Molecular MedicineOncologyHighplex FLHALO
Tracking non-genetic evolution from primary to metastatic ccRCC: TRACERx RenalFernández-Sanromán Á, Fendler A, Tan B J.Y., Cattin A-L, Spencer C, Thompson R, Au L, Lobon I, Pallikonda H A, Martin A, Byrne F, Franz A, Mikolajczak A, Rahman H, Tippu Z, Shepherd S T.C., Feng H, Deng D, Rowan A, Pickering L, Furness A J S, Young K, Nicol D, Rudman S M, O’Brien T, Edmonds K, Chandra A, Hazell S, Litchfield K, Kassiotis G, Larkin J, Turajlic S2025Cancer DiscoveryOncologyHighplex FLHALO, HALO AI
CD4+ T helper 2 cell–macrophage crosstalk induces IL-24–mediated breast cancer suppressionWang B, Xia Y, Zhou C, Zeng Y, Son HG, Demehri S2025JCI InsightImmuno-oncologyHighplex FLHALO
Phase 1 Trial of TTI-101, a First-in-Class Oral Inhibitor of STAT3 in Patients with Advanced Solid TumorsTsimberidou A M, Vining D J, Arora S P, de Achaval S, Larson J, Kauh J, Cartwright C, Avritscher R, Alibhai I, Tweardy D J, Kaseb A O2025Clinical Cancer ResearchOncologyHighplex FLHALO
Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healingKong G, Song Y, Yan Y, Calderazzo S M, Saddala M S, Rivera F D L, Cherry J D, Eckman N, Appel E A, Velenosi A, Swarup V, Kawaguchi R, Ng S S, Kwon B K, Gate D, Engwerda C R, Zhou L, Di Giovanni S2025NeuronNeuroscienceHighplex FLHALO
Efficacy and tolerability of neoadjuvant therapy with Talimogene laherparepvec in cutaneous basal cell carcinoma: a phase II trial (NeoBCC trial)Ressler J M, Plaschka M, Silmbrod R, Bachmayr V, Shaw L E, Silly T, Zila N, Stepan A, Kusienicka A, Tschandl P, Tittes J, Roka F, Haslik W, Petzelbauer P, Koenig F, Kunstfeld R, Farlik M, Halbritter F, Weninger W, Hoeller C2025Nature CancerOncologyClassifier, Spatial Analysis, Highplex FLHALO
CD36 enrichment in HER2-positive mesenchymal stem cells drives therapy refractoriness in breast cancerCastagnoli L, Franceschini A, Cancila V, Dugo M, Bigliardi M, Chiodoni C, Toneguzzo P, Regondi V, Corsetto P A, Pietrantonio F, Mazzucchelli S, Corsi F, Belfiore A, Vingiani A, Pruneri G, Ligorio F, Colombo M P, Tagliabue E, Tripodo C, Vernieri C, Triulzi T, Pupa S M2025Journal of Experimental & Clinical Cancer ResearchOncologyMultiplex IHC, Highplex FLHALO
Systemic IFN-I combined with topical TLR7/8 agonists promotes distant tumor suppression by c-Jun-dependent IL-12 expression in dendritic cellsSanlorenzo M, Novoszel P, Vujic I, Gastaldi T, Hammer M, Fari O, De Sa Fernandes C, Landau A D, Göcen-Oguz B V, Holcmann M, Monshi B, Rappersberger K, Csiszar A, Sibilia M2025Nature CancerImmuno-oncologyHighplex FLHALO
Single-cell transcriptomics identify a novel macrophage population associated with bone invasion in pituitary neuroendocrine tumorsWu X, Han X, Zhu H, Li M, Gong L, Jing S, Xie W, Liu Z, Li C, Zhang Y2025Journal of Experimental & Clinical Cancer ResearchImmuno-oncologyHighplex FLHALO
Large-scale transcript variants dictate neoepitopes for cancer immunotherapyJi S, Wang F, Wu Y, Hu H, Xing Z, Zhu J, Xu S, Han T, Liu G, Wu Z, Fei C, Kong L, Chen J, Ding Z, Huang Z, Zhang J2025Science AdvancesImmuno-oncologyHighplex FLHALO
Nanrilkefusp alfa (SOT101), an IL-15 receptor βγ superagonist, as a single agent or with anti-PD-1 in patients with advanced cancersChampiat S, Garralda E, Galvao V, Cassier P A, Gomez-Roca C, Korakis I, Grell P, Naing A, LoRusso P, Mikyskova R, Podzimkova N, Reinis M, Ouali K, Schoenenberger A, Kiemle-Kallee J, Tillmanns S, Sachse R, Moebius U, Spisek R, Bechard D, Jelinkova L P, Adkins I, Marabelle A2025Cell Reports MedicineImmuno-oncologySpatial Analysis, Highplex FL, RegistrationHALO
Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastomaLong G V, Shklovskaya E, Satgunaseelan L, Mao Y, Silva I P da, Perry K A, Diefenbach R J, Gide T N, Shivalingam B, Buckland M E, Gonzalez M, Caixeiro N, Vergara I A, Bai X, Rawson R V, Hsiao E, Palendira U, Phan T G, Menzies A M, Carlino M S, Quek C, Grimmond S M, Vissers J H A, Yeo D, Rasko J E J, Khasraw M, Neyns B, Reardon D A, Ashley D M, Wheeler H, Back M, Scolyer R A, Drummond J, Wilmott J S, Rizos H2025Nature MedicineImmuno-oncologyHighplex FLHALO
NETs-CD44-IL-17A Feedback Loop Drives Th17-Mediated Inflammation in Behçet’s UveitisWu Y, Ning K, Huang Z, Chen B, Chen J, Wen Y, Bu J, Hong H, Chen Q, Zhang Z, Jia R, Su W2025Advanced ScienceImmunologyHighplex FLHALO
Atezolizumab following definitive chemoradiotherapy in patients with unresectable locally advanced esophageal squamous cell carcinoma – a multicenter phase 2 trial (EPOC1802)Bando H, Kumagai S, Kotani D, Mishima S, Irie T, Itahashi K, Tanaka Y, Habu T, Fukaya S, Kondo M, Tsushima T, Hara H, Kadowaki S, Kato K, Chin K, Yamaguchi K, Kageyama S, Hojo H, Nakamura M, Tachibana H, Wakabayashi M, Fukui M, Fuse N, Koyama S, Mano H, Nishikawa H, Shitara K, Yoshino T, Kojima T2025Nature CancerImmuno-oncologyHighplex FLHALO
Neoleukin-2/15-armored CAR-NK cells sustain superior therapeutic efficacy in solid tumors via c-Myc/NRF1 activationLuo J, Guo M, Huang M, Liu Y, Qian Y, Liu Q, Cao X2025Signal Transduction and Targeted TherapyImmuno-oncologyHighplex FLHALO
SPARROW reveals microenvironment-zone-specific cell states in healthy and diseased tissuesZhao PA, Li R, Adewunmi T, Garber J, Gustafson C, Kim J, Malone J, Savage A, Skene P, Li XJ2025Cell SystemsOtherHighplex FLHALO, HALO AI
Diffusion and contrast-enhancement MRI phenotypes associated with immune checkpoint inhibitor exposure and with immune cell infiltration in brain metastasesSanvito F, Nocera G, Wang Z, Shiuan E, Sun L, Oshima S, Kim A, Kryukov I, Shao G, Cho N S, Salamon N, Ellingson B M, Prins R, Kim W, Yao J2025Neuro-OncologyImmuno-oncologyHighplex FLHALO
Soluble CD27 differentially predicts resistance to anti-PD1 alone but not with anti-CTLA-4 in melanomaSam I, Benhamouda N, Biard L, Da Meda L, Desseaux K, Baroudjan B, Nakouri I, Renaud M, Sadoux A, Alkatrib M, Deleuze J-F, Battistella M, Shen Y, Resche-Rigon M, Mourah S, Lebbe C, Tartour E2025EMBO Molecular MedicineImmuno-oncologySpatial Analysis, Highplex FLHALO
A single-cell atlas reveals immune heterogeneity in anti-PD-1-treated non-small cell lung cancerLiu Z, Yang Z, Wu J, Zhang W, Sun Y, Zhang C, Bai G, Yang L, Fan H, Chen Y, Zhang L, Jiang B, Liu X, Ma X, Tang W, Liu C, Qu Y, Yan L, Zhao D, Wu Y, He S, Xu L, Peng L, Chen X, Zhou B, Zhao L, Zhao Z, Tan F, Zhang W, Yi D, Li X, Gao Q, Zhang G, Wang Y, Yang M, Fu H, Guo Y, Hu X, Cai Q, Qi L, Bo Y, Peng H, She Y, Zou C, Zhu L, Cheng S, Zhang Y, Zhong W, Chen C, Gao S, Zhang Z2025CellImmuno-oncologyHighplex FLHALO
Tumor cells that resist neutrophil anticancer cytotoxicity acquire a prometastatic and innate immune escape phenotypeSzlachetko JA, Hofmann-Vega F, Budeus B, Schröder L-J, Dumitru C A, Schmidt M, Deuss E, Vollmer S, Hanschmann E-M, Busch M, Kehrmann J, Lang S, Dünker N, Hussain T, Brandau S2025Cellular and Molecular ImmunologyImmuno-oncologySpatial Analysis, Highplex FLHALO
A spatially resolved transcriptome landscape during thyroid cancer progressionLiao T, Zeng Y, Xu W, Shi X, Shen C, Du Y, Zhang M, Zhang Y, Li L, Ding P, Hu W, Huang Z, Fung M H M, Ji Q, Wang Y, Li S, Wei W2025Cell Reports MedicineOncologyHighplex FLHALO
TIMEPOINT, a phase 1 study combining MTL-CEBPA with pembrolizumab, supports the immunomodulatory effect of MTL-CEBPA in solid tumorsPlummer R, Sodergren M H, Hodgson R, Ryan B M, Raulf N, Nicholls J P, Reebye V, Voutila J, Sinigaglia L, Meyer T, Pinato D J, Sarker D, Basu B, Blagden S, Cook N, Evans T R J, Yachnin J, Chee C E, Li D, El-Khoueiry A, Diab M, Huang K W, Pai M, Spalding D, Talbot T, Noel M S, Keenan B, Mahalingam D, Song M S, Grosso M, Arnaud D, Auguste A, Zacharoulis D, Storkholm J, McNeish I, Habib R, Rossi J J, Habib N A2025Cell Reports MedicineImmuno-oncologyHighplex FLHALO
Multiplex imaging of murine bone marrow using Phenocycler 2.0™Karnik S J, Gulbronson C, Jordan P C, Kanumuri R, Ramdas B, Kumar R, Hartman M L, Khurram I, Brown D M, Pollok K E, Singh P, Kapur R, Kacena M A2025LeukemiaOtherHighplex FLHALO
Neo-adjuvant pembrolizumab in stage IV high-grade serous ovarian cancer: the phase II Neo-Pembro trialAronson S L, Thijssen B, Lopez-Yurda M, Koole S N, van der Leest P, León-Castillo A, Harkes R, Seignette I M, Sanders J, Alkemade M, Kemper I, Holtkamp M J, Mandjes I A M, Broeks A, Lahaye M J, Rijlaarsdam M A, van den Broek D, Wessels L F A, Horlings H M, van Driel W J, Sonke G S2025Nature CommunicationsImmuno-oncologyClassifier, Highplex FLHALO
Phase 2 trial of perioperative chemo-immunotherapy for gastro-esophageal adenocarcinoma: The role of M2 macrophage landscape in predicting responseAlcindor T, Tankel J, Fiset P-O, Pal S, Opu T, Strasser M, Dehghani M, Bertos N, Zuo D, Mueller C, Cools-Lartigue J, Hickeson M, Marcus V, Camilleri-Broet S, Spatz A, Evaristo G, Farag M, Artho G, Elkrief A, Saleh R, Bailey S, Park M, Huang S, Sangwan V, Ferri L2025Cell Reports MedicineImmuno-oncologyClassifier, Spatial Analysis, Highplex FLHALO
Glycine receptor activation promotes pancreatic islet cell proliferation via the PI3K/mTORC1/p70S6K pathwayZhang Z, Ye W W, Piro A L, Wang D S, Untereiner A, Lyons S A, Bhattacharjee A, Singh I, Beaudry J L, Orser B A, Dai F F, Wheeler M B2025JCI InsightOtherArea Quantification, Highplex FLHALO
Inhaled DNAI1 mRNA therapy for treatment of primary ciliary dyskinesiaHenniga M, Bhattacharjeea R B, Agarwala I, Alfaifia A, Casillasa J E, Chaveza S, Ishimarua D, Listona D, Mohapatraa S, Mollaa T, Patharea S, Sidhua M S, Wanga P, Wanga Z, Lombanaa T N, Kharitonova V G, Coucha J A, Lockharta D J, Wus B A2025Proceedings of the National Academy of SciencesOtherHighplex FLHALO
SPP1 + macrophages cause exhaustion of tumor-specific T cells in liver metastasesTrehan R, Huang P, Zhu X B, Wang X, Soliman M, Strepay D, Nur A, Kedei N, Arhin M, Ghabra S, Rodríguez-Matos F, Benmebarek M R, Ma C, Korangy F, Greten T F2025Nature CommunicationsImmuno-oncologyHighplex FLHALO
Highly conserved brain vascular receptor ALPL mediates transport of engineered AAV vectors across the blood-brain barrierMoyer T C, Hoffman B A, Chen W, Shah I, Ren X-Q, Knox T, Liu J, Wang W, Li J, Khalid H, Kulkarni A S, Egbuchulam M, Clement J, Bloedel A, Child M, Kaur R, Rouse E, Graham K, Maura D, Thorpe Z, Sayed-Zahid A, Chung C H-Y, Kutchin A, Johnson A, Yao J, Thompson J, Pande N, Nonnenmacher M E2025Molecular TherapyNeuroscienceMultiplex IHC, Highplex FLHALO, HALO AI
Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilitiesChen Q, Cai R, Wang Y, Liang G, Zhang K, Yang X, Yang D, Zhao D, Zhu X, Deng R, Tang J2025Molecular CancerOncologyClassifier, Cytonuclear, Highplex FLHALO
Dissecting small cell carcinoma of the esophagus ecosystem by single-cell transcriptomic analysisWu H-X, Chen Y-K, Wang Y-N, Chen J-Y, Xiang S-J, Jin Y, Wang Z-X, Huang C-Y, Yang L-P, He Y, Guan W-L, Bai L, Chen Y-X, Wang M, Wang C-Y, Huang R-J, Huang Y, Zhang J-L, Lv Z-D, Yang S-Q, Xu R-H, Zhao Q, Wang F2025Molecular CancerOncologyHighplex FLHALO
Spatial mapping of innate lymphoid cells in human lymphoid tissues and lymphoma at single-cell resolutionVan Acker N, Frenois F-X, Gravelle P, Tosolini M, Syrykh C, Laurent C, Brousset P2025Nature CommunicationsImmuno-oncologySpatial Analysis, Highplex FL, RegistrationHALO
Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging of 13C-labelled glucose metabolismTsyben A, Dannhorn A, Hamm G, Pitoulias M, Couturier D-L, Sawle A, Briggs M, Wright A J, Brodie C, Mendil L, Miller J L, Williams E C, Franzén L, De Jong G, Gracia T, Memi F, Bayraktar O A, Adapa R, Rao J, González-Fernández A, Consortium CRUK Rosetta Grand Challenge, Bunch J, Takats Z, Barry S T, Goodwin R J A, Mair R, Brindle K M2025Nature MetabolismOncology, MetabolismHighplex FLHALO
Synergistic blockade of SHP-2 and A2AR signal pathways with targeted nanoparticles restores anti-tumor immunity of CD8+ T cellsChen M, Zhang L, Lin W, Zhou Z, Wang Y, Wang L, Gu H, Li J, Xu Z P2025Journal of Controlled ReleaseImmuno-oncologyHighplex FLHALO
Phase II Trial of Hypofractionated Radiotherapy and Immunochemotherapy in Primary Refractory Diffuse Large B-Cell Lymphoma: Preliminary Results and Insights from Digital Spatial ProfilingYang Y, Yu J, Hu X, Chen S, Zhao R, Huang C, Guo J, Tang T, Chen C, Lin Y, Wang Y, Liu T, Zheng H, Liao S, Chen J, Fu H, Liu T2025MedCommImmuno-oncologyHighplex FLHALO
Single-cell and spatial transcriptome analyses reveal tumor heterogeneity and immune remodeling involved in pituitary neuroendocrine tumor progressionSu W, Ye Z, Liu J, Deng K, Liu J, Zhu H, Duan L, Shi C, Wang L, Zhao Y, Gong F, Zhang Y, Hou B, You H, Feng F, Ling Q, Xiao Y, Guo Y, Fan W, Zhang S, Zhang Z, Hu X, Yao Y, Zheng C, Lu L2025Nature CommunicationsOncologyHighplex FLHALO
Efficacy and safety of HBM4003 combined with toripalimab in refractory neuroendocrine neoplasms: a multicenter, phase II studyZhang P, Chen K, Yang J, Song L, Zheng F, Luo R, He Y, Li F, Yang D, Cao N, Tao X, Shen L, Lu M,2025eClinicalMedicineImmuno-oncologyHighplex FLHALO
Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodellingMulholland E J, Belnoue-Davis H L, Valbuena G N, Gunduz N, Ligeza A, Lin M, Biswas S, Vasquez E G, Omwenga S, Nasreddin N, Hodder M C, Wang L M, Ng A S, Jennings E, Midwood K S, Dedi N, Irshad S, Ridgway R A, Phesse T J, East J, Tomlinson I P M, Davies G C G, Sansom O J, Leedham S J2025Nature CommunicationsOtherFISH, Spatial Analysis, Highplex FLHALO
Targeting CD39 boosts PD-1 blockade antitumor therapeutic efficacy via strengthening CD8 + TILs function and recruiting B cells in cervical cancerJiang L, Wu T, Qu X, Li S, Jiang Q, Ren T, Liang J, Ding Y, Hua K, Tang Z, Qiu J2025Journal of NanobiotechnologyImmuno-oncologyHighplex FLHALO
Multimodal data integration for biologically-relevant artificial intelligence to guide adjuvant chemotherapy in stage II colorectal cancerXie C, Ning Z, Guo T, Yao L, Chen X, Huang W, Li S, Chen J, Zhao K, Bian X, Li Z, Huang Y, Liang C, Zhang Q, Liu Z2025eBioMedicineOncologySpatial Analysis, Highplex FLHALO
Concurrent loss of the Y chromosome in cancer and T cells impacts outcomeChen X, Shen Y, Choi S, Abdel-Hafiz H A, Basu M, Hoelzen L, Tufano M, Mani S K, Ranjpour M, Zhu J, Ramanujan V K, Koltsova E K, Calsavara V F, Knott S R V, Theodorescu D2025NatureOncologyFISH, Highplex FL, TMAHALO
Gasdermin E deficiency limits inflammation and lung damage during influenza virus infectionRosli S, Ambrose R L, Harpur C M, Lam M, Hodges C, Barry K T, West A C, Mansell A, Lawlor K E, Tate M D2025Cell Death & DiseaseInfectious DiseaseHighplex FLHALO
Cyclophilin J Reprograms Tumor-associated Macrophages to Exert an Anti-tumor Effect in Liver CancerWang J, Yao C, Zeng Q, Peng L, Zhang S, Mao Y, Fu L, Chen S, Sheng C2025International Journal of Biological SciencesImmuno-oncologyHighplex FLHALO
Anlotinib combined with benmelstobart as a chemo-free first-line treatment in advanced esophageal squamous cell carcinoma: an exploratory multicenter, single-arm phase II clinical trialMeng X, Yang X, Hong Y, Wang W, Zhang Z, Xia J, Chen Y, Zhou Y, Lu T, Song M, Shan Z, Wu T, Wu W, Shen L, Guan L, Ma M, Wang L, Luo X, Xin D, Ma Y, Jiang G, Qi Y, Jiang B, Zhang D, Hu B, Wu X, Peng Z, Wang F2025Molecular CancerOncologyHighplex FLHALO
Single-cell transcriptome reveals the reprogramming of immune microenvironment during the transition from MASH to HCCHuang Y, Xie Y, Zhang Y, Liu Z, Jiang W, Ye Y, Tang J, Li Z, Yin Z, Lin X-J2025Molecular CancerImmuno-oncologyHighplex FLHALO
Mitsugumin 53 drives stem cell differentiation easing intestinal injury and inflammationPei Y, Fang M, Wu H-K, Cui Q, Quan L, Li X, Zhang K, Xie P, Jiang P, Liu Y, Huang M, Lv F, Hu X, Chen Y-G, Hu X, Xiao R-P2025Signal Transduction and Targeted TherapyGastroenterologyHighplex FLHALO
Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor That Unleashes PD-1 Checkpoint and CAR T-Cell ImmunotherapiesWichroski M, Liu S-Q, Zasadil L M, Benci J L, Gedeon P C, Condon K J, Joshi S, Posy S, Carlson P, Maier A, Shen J, Kureshi R, Amako Y, Wang T, Powles R L, Li Y, Lai T, Katsyv I, Qiu H, Qi H, Wong J, Zhao D, Banas D, Onorato J, Locke G, Chen X, Chou W-C, Cook E, Witt A E, Barbieri C M, Zhang H, Olsen J B, Font-Tello A, Drokhlyansky E, Grünenfelder D C, Chupak L, Longmire T A, Jones J C, Hollmann T J, Kugler D G, Feder J N, Bueno R, Wain J, Sivakumar P, Liu Y, Dougan S K, Paweletz C P, Barbie D A, Lees E2025Cancer Immunology ResearchImmuno-oncologyHighplex FL, TMAHALO
IFN-I-mediated neutropoiesis bias drives neutrophil priming and inflammatory comorbiditiesLi Y, Chen Y, Deng C, Niu Y, Yang Y, Sun S, Hu Z, Wei Y, Xu M, Huang Y, Van Dyke T, Deng X2025TheranosticsImmunologyHighplex FLHALO
Cholesterol Metabolism-related Characteristics Predict Therapeutic Response and Survival in Esophageal CancerTan L, Su X, Ma Y, Zeng C, Yue H, Zeng T, Li K, Guo Q, Li Y, Zhang X2025Journal of Advanced ResearchOncologyHighplex FLHALO
Interferon-responsive HEVs drive tumor tertiary lymphoid structure formation and predict immunotherapy response in nasopharyngeal carcinomaLiu S-X, Wu T-W, Luo D-H, Zhang L-L, Zhou L, Luo Y-L, Du W-T, Huang T-T, Jiang S, Zhang Z, Han P, Zeng M-S, Zhong Q2025Cell Reports MedicineImmuno-oncologySpatial Analysis, Highplex FLHALO
RPL6 Interacts with HMGCS1 to Stabilize HIF-1𝜶 by Promoting Cholesterol Production in Hepatocellular CarcinomaYang M, Cheng S, Gu H, Zhong S, Zhang D, He X, Chen W, Deng H, Ren J, Chen P, Tan M, Zhang H, Li F, Zhang Z, Hu Y, Chen J2025Advanced ScienceOncologyHighplex FLHALO
Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccineZhang J, Chavez E C, Winkler M, Liu J, Carver S, Lin A E, Biswas A, Tamura T, Tseng A, Wang D, Benhamou A, O’ Connell A K, Matsuo M, Norton J E, Kenney D, Adamson B, Kleiner R E, Burwitz B, Crossland N A, Douam F, Ploss A2025Nature MicrobiologyInfectious DiseaseHighplex FLHALO, HALO AI
The CXCL16/CXCR6 axis is linked to immune effector cell-associated neurotoxicity in chimeric antigen receptor (CAR) T cell therapyLu I, Müller-Miny L, Krekeler C, Cheung P F-Y, Antonopoulou G, Jeibmann A, Schulte-Mecklenbeck A, Kerl K, Call S, Reicherts C, Bleckmann A, Stelljes M, Lenz G, Wiendl H, Meyer zu Hörste G, Grauer O M2025Genome MedicineImmuno-oncologySpatial Analysis, Highplex FLHALO
DLL3 serves as a pivotal hub bridging malignant progression and immunosuppression in NECC with therapeutic implications validated via organoid-TILs co-culture systemLiu Q, Qu X, Li S, Ding Y, Ren T, Jiang Q, Ding J, Hua K, Qiu J2025Genes & DiseasesOncologyHighplex FLHALO
Gene context drift identifies drug targets to mitigate cancer treatment resistanceJassim A, Nimmervoll B V, Terranova S, Nathan E, Hu L, Taylor J T, Masih K E, Ruff L, Duarte M, Cooper E, Katyal G, Akhbari M, Gilbertson R J, Coleman J C, Toker J S, Terhune C, Balmus G, Jackson S P, Liu H, Jiang T, Taylor M D, Hua K, Abraham J E, Filbin M G, Hill A, Patrizi A, Dani N, Regev A, Lehtinen M K, Gilbertson R J2025Cancer CellOncologyHighplex FLHALO
Impact of the tumor immune contexture in microsatellite-stable metastatic colorectal cancer treated with avelumab, cetuximab, and irinotecanHuyghe N, Benidovskaya E, Masoodi T, Sinapi I, De Cuyper A, Vempalli F, Beyaert S, Bouzin C, Maestre Osorio F, Ferraro L, van Baren N, Helaers R, Goffette P, Ghaye B, van Maanen A, Castella M-L, Ceccarelli M, Bedognetti D, Galon J, Hendrickx W R L, Carrasco J, Van den Eynde M2025Cell Reports MedicineImmuno-oncologyHighplex FLHALO, HALO AI
A nociceptive amygdala-striatal pathway modulating affective-motivational painWojick J A, Paranjapye A, Chiu J K, Oswell C S, Mahmood M, Wooldridge L M, Kimmey B A, Sandoval Ortega R A, McCall N M, Han S, Wu J W K, Yung M, Ejoh L L, Chehimi S N, Crist R C, Reiner B C, Korb E, Corder G2025Science AdvancesNeuroscienceHighplex FLHALO
AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progressionWang Q, Wu Y, Long Y, Li R, Shi Y, Zheng Y, Chen X, Li X, Zhou Y, Huang X, Jiang G2025Nature CommunicationsImmuno-oncologyHighplex FLHALO
Multi-omics prediction of axillary treatment response and tumour microenvironment alterations in lymph node-positive luminal breast cancerMa T, Wang Z, Zhou Z, Wang Y, Ma T, Liu X, Mao Y, Wang H2025Cell Death & DiseaseOncologyHighplex FLHALO
Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosisMa Q, Wang S, Xue H, Ni L, Yuan P, Shen Y, Zheng B, Wang Q, Zhang J, Wang H, Xie H, Jiang C, Qin A, Fan S, Xie Z, Jie Z2025Nature CommunicationsOtherHighplex FLHALO
Phase I trial of ADP-A2AFP TCR T-cell therapy in patients with advanced hepatocellular or gastric hepatoid carcinomaMeyer T, Finn R S, Borad M, Mahipal A, Edeline J, Houot R, Hausner P F, Hollebecque A, Goyal L, Frigault M, Evans T R J, Wong K M, Tan B R, Mitry E, Sarker D, Feun L, El-Rayes B, Thistlethwaite F, Kaseb A, Alese O, Jin Z, Cirillo C, Bruix J, Roddie C, Noto P, Fayngerts S, Cristiani S, Sampson J, Bai J, Isabelle M, Broad R, Sun A, Norry E, Sangro B2025Journal of HepatologyImmuno-oncologyHighplex FL, ISH-IHCHALO
Enhanced formation of tertiary lymphoid structures shapes the anti-tumor microenvironment in hepatocellular carcinoma after FOLFOX-HAIC therapyXing R, Mei J, Zuo Z, Zou H, Yu X, Xu J, Guo R, Wei W, Zheng L2025Cell Reports MedicineImmuno-oncologyMultiplex IHC, Spatial Analysis, Highplex FLHALO
Spatiotemporal analyses of the pan-cancer single-cell landscape reveal widespread profibrotic ecotypes associated with tumor immunityHan Y, Zhang L, Sun D, Cao G, Wang Y, Yue J, Hu J, Dong Z, Li F, Li T, Zhang P, Wu Q, Wang C2025Nature CancerOncologyHighplex FLHALO
PD-L1 phenotype classification based on expression in tumor and immune cells as a potential biomarker for optimizing anti-PD-1/CTLA-4 immunotherapies in NSCLCMiyakoshi J, Yoshida T, Uehara Y, Takeyasu Y, Shirasawa M, Fukuda A, Kashima J, Kumagai S, Horinouchi H, Ono H, Shiraishi K, Kohno T, Kondo S, Goto Y, Yamamoto N, Yatabe Y, Hosomi Y, Kurata T, Naoki K, Suzuki T, Ohe Y2025Journal for Immunotherapy of CancerImmuno-oncologySpatial Analysis, Highplex FLHALO
Neutrophil extracellular traps–STC1 positive feedback loop promotes immune evasion and metastasis in bladder cancerCai T, Feng T, Zhang W, Ge Q, Peng L, Wang Y, Xie J, Deng X, Zhu W, Jin S, Wang J, Ye D, Zhu Y2025Journal for Immunotherapy of CancerImmuno-oncologySpatial Analysis, Highplex FLHALO
NSD2 targeting reverses plasticity and drug resistance in prostate cancerLi J, Vasciaveo A, Karagiannis D, Sun Z, Gretarsson K, Chen X, Ouerfelli O, Socciarelli F, Frankenstein Z, Dong H, Zou M, Yuan W, Yang G, Aizenman G, Pannellini T, Xu X, Beltran H, Chen Y, Gardner K, Robinson B, de Bono J, Gozani O, Abate-Shen C, Rubin M, Loda M, Sawyers C, Califano A, Lu C, Shen M2025NatureOncologyHighplex FLHALO, HALO AI
Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitnessEskiocak O, Gewolb J, Shah V, Rouse J, Chowdhury S, Akyildiz E, Fernández-Maestre I, Boyer J, Filliol A, Harris A, Utama R, Guo G, Castro-Hernández C, Nnuji-John E, Chung C, Anderson A, Flowers S, Habel J, Romesser P, Levine R, Lowe S, Sadelain M, Beyaz S, Amor C2025Nature AgingGastroenterologyHighplex FLHALO
HMGA2 links morphological evolution and microenvironment dynamics to systemic therapy response in clear cell renal cell carcinomaNakamoto T, Yoshida T, Ohe C, Yasukochi Y, Atsumi N, Sano T, Higasa K, Uchida K, Tsuta K, Kinoshita H2025Journal for Immunotherapy of CancerOncologyHighplex FLHALO
Presence of SARS-CoV-2 in fetal organs via intraamniotic infectionWu S, Tang L, Liu Z, Wu M, He X, Shan S, Zhou Y, Lin K, Xu Q, Tan S, Zhang Z, Xu Y, Wang C, Zhu F, Wei Z, Jin L2025Nature CommunicationsInfectious DiseaseHighplex FLHALO
Efferocytosis-Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian CancerLi W, Ying F, Pang X, Wu Q, Li G, Huang L, Xin J, Liu X, Liu P, Xu X, Tan S, Gao Y, Liu T, Sun S, Wang X, Wen Y, Cai L, Du S, Zhang Y, Cai J2025Advanced ScienceOncologyHighplex FLHALO
Distinct spatially resolved tumor microenvironment trajectories define benefit from ramucirumab plus pembrolizumab in refractory PD-L1+ gastric cancerLim S, An M, Heo Y, Lee H, Min B, Mehta A, Ahn S, Kim K, Kim S, Klempner S, Lee J2025Cancer Immunology ResearchImmuno-oncologySpatial Analysis, Highplex FLHALO
USP22 drives tumor immune evasion and checkpoint blockade resistance through EZH2-mediated epigenetic silencing of MHC-ILiu K, Iyer R, Li Y, Zhu J, Cai Z, Wei J, Cheng Y, Tang A, Wang H, Gao Q, Mani N, Marx N, Gao B, Watterson D M, Khan S A, Gradishar W J, Liu H, Fang D2025The Journal of Clinical InvestigationImmuno-oncologyHighplex FLHALO
Oncolytic virus-induced IL-1β+ monocyte-IL-6+ CAF axis suppresses dendritic cell-mediated antitumor immunity in pancreatic cancerLi F, Chen J, Li Y, Wang W, Yang Y, Wang J, Han M, Wang H, Zhou F, Ma W, Wang Y, Zhang Z, Yu J, Zhao Z, Deng L, Liu S, Wan Y, Zhao Z, Xu S, Li J, Cao Y, Zhang H2025Journal for Immunotherapy of CancerImmuno-oncologyHighplex FLHALO
Tumour-reactive heterotypic CD8 T cell clusters from clinical samplesIbáñez-Molero S, Veldman J, Nieto J, Traets J, George A, Hoefakker K, Karomi A, Harkes R, van den Broek B, Pack S, Tas L, Visser N, van Hal-van Veen S, Alóndiga-Mérida P, Alkemade M, Seignette I, Tissier R, Nieuwland M, van Baalen M, Poźniak J, Mul E, Tol S, Stenqvist S, Nilsson L, Nilsson J, Haanen J, van Houdt W, Peeper D2025NatureImmuno-oncologyHighplex FLHALO
Mature tertiary lymphoid structures support B cell-mediated antitumour immunity and are disrupted by neoadjuvant therapy in rectal cancer: a multicentre, retrospective studyTian N, Wang Q, Lv Y, Zhong W, Li W, Cai H, An R, Zhu H, Sun L, Yuan Q, Dong X, Dong J, Bai J, Liu A, Chen G, Wu B, Du J2025eBioMedicineImmuno-oncologySpatial Analysis, Highplex FLHALO
Hepatic zonation determines tumorigenic potential of mutant β-cateninRaven A, Gilroy K, Jin H, Waldron J, Leslie H, Munro J, Hall H, Ridgway R, Ford C, Gulhan D, Vlahov N, Mills M, Hartley A, Anderson E, Bryson S, Sphyris N, Müller M, May S, Cadden B, Nixon C, Waddell S, Guest R, Boulter L, Barker N, Clevers H, Zhu H, Ivaska J, Strathdee D, Miller C, Jamieson N, Bushell M, Park P, Bird T, Sansom O2025NatureOncologyClassifier, Area Quantification, Highplex FLHALO
Targeting tumor-intrinsic BCL9 reverses immunotherapy resistance by eliciting macrophage-mediated phagocytosis and antigen presentationWu S, Zhu Y, Sun J, Wang C, Wang Y, Nie Y, Song F, Huang X, Chen Z, He T, Shen L, Xu Y, Huang C, Qiu S, Zhou J, Zhu A, Fan J, Zhu D, Hu B, Yang X2025Nature CommunicationsImmuno-oncologyHighplex FLHALO
ZUP1 promotes DNA repair and immune evasion to drive olaparib resistance in triple-negative breast cancerHuang S, Qiu Y, Wu L, Xie Y, He Z, Li Y, Xie X2025Journal of Advanced ResearchOncologyMicroglia, Highplex FLHALO
Microbial signals in primary and metastatic brain tumorsMorad G, Damania A, Melendez B, Singh B, Veguilla F, Soto R, Hoballah Y, Sahasrabhojane P, Wong M, Ahmed M, Rico R, Lewis K, Wani K, Shamsutdinova D, Segura R, Ingram D, Goethe E, Day A, Flores I, McDaniel L, Chelvanambi M, Johnson S, Dimitriou F, Gupta P, Oberai S, Zal M, Doss P, Jamal M, Hayase E, Wathoo C, Norberg L, Jenkins S, Nass S, Gumin J, Long L, Yang J, Bradley G, Bekal M, Dono A, Pichardo-Rojas P, Andrewes S, Ballester L, Losh J, Liang J, Huo L, Nielsen D, Kerrigan B, Brastianos P, Fowlkes N, Chang C, Jenq R, Gomez-Manzano C, Huse J, Davies M, Lazar A, Bhat K, Tandon N, Esquenazi Y, Peterson C, Puduvalli V, Lang F, Johnston C, Bullman S, Ajami N, Ferguson S, Wargo J2025Nature MedicineOncologyHighplex FLHALO
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesityXiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan D A, Wunderlich F T, Rahmouni K, Kong D, Scammell T E, Lowell B B, Kloppenburg P, Brüning J C, Hausen A C2025Nature CommunicationsNeuroscienceHighplex FLHALO
Anti-progestin therapy targets hallmarks of breast cancer riskSimões B, Pedley R, McCloskey C, Roberts M, Reed A, Twigger A, Tharmapalan P, Caruso A, Cabral S, Wilby A, Harrison H, Zhou Y, Greenhalgh A, Alghamdi S, Forestiero M, Lopez-Muñoz J, Roche J, Tuieng R, Khan M, Squires S, Astley S, Harkness E, Santiago-Gómez A, Spence K, Ritchie J, Pritchard S, Lim Y, Sherratt M, Andò S, Howell A, Evans D, Gilmore A, Khaled W, Khokha R, Clarke R, Howell S2025NatureOncologyMultiplex IHC, Highplex FLHALO
Single-cell multi-omics analysis revealed the expansion of age-associated B cells in the pancreas of type 1 autoimmune pancreatitis patientsWang J, Liu C, Zhang X, Che T, Zhao Y, Yang Q, Qin X, Chen Y, Ao X, Shen X, He X, Gong T, Zhang L, Zhang M, Wang D, Du Y, Wen L, Ye Y, Zhang Y, Zhou C, Zou D2025Genome MedicineImmunologyClassifier, Spatial Analysis, Highplex FLHALO
HDAC4/MybL1/YAP novel signaling axis is required for pancreatic cancer metastasis to the liverEdderkaoui M, Elmadbouh O, Lim A, Ou Y, Hauptschein D, Guha A, Darwish A, Calsavara V, Murali R, Bhowmick N, Osipov A, Mathison A, Urrutia R, Wang Q, Pandol S2025International Journal of Biological SciencesOncologyHighplex FLHALO
Cryoablation plus sintilimab and lenvatinib in advanced or metastatic intrahepatic cholangiocarcinoma: a phase 2 trialGu S, Luo Q, Zhang Y, Qian L, Chen K, Liang F, Hu Y, Zhou R, Wang Y, Liu J, Ning Z, Xu L, Meng Z, Li Y, Wang P2025Nature CancerImmuno-oncologyHighplex FLHALO
Empowering chemotherapy-induced antitumor immunity by multi-targeted synergistic combination nanomedicine for triple-negative breast cancerAlradwan I, Zhi P, Zetrini A, Wang L, He C, Rezaeifarimani M, Henderson J, Rauth A, Wu X2025Materials Today BioImmuno-oncologyArea Quantification, Multiplex IHC, Highplex FLHALO
Prognostic Significance of the Density and Spatial Distribution of Tumor‐Associated Macrophages in Giant Cell Tumor of Bone and Their Association With Denosumab Treatment ResponsivenessYang Y, Liu J, Han Y, Zhu G, Niu H, Zheng B, Tang X, Li J, Kang Y, Yu J, Zheng B, Zhou B2025MedCommImmuno-oncologySpatial Analysis, Highplex FLHALO
Parity and lactation induce T-cell-mediated breast cancer protectionVirassamy B, Caramia F, Savas P, Harris M, Pan J, Wang J, Brown E, O’Malley M, van Geelen C, Hun M, Burn T, Sant S, Ballan J, Kay J, Lara Gonzalez L, Clarke K, Aw Yeang H, Idrizi R, Jana M, Challice D, Salgado R, Thorne H, consortium k, Poliness C, Nightingale S, Teo S, Speed T, Visvader J, Neeson P, Darcy P, Mackay L, Loi S2025NatureImmuno-oncologySpatial Analysis, Highplex FLHALO
Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structuresCakmak P, Lun J, Singh A, Macas J, Schupp J, Schuck J, Mahmoud Z, Köhler M, Starzetz T, Burger M, Steidl E, Hasse L, Hattingen E, Plate K, Reiss Y, Imkeller K2025ImmunityImmuno-oncologySpatial Analysis, Highplex FLHALO
Smohaze-Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non-Small Cell Lung CancerShi X, Shen Y, Lv M, Sun Y, Lin Y, Wang Z, Jie X, Liu Z, Liu Y, Fu Y, Ren Z, Wang G, Zhou G2025Advanced ScienceOncologySpatial Analysis, Highplex FLHALO
Adjuvant nivolumab and relatlimab in stage III/IV melanoma: the randomized phase 3 RELATIVITY-098 trialLong G, Garnett-Benson C, Dolfi S, Ascierto P, Guo J, Tarhini A, Chandra S, Muñoz-Couselo E, Del Vecchio M, de Melo A, Callahan M, Gogas H, Dummer R, Schadendorf D, Koelblinger P, Quereux G, Thomas I, Yu J, Fisher A, Wang B, Djidel P, Chouzy A, Semaan M, Chen B, Cheong A, Tawbi H2025Nature MedicineImmuno-oncologyHighplex FLHALO, HALO AI
αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in mouse modelsWang T, Xu Y, Zhang Z, Wu Y, Chen L, Zheng X, Peng H, Zou Q, Sun R, Ma H, Sun H, Tian Z, Zheng X2025Nature CommunicationsImmuno-oncologyHighplex FLHALO
Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cellsPucella J, Maqueda-Alfaro R, Ni H, Sulczewski F, Eichinger A, Esteva E, Ra A, Das A, Perez O, Feng J, Stoeckius M, Smibert P, Khodadadi-Jamayran A, Dolgalev I, Ivanova E, Sota S, Cadwell K, Koralov S, Zhong J, Soni C, Stetson D, Weisberg S, Farber D, Idoyaga J, Reizis B2025Nature ImmunologyImmunologyHighplex FLHALO
Age-related severity of nontuberculous mycobacterial lung disease is mediated by aberrant macrophage responses and lung microbial dysbiosisNapier E, Doratt B, Cinco I, Stuart E, Geron R, Davies M, Malherbe D, Kohama S, Bermudez L, Winthrop K, Fuss C, Spindel E, Messaoudi I2025Journal of InfectionInfectious DiseaseHighplex FLHALO
Extracellular vesicles derived EBV tegument protein BRRF2 suppresses cGAS phase separation to promote anti-viral innate immune evasionHu Z, Li Z, Wang Y, Luo Y, Guo W, Meng N, Bu G, Zhang L, Li S, Kong X, Fang X, Wang Q, Han R, Zhao Z, Zhao G, Jiang Z, Jin R, Zeng M, Zhong Q2025Nature CommunicationsInfectious DiseaseSpatial Analysis, Highplex FLHALO
Signal Amplification for Fluorescent Staining of Single Particles in Liquid Biopsies: Circulating Tumour Cells and Extracellular VesiclesCavallaro S, Veiga S, Ahmad R, Aldikacti B, Bienstock M, Capen D, Rabe D, Ho U, Lee D, Ruiz-Torres D, Wakimoto H, Dietrich J, Nahed B, Stott S2025Journal of Extracellular VesiclesOtherHighplex FLHALO, HALO AI
Microglial glycolytic reprogramming in alzheimer’s disease: association with impaired phagocytic function and altered vascular proximityLu N, Jin Z, Liu N, Zhu C, Wei H, Xu Q2025Journal of NeuroinflammationNeuroscienceObject Colocalization, Highplex FLHALO
Characterizing the Immune Response in Pig-to-Human Heart Xenografts Using a Multimodal Diagnostic SystemGiarraputo A, Morgand E, Stern J, Mezine F, Coutance G, Goutaudier V, Sannier A, Certain A, Hauet T, Giraud S, Kerforne T, Allain G, Ayares D, Khalil K, Kim J, Mehta S, Narula N, Reyentovich A, Smith D, Tissier R, Saraon T, Kadosh B, Divita M, Goldberg R, Pass H, Mangiola M, Bruneval P, Griesemer A, Moazami N, Montgomery R, Loupy A2025CirculationImmunologyHighplex FLHALO, HALO AI
High Treg and PMN-MDSC densities are a hallmark of tertiary lymphoid structures in fatal cases of cervical cancerSyding L, Plačková K, Pavelková L, Aquino-Perez C, Santegoets S, Laco J, Grega M, Dundr P, Němejcová K, Hodek M, Bouček J, Zábrodský M, Vošmiková H, Halaška M, Rob L, Čelakovský P, Chrobok V, Iheme M, Práznovec I, Vošmik M, Katina S, Cibula D, Ryška A, van der Burg S, Špíšek R, Fialová A2025Journal for Immunotherapy of CancerImmuno-oncologyMultiplex IHC, Highplex FLHALO
CCL5hi Macrophages Interact with CD8+ T Cells and Potentiate Responsiveness to PD-1 Blockade Plus Chemotherapy in Esophageal Squamous Cell CarcinomaMa Y, Su X, Zeng T, Zhou C, Yang G, Xia Z, Zeng C, Zhan J, Guan X, Zhang X, Li Y2025Advanced ScienceImmuno-oncologySpatial Analysis, Highplex FLHALO
Tertiary lymphoid structures in Merkel cell carcinoma facilitate naïve and central memory T-cell infiltration linked to immunotherapy responseSrinivas N, Spassova I, Lei K, Gao J, Pino M, Giglio G, Kitanovski S, Dalkoohi M, Livingstone E, Leiter U, Mohr P, Gambichler T, Stoffels I, Ugurel S, Cheung P, Engblom C, Lui W, Becker J2025Journal for Immunotherapy of CancerImmuno-oncologySpatial Analysis, Highplex FLHALO
Autophagy inhibition improves the efficacy of anlotinib and PD-1 inhibitors in the treatment of NSCLCTang H, You T, Ge H, Bai C, Wang Y, Sun Z, Han Q, Zhao RC2025Journal for Immunotherapy of CancerOncologyMultiplex IHC, Highplex FLHALO
Repeated head trauma causes neuron loss and inflammation in young athletesButler M, Pervaiz N, Breen K, Calderazzo S, Ypsilantis P, Wang Y, Cammasola Breda J, Mazzilli S, Nicks R, Spurlock E, Hefti M, Fiock K, Huber B, Alvarez V, Stein T, Campbell J, McKee A, Cherry J2025NatureNeuroscienceObject Colocalization, FISH, Spatial Analysis, Highplex FL, FISH-IFHALO, HALO AI
A novel molecular subtyping based on multi-omics analysis for prognosis predicting in colorectal melanoma: A 16-year prospective multicentric studyLiu C, Cheng X, Han K, Hong L, Hao S, Sun X, Xu J, Li B, Jin D, Tian W, Jin Y, Wang Y, Fang W, Bao X, Zhao P, Chen D2024Cancer LettersOncologyHighplex FLHALO
Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancerWang J, Wei J, Pu T, Zeng A, Karthikeyan V, Bechtold B, Vo K, Chen J, Lin TP, Chang AP, Corey E, Puhr M, Klocker H, Culig Z, Bland T, Wu BJ2024Cell Reports MedicineOncologyHighplex FLHALO
Preclinical evaluation of a novel CAR-T therapy utilizing a scFv antibody highly specific to MAGE-A4p230-239/HLA-A*02:01 complexWang L, Matsumoto M, Akahori Y, Seo N, Shirakura K, Kato T, Katsumoto Y, Miyahara Y, Shiku H2024Molecular TherapyImmuno-oncologyHighplex FLHALO
Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysisFrei AL, McGuigan A, Sinha RAK, Jabbar F, Gneo L, Tomasevic T, Harkin A, Iveson T, Saunders MP, Oien KA, Maka N, Pezzella F, Campo L, Browne M, Glaire M, Kildal W, Danielsen HE, Hay J, Edwards J, Sansom O, Kelly C, Tomlinson I, Kerr R, Kerr D, Domingo E, consortium T, Church DN, Koelzer VH2024The Lancet OncologyImmuno-oncologyArea Quantification, Highplex FLHALO, HALO AI
Early immune remodeling steers clinical response to frontline chemoimmunotherapy in advanced gastric cancerAn M, Mehta A, Min BH, Geo YJ, Wright SJ, Parikh M, Bi L, Lee H, Kim TJ, Lee SY, Moon J, Park RJ, Strickland MR, Park WY, Kang WK, Kim KM, Kim ST, Lempner SJ, Lee J2024Cancer DiscoveryImmuno-oncologyClassifier, Highplex FLHALO
Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cellsWANG J, GAI J, ZHANG T, NIU N, QI H, THOMAS II D L, LI K, XIA T, RODRIGUEZ C, PARKINSON R, DURHAM J, MCPHAUL T, NARANG A K, ANDERS R A, OSIPOV A, WANG H, HE J, LAHERU D A, HERMAN J M, LEE V, JAFFEE E M, THOMPSON E D, ZHU Q, ZHENG L2024Science AdvancesImmuno-oncologySpatial Analysis, Highplex FL, RegistrationHALO
Stromal-derived MAOB promotes prostate cancer growth and progressionPu T, Wang J, Wei J, Zeng A, Zhang J, Chen J, Yin L, Li J, Lin T, Melamed J, Corey E, Gao A, Wu B2024Science AdvancesOncologyMultiplex IHC, Highplex FLHALO
Multiomic molecular characterization of the response to combination immunotherapy in MSS/pMMR metastatic colorectal cancerTakei S, Tanaka Y, Lin Y, Koyama S, Fukuoka S, Hara H, Nakamura Y, Kuboki Y, Kotani D, Kojima T, Bando H, Mishima S, Ueno T, Kojima S, Wakabayashi M, Sakamoto N, Kojima M, Kuwata T, Yoshino T, Nishikawa H, Mano H, Endo I, Shitara K, Kawazoe A2024Journal for Immunotherapy of CancerImmuno-oncologyHighplex FLHALO
Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancerHirai T, Naito Y, Koyama S, Nakanishi Y, Masuhiro K, Izumi M, Kuge T, Naito M, Mizuno Y, Yamaguchi Y, Kang S, Yaga M, Futami Y, Nojima S, Nishide M, Morita T, Kato Y, Tsuda T, Takemoto N, Kinugasa-Katayama Y, Aoshi T, Villa J K, Yamashita K, Enokida T, Hoshi Y, Matsuura K, Tahara M, Takamatsu H, Takeda Y, Inohara H, Kumanogoh A2024JCI InsightImmuno-oncologyHighplex FLHALO
Myeloid-Mas Signaling Modulates Pathogenic Crosstalk among MYC+CD63+ Endothelial Cells, MMP12+ Macrophages, and Monocytes in Acetaminophen-Induced Liver InjuryChen S, Lu Z, Zhao Y, Xia L, Liu C, Zuo S, Jin M, Jia H, Li S, Zhang S, Yang B, Wang Z, Li J, Wang F, Yang C2024Advanced ScienceGastroenterologyHighplex FLHALO
Cooperative pro-tumorigenic adaptation to oncogenic RAS through epithelial-to-mesenchymal plasticityDe Blander H, Tonon L, Fauvet F, Pommier R M, Lamblot C, Benhassoun R, Angileri F, Gibert B, Rodriguez R, Ouzounova M, Morel A P, Puisieux A2024Science AdvancesOncologyHighplex FLHALO
Impact of metronomic trabectedin combined with low-dose cyclophosphamide on sarcoma microenvironment and correlation with clinical outcome: results from the TARMIC studySun C-M, Toulmonde M, Spalato-Ceruso M, Peyraud F, Bessede A, Kind M, Cousin S, Buy X, Palussiere J, Bougouin A, Sautès-Fridman C, Fridman H W, Pulido M, Italiano A2024Molecular CancerOncologyMultiplex IHC, Highplex FLHALO
Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitisMennillo E, Kim Y, Lee G, Rusu I, Patel R K, Dorman L C, Flynn E, Li S, Bain J L, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Lotstein M L, Rahim M, Naser M, Bernard-Vazquez F, Eckalbar W, Cho S, Beck K, El-Nachef N, Lewin S, Selvig D R, Terdiman J P, Mahadevan U, Oh D Y, Fragiadakis G K, Pisco A, Combes A J, Kattah M G2024Nature CommunicationsImmunologyISH, Spatial Analysis, Highplex FL, TMAHALO, HALO AI
PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinomaShu G, Chen M, Liao W, Fu L, Lin M, Gui C, Cen J, Lu J, Chen Z, Wei J, Chen W, Wang Y, Zhu J, Zhao T, Liu X, Jing J, Liu G, Pan Y, Luo J, Zhang J2024Cancer ResearchOncologyHighplex FLHALO, HALO AI
Identification of tyrosine brominated extracellular matrix proteins in normal and fibrotic lung tissuesCruz LC, Habibovic A, Dempsey B, Massafera MP, Janssen-Heininger YM, Lin MJ, Hoffman ET, Weiss DJ, Huang SK, van der Vliet A, Meotti FC2024Redox BiologyFibrosisArea Quantification, Highplex FLHALO
Identification of the metaphyseal skeletal stem cell building trabecular boneYang G, He Q, Guo X, Li R, Lin J, Lang Y, Tao W, Liu W, Lin H, Xing S, Qi Y, Xie Z, Han J, Zhou B, Teng Y, Yang X2024Science AdvancesOtherHighplex FLHALO
Serum amyloid A promotes glycolysis of neutrophils during PD-1 blockade resistance in hepatocellular carcinomaHe M, Liu Y, Chen S, Deng H, Feng C, Qiao S, Chen Q, Hu Y, Chen H, Wang X, Jiang X, Xia X, Zhao M, Lyu N2024Nature CommunicationsImmuno-oncologySpatial Analysis, Highplex FLHALO
PDGFRa+ ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplayZheng H, An M, Luo Y, Diao X, Zhong W, Pang M, Lin Y, Chen J, Li Y, Kong Y, Zhao Y, Yin Y, Ai L, Huang J, Chen C, Lin T2024Cancer CellOncologySpatial Analysis, Highplex FLHALO
Multi-omics and imaging mass cytometry characterization of human kidneys to identify pathways and phenotypes associated with impaired kidney function.Asowata E O, Romoli S, Sargeant R, Tan J Y, Hoffmann S, Huang M M, Mahbubani K T, Krause F N, Jachimowicz D, Agren R, Koulman A, Jenkins B, Musial B, Griffin J L, Soderberg M, Ling S, Hansen P B L, Saeb-Parsy K, Woollard K J2024Kidney InternationalOtherISH, Spatial Analysis, Highplex FLHALO, HALO AI
An immune cell map of human lung adenocarcinoma development reveals an anti-tumoral role of the Tfh-dependent tertiary lymphoid structureLiu W, You W, Lan Z, Ren Y, Gao S, Li S, Chen W, Huang C, Zeng Y, Xiao N, Wang Z, Xie H, Ma H, Chen Y, Wang G, Chen C, Li H2024Cell Reports MedicineImmuno-oncologyMultiplex IHC, Highplex FLHALO
Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer (NECTAR): a multi-center phase 2 studyYang Z, Gao J, Zheng J, Han J, Li A, Liu G, Sun Y, Zhang J, Chen G, Xu R, Zhang X, Liu Y, Bai Z, Deng W, He W, Yao H, Zhang Z2024Signal Transduction and Targeted TherapyImmuno-oncologyHighplex FLHALO
HSPA4 upregulation induces immune evasion via ALKBH5/CD58 axis in gastric cancerSuo D, Gao X, Chen Q, Zeng T, Zhan J, Li G, Zheng Y, Zhu S, Yun J, Guan XY, Li Y2024Journal of Experimental & Clinical Cancer ResearchImmuno-oncologySpatial Analysis, Highplex FLHALO
Single-cell RNA sequencing reveals inflammatory retinal microglia in experimental autoimmune uveitisLiu J, Liao X, Li N, Xu Z, Yang W, Zhou H, Liu Y, Zhang Z, Wang G, Hou S2024MedCommImmunologyHighplex FLHALO
Targeting pathogenic CD8+ tissue-resident T cells with chimeric antigen receptor therapy in murine autoimmune cholangitisZhu HX, Yang SH, Gao CY, Bian ZH, Chen XM, Huang RR, Meng QL, Li X, Jin H, Tsuneyama K, Han Y, Li L, Zhao ZB, Gershwin ME, Lian ZX2024Nature CommunicationsImmunologySpatial Analysis, Highplex FLHALO
Loss of GABARAP mediates resistance to immunogenic chemotherapy in multiple myelomaGulla A, Morelli E, Johnstone M, Turi M, Samur M K, Botta C, Cifric S, Folino P, Vinaixa D, Barello F, Clericuzio C, Favasuli V K, Maisano D, Talluri S, Prabhala R H, Bianchi G, Fulciniti M, Wen K, Kurata K, Liu J, Penailillo J, Bragoni A, Sapino A, Richardson P G, Chauhan D, Carrasco R D, Hideshima T, Munshi N C, Anderson K C2024BloodOncologyHighplex FLHALO
OH2 oncolytic virus: A novel approach to glioblastoma intervention through direct targeting of tumor cells and augmentation of anti-tumor immune responsesZheng Y, Wang X, Ji Q, Fang A, Song L, Xu X, Lin Y, Peng Y, Yu J, Xie L, Chen F, Li X, Zhu S, Zhang B, Zhou L, Yu C, Wang Y, Wang L, Hu H, Zhang Z, Li W2024Cancer LettersOncologyHighplex FLHALO
Molecular assessment of intratumoral immune cell subsets and potential mechanisms of resistance to odronextamab, a CD20×CD3 bispecific antibody, in patients with relapsed/refractory B-cell non-Hodgkin lymphomaBrouwer-Visser J, Fiaschi N, Deering R P, Cygan K J, Scott D, Jeong S, Boucher L, Gupta N T, Gupta S, Adler C, Topp M S, Bannerji R, Duell J, Advani R H, Flink D M, Chaudhry A, Thurston G, Ambati S R, Jankovic V2024Journal for Immunotherapy of CancerImmuno-oncologyHighplex FLHALO
Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancerKasikova L, Rakova J, Hensler M, Lanickova T, Tomankova J, Pasulka J, Drozenova J, Mojzisova K, Fialova A, Vosahlikova S, Laco J, Ryska A, Dundr P, Kocian R, Brtnicky T, Skapa P, Capkova L, Kovar M, Prochazka J, Praznovec I, Koblizek V, Taskova A, Tanaka H, Lischke R, Mendez F C, Jr J V, Heinzelmann-Schwarz V, Jacob F, McNeish I A, Halaska M J, Rob L, Cibula D, Orsulic S, Galluzzi L, Spisek R, Fucikova J2024Nature CommunicationsOncologyClassifier, Highplex FL, RegistrationHALO
Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomasBroz M T, Ko E Y, Ishaya K, Xiao J, De Simone M, Hoi X P, Piras R, Gala B, Tessaro F H G, Karlstaedt A, Orsulic S, Lund A W, Chan K S, Guarnerio J2024Nature CommunicationsOncologyHighplex FLHALO
CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancerLim R J, Salehi-Rad R, Tran M L, Oh M S, Dumitras C, Crosson W P, Li R, Patel T S, Man S, Yean C E, Abascal J, Huang Z, Ong S L, Krysan K, Dubinett S M, Liu B2024Cell Reports MedicineImmuno-oncologySpatial Analysis, Highplex FLHALO
N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1Li J, Xu X, Xu K, Zhou X, Wu K, Yao Y, Liu Z, Chen C, Wang L, Sun Z, Jiao D, Han X2024Journal of Experimental & Clinical Cancer ResearchOncologyArea Quantification, FISH, Highplex FL, TMAHALO
Nivolumab for mismatch-repair-deficient or hypermutated gynecologic cancers: a phase 2 trial with biomarker analysesFriedman C, Manning-Geist B, Zhou Q, Soumerai T, Holland A, Da Cruz Paula A, Green H, Ozsoy M, Iasonos A, Hollmann T, Leitao Jr. M, Mueller J, Makker V, Tew W, O’Cearbhaill R, Liu Y, Rubinstein M, Troso-Sandoval T, Lichtman S, Schram A, Kyi C, Grisham R, Andrieu P, Wherry E, Aghajanian C, Weigelt B, Hensley M L, Zamarin D2024Nature MedicineImmuno-oncologySpatial Analysis, Highplex FLHALO
Interferon-gamma signature as prognostic and predictive marker in macroscopic stage III melanomaVersluis J M, Blankenstein S A, Dimitriadis P, Wilmott J S, Elens R, Blokx W A M, van Houdt W, Menzies A M, Schrage Y M, Wouters M W J M, Sanders J, Broeks A, Scolyer R A, Suijkerbuijk K P M, Long G V, van Akkooi A C J, Blank C U2024Journal for Immunotherapy of CancerImmuno-oncologyHighplex FLHALO, HALO AI
Meteorin-like protein/METRNL/Interleukin-41 ameliorates atopic dermatitis-like inflammationHuang D, Liu X, Gao X, Choi C, Giglio G, Farah L, Leung T, Wong K, Kan L, Chong J, Meng Q, Liao J, Cheung P, Wong C2024AllergyImmunologySpatial Analysis, Highplex FLHALO
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistryEllis M J, Lekka C, Holden K L, Tulmin H, Seedat F, O’Brien D P, Dhayal S, Zeissler M-L, Knudsen J G, Kessler B M, Morgan N G, Todd J A, Richardson S J, Stefana M I2024Acta NeuropathologicaNeuroscienceHighplex FL, Figure MakerHALO
IL-2-free tumor-infiltrating lymphocyte therapy with PD-1 blockade demonstrates potent efficacy in advanced gynecologic cancerGuo J, Wang C, Luo N, Wu Y, Huang W, Zhu J, Shi W, Ding J, Ge Y, Liu C, Lu Z, Bast Jr RC, Ai G, Yang W, Wang R, Li C, Chen R, Liu S, Jin H, Zhao B, Cheng Z2024BMC MedicineImmuno-oncologyHighplex FLHALO
Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesisNightingale R, Reehorst C, Vukelic N, Papadopoulos N, Liao Y, Guleria S, Bell C, Vaillant F, Paul S, Luk I Y, Dhillon A S, Jenkins L J, Morrow R J, Jackling F C, Chand A L, Chisanga D, Chen Y, Williams D S, Anderson R L, Ellis S, Meikle P J, Shi W, Visvader J E, Pal B, Mariadason J M2024Developmental CellOtherHighplex FLHALO
L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy in newly-diagnosed glioblastoma: dose escalation of the phase I/II GLORIA trialGiordano F, Layer J, Leonardelli S, Friker L, Turiello R, Corvino D, Zeyen T, Schaub C, Müller W, Sperk E, Schmeel L, Sahm K, Oster C, Kebir S, Hambsch P, Pietsch T, Bisdas S, Platten M, Glas M, Seidel C, Herrlinger U, Hölzel M2024Nature CommunicationsOncologyHighplex FLHALO, HALO AI
IL-6 inhibition prevents costimulation blockade-resistant allograft rejection in T cell-depleted recipients by promoting intragraft immune regulation in miceMuckenhuber M, Mengrelis K, Weijler A, Steiner R, Kainz V, Buresch M, Regele H, Derdak S, Kubetz A, Wekerle T2024Nature CommunicationsImmunologyHighplex FLHALO
LINC00982-encoded protein PRDM16-DT regulates CHEK2 splicing to suppress colorectal cancer metastasis and chemoresistanceHu H-F, Han L, Fu J-Y, He X, Tan J-F, Chen Q-P, Han J-R, He Q-Y2024TheranosticsOncologyHighplex FLHALO
Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumorsRidnour L, Cheng R, Kedei N, Somasundaram V, Bhattacharyya D, Basudhar D, Wink A, Walke A, Kim C, Heinz W, Edmondson E, Butcher D, Warner A, Dorsey T, Pore M, Kinders R, Lipkowitz S, Bryant R, Rittscher J, Wong S, Hewitt S, Chang J, Shalaby A, Callagy G, Glynn S, Ambs S, Anderson S, McVicar D, Lockett S, Wink D2024JCI InsightImmuno-oncologyClassifier, FISH, Spatial Analysis, Highplex FLHALO
A High Immune-Related Index with the Suppression of cGAS-STING Pathway is a Key Determinant to Herceptin Resistance in HER2+ Breast CancerCai R, Chen Q, Zhao D, Wang Y, Zhou L, Zhang K, Shan J, Li Z, Chen Y, Zhang H, Feng G, Zhu X, Deng R, Tang J2024International Journal of Biological SciencesImmuno-oncologyMultiplex IHC, Highplex FLHALO
Development of human pancreatic cancer avatars as a model for dynamic immune landscape profiling and personalized therapyHughes D, Evans A, Go S, Eyres M, Pan L, Mukherjee S, Soonawalla Z, Willenbrock F, O’Neill E2024Science AdvancesImmuno-oncologyClassifier, Spatial Analysis, Highplex FLHALO
SHISA3 Reprograms Tumor-Associated Macrophages Toward an Antitumoral Phenotype and Enhances Cancer ImmunotherapyZhang S, Yu B, Sheng C, Yao C, Liu Y, Wang J, Zeng Q, Mao Y, Bei J, Zhu B, Chen S2024Advanced ScienceImmuno-oncologyHighplex FLHALO
Pan-cancer single-cell dissection reveals phenotypically distinct B cell subtypesYang Y, Chen X, Pan J, Ning H, Zhang Y, Bo Y, Ren X, Li J, Qin S, Wang D, Chen M, Zhang Z2024CellImmuno-oncologySpatial Analysis, Highplex FL, RegistrationHALO
Hyperactivation of mTOR/eIF4E Signaling Pathway Promotes the Production of Tryptophan-To-Phenylalanine Substitutants in EBV-Positive Gastric CancerZheng Z, Zhong C, Wei C, Chen X, Chen G, Nie R, Chen Z, Zhang F, Li Y, Zhou Z, Liang Y2024Advanced ScienceOncologyHighplex FLHALO
TSG-6+ cancer-associated fibroblasts modulate myeloid cell responses and impair anti-tumor response to immune checkpoint therapy in pancreatic cancerAnandhan S, Herbrich S, Goswami S, Guan B, Chen Y, Macaluso M D, Jindal S, Natarajan S M, Andrewes S W, Xiong L, Nagarajan A, Basu S, Ng Tang D, Liu J, Min J, Maitra A, Sharma P2024Nature CommunicationsImmuno-oncologySpatial Analysis, Highplex FLHALO
Mitochondrial DNA-boosted dendritic cell-based nanovaccination triggers antitumor immunity in lung and pancreatic cancersShang L, Jiang X, Zhao X, Huang X, Wang X, Jiang X, Kong X, Yao M, Jiang S, Wong P2024Cell Reports MedicineImmuno-oncologySpatial Analysis, Highplex FLHALO
Human organoids with an autologous tissue-resident immune compartmentRecaldin T, Steinacher L, Gjeta B, Harter M, Adam L, Kromer K, Mendes M, Bellavista M, Nikolaev M, Lazzaroni G, Krese R, Kilik U, Popovic D, Stoll B, Gerard R, Bscheider M, Bickle M, Cabon L, Camp J, Gjorevski N2024NatureImmunologyHighplex FLHALO, HALO AI
LIM domain only 7: a novel driver of immune evasion through regulatory T cell differentiation and chemotaxis in pancreatic ductal adenocarcinomaDai S, Peng Y, Wang G, Chen C, Chen Q, Yin L, Yan H, Zhang K, Tu M, Lu Z, Wei J, Li Q, Wu J, Jiang K, Zhu Y, Miao Y2024Cell Death & DifferentiationImmuno-oncologySpatial Analysis, Highplex FLHALO
Spatial transcriptomic characterization of pathologic niches in IPFMayr C H, Santacruz D, Jarosch S, Bleck M, Dalton J, McNabola A, Lempp C, Neubert L, Rath B, Kamp J C, Jonigk D, Kühnel M, Schlüter H, Klimowicz A, Doerr J, Dick A, Ramirez F, Thomas M J2024Science AdvancesFibrosisHighplex FLHALO, HALO Link
PD‐L1+ macrophage and tumor cell abundance and proximity to T cells in the pretreatment large B‐cell lymphoma microenvironment impact CD19 CAR‐T cell immunotherapy efficacyHirayama A V, Wright J H, Smythe K S, Fiorenza S, Shaw A N, Gauthier J, Maloney D G, Naresh K N, Yeung C C S, Turtle C J2024HemasphereImmuno-oncologyClassifier, Spatial Analysis, Highplex FLHALO, HALO Link
Indoleamine-2,3-dioxygenase inhibition improves immunity and is safe for concurrent use with cART during Mtb/SIV coinfectionSingh B, Sharan R, Ravichandran G, Escobedo R, Shivanna V, Dick E J, Hall-Ursone S, Arora G, Alvarez X, Singh D K, Kaushal D, Mehra S2024JCI InsightInfectious DiseaseClassifier, Highplex FLHALO
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistanceThatikonda V, Lyu H, Jurado S, Kostyrko K, Bristow C A, Albrecht C, Alpar D, Arnhof H, Bergner O, Bosch K, Feng N, Gao S, Gerlach D, Gmachl M, Hinkel M, Lieb S, Jeschko A, Machado A A, Madensky T, Marszalek E D, Mahendra M, Melo-Zainzinger G, Molkentine J M, Jaeger P A, Peng D H, Schenk R L, Sorokin A, Strauss S, Trapani F, Kopetz S, Vellano C P, Petronczki M, Kraut N, Heffernan T P, Marszalek J R, Pearson M, Waizenegger I C, Hofmann M H2024Nature CancerOncologyFISH, Highplex FLHALO
Targeting fatty acid oxidation enhances response to HER2-targeted therapyNandi I, Ji L, Smith H W, Avizonis D, Papavasiliou V, Lavoie C, Pacis A, Attalla S, Sanguin-Gendreau V, Muller W J2024Nature CommunicationsOncology, MetabolismHighplex FLHALO
Non-human primate model of long-COVID identifies immune associates of hyperglycemiaPalmer C S, Perdios C, Abdel-Mohsen M, Mudd J, Datta P K, Maness N J, Lehmicke G, Golden N, Hellmers L, Coyne C, Green K M, Midkiff C, Williams K, Tiburcio R, Fahlberg M, Boykin K, Kenway C, Russell-Lodrigue K, Birnbaum A, Bohm R, Blair R, Dufour J P, Fischer T, Saied A A, Rappaport J2024Nature CommunicationsInfectious DiseaseISH, Highplex FLHALO
Chemotherapy drives tertiary lymphoid structures that correlate with ICI-responsive TCF1+CD8+ T cells in metastatic ovarian cancerLanickova T, Hensler M, Kasikova L, Vosahlikova S, Angelidou A, Pasulka J, Griebler H, Drozenova J, Mojzisova K, Vankerckhoven A, Laco J, Ryška A, Dundr P, Kocian R, Cibula D, Brtnicky T, Skapa P, Jacob F, Kovar M, Praznovec I, McNeish I A, Halaska M J, Rob L, Coosemans A, Orsulic S, Galluzzi L, Spisek R, Fucikova J2024Clinical Cancer ResearchImmuno-oncologyClassifier, Highplex FL, RegistrationHALO
Intra-patient spatial comparison of non-metastatic and metastatic lymph nodes reveals the reduction of CD169+ macrophages by metastatic breast cancersMaeshima Y, Kataoka T. R, Vandenbon A, Hirata M, Takeuchi Y, Suzuki Y, Fukui Y, Kawashima M, Takada M, Ibi Y, Haga H, Morita S, Toi M, Kawaoka S, Kawaguchi K2024ebiomedicineImmuno-oncologyHighplex FLHALO
Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase ReductaseYang X, Lin G, Chen Y, Lei X, Ou Y, Yan Y, Wu R, Yang J, Luo Y, Zhao L, Zhang X, Yang Z, Qin A, Sun P, Yu X-Y, Hu W2024ACS Central ScienceFibrosisArea Quantification, Highplex FLHALO
Angiotensin receptor blocker attacks armored and cold tumors and boosts immune checkpoint blockadeMei J, Chu J, Yang K, Luo Z, Yang J, Xu J, Li Q, Zhang Y, Zhang Q, Wan M, Xue N, Ding J, Zhu Y, Cai Y, Yin Y2024Journal for Immunotherapy of CancerImmuno-oncologyArea Quantification, Multiplex IHC, Highplex FLHALO
Intratumoral CXCL13+ CD160+ CD8+ T cells promote the formation of tertiary lymphoid structures to enhance the efficacy of immunotherapy in advanced gastric cancerWang J, Liang Y, Xue A, Xiao J, Zhao X, Cao S, Li P, Dong J, Li Y, Xu Z, Yang L2024Journal for Immunotherapy of CancerImmuno-oncologyHighplex FLHALO
Cellular origin and clonal evolution of human dedifferentiated liposarcomaGruel N, Quignot C, Lesage L, El Zein S, Bonvalot S, Tzanis D, Ait Rais K, Quinquis F, Manciot B, Vibert J, El Tannir N, Dahmani A, Derrien H, Decaudin D, Bièche I, Courtois L, Mariani O, Linares L K, Gayte L, Baulande S, Waterfall J J, Delattre O, Pierron G, Watson S2024Nature CommunicationsOncologyHighplex FLHALO
Cancer cell-specific PD-L1 expression is a predictor of poor outcome in patients with locally advanced oral cavity squamous cell carcinomaWang M, Qin L, Thia K, Nguyen T, MacDonald S, Belobrov S, Kranz S, Goode D, Trapani J A, Wiesenfeld D, Neeson P J2024Journal for Immunotherapy of CancerOncologyHighplex FLHALO
MerTK+ macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activationWu N, Li J, Li L, Yang L, Dong L, Shen C, Sha S, Fu Y, Dong E, Zheng F, Tan Z, Tao J2024Science AdvancesImmuno-oncologyHighplex FLHALO
Neoadjuvant toripalimab plus axitinib for clear cell renal cell carcinoma with inferior vena cava tumor thrombus: NEOTAX, a phase 2 studyGu L, Peng C, Liang Q, Huang Q, Lv D, Zhao H, Zhang Q, Zhang Y, Zhang P, Li S, Xu J, Chen L, Xie Y, Li J, Guo G, Zhang X, Wang B, Ma X2024Signal Transduction and Targeted TherapyImmuno-oncologyHighplex FLHALO
Single intravenous administration of oncolytic adenovirus TILT-123 results in systemic tumor transduction and immune response in patients with advanced solid tumorsJirovec E, Quixabeira D C A, Clubb J H A, Pakola S A, Kudling T, Arias V, Haybout L, Jalkanen K, Alanko T, Monberg T, Khammari A, Dreno B, Svane I M, Block M S, Adamo D A, Mäenpää J, Kistler C, Sorsa S, Hemminki O, Kanerva A, Santos J M, Cervera-Carrascon V, Hemminki A2024Journal of Experimental & Clinical Cancer ResearchOncologyMultiplex IHC, Highplex FLHALO
Perioperative sintilimab and neoadjuvant anlotinib plus chemotherapy for resectable non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 2 trial (TD-NeoFOUR trial)Duan H, Shao C, Luo Z, Wang T, Tong L, Liu H, Yao X, Lei J, Zhao J, Gao Y, Jiang T, Yan X2024Signal Transduction and Targeted TherapyImmuno-oncologyArea Quantification, Spatial Analysis, Highplex FLHALO
SPI1+CD68+ macrophages as a biomarker for gastric cancer metastasis: a rationale for combined antiangiogenic and immunotherapy strategiesDeng G, Wang P, Su R, Sun X, Wu Z, Huang Z, Gu L, Yu H, Zhao Z, He Y, Huo M, Zhang C, Yin S2024Journal for Immunotherapy of CancerImmuno-oncologySpatial Analysis, Highplex FLHALO
Systemic longitudinal immune profiling identifies proliferating Treg cells as predictors of immunotherapy benefit: biomarker analysis from the phase 3 CONTINUUM and DIPPER trialsHuang S-W, Jiang W, Xu S, Zhang Y, Du J, Wang Y-Q, Yang K-Y, Zhang N, Liu F, Zou G-R, Jin F, Wu H-J, Zhou Y-Y, Zhu X-D, Chen N-Y, Xu C, Qiao H, Liu N, Sun Y, Ma J, Liang Y-L, Liu X2024Signal Transduction and Targeted TherapyImmuno-oncologySpatial Analysis, Highplex FLHALO, HALO AI
Diversity of the immune microenvironment and response to checkpoint inhibitor immunotherapy in mucosal melanomaVos J L, Traets J J H, Qiao X, Seignette I M, Peters D, Wouters M W J M, Hooijberg E, Broeks A, van der Wal J E, Karakullukcu M B, Klop W M C, Navran A, van Beurden M, Brouwer O R, Morris L G T, van Poelgeest M I E, Kapiteijn E, Haanen J B A G, Blank C U, Zuur C L2024JCI InsightImmuno-oncologyClassifier, Spatial Analysis, Highplex FLHALO
JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopeciaStrobl K, Klufa J, Jin R, Artner-Gent L, Krauß D, Novoszel P, Strobl J, Stary G, Vujic I, Griss J, Holcmann M, Farlik M, Homey B, Sibilia M, Bauer T2024EMBO Molecular MedicineImmunologyHighplex FLHALO
Oncolytic immunotherapy with nivolumab in muscle-invasive bladder cancer: a phase 1b trialLi R, Villa N Y, Yu X, Johnson J O, Borjas G, Dhillon J, Moran-Segura C M, Kim Y, Francis N, Dorman D, Powers J J, Sexton W J, Spiess P E, Poch M A, Zemp L, Gilbert S M, Zhang J, Pow-Sang J M, Anderson A R A, Li T, Wang X, Grass G D, Burke J M, Dinney C P N, Rodriguez P C, Jain R K, Mulé J J, Conejo-Garcia J R2024Nature MedicineImmuno-oncologyHighplex FLHALO, HALO AI
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβKiourtis C, Terradas-Terradas M, Gee L M, May S, Georgakopoulou A, Collins A L, O’Sullivan E D, Baird D P, Hassan M, Shaw R, Tan E H, Müller M, Engelmann C, Andreola F, Hsieh Y C, Reed L H, Borthwick L A, Nixon C, Clark W, Hanson P S, Sumpton D, Mackay G, Suzuki T, Najumudeen A K, Inman G J, Campbell A, Barry S T, Quaglia A, Morris C M, LeBeau F E N, Sansom O J, Kirschner K, Jalan R, Oakley F, Bird T G2024Nature Cell BiologyOtherArea Quantification, Multiplex IHC, Highplex FLHALO
Differences in the pathological, transcriptomic, and prognostic implications of lymphoid structures between primary and metastatic cutaneous melanomasKarapetyan L, Li A, De Stefano D, Abushukair H M, Al-Bzour A N, Knight A, Layding C, Wang H, Xu J, Yao J, Song X, Joy M, Nguyen J, Moran-Segura C, Bruno S, Sander C, Messina J, Mule J J, Storkus W J, Kirkwood J M2024Journal for Immunotherapy of CancerOncologyHighplex FLHALO
Granzyme K+CD8+ T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polypsGuo C-L, Wang C-S, Wang Z-C, Liu F-F, Liu L, Yang Y, Li X, Guo B, Lu R-Y, Liao B, Liu J-X, Wang H, Song J, Yao Y, Zhu L-P, Yu D, Liu Z2024Nature CommunicationsImmunologySpatial Analysis, Highplex FLHALO
Immune checkpoint landscape of human atherosclerosis and influence of cardiometabolic factorsBarcia Durán J G, Das D, Gildea M, Amadori L, Gourvest M, Kaur R, Eberhardt N, Smyrnis P, Cilhoroz B, Sajja S, Rahman K, Fernandez D M, Faries P, Narula N, Vanguri R, Goldberg I J, Fisher E A, Berger J S, Moore K J, Giannarelli C2024Nature Cardiovascular ResearchImmunologyHighplex FLHALO, HALO AI
Cryoablation-induced neutrophil Ca2+ elevation and NET formation exacerbate immune escape in colorectal cancer liver metastasisTan H, Jiang Y, Shen L, Nuerhashi G, Wen C, Gu L, Wang Y, Qi H, Cao F, Huang T, Liu Y, Xie W, Deng W, Fan W2024Journal of Experimental & Clinical Cancer ResearchImmuno-oncologySpatial Analysis, Highplex FLHALO
Castrate-resistant prostate cancer response to taxane is determined by an HNF1-dependent apoptosis resistance circuitSenatorov I S, Bowman J, Jansson K H, Alilin A N, Capaldo B J, Lake R, Riba M, Abbey Y C, Mcknight C, Zhang X, Raj S, Beshiri M L, Shinn P, Nguyen H, Thomas C J, Corey E, Kelly K2024Cell Reports MedicineOncologyHighplex FLHALO
Lurbinectedin sensitizes PD-L1 blockade therapy by activating STING-IFN signaling in small-cell lung cancerChakraborty S, Sen U, Ventura K, Jethalia V, Coleman C, Sridhar S, Banerjee A, Ozakinci H, Mahendravarman Y, Snioch K, Stanchina E, Shields M D, Tomalin L E, Demircioglu D, Boyle T A, Tocheva A, Hasson D, Sen T2024Cell Reports MedicineImmuno-oncologyClassifier, Highplex FLHALO
Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastomaJourdin R C, Salerno A, Shai-Hee T, Murray J E, Castrogiovanni G, McHenry C, Jue T R, Pham V, Bell J L, Poursani E, Valli E, Cazzoli R, Damstra N, Nelson D J, Stevens K L P, Chee J, Slapetova I, Kasherman M, Whan R, Lin F, Cochran B J, Tedla N, Colakoglu Veli F, Yuksel A, Vittorio O2024Nature CommunicationsImmuno-oncologyHighplex FLHALO, HALO AI
Neoadjuvant atezolizumab + chemotherapy for resectable NSCLC: 3-year clinical update of phase II clinical trial results and translational findingsHenick B S, Koch P D, Gainor J F, Awad M M, Chiuzan C, Izard S, Georgis Y, Mallick S, Garofano R F, Wong C V, Saqi A, Grindheim J, Schulze K, Sonett J R, Rizvi N A, Izar B, Taylor A M, Shu C A2024Journal for Immunotherapy of CancerImmuno-oncologyHighplex FLHALO, HALO AI
Comprehensive analysis of heterogeneity and cell-cell interactions in Crohn’s disease reveals novel location-specific insightsFeng J, He LN, Yao R, Qiao Y, Yang T, Cui Z, Meng X, Tong J, Jia K, Zuo Z, Shen J2024Journal of Advanced ResearchImmunologySpatial Analysis, Highplex FLHALO
Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-driven inflammationO’Brien VP, Kang Y, Shenoy MK, Finak G, Young WC, Dubrulle J, Koch L, Rodriguez Martinez AE, Williams J, Donato E, Batra SK, Yeung CCS, Grady WM, Koch MA, Gottardo R, Salama NR2023Cancer Research CommunicationsOncology, Infectious DiseaseHighplex FLHALO
Autologous T cell therapy for MAGE-A4+ solid cancers in HLA-A*02+ patients: a phase 1 trialHong D, Van Tine B, Biswas S, McAlpine C, Johnson M, Olszanski A, Clarke J, Araujo D, Blumenschein G, Kebriaei P, Lin Q, Tipping A, Sanderson J, Wang R, Trivedi T, Annareddy T, Bai J, Rafail S, Sun A, Fernandes L, Navenot J-M, Bushman F, Everett J, Karadeniz D, Broad R, Isabelle M, Naidoo R, Bath N, Betts G, Wolchinsky Z, Batrakou D, Van Winkle E, Elefant E, Ghobadi A, Cashen A, Grand’Maison A, McCarthy P, Fracasso P, Norry E, Williams D, Druta M, Liebner D, Odunsi K, Butler M2023Nature MedicineImmuno-oncologyISH/FISH, Spatial Analysis, Highplex FLHALO
Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancerWang F, Long J, Li L, Wu Z, Da T, Wang X, Huang C, Jiang Y, Yao X, Ma H, Lian Z, Zhao Z, Cao J2023Science AdvancesOncologyMultiplex IHC, Spatial Analysis, Highplex FLHALO
Single-cell RNA sequencing identifies a population of human liver-type ILC1sKramer B, Nalin A, Ma F, Eickoff S, Lutz P, Leonardelli S, Foeser F, Finnemann C, Hack G, Raabe J, ToVinh M, Ahmad S, Hoffmeister C, Kaiser K, Manekeller S, Branchi V, Bald T, Holzel M, Huneburg R, Nischalke H, Semaan A, Langhans B, Kaczmarek D, Benner B, Lordo M, Kowalski J, Gerhardt A, Timm J, Toma M, Mohr R, Turler A, Charpentier A, van Bremen T, Felmann G, Sattler A, Kotsch K, Abdallah A, Strassburg C, Spengler U, Carson W, Mundy-Bosse B, Pellegrini M, O’Sullivan T, Greud A, Nattermann J2023Cell ReportsImmunologyHighplex FLHALO
Tertiary lymphoid structures in desmoplastic melanoma have increased lymphocyte density, lymphocyte proliferation, and immune cross talk with tumor when compared to non-desmoplastic melanomasEdmonds N, Gradecki S, Katyal P, Lynch K, Stowman A, Gru A, Engelhard V, Slingluff Jr. C, Mauldin I2023OncoImmunologyImmuno-oncologyHighplex FLHALO
Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironmentsBeach C, MacLean D, Majorova D, Melemenidis S, Nambiar D, Kim R, Valbuena G, Guglietta S, Krieg C, Darvish D, Suwa T, Eason A, Domingo E, Moon E, Jiang D, Jiang Y, Koong A, Woodruff T, Graves E, Maughan T, Buczacki S, Stucki M, Le Q-T, Leedham S, Giaccia A, Olcina M2023bioRxivImmuno-oncologyClassifier, Area Quantification, Highplex FLHALO
A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migrationHwang P, Mathur J, Cao Y, Almeida J, Ye J, Morikis V, Cornish D, Clarke M, Stewart S, Pathak A, Longmore G2023Developmental CellOncologyHighplex FL, RegistrationHALO
Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methodsBayer F, Bejarano D, Bartacchi G, Doffin A-C, Gobbini E, Hubert M, Li L, Meiser P, Pedde A-M, Posch W, Rupp L, Schlitzer A, Schmitz M, Schraml B, Uderhardt S, Balladeau-Guilemond J, Wilflingseder D, Zaderer V, Bottcher J2023European Journal of ImmunologyOtherHighplex FLHALO
Standardized pathology screening of mature Tertiary Lymphoid Structures in cancersVanhersecke L, Bougouin A, Crombe A, Brunet M, Sofeu C, Parrens M, Pierron H, Bonhomme B, Lembege N, Rey C, Velasco V, Soubeyran I, Begueret H, Bessede A, Bellera C, Scoazec J-Y, Italiano A, Fridman C, Fridman W, Le Loarer F2023Laboratory InvestigationOtherHighplex FL, RegistrationHALO
Effects of electroacupuncture on the kisspeptin-gonadotropin-releasing hormone (GnRH) /luteinizing hormone (LH) neural circuit abnormalities and androgen receptor expression of kisspeptin/neurokinin B/dynorphin neurons in PCOS rats.Xu G, Zhao X, Li Z, Hu J, Li X, Li J, Chen Y2023Journal of Ovarian ResearchOtherHighplex FLHALO
Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapySingh B, Moodley C, Singh D, Escobedo R, Sharan R, Arora G, Ganatra S, Shivanna V, Gonzalez O, Hall-Ursone S, Dick Jr. E, Kaushal D, Alvarez X, Mehra S2023JCI InsightInfectious Disease, FibrosisArea Quantification, Highplex FLHALO
Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trialTian J, Chen J, Chao S, Pelka K, Giannakis M, Hess J, Burke K, Jorgji V, Sindurakar P, Braverman J, Mehta A, Oka T, Huang M, Lieb D, Spurrell M, Allen J, Abrams T, Clark J, Enzinger A, Enzinger P, Klempner S, McCleary N, Meyerhardt J, Ryan D, Yurgelun M, Kanter K, Van Seventer E, Baiev I, Chi G, Jarnagin J, Bradford W, Wong E, Michel A, Fetter I, Siravegna G, Gemma A, Sharpe A, Demehri S, Leary R, Campbell C, Yilmaz Om Getz G, Parikh A, Hacohen N, Corcoran R2023Nature MedicineOncologyHighplex FLHALO
Gold Nanoparticles for Monitoring of Mesenchymal Stem Cell–Loaded Bioresorbable Polymeric Wraps for Arteriovenous FistulasBarcena A, Perez J, Damasco J, Bernardino M, San Valentin E, Klusman C, Martin B, Cortes A, Canlas G, Heralde III, F, Avritscher R, Fowlkes N, Bouchard R, Cheng J, Huang S, Melancon M2023bioRxivBiomaterialsHighplex FLHALO
Discovery of NRG1-VII: a novel myeloid-derived class of NRG1 isoformsBerrocal-Rubio M, Pawer Y, Dinevska M, De Paoli-Iseppi R, Widodo S, Rajab N, De Nardo W, Hallab J, Li A, Mantamadiotis T, Clark M, Wells C2023bioRxivImmunologyHighplex FLHALO
Single-cell spatial immune landscapes of primary and metastatic brain tumoursKarimi E, Yu M, Maritan S, Perus L, Rezanejad M, Sorin M, Kankner M, Fallah P, Doré S, Zuo D, Fiset B, Kloosterman D, Ramsay L, Wei Y, Lam S, Alsajjan R, Watson I, Urgoiti G, Park M, Randsma D, Senger D, Chan J, Akkari L, Petrecca K, Guiot M-C, Siegel P, Quail D, Walsh L2023NatureImmuno-oncologyHighplex FLHALO
Multiplex immune profiling reveals the role of serum immune proteomics in predicting response to preoperative chemotherapy of gastric cancerTang Z, Gu Y, Shi Z, Min L, Zhang Z, Zhou P, Luo R, Wang Ym, Cui Y, Sun Y, Wang X2023Cell Reports MedicineImmuno-oncologyHighplex FLHALO
Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analysesHirz T, Mei S, Sarkar H, Kfoury Y, Wu S, Verhoeven B, Subtelny A, Zlatev D, Wszolek M, Salari K, Murray E, Chen F, Macosko E, Wu C, Scadden D, Dahl D, Baryawno N, Saylor P, Kharchenko P, Sykes D2023Nature CommunicationsImmuno-oncologyHighplex FLHALO
Impact of aging on the immunological and microbial landscape of the lung during nontuberculous mycobacterial infectionCinco I, Rhoades N, Napier E, Davies M, Allison D, Kohama S, Bermudez L, Winthrop K, Fuss C, Spindel E, Messaoudi I2023bioRxivInfectious DiseaseHighplex FLHALO
Effects of KMT2D mutation and its exon 39 mutation on the immune microenvironment and drug sensitivity in colorectal adenocarcinomaLiu C, Jin Y, Zhang H, Yan J, Guo Y, Bao X, Zhao P2023HeliyonOncologyHighplex FLHALO
Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progressionNandi I, Smith H, Sanguin-Gendreau V, Ji L, Pacis A, Papavasiliou V, Zuo D, Nam S, Attala S, Kim S, Lusson S, Kuasne H, Fortier A, Savage P, Ramirez C, Park M, Katzenellenbogen J, Katzenellenbogen B, Muller W2023Journal of Clinical InvestigationOncologyHighplex FLHALO
NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasisIlter D, Drapela S, Schild T, Ward N, Adhikari E, Low V, Asara J, Oskarsson T, Lau E, DeNicola G, McReynolds M, Gomes A2023Redox BiologyOncology, MetabolismClassifier, Highplex FL, TMAHALO
Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine modelXin J, Yang T, Wu X, Wu Y, Liu Y, Liu X, Jiang M, Gao W2023Communications BiologyGastroenterologyHighplex FLHALO
Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent mannerMahadevan K, McAndrews K, LeBlue V, Yang S, Lyu H, Li B, Sockwell A, Kirtley M, Morse S, Diaz B, Kim M, Feng N, Lopez A, Guerrero P, Sugimoto H, Arian K, Ying H, Barekatain Y, Kelly P, Maitra A, Heffernan T, Kalluri R2023bioRxivOncologyFISH, Highplex FLHALO
PD-1+CD8+ T Cells Proximal to PD-L1+CD68+ Macrophages Are Associated with Poor Prognosis in Pancreatic Ductal Adenocarcinoma PatientsYang X, Wang G, Song Y, Zhuang T, Li Y, Xie Y, Fei X, Zhao Y, Xu D, Hu Y2023CancersOncology, Immuno-oncologyClassifier, Spatial Analysis, Highplex FL, RegistrationHALO
Donor Batf3 inhibits murine lung allograft rejection and airway fibrosisWatanabe T, Lam C, Oliver J, Oishi H, Teskey G, Beber S, Boonstra K, Mauricio J, Buhari H, Joe B, Guan Z, Horie M, Keshavjee S, Martinu T, Juvet S2023Mucosal ImmunityOther, FibrosisHighplex FLHALO
Loss of Hepatic Leucine-Rich RepeatContaining G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver DiseaseSaponara E, Penno C, Orsini V, Wang Z, Fischer A, Aebi A, Matadamas-Guzman M, Brun V, Fischer B, Brousseau M, O’Donnell P, Turner J, Meyer A, Bollepalli L, d’Ario G, Roma G, Carbone W, Annunziato S, Obrecht M, Beckmann N, Saravanan C, Osmont A, Tropberger P, Richards S, Genoud C, Ley S, Ksiazek I, Nigsch F, Terracciano L, Schadt H, Bouwmeester T, Tchorz J, Ruffner H2023The American Journal of PathologyGastroenterologyHighplex FLHALO
Single-cell analysis reveals changes in BCG vaccine-injected mice modeling tuberculous meningitis brain infectionZhang X, Zhao Z, Wu Q, Wang L, Li L, Wang M, Ren Y, Pan L, Tang H, Li F2023Cell ReportsInfectious DiseaseMultiplex IHC, Highplex FLHALO
Spatial multi-omics revealed the impact of tumor ecosystem heterogeneity on immunotherapy efficacy in patients with advanced non-small cell lung cancer treated with bispecific antibodySong X, Xiong A, Wu F, Li X, Wang J, Jiang T, Chen P, Zhang X, Zhao Z, Liu H, Cheng L, Zhao C, Wang Z, Pan C, Cui X, Xu T, Luo H, Zhou C2023Journal for ImmunoTherapy of CancerImmuno-oncologyHighplex FLHALO
Co-enrichment of CD8-positive T cells and macrophages is associated with clinical benefit of tislelizumab in solid tumorsYe D, Desai J, Shi J, Liu S, Shen W, Liu T, Shi Y, Wang D, Liang L, Yang S, Ma X, Jin W, Zhang P, Huang R, Shen Z, Zhang Y, Wu Y2023Biomarker ResearchImmuno-oncologySpatial Analysis, Highplex FLHALO
Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K+ CD8+T cells in primary Sjögren’s syndromeXu T, Zhu H, Ma J, Li X, Luo P, Li Y, Lian Z, Gao C2023JCI InsightImmunologyHighplex FLHALO
Melanotransferrin Functions as a Pro-Oncogenic WNT Agonist: A Yin-Yang Relationship in Melanoma with the WNT Antagonist and Metastasis Suppressor, NDRG1Paluncic J, Cholam M, Lane D, Skoda J, Park K, Chiang S, Bae D, Scolyer R, Afroz R, Babu G, Wilmott J, Loh K, Jansson P, Dharmasiviam M, Huang M, Zhao X, Kovacevic Z, Richardson D2023bioRxivOncologyHighplex FLHALO
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescenceGioia U, Tavella S, Martinez-Orellana P, Cicio G, Colliva A, Ceccon M, Cabrini M, Henriques A, Fumagalli V, Paldino A, Presot E, Rajasekharan S, Iacomino N, Pisati F, Matti V, Sepe S, Conte M, Barozzi S, Lavagnino Z, Carletti T, Volpe M, Cavalcante P, Iannacone M, Rampazzo C, Bussani R, Tripodo C, Zacchigna S, Marcello A, di Fagagna F2023Nature Cell BiologyInfectious DiseaseISH/FISH, Highplex FLHALO
TIPE2 Inhibits MGD Inflammation by Regulating Macrophage PolarizationZhao S, Shen Y, Wu S, Shao Y, Shi R, Yan Y, Zhao H2023Journal of Personalized MedicineImmunologyArea Quantification, Highplex FLHALO
High tumor mutational burden predicts favorable response to anti-PD-(L)1 therapy in patients with solid tumor: a real-world pan-tumor analysisJung J, Heo Y, Park S2023Journal for ImmunoTherapy of CancerImmuno-oncologySpatial Analysis, Highplex FLHALO
Bi-allelic mutation in SEC16B alters collagen trafficking and increases ER stressEl-Gazzar A, Voraberger B, Rauch F, Mairhofer M, Schmidt K, Guillemyn B, Mitulovic G, Reiterer V, Haun M, Mayr M, Mayr J, Kimeswenger S, Drews O, Saraff V, Shaw N, Fratzl-Zelman N, Symoens S, Farhan H, Hogler W2023EMBO Molecular MedicineOtherArea Quantification, Highplex FLHALO
Tumour Extracellular Vesicles Induce Neutrophil Extracellular Traps To Promote Lymph Node MetastasisSu X, Brassard A, Bartolomucci A, Dhoparee-Dooma I, Qiu Q, Tsering T, Rohanizadeh R, Koufos O, Giannias B, Bourdeau F, Feng L, Leo S, Sangwan V, Tankel J, Quail D, Spicer J, Burnier J, Bailey S, Ferri L, Cools-Lartigue J2023bioRxivImmuno-oncologyArea Quantification, Highplex FLHALO
Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaquesByrnes S, Busman-Sahay K, Angelovich T, Younger S, Taylor-Brill S, Nekorchuk M, Bondoc S, Dannay R, Terry M, Cochrane C, Jenkins T, Roche M, Deleage C, Bosinger S, Paiardini M, Brew B, Estes J, Churchill M2023PLOS PathogensInfectious DiseaseArea Quantification, Object Colocalization, ISH, Highplex FLHALO
Development of a deep pathomics score for predicting hepatocellular carcinoma recurrence after liver transplantationQu W, Tian M, Lu H, Zhou Y, Liu W, Tang Z, Yao Z, Huang R, Zhu G, Jiang X, Tao C, Fang Y, Gao J, Wu X, Chen J, Zhao Q, Yang R, Chu T, Zhou J, Fan J, Yu J, Shi Y2023Hepatology InternationalOncologySpatial Analysis, Highplex FLHALO
Early Identication of High-Risk Patients with HCC Relapse: A Spatial Immune Scoring System Enabled by Articial IntelligenceSun C, Jia G, He P, Goh D, Li F, Wee F, Sun M, Dai T, Lim J, Hao S, Liu L, Yeong J, Tian Z2023Research SquareOncologyHighplex FLHALO
Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancerShakfa N, Li D, Conseil G, Lightbody E, Wilson-Sanchez J, Hamade A, Chenard S, Jawa N, Laight B, Afriyie-Asante A, Tyryshkin K, Koebel M, and Koti M2023Journal for ImmunoTherapy of CancerOncologyHighplex FLHALO, HALO Link
Prognostic value of tumor immune microenvironment factors in patients with stage I lung adenocarcinomaXue Q, Wang Y, Zheng Q, Chen L, Lin Y, Jin Y, Shen X, Li Y2023American Journal of Cancer ResearchOncologyClassifier, Multiplex IHC, Highplex FLHALO
Immune Checkpoint Neuropilins as Novel Biomarkers and Therapeutic Targets for Pancreatic CancerHe L, Zhang X, Lao M, Zhang H, Yang H, Bai X2023CancersImmuno-oncologyHighplex FLHALO
Cannabinoid enhancement of lncRNA MMP25-AS1/MMP25 interaction reduces neutrophil infiltration and intestinal epithelial injury in HIV/SIV infectionPremadasa L, Lee E, McDew-White M, Alvarez X, Jayakumar S, Ling B, Okeoma C, Byrareddy S, Kulkarni S, and Mohan M2023JCI InsightInfectious DiseaseArea Quantification, Highplex FLHALO
Phenotypic plasticity and reduced tissue retention of exhausted tumor-infiltrating T cells following neoadjuvant immunotherapy in head and neck cancerSievers C, Craveiro M, Friedman J, Robbins Y, Yang X, Bai K, Nguyen A, Redman J, Chari R, Soon-Shiong P, Schlom J, Gulley J, Allen C.2023Cancer CellImmuno-oncologyClassifier, Highplex FLHALO, HALO AI
A five-protein prognostic signature with GBP2 functioning in immune cell infiltration of clear cell renal cell carcinomaMeng K, Li Y, Liu D, Hu L, Pan Y, Zhang C, He Q2023Computational and Structural Biotechnology JournalOncologyHighplex FLHALO
Transcriptional-translational conflict is a barrier to cellular transformation and cancer progressionJana S, Brahma S, Arora S, Wladyka C, Hoang P, Blinka S, Hough R, Horn J, Liu Y, Wang L, Depeille P, Smith E, Montgomery R, Lee J, Haffner M, Vakar-Lopez F, Grivas P, Wright J, Lam H, Black P, Roose J, Ryazanov A, Subramaniam A, Henikoff S, and Hsieh A2023Cancer CellOncologyMultiplex IHC, Highplex FLHALO
Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinomaChakiryan N, Kim Y, Berglund A, Chang A, Kimmel G, Hajiran A, Nguyen J, Moran-Segura C, Saeed-Vafa D, Katende E, Lopez-Blanco N, Chahoud J, Rappold P, Spiess P, Fournier M, Jeong D, Wang L, Teer J, Dhillon J, Kuo F, Hakimi A, Altrock P, Mulé J, Manley B2023Journal for ImmunoTherapy of CancerImmuno-oncologyHighplex FLHALO
Adrenal cortex size and homeostasis are regulated by gonadal hormones via androgen receptor/β-catenin signaling crosstalkLyraki R, Grabek A, Tison A, Weerasinghe-Arachchige L, Peitzsch M, Bechman N, Youssef S, de Bruin A, Bakker E, Claessens F, Chaboissier M, Schedl A2023Disease Models & MechanismsOtherFISH, Highplex FLHALO
Multi-organ landscape of therapy-resistant melanomaLiu S, Dharanipragada P, Lomeli S, Wang Y, Zhang X, Yang Z, Lim R, Dumitras C, Scumpia P, Dubinett S, Moriceau G, Johnson D, Moschos S, Lo R2023Nature MedicineOncology, Immuno-oncologyHighplex FLHALO
Somatic mutation profiling, tumor-infiltrating leukocytes, tertiary lymphoid structures and PD-L1 protein expression in HER2-amplified colorectal cancerLiu X, Kou Z, Zhang H, Dong J, Zhang J, Peng Y, Ma S, Liang L, Meng X, Zhou Y, Yang J2023PeerJImmuno-oncologyHighplex FLHALO
Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of gliomaYang X, Ji C, Qi Y, Huang J, Hu L, Zhou Y, Zou L, Xia Y, Tan F, Yao Y, Chen D2023Research SquareOncologyHighplex FLHALO
Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastomaBurger M, Forster M, Romanski A, Straßheimer F, Macas J, Zeiner P, Steidl E, Herkt S, Weber K, Schupp J, Lun J, Strecker M, Wlotzka K, Cakmak P, Opitz C, George R, Mildenberger I, Nowakowska P, Zhang C, Röder J, Müller E, Ihrig K, Langen K, Rieger M, Herrmann E, Bonig H, Harter P, Reiss Y, Hattingen E, Rödel F, Plate K, Tonn T, Senft C, Steinbach J, Wels W2023Neuro-OncologyImmuno-oncologyHighplex FLHALO
Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosisConroy L, Clarke H, Allison D, Valenca S, Sun Q, Hawkinson T, Young L, Ferreira J, Hammonds A, Dunne J, McDonald R, Absher K, Dong B, Bruntz R, Markussen K, Juras J, Alilain W, Liu J, Gentry M, Angel P, Waters C, Sun R2023Nature CommunicationsFibrosisMultiplex IHC, Highplex FLHALO
Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironmentsFeng Y, Yang T, Zhu J, Li M, Doyle M, Ozcoban V, Bass G, Pizzolla A, Cain L, Weng S, Pasam A, Kocovski N, Huang Y, Keam S, Speed T, Neeson P, Pearson R, Sandhu S, Goode D, Trigos A2023Nature CommunicationsOtherHighplex FLHALO
High expression ITGA2 affects the expression of MET,PD-L1, CD4 and CD8 with the immune microenvironment in pancreatic cancer patientsJin L, Duan Y, Li Z, Hu J, Shi H, Su Z, Li Z, Du B, Chen Y, Tan Y2023Research SquareOncologyHighplex FLHALO
Tumor-derived semaphorin 4A improves PD-1–blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferationNAITO Y, KOYAMA S, MASUHIRO K, HIRAI T, UENAMI T, INOUE T, OSA A, MACHIYAMA H, WATANABE G, SAX N, VILLA J, KINUGASA-KATAYAMA Y, NOJIMA S, YAGA M, HOSONO Y, OKUZAKI D, SATOH S, TSUDA T, NAKANISHI Y, SUGA Y, MORITA T, FUKUSHIMA K, NISHIDE M, SHIROYAMA T, MIYAKE K, IWAHORI K, HIRATA H, NAGATOMO I, YANO Y, TAMIYA M, KUMAGAI T, TAKEMOTO N, INOHARA H, YAMASAKI S, YAMASHITA K, AOSHI T, AKBAY E, HOSEN N, SHINTANI Y, TAKAMATSU H, MORI M, TAKEDA Y, KUMANOGOH A2023Science AdvancesImmuno-oncologyMultiplex IHC, Highplex FLHALO
A Pilot Study of Neoadjuvant Nivolumab, Ipilimumab, and Intralesional Oncolytic Virotherapy for HER2-negative Breast CancerNguyen V, Campbell K, Nowicki T, Elumalai N, Medina E, Baselga-Carretero I, DiNome M, Chang H, Oseguera D, Ribas A, Glaspy J2023Cancer Research CommunicationsImmuno-oncologyHighplex FLHALO
Imaging mass cytometry reveals tissue-specific cellular immune phenotypes in the mouse knee following ACL injurySouth SM, Marlin MC, Mehta-D’souza P, Stephens T, Conner T, Burt KG, Guthridge JM, Scanzello CR, Griffin TM2023Osteoarthritis and Cartilage OpenImmunologyHighplex FLHALO
Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunityLiu X, Hogg G, Zuo C, Borcherding N, Baer J, Lander V, Kang LI, Knolhoff B, Ahmad F, Osterhout R, Galkin A, Bruey J, Carter L, Mpoy C, Vij K, Fields R, Schwarz J, Park H, Gupta V, DeNardo D2023Cancer CellImmuno-oncologyArea Quantification, Cytonuclear, Highplex FLHALO
Sequential pembrolizumab cooperates with platinum/5FU to remodel the tumor immune microenvironment in advanced gastric cancer: A phase II chemoimmunotherapy trialKlempner S, Lee J, Mehta A, An M, Min B, Heo Y, Parikh M, Bi L, Cristescu R, Lee H, Kim T, Lee S, Moon J, Park R, Strickland M, Park W, Kang W, Kim K, Kim S2023Research SquareImmuno-oncologyClassifier, Highplex FLHALO
An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicityCheng L, Zhu M, Gao Y, Liu W, Yin W, Zhou P, Zhu Z, Niu L, Zeng X, Zhang D, Fang Q, Wang F, Zhao Q, Zhang Y, Shen G2023Cellular and Molecular Biology LettersImmuno-oncologyMultiplex IHC, Highplex FLHALO
Activation of IGFBP4 via unconventional mechanism of miRNA attenuates metastasis of intrahepatic cholangiocarcinomaTao L, Wang Y, Shen Z, Cai J, Zheng J, Xia S, Lin Z, Wan Z, Qi H, Jin R, Wang L, Xu J, Liang X2023Hepatology InternationalOncologyHighplex FLHALO
Characterization of intratumoral tertiary lymphoid structures in pancreatic ductal adenocarcinoma: cellular properties and prognostic significanceZou X, Lin X, Cheng H, Chen Y, Wang R, Ma M, Liu Y, Dai Z, Tasiheng Y, Yan Y, Hou Q, Ding F, Chen H, Yu X, Wang X, Liu C2023Journal for ImmunoTherapy of CancerImmuno-oncologyHighplex FLHALO, HALO AI
Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor MicroenvironmentDerry J, Burns C, Frazier J, Beirne E, Grenley M, DuFort C, Killingbeck E, Leon M, Williams C, Gregory M, Houlton J, Clayburgh D, Swiecicki P, Huszar D, Berger A, Klinghoffer R2023Clinical Cancer ResearchOncologyHighplex FLHALO, HALO AI
A cellular and molecular spatial atlas of dystrophic muscleStec M, Su Q, Adler C, Zhang L, Golann D, Khan N, Panagis L, Villalta S, Ni M, Wei Y, Walls J, Murphy A, Yancopoulos G, Atwal G, Kleiner S, Halasz G, Sleeman M2023Proceedings of the National Academy of SciencesMyologyISH, Highplex FLHALO
Stem cell-like T cell depletion in the recurrent head and neck cancer immune microenvironmentChen L, Lee N, Sarkar R, Katabi N, Li Y, Morris L, Wong R, Sherman E, Reis-Filho J, Hollmann T, Riaz N2023OncoImmunologyImmuno-oncologySpatial Analysis, Highplex FLHALO
TSLP/dendritic cell axis promotes CD4+ T cell tolerance to the gut microbiomeMesserschmidt J, Azin M, Dempsey K, Demehri S2023JCI InsightImmunologyHighplex FLHALO
Poor outcome in postpartum breast cancer patients is associated with distinct molecular and immunological featuresLefrère H, Moore K, Floris G, Sanders J, Seignette I, Bismeijer T, Peters D, Broeks A, Hooijberg E, Van Calsteren K, Neven P, Warner E, Peccatori F, Loibl S, Maggen C, Han S, Jerzak K, Annibali D, Lambrechts D, de Visser K, Wessels L, Lenaerts L, Amant F2023Clinical Cancer ResearchOncologyClassifier, Highplex FLHALO, HALO AI
Differential expression of CD8 defines phenotypically distinct cytotoxic T cells in cancer and multiple sclerosisBurkard T, Herrero San Juan M, Dreis C, Kiprina A, Namgaladze D, Siebenbrodt K, Luger S, Foerch C, Pfeilschifter J, Weigert A, Radeke H2023Clinical and Translational MedicineOncology, ImmunologyClassifier, Spatial Analysis, Highplex FL, TMAHALO
An intestinal Th17 subset is associated with inflammation in Crohn’s Disease and activated by adherent-invasive Escherichia coli (AIEC)Paroni M, Leccese G, Ranzani V, Moschetti G, Chiara M, Perillo F, Ferri S, Clemente F, Noviello D, Conforti FS, Ferrero S, Karnani B, Bosotti R, Vasco C, Curti S, Crosti MC, Gruarin P, Rossetti G, Conte MP, Vecchi M, Pagani M, Landini P, Facciotti F, Abrignani S, Caprioli F, Geginat J2023Journal of Crohn’s and ColitisImmunologyHighplex FLHALO
Single-cell characterization of pulmonary nodules implicates suppression of immunosurveillance across early stages of lung adenocarcinomaYanagawa J, Tran L, Salehi-Rad R, Lim R, Dumitras C, Fung E, Wallace W, Prosper A, Fishbein G, Shea C, Hong R, Kahangi B, Deng J, Gower A, Liu B, Campbell J, Mazzilli S, Beane J, Kadara H, Lenburg M, Spira A, Aberle D, Krysan K, Dubinett S2023Cancer ResearchImmuno-oncologyHighplex FLHALO
The CD73 is induced by TGF-β1 triggered by nutrient deprivation and highly expressed in dedifferentiated human melanomaGiraulo C, Turiello R, Orlando L, Leonardelli S, Landsberg J, Belvedere R, Rolshoven G, Muller C, Holzel M, Morello S2023Biomedicine & PharmacotherapyOncologyHighplex FL, TMAHALO, HALO AI
Clinical validation of an elastin-derived trifunctional peptide for skin regenerationAbraham JD, Vaissière A, Desouches C, Thiery G, Bertrand B, Alfandari B, Courtois I, Azencot A, Casoli V, Haen P, Colson T, Hornebeck W, Ritter D2023American Journal of Translational ResearchDermatologyHighplex FLHALO
Multiplex Immunohistochemistry and Immunofluorescence: A Practical Update for PathologistsHarms P, Frankel T, Moutafi M, Rao A, Rimm D, Taube J, Thomas D, Chang M, Pantanowitz L2023Modern PathologyReviewSpatial Analysis, Highplex FLHALO
Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancerQuan Y, He J, Zou Q, Zhang L, Sun Q, Huang H, Li W, Xie K, Wie F2023Journal for ImmunoTherapy of CancerImmuno-oncologyClassifier, Multiplex IHC, Highplex FLHALO
Immune checkpoint blockade induces distinct alterations in the microenvironments of primary and metastatic brain tumorsSun L, Kienzler JC, Reynoso JG, Lee A, Shiuan E, Li S, Kim J, Ding L, Monteleone AJ, Owens GC, Phillips JJ, Everson RG, Nathanson D, Cloughesy TF, Li G, Liau LM, Hugo W, Kim W, Prins RM2023Journal of Clinical InvestigationImmuno-oncologyHighplex FLHALO
Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytomaPicard D, Felsberg J, Langini M, Stachura P, Qin N, Macas J, Reiss Y, Bartl J, Selt F, Sigaud R, Meyer FD, Stefanski A, Stühler K, Roque L, Roque R, Pandyra AA, Brozou T, Knobbe-Thomsen C, Plate KH, Roesch A, Milde T, Reifenberger G, Leprivier G, Faria CC, Remke M2023Acta NeuropathologicaOncologyHighplex FLHALO
Integration of peripheral blood- and tissue-based biomarkers of response to immune checkpoint blockade in urothelial carcinomaVanguri RS, Smithy JW, Li Y, Zhuang M, Maher CA, Aleynick N, Peng X, Al-Ahmadie H, Funt SA, Rosenberg JE, Iyer G, Bajorin D, Mathews JC, Nadeem S, Panageas KS, Shen R, Callahan MK, Hollmann TJ2023Journal of PathologyImmuno-oncologyHighplex FLHALO, HALO AI
A pan-cancer single-cell panorama of human natural killer cellsTang F, Li J, Qi L, Liu D, Bo Y, Qin S, Miao Y, Yu K, Hou W, Li J, Peng J, Tian Z, Zhu L, Peng H, Wang D, Zhang Z2023CellImmuno-oncologyHighplex FLHALO
Macrophage reprogramming—rather than depletion —is efficacious in a specific subset of colorectal tumor modelsMohamed N, Amirkhah R, Lavaud X, Gilroy K, Bartolini R, Mulholland E, Garg A, Pennel K, Jackstadt R, Ridgway R, Nixon C, Hatthakarnku P, Campbell A, Leedham S, Edwards J, Dunne P, Barry S, Graham G, Sansom O2023Research SquareImmuno-oncologyMultiplex IHC, Highplex FLHALO
Proteogenomic analysis of chemo-refractory highgrade
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Early Detection of Genotoxic Hepatocarcinogens in Rats Using γH2AX and Ki-67: Prediction by Machine LearningMichiba A, Gi M, Yokohira M, Sakurai E, Teramoto A, Kiriyama Y, Yamada S, Wanibuchi H, Tsukamoto T2023Toxicological SciencesOncologyMultiplex IHC, Highplex FLHALO
Regulation of antigen-specific T cell infiltration and spatial architecture in multiple myeloma and premalignancyRobinson MH, Villa NY, Jaye DL, Nooka AK, Duffy A, McCachren SS, Manalo J, Switchenko JM, Barnes S, Potdar S, Azeem MI, Horvat AA, Parihar VC, Gong J, Liang Y, Smith GH, Gupta VA, Boise LH, Kaufman JL, Hofmeister CC, Joseph NS, Lonial S, Dhodapkar KM, Dhodapkar MV2023Journal of Clinical InvestigationImmuno-oncologyHighplex FLHALO
ATR-binding lncRNA ScaRNA2 promotes cancer resistance through facilitating efficient DNA end resection during homologous recombination repairChen Y, Shen H, Liu T, Cao K, Wan Z, Du Z, Wang H, Yu Y, Ma S, Lu E, Zhang W, Cai J, Gao F, Yang Y2023Journal of Experimental & Clinical Cancer ResearchOncologyHighplex FL, TMAHALO
Combined toxic effects of MWCNTs and ZnO nanoparticle on the liver of common carpGao X, Huang Y, Ren H, Li Y, Chen J, Xu R2023Research SquareToxicologyHighplex FLHALO
GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritisYang X, Zhao Y, Wei Q, Zhu X, Wang L, Zhang W, Liu X, Kuai J, Wang F, Wei W2023Acta Pharmaceutica Sinica BImmunologyHighplex FLHALO
Perspectives for immunotherapy of EBV-associated GLELC: A relatively “hot” tumor microenvironmentLei Y, Cao P, Zheng X, Wi J, Cheng M, Liu M2023Cancer MedicineOncologyHighplex FLHALO
Remodeling Tumor Immune Microenvironment by Using Polymer-Lipid-Manganese Dioxide Nanoparticles with Radiation Therapy to Boost Immune Response of Castration-Resistant Prostate CancerZetrini AE, Lip H, Abbasi AZ, Alradwan I, Ahmed T, He C, Henderson JT, Rauth AM, Wu XY2023ResearchImmuno-oncology, BiomaterialsHighplex FLHALO
Effects and Mechanisms of the Subtypes of Apolipoprotein E to the Immune State and Prognosis of hepatocellular carcinoma patientsGao B, Zhou P, Wang L, Wang Z, Yi Y, Zhou J, Fan J, Qiu S, Xu Y2023Research SquareImmuno-oncologyMultiplex IHC, Highplex FLHALO
Single-cell RNA-sequencing reveals heterogeneity and intercellular crosstalk in human tuberculosis lungWang, H, Wen, Z, Niu, L, Chen, X, Liu, H, Zhang, S, Xu, J, Zhu, Y, Li, H, Chen, H, Shi, L, Wan, L, Li, L, Li, M, Wong, K, Song, Y2023Journal of InfectionImmunology, Infectious DiseaseSpatial Analysis, Highplex FLHALO
An immune cell atlas reveals the dynamics of human macrophage specification during prenatal developmentWang Z, Wu Z, Wang H, Feng R, Wang G, Li M, Wang S, Chen X, Su Y, Wang J, Zhang W, Bao Y, Lan Z, Song Z, Wang Y, Luo X, Zhao L, Hou A, Tian S, Gao H, Miao W, Liu Y, Wang H, Yin C, Ji Z, Feng M, Liu H, Diao L, Amit I, Chen Y, Zeng Y, Ginhoux F, Wu X, Zhu Y, Li H2023CellImmunologyHighplex FLHALO
The prognostic value of CD39 +CD8 + T cells as a potential surrogate marker of tumor-specific T cells in Asian triple-negative breast cancerMeng J, Tira TJY, Joseph CR, Ye J, Lim JCT, Goh D, Yuezhen X, Lim X, Koh VCY, Wee F, Tay TKY, Chan JV, Ng CCY, Iqbal J, Lau MC, Elaine LH, Chong TH, The BT, Dent RA, Tan PH, Sheng JYP2023Research SquareImmuno-oncologyHighplex FLHALO
Protocol for investigating tertiary lymphoid structures in human and murine fixed tissue sections using Opal™-TSA multiplex immunohistochemistryQuigley L, Pang L, Tavancheh E, Ernst M, Behren A, Huynh J, Da Gama Duarte J2023STAR ProtocolsOtherHighplex FLHALO
Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive marginRuf B, Bruhns M, Babaei S, Kedei N, Ma L, Revsine M, Benmebarek MR, Ma C, Heinrich B, Subramanyam V, Qi J, Wabitsch S, Green BL, Bauer KC, Myojin Y, Greten LT, McCallen JD, Huang P, Trehan R, Wang X, Nur A, Soika DQM, Pouzolles M, Evans CN, Chari R, Kleiner DE, Telford W, Dadkhah K, Ruchinskas A, Stovroff MK, Kang J, Oza K, Ruchirawat M, Kroemer A, Wang XW, Claassen M, Korangy F, Greten TF2023CellImmuno-oncologyClassifier, Spatial Analysis, Highplex FL, Figure MakerHALO
Comprehensive analysis of immune subtypes reveals the prognostic value of cytotoxicity and FAP+ fibroblasts in stomach adenocarcinomaWang X, Hui S, Tan C, Deng Z, Wang X, Weng W, Zhang M, Ni S, Wang L, Huang D, Wang W, Xu M, Sheng W2023Cancer Immunology, ImmunotherapyImmuno-oncologyHighplex FLHALO
Tumor cell HLA class I expression and pathologic response following neoadjuvant immunotherapy for newly diagnosed head and neck cancerRobbins Y, Friedman J, Redman J, Sievers C, Lassoued W, Gulley J, Allen C2023Oral OncologyImmuno-oncologyClassifier, Spatial Analysis, Highplex FLHALO
Anticoagulants Enhance Molecular and Cellular Immunotherapy of Cancer by Improving Tumor Microcirculation Structure and Function and Redistributing Tumor InfiltratesWei F, Su Y, Quan Y, Li X, Zou Q, Zhang L, Li S, Jiang M, Lin G, Liang P, He J, Xie K2023Clinical Cancer ResearchImmuno-oncologyClassifier, Multiplex IHC, Spatial Analysis, Highplex FLHALO
Combination IFNβ and membrane-stable CD40L maximize tumor dendritic cell activation and lymph node trafficking to elicit systemic T-cell immunityZheng H, Yu X, Ibrahim M, Foresman D, Xie M, Johnson J, Boyle T, Ruffell B, Perez B, Antonia S, Ready N, Saltos A, Cantwell M, Beg A2023Cancer Immunology ResearchImmuno-oncologyHighplex FLHALO
Key Residue in the Precursor Region of M Protein Contributes to the Neurovirulence and Neuroinvasiveness of the African Lineage of Zika VirusHe M, Wang H, Yan X, Lou Y, Song G, Li R, Zhu Z, Zhang R, Qin C, Li X2023Journal of VirologyInfectious DiseaseHighplex FLHALO
Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancerBancaro N, Cali B, Troiani M, Elia A, Arzola R, Attanasio G, Lai P, Crespo M, Gurel B, Pereira R, Guo C, Mosole S, Brina D, D’Ambrosio M, Pasquini E, Spataro C, Zagato E, Rinaldi A, Pedotti M, Lascio S, Meani F, Montopoli M, Ferrari M, Gallina A, Varani L, Mestre R, Bolis M, Sommer S, de Bono J, Calcinotto A, Alimonti A2023Cancer CellOncologyClassifier, Highplex FLHALO
Acute Influenza Infection Promotes Lung Tumor Growth by Reprogramming the Tumor MicroenvironmentGarmendia I, Varthaman A, Marmier S, Angrini M, Matchoua I, Darbois-Delahousse A, Josseaume N, Foy P, Roumenina L, Naouar N, Meylan M, Siberil S, Russick J, Joubert P, Leroy K, Damotte D, Mansuet-Lupo A, Wislez M, Alifano M, Menger L, Garcia-Verdugo I, Sallenave J, Lantz O, Petitprez F, Cremer I2023Cancer Immunology ResearchOncology, Infectious DiseaseHighplex FLHALO
Spatial mapping reveals granuloma diversity and histopathological superstructure in human tuberculosisSawyer A, Patrick E, Edwards J, Wilmott J, Fielder T, Yang Q, Barber D, Ernst J, Britton W, Palendira U, Chen X, Feng C2023Journal of Experimental MedicineImmunologyMultiplex IHC, Spatial Analysis, Highplex FLHALO
Measurement of ovarian tumor immune profiles by multiplex immunohistochemistry: implications for epidemiologic studiesHathaway C, Conejo-Garcia J, Fridley B, Rosner B, Saeed-Vafa D, Segura C, Nguyen J, Hecht J, Sasamoto N, Terry K, Tworoger S, Townsend M2023Cancer Epidemiology, Biomarkers & PreventionImmuno-oncologyHighplex FLHALO
New insight on the correlation of immune landscapes with immune markers expression in different risk classification of gastrointestinal stromal tumorsZhang Q, Sun X, Hou Y, Gao X, Shen K, Qin X2023Journal of GastroenterologyImmuno-oncologyHighplex FLHALO
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variantsHirschhorn D, Budhu S, Kraehenbuehl L, Gigoux M, Schröder D, Chow A, Ricca J, Gasmi B, De Henau O, Mangarin L, Li Y, Hamadene L, Flamar A, Choi H, Cortez C, Liu C, Holland A, Schad S, Schulze I, Warner A, Hollmann T, Arora A, Panageas K, Rizzuto G, Duhen R, Weinberg A, Spencer C, Ng D, He X, Albrengues J, Redmond D, Egeblad M, Wolchok J, Merghoub T2023CellImmuno-oncologyArea Quantification, Highplex FLHALO
Plaque Macrophage-Targeting Nanosystems with Cooperative Co-Regulation of ROS and TRAF6 for Stabilization of Atherosclerotic PlaquesYang Q, Jiang H, Wang Y, Leng X, Wang Y, Tong J, Zhou Y, Mo C, Peng J, Gao H2023Advanced Functional MaterialsBiomaterialsHighplex FLHALO
Functional specialization of short-lived and long-lived macrophage subsets in human tonsilsAlaoui L, Villar J, Leclere R, Le Gallou S, Relouzat F, Michaud H, Tarte K, Teissier N, Favier B, Roussel M, Segura E2023Journal of Experimental MedicineImmunologyHighplex FLHALO
Hepatic proinflammatory myeloid phenotypes are a hallmark of Ebola virus Kikwit pathogenesis in rhesus monkeysTseng A, Carossino M, Gertje H, O’Connell A, Gummuluru S, Kolachalama V, Balasuriya U, Connor J, Bennett R, Liu D, Hensley L, Crossland N2023Veterinary PathologyInfectious DiseaseArea Quantification, Highplex FLHALO
Circulating and intratumoral immune determinants of response to atezolizumab plus bevacizumab in patients with variant histology or sarcomatoid renal cell carcinomaSaliby R, Zarif T, Bakouny Z, Shah V, Xie W, Flippot R, Denize T, Kane M, Madsen K, Ficial M, Hirsch L, Wei X, Steinarter J, Harshman L, Vaishampayan U, Severgnini M, McDermott D, Lee G, Xu W, Van Allen E, McGregor B, Signoretti S, Choueiri T, McKay R, Braun D2023Cancer Immunology ResearchImmuno-oncologyHighplex FLHALO
The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatmentLv J, Wei Y, Yin J, Chen Y, Zhou G, Wei C, Liang X, Zhang Y, Zhang C, He S, He Q, Huang Z, Guan J, Shen J, Li X, Li J, Li W, Tang L, Mao Y, Guo R, Sun R, Zheng Y, Zhou W, Xiong K, Wang S, Jin X, Liu N, Li G, Kuang D, Sun Y, Ma J2023Nature MedicineOncologyMultiplex IHC, Highplex FLHALO
Bavituximab decreases immunosuppressive myeloid-derived suppressor cells in newly diagnosed glioblastoma patientsLy K, Richardson L, Liu M, Muzikansky A, Cardona J, Lou K, Beers A, Chang K, Brown J, Ma X, Reardon D, Arrillaga-Romany I, Forst D, Jordan J, Lee E, Dietrich J, Nayak L, Wen P, Chukwueke U, Giobbie-Hurder A, Choi B, Batchelor T, Kalpathy-Cramer J, Curry W, Gerstner E2023Clinical Cancer ResearchImmuno-oncologyHighplex FLHALO
Single-cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironmentCao G, Yue J, Ruan Y, Han Y, Zhi Y, Lu J, Liu M, Xu X, Wang J, Gu Q, Wen X, Gao J, Zhang Q, Kang J, Wang C, Li F2023The EMBO JournalImmuno-oncologyHighplex FLHALO
Molecular determinants of clinical outcomes of pembrolizumab in recurrent ovarian cancer: Exploratory analysis of KEYNOTE-100Ledermann JA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Kobie J, Nebozhyn M, Edmondson M, Sun Y, Cristescu R, Jelinic P, Keefe SM, Matulonis UA2023Gynecologic OncologyImmuno-oncologyClassifier, Highplex FLHALO
Classification of the tumor immune microenvironment and associations with outcomes in patients with metastatic melanoma treated with immunotherapiesAdegoke N, Gide T, Mao Y, Quek C, Patrick E, Carlino M, Lo S, Menzies A, da Silva P, Vergara I, Long G, Scolyer R, Wilmott J2023Journal for ImmunoTherapy of CancerImmuno-oncologyClassifier, Highplex FLHALO
The PD-1- and LAG-3-targeting bispecific molecule tebotelimab in solid tumors and hematologic cancers: a phase 1 trialLuke J, Patel R, Blumenschein R, Hamilton E, Chmielowski B, Ulahannan S, Connolly R, Santa-Maria C, Wang J, Bahadur S, Weickhardt A, Asch A, Mallesara G, Clingan P, Dlugosz-Danecka M, Tomaszewska-Kiecana M, Pylypenko H, Hamad N, Kindler H, Sumrow B, Kaminker P, Chen F, Zhang X, Shah K, Smith D, De Costa A, Li J, Li H, Sun J, Moore P2023Nature MedicineImmuno-oncologyHighplex FLHALO
High-plex spatial transcriptomic profiling reveals distinct immune components and the HLA class I/DNMT3A/CD8 modulatory axis in mismatch repair-deficient endometrial cancerGuo J, Tang B, Fu J, Zhu X, Xie W, Wang N, Ding Z, Song Z, Yang Y, Xu G, Xiao X2023Cellular OncologyImmuno-oncologyHighplex FL, Figure MakerHALO
Carcinogen exposure enhances cancer immunogenicity by blocking the development of an immunosuppressive tumor microenvironmentHuang M, Xia Y, Li K, Shao F, Feng Z, Li T, Azin M, Demehri S2023The Journal of Clinical InvestigationImmuno-oncologyHighplex FLHALO
The Expression of the Alpha7 Nicotinic Acetylcholine Receptor and the Effect of Smoking in Curdlan-Administered SKG MiceKim YE, Lee JH, Lee EJ, Kim DH, Jeong MR, Hong S, Lee CK, Yoo B, Youn J, Chang EJ, Kim YG2023BiomedicinesImmunologyHighplex FLHALO
Targeting pancreatic cancer metabolic dependencies through glutamine antagonismEncarnación-Rosado J, Sohn A S W, Biancur D E, Lin E Y, Osorio-Vasquez V, Rodrick T, González-Baerga D, Zhao E, Yokoyama Y, Simeone D M, Jones D R, Parker S J, Wild R, Kimmelman A C2023Nature CancerOncologyHighplex FLHALO, HALO AI
Anti-PD-1 immunotherapy with androgen deprivation therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancerHawley J E, Obradovic A Z, Dallos M C, Lim E A, Runcie K, Ager C R, McKiernan J, Anderson C B, Decastro G J, Weintraub J, Virk R, Lowy I, Hu J, Chaimowitz M G, Guo X V, Zhang Y, Haffner M C, Worley J, Stein M N, Califano A2023Cancer CellImmuno-oncologyHighplex FLHALO
Epigenetic regulation during cancer transitions across 11 tumour typesTerekhanova N V, Karpova A, Liang W W, Strzalkowski A, Chen S, Li Y, Southard-Smith A N, Iglesia M D, Wendl M C, Jayasinghe R G, Liu J, Song Y, Cao S, Houston A, Liu X, Wyczalkowski M A, Lu R J, Caravan W, Shinkle A, Naser Al Deen N, Herndon J M, Mudd J, Ma C, Sarkar H, Sato K, Ibrahim O M, Mo C K, Chasnoff S E, Porta-Pardo E, Held J M, Pachynski R, Schwarz J K, Gillanders W E, Kim A H, Vij R, DiPersio J F, Puram S V, Chheda M G, Fuh K C, DeNardo D G, Fields R C, Chen F, Raphael B J, Ding L2023NatureOncologyHighplex FLHALO
Tumor‐derived Vimentin as a novel biomarker for distinct subtypes predicting adjuvant chemotherapy resistance and T‐cell‐inflamed phenotype in small cell lung cancerDeng C, Wang Y, Fu F, Li D, Zheng Q, Jin Y, Li Y, Chen H, Zhang Y2023MedCommOncologyHighplex FLHALO
Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavageKumar ST, Nazarov S, Porta S, Majarjan N, Cendrowska U, Kabani M, Finamore F, Xu Y, Lee VMY, Lashuel HA2023Nature NeuroscienceNeuroscienceArea Quantification, Highplex FLHALO
ACE2-independent SARS-CoV-2 virus entry through cell surface GRP78 on monocytes – evidence from a translational clinical and experimental approachHan B, Lv Y, Moser D, Zhou X, Woehrle T, Han L, Osterman A, Rudelius M, Choukér A, Lei P2023EBioMedicineInfectious DiseaseHighplex FLHALO
A neutrophil extracellular traps-related classification predicts prognosis and response to immunotherapy in colon cancerFeng C, Li Y, Tai Y, Zhang W, Wang H, Lian S, Jin-si-han E, Liu Y, Li X, Chen Q, He M, Lu Z2023Scientific ReportsImmuno-oncologySpatial Analysis, Highplex FL, Figure MakerHALO
Reversing immunosuppression in the tumor microenvironment of fibrolamellar carcinoma via PD-1 and IL-10 blockadeDaniel S, Sullivan K, Dickerson L, van den Bijgaart R, Utria A, Labadie K, Kenerson H, Jiang X, Smythe K, Campbell J, Pierce R, Kim T, Riehle K, Yeung R, Carter J, Barry K, Pillarisetty V2023Research SquareImmuno-oncologyHighplex FLHALO
Digital analysis of the prostate tumor microenvironment with high-order chromogenic multiplexingRajendran R, Beck RC, Waskasi MM, Kelly BD, Bauer DR2023Journal of Pathology InformaticsOncologyHighplex FLHALO, HALO AI
Liver cancer stem cell dissemination and metastasis: uncovering the role of NRCAM in hepatocellular carcinomaZhou L, He L, Liu C, Qiu H, Zheng L, Sample KM, Wu Q, Li J, Xie K, Ampuero J, Li Z, Lv D, Liu M, Romero-Gómez M, Hu Y, Tang H2023Journal of Experimental & Clinical Cancer ResearchOncologyHighplex FLHALO
IFN-γ in ovarian tumor microenvironment upregulates HLA-E expression and predicts a poor prognosisZheng H, Guan X, Meng X, Tong Y, Wang Y, Xie S, Guo L, Lu R2023Journal of Ovarian ResearchOncologyHighplex FLHALO
Patient-derived exosomes facilitate therapeutic targeting of oncogenic MET in advanced gastric cancerHyung S, Ko J, Heo YJ, Blum SM, Kim ST, Park SH, Park JO, Kang WK, Lim HY, Klempner SJ, Lee J2023Science AdvancesOncologyHighplex FLHALO
Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young miceCrossland NA, Beck S, Tan WY, Lo M, Mason JB, Zhang C, Guo W, Crott JW2023Gut MicrobesOtherArea Quantification, Highplex FLHALO
The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancerTaifour T, Attalla SS, Zuo D, Gu Y, Sanguin-Gendreau V, Proud H, Solymoss E, Bui T, Kuasne H, Papavasiliou V, Lee CG, Kamle S, Siegel PM, Elias JA, Park M, Muller WJ2023ImmunityImmuno-oncologyMultiplex IHC, Spatial Analysis, Highplex FLHALO
A machine learning approach toward automating spatial identification of LAG3+/CD3+ cells in ulcerative colitisBonnevie ED, Dobrzynski E, Steiner D, Hildebrand D, Monslow J, Singh M, Decman V, Krull DL2023Scientific ReportsGastroenterologyHighplex FL, RegistrationHALO, HALO AI
The function role of HIGD1A in nonalcoholic steatohepatitis from chronic hepatitis BLi M, Li J, Wang D, Li T, Ye L, Liang X, Zhang H, Liu Z, Zhang X, Li J, Liu Y, Pan C Q, Dai E2023Scandinavian Journal of GastroenterologyGastroenterologyHighplex FLHALO
Tanshinone IIA alleviates early brain injury after subarachnoid hemorrhage in rats by inhibiting the activation of NF-κB/NLRP3 inflammasomeYang F, Ma N, Li S, Chen F, Huang X, Zhao L, Cao L2023Biological and Pharmaceutical BulletinNeuroscienceHighplex FLHALO
Rosmarinic acid alleviate CORT-induced depressive-like behavior by promoting neurogenesis and regulating BDNF/TrkB/PI3K signaling axisZeng J, Xie Z, Chen L, Peng X, Luan F, Hu J, Xie H, Liu R, Zeng N2023Biomedicine & PharmacotherapyNeuroscienceHighplex FLHALO
Components of the tumor immune microenvironment based on m-IHC correlate with prognosis and subtype of triple-negative breast cancerLin L, Li H, Wang X, Wang Z, Su G, Zhou J, Sun S, Ma X, Chen Y, You C, Gu Y2023Cancer MedicineImmuno-oncologyClassifier, Spatial Analysis, Highplex FLHALO
COVID-19 and influenza infections mediate distinct pulmonary cellular and transcriptomic changesWang C, Khatun M S, Zhang Z, Allen M J, Chen Z, Ellsworth C R, Currey J M, Dai G, Tian D, Bach K, Yin X-M, Traina-Dorge V, Rappaport J, Maness N J, Blair R V, Kolls J K, Pociask D A, Qin X2023Communications BiologyInfectious DiseaseArea Quantification, Highplex FL, Figure MakerHALO, HALO AI
Bioinformatics Prediction and Experimental Validation of the Role of Macrophage Polarization and Ferroptosis in Gestational Diabetes MellitusChen C, Yang Z, Qiu Z2023Journal of Inflammation ResearchImmunologyHighplex FLHALO
Comprehensive prognostic and immune analysis of a glycosylation related risk model in pancreatic cancerLiu XA, Shi J, Tian L, Xiao B, Zhang K, Zhu Y, Zhang YF, Jiang KR, Zhu Y, Yuan H2023BMC CancerOncologyHighplex FLHALO
Chondrocyte Apoptosis as a Potential Mechanism in Ostrich Limb and Toe Disorders: A Pathological InvestigationXian M, Duan B, Tang L, Zhou H, Wang L, Wang R, Chen Z, Fang J, Huang C, Liu W, Geng Y, OuYang P, Guo H, Deng H, Lai W2023Pakistan Veterinary JournalOtherHighplex FLHALO
Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched intestinal organoids and tumouroidsHarter MF, Recaldin T, Gerard R, Avignon B, Bollen Y, Esposito C, Guja-Jarosz K, Kromer K, Filip A, Aubert J, Schneider A, Bacac M, Bscheider M, Stokar-Regenscheit N, Piscuoglio S, Beumer J, Gjorevski N2023Nature Biomedical EngineeringImmuno-oncologyHighplex FLHALO, HALO AI
Quantitative performance assessment of Ultivue multiplex panels in formalin-fixed, paraffinembedded human and murine tumor specimensRam S, Mojtahedzadeh S, Aguilar JK, Coskran T, Powell E, O’Neil S2023Research SquareOtherSpatial Analysis, Highplex FLHALO
A phase 2 trial of peri-operative avelumab and chemotherapy for locally advanced gastroesophageal adenocarcinoma: Association of
AGR2/AP-1 complex CD8 T-cells and M2-Tumour Associated Macrophages with treatment response		Ferri L, Alcindor T, Tankel J, Fiset P, Pal S, Opu T, Strasser M, Dehghani M, Bertos N, Zuo D, Mueller C, Cools-Lartigue J, Hickeson M, Marcus V, Camilleri-Broët S, Spatz A, Evaristo G, Farag M, Artho G, Elkrief A, Saleh R, Park M, Huang S, Sanwan V2023Research SquareImmuno-oncologySpatial Analysis, Highplex FLHALO
Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinomaSun Y, Wu P, Zhang Z, Wang Z, Zhou K, Song M, Ji Y, Zang F, Lou L, Rao K, Wang P, Gu Y, Gu J, Lu B, Chen L, Pan X, Zhao X, Peng L, Liu D, Chen X, Wu K, Lin P, Wu L, Su Y, Du M, Hou Y, Yang X, Qiu S, Shi Y, Sun H, Zhou J, Huang X, Peng D, Zhang L, Fan J2023Cancer CellOncologyClassifier, Multiplex IHC, Spatial Analysis, Highplex FLHALO
Cholesterol efflux drives the generation of immunosuppressive macrophages to promote the progression of human hepatocellular carcinomaLi Z, Wang Y, Xing R, Zeng H, Yu X, Zhang Y, Xu J, Zheng L2023Cancer Immunology ResearchImmuno-oncologyMultiplex IHC, Highplex FLHALO
Effects of estradiol, progesterone or cAMP on expression of PGRMC1 and progesterone receptor in a xenograft model of human endometrium and in endometrial cell cultureVan Wynendaele M, Thieffry C, Samain L, Pierreux C, Tyteca D, Marbaix E, Henriet P2023SteroidsOtherHighplex FLHALO
Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapyZuo Chong, Baer J, Knolhoff B, Belle J, Liu X, De La Lastra A, Fu C, Hogg G, Kingston N, Breden M, Dodhiawala P, Zhou D, Lander V, James C, Ding L, Lim K, Fields R, Hawkins W, Wber J, Zhao G, DeNardo D2023Journal of Experimental MedicineImmuno-oncologyHighplex FLHALO
Tumor Microenvironment Modifications Induced by Afatinib in Squamous Cell Carcinoma of the Head and Neck: A Window-of-Opportunity Study (EORTC-90111–24111)Beyaert SP, Loriot AE, Huyghe ND, Goebbels RM, Mendola A, Govaerts AS, Fortpied C, Baldin P, Licitra LF, Lalami Y, Clement PM, Machiels JPH, Schmitz S2023Clinical Cancer ResearchOncologyHighplex FLHALO
Complex Urban Atmospheres alters Alveolar Stem Cells Niche Properties and drives Lung FibrosisBelgacemi R, Baptista BR, Justeau G, Toigo M, Frauenpreis A, Yilmaz R, Der Vartanian A, Cazaunau M, Pangui E, Bergé A, Gratien A, Macias Rodriguez JC, Bellusci S, Derumeaux G, Boczkowski J, Al Alam D, Coll P, Lanone S, Boyer L2023American Journal of Physiology – Lung Cellular and Molecular PhysiologyFibrosisClassifier, Area Quantification, Highplex FLHALO
Modified Bushen Yiqi formula enhances antitumor immunity by reducing the chemotactic recruitment of M2-TAMs and PMN-MDSCs in Lewis lung cancer-bearing miceKong Q, Zhu H, Gong W, Deng X, Liu B, Dong J2023Journal of EthnopharmacologyImmuno-oncologyMultiplex IHC, Highplex FLHALO
TRβ Agonism Induces Tumor Suppression and Enhances Drug Efficacy in Anaplastic Thyroid Cancer in Female MiceGillis NE, Cozzens LM, Wilson ER, Smith NM, Tomczak JE, Bolf EL, Carr FE2023EndocrinologyOncologyHighplex FLHALO
Characterization of immunosuppressive myeloid cells in Merkel cell carcinoma: correlation with resistance to PD-1 pathway blockade.Tabachnick-Cherny S, Pulliam T, Rodriguez H, Fan X, Hippe D, Jones D, Moshiri A, Smythe K, Kulikauskas R, Zaba L, Paulson K, Nghiem P2023Clinical Cancer ResearchImmuno-oncologyHighplex FLHALO
Unlocking the Hidden Depths: Multi-Modal Integration of Imaging Mass Spectrometry-Based and Molecular Imaging TechniquesAkbari B, Huber BR, Sherman JH2023Critical Reviews in Analytical ChemistryReviewHighplex FLHALO, HALO AI, HALO Link, HALO AP
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PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleenLiu M, Wu C, Luo S, Hua Q, Chen H, Weng Y, Xu J, Lin H, Wang L, Li J, Zhu L, Guo Z, Zhuang S, Kang T, Zheng L2022Journal of Experimental MedicineOncologyHighplex FL, RegistrationHALO
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Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body RadiotherapyMills B, Qiu H, Drage M, Chen C, Mathew J, Garrett-Larsen J, Ye J, Uccello T, Murphy J, Belt B, Lord E, Katz A, Linehan D, Gerber S2022Clinical Cancer ResearchOncologyClassifier, Spatial Analysis, Highplex FLHALO
Plasma CD27, a surrogate of the intratumoral CD27-CD70 interaction, correlates with immunotherapy resistance in renal cell carcinomaBenhamouda N, Sam I, Epaillard N, Gey A, Phan L, Pham H, Gruel N, Saldmann A, Pineau J, Hasan M, Quiniou V, Nevoret C, Verkarre V, Libri V, Mella S, Granier C, Broudin C, Ravel P, De Guillebon E, Mauge L, Helley D, Jabla B, Chaput N, Albiges L, Katsahian S, Adam J, Mejean A, Adotevi O, Vano Y, Oudard S, Tartour E2022Clinical Cancer ResearchOncologySpatial Analysis, Highplex FLHALO
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CD38 in Advanced Prostate CancersGuo C, Crespo M, Gurel B, Dolling D, Rekowski J, Sharp A, Petremolo A, Sumanasuriya S, Rodrigues DN, Ferreira A, Pereira R, Figueiredo I, Mehra N, Lambros MBK, Neeb A, Gil V, Seed G, Terstappen L, Alimonti A, Drake CG, Yuan W, de Bono JS2021European UrologyOncologyClassifier, Highplex FLHALO
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Activated Regulatory T-Cells, Dysfunctional and SenescentT-Cells Hinder the Immunity in Pancreatic CancerSivakumar S, Abu-Shah E, Ahern DJ, Arbe-Barnes EH, Jainarayanan AK, Mangal N, Reddy S, Rendek A, Easton A, Kurz E, Silva M, Soonawalla Z, Heij LR, Bashford-Rogers R, Middleton MR, DUstin ML2021cancersImmuno-oncologyClassifier, Multiplex IHC, Spatial Analysis, Highplex FLHALO
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Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanomaJacquelot N, Seillet C, Wang M et al.2021Nature ImmunologyImmuno-oncologyClassifier, Highplex FLHALO
T-regulatory cells predict clinical outcome in soft tissue sarcoma patients: a clinico-pathological studySmolle M, Herbsthofer L, Granegger B, Goda M, Brcic I, Bergovec M, Scheipl S, Prietl B, Pichler M, Gerger A, Rossmann C, Riedl J, Tomberger M, López-García P, El-Heliebi A, Leithner A, Liegl-Atzwanger B, Szkandera J2021British Journal of CancerOncologyHighplex FLHALO
High density of cytotoxic T-lymphocytes is linked to tumoral PD-L1 expression regardless of the mismatch repair status in colorectal cancerMöller K, Blessin N, Höflmayer D, et al.2021Acta OncologicaImmuno-oncologyHighplex FLHALO
Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stressZaman R, Hamidzada H, Kantores C, Wong A, Dick S, Wang Y, Momen A, Aronoff L, Lin J, Razani B, Mital S, Billia F, Lavine K, Nejat S, Epelman S2021ImmunityImmunologyHighplex FLHALO
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Androgen Receptor Signalling in Macrophages Promotes TREM-1-mediated Cancer Cell Line Migration and InvasionCioni B, Zaalberg A, van Beihnum J, Melis M, van Brugsteden J, Muraro M, Hooijberg E, Peters D, Hofland I, Lubeck Y, de Jong J, Sanders J, Vivie J, van der Poel J, Griffioen A, Zwart W, Bergman A2021Nature CommunicationsOncologyHighplex FLHALO
Dysregulation of Innate Lymphoid Cells in Patients with Active Rheumatoid Arthritis and Mice with Collagen-Induced ArthritisYang F, Luo X, Zhu W, Li J, Zheng Z, Zhu P2021Mediators of InflammationImmunologySpatial Analysis, Highplex FLHALO
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Local radiotherapy and E7 RNA-LPX vaccination show enhanced therapeutic efficacy in preclinical models of HPV16+ cancerSalomon N, Selmi A, Grunwitz C, Kong A, Stanganello E, Neumaier J, Petschenka J, Diken M, Kreiter S, Tureci O, Sahin U, Vascotto F2021Cancer Immunology, ImmunotherapyOncology, Infectious DiseaseHighplex FLHALO
Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinomaVos J, Elbers J, Krijgsman O, Traets J, Qiao X, van der Leun A, Lubeck Y, Seignette I, Smit L, Willems S, van den Brekel M, Dirven R, Karakullukcu B, Karssemakers L, Klop W, Lohuis P, Schreuder W, Smeele L, van der Velden L, Tan I, Onderwater S, Jasperse B, Vogel W, Al-Mamgani A, Keijser A, van der Noort V, Broeks A, Hooijberg E, Peeper D, Schumacher T, Blank C, de Boer J, Haanen J, Zuur C2021Nature CommunicationsOncologyClassifier, Highplex FLHALO
T cell-mediated anti-tumor immunity cooperatively induced by TGFβR1 antagonism and gemcitabine counteracts reformation of the stromal barrier in pancreatic cancerLi D, Schaub N, Guerin T, Bapiro T, Richards F, Chen V, Talsania K, Kumar P, Gilbert D, Scholmer J, Kim S, Sorber R, Teper Y, Bautista W, Palena C, Ock C, Jodrell D, Pate N, Mehta M, Zhao Y, Kozlov S, Rudloff U2021Molecular Cancer TherapyImmuno-oncologyHighplex FLHALO
T Cell–Mediated Antitumor Immunity Cooperatively Induced By TGFbR1 Antagonism and Gemcitabine Counteracts Reformation of the Stromal Barrier in Pancreatic CancerLi D, Schaub N, Guerin T, Bapiro T, Richards F, Chen V, Talsania K, Kumar P, Gilbert D, Schlomer J, Kim S, Sorber R, Teper Y, Bautista W, Palena C, Ock C, Jodrell D, Pate N, Mahta M, Zhao Y, Kozlov S, Ridloff U2021Molecular Cancer TherapeuticsImmuno-oncologyHighplex FLHALO
Multiplex Immunohistochemical Phenotyping of T Cells in Primary Prostate CancerOzbek B, Ertunc O, Erickson A, Vidal I, Alexandre C, Guner G, Hicks J, Jones T, Taube J, Sfanos K, Yegnasubramanian S, DeMarzo A2021medRxivImmuno-oncologyClassifier, Cytonuclear, Highplex FL, Serial Section, RegistrationHALO
Myeloid cell-driven nonregenerative pulmonary scarring is conserved in multiple nonhuman primate species regardless of SARS-CoV-2 infection modalityFears A, Beddingfield B, Chirichella N, Slisarenko N, Kileen S, Redmann R, Goff K, Spencer S, Picou B, Golden N, Bush D, Branco L, Boisen M, Gao H, Montefiori D, Blair R, Doyle-Meyers L, Russel-Lodrigue K, Maness N, Roy C2021bioRxivInfectious DiseaseHighplex FLHALO, HALO AI
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Addition of camrelizumab to docetaxel, cisplatin, and radiation therapy in patients with locally advanced esophageal squamous cell carcinoma: a phase 1b studyZhang W, Yan C, Zhang T, Chen X, Dong J, Zhao J, Han D, Wang J, Zhao G, Cao F, Zhou D, Jiang H, Tang P, Zhao L, Yuan Z, Wang Q, Wang P, Pang Q2021OncoimmunologyOncologyHighplex FLHALO
Spatial Distribution and Predictive Significance of Dendritic Cells and Macrophages in Esophageal Cancer Treated With Combined Chemoradiotherapy and PD-1 BlockadeMa X, Guo Z, Wie X, Zhao G, Han D, Zhang T, Chen X Cao F, Dong J, Zhao L, Yuan Z, Wang P, Pang Q, Yan C, Zhang W2021Frontiers in immunologyOncologySpatial Analysis, Highplex FLHALO
Heterogeneity of programmed death-ligand 1 expression and infiltrating lymphocytes in paired resected primary and metastatic non-small cell lung cancerWu J, Sun W, Yang X, Wang H, Liu X, Chi K, Zhou L, Huang X, Mao L, Zhao S, Ding T, Meng B, Lin D2021Modern PathologyImmuno-oncologySpatial Analysis, Highplex FLHALO
Functional expression of TRPA1 channel, TRPV1 channel and TMEM100 in human odontoblastsLiu Y, Wang Y, Lou Y, Tian W, Que K2021Journal of Molecular HistologyOtherHighplex FLHALO
Recipient bone marrow-derived IL-17 receptor A-positive cells drive allograft fibrosis in a mouse intrapulmonary tracheal transplantation modelWatanabe T, Juvet S, Boonstra K, Guan Z, Joe B, Teskey G, Keshavjee S, Martinu T2021Transplant ImmunologyOtherHighplex FLHALO
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Single-cell profiling of tumor-infiltrating TCF1/TCF7+ T cells reveals a T lymphocyte subset associated with tertiary lymphoid structures/organs and a superior prognosis in oral cancerPeng Y, Xiao L, Rong H, Ou Z, Cai T, Liu N, Li B, Zhang L, Wu F, Lan T, Lin X, Li Q, Ren S, Fan S, Li J2021Oral OncologyOncologySpatial Analysis, Highplex FLHALO
Splenic T lymphocytes induce the formation of immunosuppressive neutrophils through IFN-γ in sepsisHuang J, Sun R, Yang Y, Li L, Liu L, Shao Y, Ji D, Sun B2021Inflammation ResearchImmunologyHighplex FLHALO
Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body diseaseUemura M, Robinson J, Cousins K, Tropea T, Kargilis D, McBride J, Suh E, Xie S, Xu Y, Porta S, Uemura N, Van Deerlin V, Wolk D, Irwin D, Brunden K, Lee V, Lee E, Trojanowski J2021Acta NeuropathologicaNeuroscienceHighplex FLHALO
Tailoring Chemoimmunostimulant Bioscaffolds for Inhibiting Tumor Growth and Metastasis after Incomplete Microwave AblationShen Y, Chen L, Guan X, Han X, Bo X, Li S, Sun L, Chen Y, Yue W, Xu H2021ACS NanoOncology, BiomaterialsHighplex FLHALO
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Trajectory and Functional Analysis of PD-1high CD4+CD8+ T Cells in Hepatocellular Carcinoma by Single-Cell Cytometry and Transcriptome SequencingZheng B, Wang D, Qiu X, Luo G, Wu T, Yang S, Li Z, Zhu Y, Wang S, Wu R, Sui C, Gu Z, Shen S, Jeong S, Wu Z, Gu J, Wang H, Chen L2020Advanced ScienceImmuno-oncologyHighplex FLHALO
Safety, immunogenicity, and clinical efficacy of durvalumab in combination with folate receptor alpha vaccine TPIV200 in patients with advanced ovarian cancer: a phase II trialZamarin D, Walderich S, Holland A, Zhou Q, Iasonos AE, Torrisi JM, Merghoub T, Chesebrough LF, Mcdonnell AS, Gallagher JM, Li Y, Hollmann TJ, Grisham RN, Erskine CL, Block MS, Knutson KL, O’Cearbhaill RE, Aghajanian C, Konner JA2020Journal for ImmunoTherapy of CancerImmuno-oncologyHighplex FLHALO
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Pulmonary Mycobacterium tuberculosis control associates with CXCR3- and CCR6-expressing antigen-specific Th1 and Th17 cell recruitmentShanmugasundaram U, Bucsan AN, Ganatra SR, Ibegbu C, Quezada M, Blair RV, Alvarez X, Velu V, Kaushal D, Rengarajan J2020JCI InsightInfectious DiseaseHighplex FLHALO, HALO AI
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Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcomaChan JY, Lim JQ, Yeong J, Ravi V, Guan P, Boot A, Tay TKY, Selvarajan S, Nasir NDM, Loh JH, Ong CK, Huang D, Tan J, Li Z, Ng CC-Y, Tan TT, Masuzawa M, Sung KW-K, Farid M, Quek RHH, Tan NC, Teo MCC, Rozen SG, Tan P, Fotreal A, The BT, Soo KC2020The Journal of Clinical InvestigationImmuno-oncologyHighplex FLHALO
Rova-T enhances the anti-tumor activity of anti-PD1 in a murine model of small cell lung cancer with endogenous Dll3 expressionVitorino P, Chuang C-H, Iannello Z, Zhao X, Anderson W, Ferrando R, Zhang Z, Madhavan S, Karsunky H, Saunders LR2020Translational OncologyImmuno-oncologyHighplex FLHALO
Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancerZou J, Qin W, Wang L, Wang Y, Shen J, Xiong W, Yu S, Song S, Ajani JA, Lin S-Y, Mills GB, Yuan X, Chen J, Peng G2020American Journal of Cancer ResearchImmuno-oncologySpatial Analysis, Highplex FLHALO
Tumoral PD-1hiCD8+ 1 T cells are partially exhausted and 2 predict favorable outcome in triple-negative breast cancerGuo L, Cao C, Goswami S, Huang X, Ma L, Guo Y, Yang B, Li T, Chi Y, Zhang X, Wu J2020Clinical ScienceImmuno-oncologyHighplex FLHALO, HALO AI
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Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinomaBraun DA, Hou Y, Bakouny Z, Ficial M, Sant’ Angelo M, Forman J, Ross-Macdonald P, Berger AC, Jegede OA, Elagina L, Steinharter J, Sun M, Wind=Rotolo M, Pignon J-C, Cherniack AD, Lichtenstein L, Neuberg D, Catalano P, Freeman GJ, Sharpe AH, McDermott DF, Van Allen EM, Signoretti S, Wu CJ, Shukla SA, Choueiri TK2020Nature MedicineImmuno-oncologyHighplex FLHALO
Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trialvan Dijk N, Gil-Jimenez A, Silina K, Hendricksen K, Smit LA, de Feijter JM, van Montfoort ML, van Rooijen C, Peters D, Broeks A, van der Poel HG, Bruining A, Lubeck Y, Sikorska K, Boellaard TN, Kvistborg P, Vis DJ, Hooijberg E, Schumacher TN, van den Broek M, Wessels LFA, Blank CU, van Rhijn BW, van der Heijden MS2020Nature MedicineImmuno-oncologyClassifier, Highplex FLHALO
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint BlockadeSrivastava S, Furlan SN, Jaeger-Ruckstuhl CA, Sarvothama M, Berger C, Smythe KS, Garrison SM, Specht JM, Lee SM, Amezquita RA, Voillet V, Muhunthan V, Yechan-Gunja S, Pillai SPS, Rader C, Houghton AM, Pierce RH, Gottardo R, Maloney DG, Riddell SR2020Cancer CellImmuno-oncologyMultiplex IHC, Highplex FLHALO
The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING SignalingMohamed E, Sierra RA, Trillo-Tinoco J, Cao Y, Innamarato P, Payne KK, Pulido M, Mandula J, Zhang S, Thevenot P, Biswas S, Abdalla SK, Costich TL, Hanggi K, Anadon CM, Flores ER, Haura EB, Mehrotra, Pilon-Thomas S, Ruffel B, Munn DH, Cubillos-Ruiz JR, Conejo-Garcia JR, Rodriguez PC2020ImmunityImmuno-oncologyHighplex FLHALO
Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interfaceRapiteanu R, Karagyozova T, Zimmerman N, Singh K, Wayne G, Martufi M, Belyaev NN, Hessel EM, Michalovich D, Macarron R, Rowan WC, Cairns WJ, Roger J, Betts J, Beinke S, Maratou K2020European Respiratory JournalOtherHighplex FLHALO
A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell CycleMiao Z-F, Lewis MA, Cho CJ, Adkins-Threats M, Park D, Brown JW, Sun J-X, Burclaff JR, Kennedy S, Lu J, Mahar M, Vietor I, Huber LA, Davidson NO, Cavalli V, Rubin DC, Wang Z-N, Mills JC2020Developmental CellOncologyHighplex FLHALO
STAT3 antisense oligonucleotide remodels the suppressive tumor microenvironment to enhance immune activation in combination with anti-PD-L1Proia T, Singh M, Woessner R, Carnevalli LS, Bommakanti G, Magiera L, Srinivasan SS, Grosskurth SE, Collins M, Womack C, Griffin M, Ye M, Cantin S, Russell DL, Xie M, Hughes AM, Deng N, Mele DA, Fawell SE, Barry ST, Reimer C, Barrett JC, McCoon P2020Clinical Cancer ResearchImmuno-oncologyMultiplex IHC, Highplex FLHALO
Chemoradiotherapy efficacy is predicted by intra-tumour CD8+/FoxP3+ double positive T cell density in locally advanced N2 non–small-cell lung carcinomaBoulle G, Velut Y, Mansuet-Lupo A, Gibault L, Blons H, Fournel L, Boni A, Cremer I, Wislez M, Duchatelle V, Tredaniel J, Hammond SA, Herbst R, Alifano M, Giraud P, Damotte D2020European Journal of CancerOncologyHighplex FLHALO
Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic miceGoulding DS, Vogel RC, Pandya CD, Shula C, Gensel JC, Mangano FT, Goto J, Miller BA2020Journal of NeurosurgeryImmunology, NeuroscienceMultiplex IHC, Highplex FLHALO
RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exonsThomas JD, Polaski JT, Feng Q, De Neef EJ, Hoppe ER, McSharry MV, Pangallo J, Gabel AM, Belleville AE, Watson J, Nkinsi NT, Berger AH, Bradley RK2020Nature GeneticsOtherHighplex FLHALO
PIK3CA mutation and CNV status and post-chemoradiotherapy survival in patients with cervical cancerMartell K, McIntyre JB, Kornaga EN, Chan AMY, Phan T, Kobel M, Enwere EK, Dean ML, Ghatage P, Lees-Miller SP, Doll CM2020Gynecologic OncologyOncologyClassifier, Highplex FL, TMAHALO
IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancerHubert M, Gobbini E, Couillault C, Manh T-PV, Doffin A-C, Berthet J, Rodriguez C, Ollion V, Kielbassa J, Sajous C, Treilleux I, Tredan O, Dubois B, Dalod M, Bendriss-Vermare N, Caux C, Valladeau-Guilemond J2020ImmunologyOncologyHighplex FLHALO
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Discoidin Domain Receptor 1 (DDR1) is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal AdenocarcinomaRuggeri JM, Franco-Barraza J, Sohail A, Zhang Y, Long D, di Magliano MP, Cukierman E, Fridman R, Crawford HC2020The American Journal of PathologyOncology, ImmunologyCytonuclear, Multiplex IHC, Highplex FLHALO
CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cellsMaurice NJ, McElrath MJ, Andersen-Nissen E, Frahm N, Prlic M2019Nature CommunicationsImmunologyHighplex FLHALO
Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted TherapyHirukawa A, Singh S, Wang J, Rennhack JP, Swiatnicki M, Sanguin-Gendreau V, Zuo D, Daldoul K, Lavoie C, Park M, Andrechek ER, Westbrook TF, Harris LN, Varadan V, Smith HW, Muller WJ2019Cell ReportsOncologyHighplex FLHALO
Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint BlockadeHouse IG, Savas P, Lai J, Chen AXY, Oliver AJ, Teo ZL, Todd KL, Henderson MA, Giuffrida L, Petley EV, Sek K, Mardiana S, Gide TN, Quek C, Scolyer RA, Long GV, Wilmott JS, Loi S, Darcy PK, Beavis PA2019Clinical Cancer ResearchImmuno-oncologyHighplex FLHALO
Validation and characterisation of prognostically significant PD-L1+ immune cells in HPV+ oropharyngeal squamous cell carcinomaYoung RJ, Bressel M, Porceddu S, Cernelc J, Savas P, Liu H, Urban D, Thai AA, Cooper C, Fua T, Neeson P, Rischin D, Solomon B2019Oral OncologyOncology, Infectious DiseaseClassifier, Highplex FLHALO
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Multiplex Immunofluorescence of Bone Marrow Core Biopsies: Visualizing the Bone Marrow Immune ContextureWalters DK, Jelinek DF2019Journal of Histochemistry & CytochemistryImmunologySpatial Analysis, Highplex FLHALO
A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanomaHuang AC, Orlowski RJ, Xu X, Mick R, George SM, Yan PK, Manne S, Kraya AA, Wubbenhorst B, Dorfman L, D’Andrea K, Wenz BM, Liu S, Chilukuri L, Kozlov A, Carberry M, Giles L, Kier MW, Quagliarello F, McGettigan S, Kreider K, Annamalai L, Zhao Q, Mogg R, Xu W, Blumenschein WM, Yearley JH, Linette GP, Amaravadi RK, Schuchter LM, Herati RS, Bengsch B, Nathanson KL, Farwell MD, Karakousis GC, Wherry EJ, Mitchell TC2019Nature MedicineOncology, Immuno-oncologyHighplex FLHALO
MYB-NFIB gene fusions identified in archival adenoid cystic carcinoma tissue employing NanoString analysis: an exploratory studyMcIntyre JB, Ko JJ, Siever J, Chan AMY, Simpson RHW, Hao D, Lau HY2019Diagnostic PathologyOncologyClassifier, Highplex FLHALO
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastomaCloughesy TF, Mochizuki AY, Orpilla JR, Hugo W, Lee AH, Davidson TB, Wang AC, Ellingson BM, Rytlewski JA, Sanders CM, Kawaguchi ES, Du L, Li G, Yong WH, Gaffey SC, Cohen AL, Mellinghoff IK, Lee EQ, Reardon DA, O’Brien BJ, Butowski NA, Nghiemphu PL, Clarke JL, Arrillaga-Romany IC, Colman H, Kaley TJ, de Groot JF, Liau LM, Wen PY, Prins RM2019Nature MedicineOncology, Immuno-oncologySpatial Analysis, Highplex FLHALO
T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal AdenocarcinomaStromnes IM, Hulbert A, Pierce RH, Greenberg PD, Hingorani SR2017Cancer Immunology ResearchOncology, Immuno-oncologyHighplex FLHALO
Cell signaling activation and extracellular matrix remodeling underpin glioma tumor microenvironment heterogeneity and organizationDinevska M, Widodo S, Furst L, Cuzcano L, Fang Y, Mangiola S, Neeson P, Darcy P, Ramsay R, Hutchinson R, MacKay F, Christie M, Stylli S, Mantamadiotis T2022Cellular OncologyOncologyClassifier, Highplex FL, RegistrationHALO
Inosine monophosphate dehydrogenase intranuclear inclusions are markers of aging and neuronal stress in the human substantia nigraWoulfe J, Munoz DG, Gray DA, Jinnah HA, Ivanova A2023Neurobiology of AgingNeuroscienceHighplex FLHALO

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Quantify expression of up to five brightfield stains in any cellular compartment - membrane, nucleus or cytoplasm.

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Plot cells and objects from one or more images and perform nearest neighbor analysis, proximity analysis, and tumor infiltration analysis.

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New! High Dimensional Analysis Module​

Acquire deeper insights into complex data sets using dimensional reduction and unsupervised clustering with interactive plotting.

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