Simultaneously analyze up to five IHC stains in any cellular compartment (nucleus, cytoplasm, and/or membrane) with the HALO® Multiplex IHC module. This module is ideally suited for applications in immuno-oncology where multiple markers are required to characterize distinct immune and tumor cell populations within the tissue. Optimize your image analysis with available pre-trained AI-based membrane and/or nuclear segmentation, use threshold assistance features to set data-driven positivity thresholds, and define cell types of interest with the streamlined phenotype editor. Once optimized, leverage interactive markups to dynamically explore colocalization and combined cell phenotypes.
File formats supported by the HALO image analysis platform:
- Non-proprietary (JPG, TIF, OME.TIFF)
- Nikon (ND2)
- 3D Histech (MRXS)
- Akoya (QPTIFF, component TIFF)
- Olympus / Evident (VSI)
- Hamamatsu (NDPI, NDPIS)
- Aperio (SVS, AFI)
- Zeiss (CZI)
- Leica (SCN, LIF)
- Ventana (BIF)
- Philips (iSyntax, i2Syntax)
- KFBIO (KFB, KFBF)
- DICOM (DCM*)
*whole-slide images
Glomeruli Quantification and Characterization Application Note
Don’t let varied stain selections hold back your digital image analysis of kidney sections! With HALO AI you can develop a tissue classifier that accurately detects and segments glomeruli in sections across a range of stains including H&E, trichrome, PAMS, and DAB with hematoxylin.
HALO Image Analysis in Drug Discovery
Review this publication list to learn how HALO platforms are advancing image analysis and helping accelerate findings throughout the drug discovery and development pipeline.
HALO AI High Impact Publications
Review this selection of high-impact publications for examples of HALO AI applications in fields ranging from metabolism to immuno-oncology and myology.
Chromogenic triplex characterization of breast and gastrointestinal cancers
Check out this collaborative poster to learn about a streamlined triplex chromogenic workflow leveraging HALO and HALO AI for analysis of slides assayed with Leica Biosystems’ ChromoPlex III Triple Detection RUO.
Unlocking Deeper Insights with the HALO® High Dimensional Analysis Module
Extracting biological insights from highly multiplexed data requires both powerful image analysis tools and intuitive methods to navigate high-dimensional data. In this blog, we’ll cover
Interactive Markup Images: Providing a Dynamic Look at HALO® Analysis Results
At Indica Labs, our HALO platforms are optimized for ease-of-use as well as powerful, accurate analysis, and include multiple features to help users get the
HALO®, HALO AI, and HALO Link 3.6 Features and Functionalities
In this blog post, you can learn about some of the new features in these modules, where to find the user guides, tutorial videos, and
Getting Started with Brightfield Image Analysis in HALO®
3 April 2025 | Join us for an introductory webinar on brightfield image analysis in HALO®, designed for beginners. We’ll walk through key digital pathology
Masterclass Webinar 2: Advanced Techniques and Workflows for Multiplex IHC Analysis using HALO® and HALO AI
25 May 2023 | Following up on our Masterclass Webinar 1 for Multiplex IHC analysis, Masterclass 2 will discuss advanced workflows to help users tackle
Masterclass Webinar: Optimizing a 3-plex Multiplex IHC Assay Using Roche Discovery Reagents and HALO® Image Analysis
11 May 2023 | In this 60-minute webinar, we discuss best practices and optimization techniques for advanced quantitative multiplex immunohistochemical (mIHC) image analysis.
Maximizing use of HALO® and HALO AI for a comprehensive image analysis for HUMAN Brain FFPE Tissue samples in Alzheimer’s Disease
25 May 2022 | In this 60-min webinar, Learn how HALO and HALO AI are advancing neuropathology research at the UW Medicine Biorepository and Integrated
Indica Labs Announces Launch of High Dimensional Analysis Module for the HALO® Image Analysis Platform
Albuquerque, NM, 8 April 2025 – Indica Labs today announces the launch of the High Dimensional Analysis module for the HALO® image analysis platform. This
Publication Spotlight
The table below includes publications that cite the Multiplex IHC module.
Your publication not on the list? Drop us an email to let us know about it!
| Title | Authors | Year | Journal | Topics | HALO Modules | Products |
|---|---|---|---|---|---|---|
| Chimeric antigen receptor macrophages (CAR-M) sensitize HER2+ solid tumors to PD1 blockade in pre-clinical models | Pierini S, Gabbasov R, Oliveira-Nunes M C, Qureshi R, Worth A, Huang S, Nagar K, Griffin C, Lian L, Yashiro-Ohtani Y, Ross K, Sloas C, Ball M, Schott B, Sonawane P, Cornell L, Blumenthal D, Chhum S, Minutolo N, Ciccaglione K, Shaw L, Zentner I, Levitsky H, Shestova O, Gill S, Varghese B, Cushing D, DeLong S C, Abramson S, Condamine T, Klichinsky M | 2025 | Nature Communications | Immuno-oncology | ISH, Multiplex IHC | HALO |
| CD36 enrichment in HER2-positive mesenchymal stem cells drives therapy refractoriness in breast cancer | Castagnoli L, Franceschini A, Cancila V, Dugo M, Bigliardi M, Chiodoni C, Toneguzzo P, Regondi V, Corsetto P A, Pietrantonio F, Mazzucchelli S, Corsi F, Belfiore A, Vingiani A, Pruneri G, Ligorio F, Colombo M P, Tagliabue E, Tripodo C, Vernieri C, Triulzi T, Pupa S M | 2025 | Journal of Experimental & Clinical Cancer Research | Oncology | Multiplex IHC, Highplex FL | HALO |
| Cross-species comparisons between pigs and mice reveal conserved sex-specific intraspinal inflammatory responses after spinal cord injury | Kumari R, Hammers G V, Hammons R H, Stewart A N, MacLean S M, Niedzielko T, Schneider L E, Floyd C L, Gensel J C | 2025 | Journal of Neuroinflammation | Neuroscience | Area Quantification, Multiplex IHC | HALO |
| Stroma-derived Dickkopf-1 contributes to the suppression of NK cell cytotoxicity in breast cancer | Lee S, Ricci B, Tran J, Eul E, Ye J, Ren Q, Clever D, Wang J, Wong P, Haas M S, Stewart S A, Ma C X, Fehniger T A, Faccio R | 2025 | Nature Communications | Immuno-oncology | Multiplex IHC | HALO |
| Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms | Sivakumar S, Jainarayanan A, Arbe-Barnes E, Sharma P K, Leathlobhair M N, Amin S, Reiss D J, Heij L, Hegde S, Magen A, Tucci F, Sun B, Wu S, Anand N M, Slawinski H, Revale S, Nassiri I, Webber J, Hoeltzel G D, Frampton A E, Wiltberger G, Neumann U, Charlton P, Spiers L, Elliott T, Wang M, Couto S, Lila T, Sivakumar P V, Ratushny A V, Middleton M R, Peppa D, Fairfax B, Merad M, Dustin M L, Abu-Shah E, Bashford-Rogers R | 2025 | Nature Communications | Immuno-oncology | Classifier, Multiplex IHC, Registration | HALO |
| A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma | Rendo V, Lee E Q, Bossi C, Khuu N, Rudek M A, Pal S, Azazmeh N, Rashid R, Lin J R, Cusick M, Reynolds A R N, Fassinou A C R, Ayoub G, Malinowski S, Lapinskas E, Pisano W, Jeang J, Stopka S A, Regan M S, Spetz J, Desai A, Lieberman F, Palanichamy K, Fisher J D, Pelton K, Huang R Y, Sarosiek K A, Nabors L B, Holdhoff M, Danda N, Strowd R, Desideri S, Walbert T, Ye X, Chakravarti A, Sorger P K, Santagata S, Agar N Y R, Grossman S A, Alexander B M, Wen P Y, Ligon K L, Beroukhim R | 2025 | Science Translational Medicine | Oncology | Multiplex IHC | HALO, HALO AI |
| Prevention of tuberculosis in cynomolgus macaques by an attenuated Mycobacterium tuberculosis vaccine candidate | Singh D K, Ahmed M, Akter S, Shivanna V, Bucşan A N, Mishra A, Golden N A, Didier P J, Doyle L A, Hall-Ursone S, Roy C J, Arora G, Dick E J, Jagannath C, Mehra S, Khader S A, Kaushal D | 2025 | Nature Communications | Infectious Disease | Area Quantification, Multiplex IHC | HALO |
| Human-correlated genetic models identify precision therapy for liver cancer | Müller M, May S, Hall H, Kendall T J, McGarry L, Blukacz L, Nuciforo S, Georgakopoulou A, Jamieson T, Phinichkusolchit N, Dhayade S, Suzuki T, Huguet-Pradell J, Powley I R, Officer-Jones L, Pennie R L, Esteban-Fabró R, Gris-Oliver A, Pinyol R, Skalka G L, Leslie J, Hoare M, Sprangers J, Malviya G, Mackintosh A, Johnson E, McCain M, Halpin J, Kiourtis C, Nixon C, Clark G, Clark W, Shaw R, Hedley A, Drake T M, Tan E H, Neilson M, Murphy D J, Lewis D Y, Reeves H L, Le Quesne J, Mann D A, Carlin L M, Blyth K, Llovet J M, Heim M H, Sansom O J, Miller C J, Bird T G | 2025 | Nature | Oncology | Area Quantification, Multiplex IHC | HALO |
| Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer | Güç E, Treveil A, Leach E, Broomfield A, Camera A, Clubley J, Nieto Garcia P, Kazachenka A, Khanolkar R, del Carpio L, Heyn H, Hassel J C, Sacco J J, Stanhope S, Collins L, Piulats J M, Ranade K, Benlahrech A | 2025 | Nature Communications | Immuno-oncology | Multiplex IHC | HALO |
| Involvement of lncRNA MIR205HG in idiopathic pulmonary fibrosis and IL-33 regulation via Alu elements | Takashima T, Zeng C, Murakami E, Fujiwara N, Kohara M, Nagata H, Feng Z, Sugai A, Harada Y, Ichijo R, Okuzaki D, Nojima S, Matsui T, Shintani Y, Kawai G, Hamada M, Hirose T, Nakatani K, Morii E | 2025 | JCI Insight | Fibrosis | ISH, Multiplex IHC | HALO |
| Potential pulmonary toxicity risks of metal products from hip implants: Using A549 lung cell and animal model | Konety R, Kanniyappan H, Walkay T, Jacob A, Barba M, Deaton R, Mathew MT | 2025 | Chemical Engineering Journal | Other | Multiplex IHC | HALO |
| A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system | Wilde J H, Sun Y-Y, Simpson S R, Hill E R, Fu Z, Bian E J, Kinkaid M M, Villanueva P, Weybright A F, Terrell W R, Qureshi Z, Perera S S, Sheppard H S, Stone J R, Kundu B K, Kuan C-Y, Neumann K D | 2025 | Nature Biomedical Engineering | Neuroscience | Multiplex IHC | HALO |
| PARP inhibitor radiosensitization enhances anti-PD-L1 immunotherapy through stabilizing chemokine mRNA in small cell lung cancer | Ran X, Wu X, Vidhyasagar V, Song L, Zhang X, Ladak R, Teng M, Ba-alawi W, Philip V, He H, Sonenberg N, Lok B H | 2025 | Nature Communications | Immuno-oncology | Multiplex IHC | HALO |
| A human model to deconvolve genotype-phenotype causations in lung squamous cell carcinoma | Ogden J, Sellers R, Sahoo S, Oojageer A, Chaturvedi A, Dive C, Lopez-Garcia C | 2025 | Nature Communications | Oncology | Multiplex IHC | HALO |
| Neoadjuvant toripalimab plus nimotuzumab combined with taxol-based chemotherapy in locally advanced penile squamous cell carcinoma | An X, Guo S J, Yan R, Xue T, Xiong L B, Ma H L, Xue C, Zhang Y C, Li J B, Chen M T, Li Z S, Liu T Y, Zhang Z L, Dong P, Li Y H, Yao K, Hu Z Q, Chen X F, Luo J X, Lei Y H, Liang P Y, Liu Z Z, Qi L, Xu W F, Cao Z G, Chen N H, Li X, Sheng X N, Luo G H, Shi B K, Xie Q, Liu Z W, Zhou F J, Spiess P E, Shi Y X, Han H | 2025 | Cancer Cell | Immuno-oncology | Multiplex IHC | HALO |
| Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity | Huang Y, Zhong W-Q, Yang X-Y, Shan J-L, Zhou L, Li Z-L, Guo Y-Q, Zhang K-M, Du T, Zhang H-L, Hu B-X, Chen Y-H, Yang D, Feng G-K, Tang J, Zhu X-F, Deng R | 2025 | Nature Communications | Immuno-oncology | Multiplex IHC | HALO |
| Evolution of the tumor immune landscape during treatment with tebentafusp, a T cell receptor-CD3 bispecific | Sacco J, Kirk P, Leach E, Shoushtari A N, Carvajal R D, Britton-Rivet C, Khakoo S, Collins L, de la Cruz-Merino L, Eroglu Z, Ikeguchi A P, Nathan P, Hamid O, Butler M O, Stanhope S, Ranade K, Sato T | 2025 | Cell Reports Medicine | Immuno-oncology | Multiplex IHC | HALO |
| Efficacy of ATR kinase inhibitor elimusertib monotherapy or combination in tumors with DNA damage response pathway and other genomic alterations | Varadarajan K, Cruz Pico C X, Evans K W, Raso M G, Rizvi Y Q, Zheng X, Chachad D, DiPeri T P, Wang B, Scott S M, Zhao M, Akcakanat A, Wengner A M, Yap T A, Meric-Bernstam F | 2025 | Molecular Cancer | Oncology | Multiplex IHC | HALO |
| Harnessing the FGFR2/NF2/YAP signaling-dependent necroptosis to develop an FGFR2/IL-8 dual blockade therapeutic strategy | Chen D, Zhao Z, Hong R, Yang D, Gong Y, Wu Q, Wang Y, Cao Y, Chen J, Tai Y, Liu H, Li J, Fan J, Zhang W, Song Y, Zhan Q | 2025 | Nature Communications | Oncology | Multiplex IHC | HALO |
| Cancer‐Specific RNA Modifications in Tumour‐Derived Extracellular Vesicles Promote Tumour Growth | Monoe Y, Jingushi K, Taniguchi K, Hirosuna K, Arima J, Inomata Y, Takano Y, Hamamoto H, Komura K, Tanaka T, Hase H, Lee S-W, Tsujikawa K | 2025 | Journal of Extracellular Vesicles | Oncology | Multiplex IHC | HALO |
| Highly conserved brain vascular receptor ALPL mediates transport of engineered AAV vectors across the blood-brain barrier | Moyer T C, Hoffman B A, Chen W, Shah I, Ren X-Q, Knox T, Liu J, Wang W, Li J, Khalid H, Kulkarni A S, Egbuchulam M, Clement J, Bloedel A, Child M, Kaur R, Rouse E, Graham K, Maura D, Thorpe Z, Sayed-Zahid A, Chung C H-Y, Kutchin A, Johnson A, Yao J, Thompson J, Pande N, Nonnenmacher M E | 2025 | Molecular Therapy | Neuroscience | Multiplex IHC, Highplex FL | HALO, HALO AI |
| Neo-antigen tumor vaccination depends on CD4-licensing conveyed by adenoassociated virus like particles | Neukirch L, Uhrig-Schmidt S, von Werthern K, Tuch A, Kraske J A, Lyu Y, Lenoir B, Eichmüller S B, Meyer M, Zörnig I, Jäger D, Schmidt P | 2025 | Molecular Therapy | Immuno-oncology | Multiplex IHC, Spatial Analysis | HALO |
| KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer | Galan-Cobo A, Vokes N I, Qian Y, Molkentine D, Ramkumar K, Paula A G, Pisegna M, McGrail D J, Poteete A, Cho S, Do M T, Karimi A, Kong Y, Solanki A, Karmokar A, Floc’h N, Hughes A, Sargeant R, Young L, Shen L, Kar G, Keshvani C, Arrechedera C, Hernandez S, Schlacher K, Wang J, Iyer S, Conway J, Keddar M R, Milo M, de Toma I, Critchlow S E, Barrett J C, Cosaert J, Lau A, Valge-Archer V, Byers L A, Barry S T, Heymach J V | 2025 | Cancer Cell | Oncology | Multiplex IHC | HALO |
| Incidence and Immunopathology of Myositis in Rectal Cancer Patients Treated With Neoadjuvant Immune Checkpoint Inhibitors and Chemoradiotherapy: Findings From the CHINOREC Trial | Zirnbauer R, Hametner S, Bergler‐Klein J, Kuehrer I, Kulu A, Ammon D, Kabiljo J, Stift A, Schmid R, Müllauer L, Bittermann C, Laengle F, Machold K, Blüml S, Bergmann M, Laengle J | 2025 | MedComm | Immuno-oncology | Multiplex IHC | HALO, HALO AI |
| Enhancing CAR-T Cell Metabolic Fitness and Memory Phenotype for Improved Efficacy against Hepatocellular Carcinoma | You J, Yang X, Zhao J, Chen H, Tang Y, Ouyang D, Liu Y, Wang Y, Xie S, Chen Y, Liao J, Xiang T, Xia J, Yang C, Weng D | 2025 | International Journal of Biological Sciences | Immuno-oncology | Multiplex IHC | HALO |
| Unravelling relatlimab-specific biology using biomarker analyses in patients with advanced melanoma in RELATIVITY-047 | Lipson E, Dolfi S, Tang H, Tawbi H, Medina-Soto F, Castillo Gutiérrez E, Rutkowski P, Gogas H, Murillo E, Ascierto P, Desai K, Maio M, Demers K, Mazzei A, Keidel S, Miller-Moslin K, Yu J X, Hodi F S, Schadendorf D, Long G V, Garnett-Benson C | 2025 | Clinical Cancer Research | Immuno-oncology | Multiplex IHC | HALO |
| Overcoming multidrug resistance in gastrointestinal cancers with a CDH17-targeted ADC conjugated to a DNA topoisomerase inhibitor | Wang R, Fang P, Chen X, Ji J, Yu D, Mei F, Wang Z, Zhou W, Peng W, Wang R, Wang J, Guo C, Wu H, Liu D, Tan X, Gui X | 2025 | Cell Reports Medicine | Oncology | Multiplex IHC | HALO |
| B7-H3 CAR T-cells are effective against ependymomas, but limited by tumor size and immune response | Mehta S, Ippagunta S, Varadharajan S, Kardian A, Laboe N, Dinh D, Jones A B, Meehl M M, Ibañez J, Emanus E, Dao T, Ward M B, Orisme W, Lange S, Langfitt D, Steinberg J, Chiang J, Vogel P, Sheppard H, Ellison D W, Mack S C, Krenciute G | 2025 | Clinical Cancer Research | Immuno-oncology | Area Quantification, Multiplex IHC | HALO |
| ACLY inhibition promotes tumour immunity and suppresses liver cancer | Gautam J, Wu J, Lally J S V, McNicol J D, Fayyazi R, Ahmadi E, Oniciu D C, Heaton S, Newton R S, Rehal S, Bhattacharya D, Di Pastena F, Nguyen B, Valvano C M, Townsend L K, Banskota S, Batchuluun B, Jabile M J T, Payne A, Lu J, Desjardins E M, Kubota N, Tsakiridis E E, Mistry B, Aganostopoulos A, Houde V, Dansercoer A, Verschueren K H G, Savvides S N, Hammill J A, Bezverbnaya K, Muti P, Tsakiridis T, Dai W, Jiang L, Hoshida Y, Larché M, Bramson J L, Friedman S L, Verstraete K, Wang D, Steinberg G R | 2025 | Nature | Immuno-oncology | Multiplex IHC | HALO |
| Preclinical advances in glofitamab combinations: a new frontier for non-Hodgkin lymphoma | Sam J, Leclercq-Cohen G, Gebhardt S, Surowka M, Herter S, Lechner K, Relf J, Briner S, Varol A, Appelt B, Domocos I, Nicolini V G, Bez M, Bommer E, Jenni S, Schoenle A, Le Clech M, Colombetti S, Klein C, Umaña P, Lundberg P, Korfi K, Bottos A, Bacac M | 2025 | Blood | Immuno-oncology | Multiplex IHC | HALO |
| Enhanced formation of tertiary lymphoid structures shapes the anti-tumor microenvironment in hepatocellular carcinoma after FOLFOX-HAIC therapy | Xing R, Mei J, Zuo Z, Zou H, Yu X, Xu J, Guo R, Wei W, Zheng L | 2025 | Cell Reports Medicine | Immuno-oncology | Multiplex IHC, Spatial Analysis, Highplex FL | HALO |
| Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy | Baruch E N, Gleber-Netto F O, Nagarajan P, Rao X, Akhter S, Eichwald T, Xie T, Balood M, Adewale A, Naara S, Sathishkumar H N, Islam S, McCarthy W, Mattson B J, Ferrarotto R, Wong M K, Davies M A, Jindal S, Basu S, Roversi K, Nikpoor A R, Ahmadi M, Ahmadi A, Harwood C, Leigh I, Gong D, Tallón de Lara P, Tao D L, Davidson T M, Ajami N J, Futreal A, Rai K, Kochat V, Castillo M, Gunaratne P, Goepfert R P, Hernandez S D, Khushalani N I, Wang J, Watowich S S, Calin G A, Migden M R, Yuan M, Liu N, Ye Y, Hwang W L, Vermeer P D, D’Silva N J, Bunimovich Y L, Yaniv D, Burks J K, Gomez J, Dougherty P M, Tsai K Y, Allison J P, Sharma P, Wargo J A, Myers J N, Talbot S, Gross N D, Amit M | 2025 | Nature | Immuno-oncology | Multiplex IHC | HALO |
| Development and Preclinical Evaluation of Next-generation ΔsigH-based Live Candidate Vaccines | Arora G, Munson C W, Ahmed M, Shivanna V, Devi A, Devireddy V S, Antony B, Hall-Ursone S, Gonzalez O D, Dick E Jr, Jagannath C, Alvarez X, Mehra S, Khader S A, Singh D K, Kaushal D | 2025 | JCI Insight | Infectious Disease | Multiplex IHC | HALO |
| Chronic integrated stress response causes dysregulated cholesterol synthesis in white matter disease | Lin K, Ly N, Kunjamma R B, Vu N, King B, Robb H M, Mohler E G, Sridar J, Hao Q, Zavala-Solorio J, Zhang C, Shahryari V, van Bruggen N, Connelly C F, Bennett B D, Lee J J, Sidrauski C | 2025 | JCI Insight | Neuroscience | Area Quantification, Multiplex IHC | HALO |
| Paris polyphylla var. yunnanensis Leaf-Derived Extracellular Vesicle-Like Particles Enhance Periodontal Regeneration | Huang G, Liu A, Hu Y, Yang R, Dai Z, Meng W, Yan Y, Yang H, Li S | 2025 | Biomaterials Research | Biomaterials | Area Quantification, Multiplex IHC | HALO |
| Immuno-oncologic profiling of renal masses using multiparametric MRI: a pilot study | Liu M, Bane O, Mu X, Al-Mubarak H, Abboud G, Reddy A, Kennedy P, Robson P, Meilika K, Zuluaga L, Horowitz A, Kuhn B, Thin T, Garcia-Barros M, Brody R, Badani K, Taouli B, Lewis S | 2025 | Journal for Immunotherapy of Cancer | Immuno-oncology | Multiplex IHC | HALO |
| Anti-progestin therapy targets hallmarks of breast cancer risk | Simões B, Pedley R, McCloskey C, Roberts M, Reed A, Twigger A, Tharmapalan P, Caruso A, Cabral S, Wilby A, Harrison H, Zhou Y, Greenhalgh A, Alghamdi S, Forestiero M, Lopez-Muñoz J, Roche J, Tuieng R, Khan M, Squires S, Astley S, Harkness E, Santiago-Gómez A, Spence K, Ritchie J, Pritchard S, Lim Y, Sherratt M, Andò S, Howell A, Evans D, Gilmore A, Khaled W, Khokha R, Clarke R, Howell S | 2025 | Nature | Oncology | Multiplex IHC, Highplex FL | HALO |
| Prostate cancer in situ autovaccination with the intratumoral viral mimic poly-ICLC: Modulating the cold tumor microenvironment | Nair S, Chakravarty D, Balan S, Hakansson A, Duval M, Davicioni E, Liu Y, Bhardwaj S, Thin T, Garcia-Barros M, Haines K, Al Shaarani M, Weil R, Meseck M, Ratnani P, Fatterpekar M, Gonzalez-Gugel E, Farkas A, Wagaskar V, Jambor I, Schlussel K, Pasat-karasik C, Bhatt K, Dovey Z, Pedraza A, Gupta A, Lundon D, Peros A, Parekh S, Davenport L, Zhang X, Gupta R, Robison M, Knauer C, Ellis E, Rykunov D, Reva B, Padanilam B, Galsky M, Brody R, Menon M, Salazar A, Bhardwaj N, Tewari A | 2025 | Med | Immuno-oncology | Multiplex IHC | HALO |
| Empowering chemotherapy-induced antitumor immunity by multi-targeted synergistic combination nanomedicine for triple-negative breast cancer | Alradwan I, Zhi P, Zetrini A, Wang L, He C, Rezaeifarimani M, Henderson J, Rauth A, Wu X | 2025 | Materials Today Bio | Immuno-oncology | Area Quantification, Multiplex IHC, Highplex FL | HALO |
| Spatiotemporal transcriptomics deciphered neutrophil-activated interleukin-36 as driver and effective therapeutic target in Sweet syndrome | Fu Y, Wu C, Pang Z, Liu T, Jia Q, Liu Y, Li H, Zhang S, Zhang H, Li X, Wang S, Feng J, Liu J, Lv Y, Zhang F, Chen W, Jin H | 2025 | British Journal of Dermatology | Dermatology | Multiplex IHC | HALO |
| Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers | Tan P, Verschoor Y, van den Berg J, Balduzzi S, Kok N, Ijsselsteijn M, Moore K, Jurdi A, Tin A, Kaptein P, van Leerdam M, Haanen J, Voest E, de Miranda N, Schumacher T, Wessels L, Chalabi M | 2025 | Nature | Immuno-oncology | Multiplex IHC | HALO |
| Mesenchymal stromal cells induce neutrophil aggregation and extracellular vesicle storms for systemic lupus erythematosus | Ou Q, Niu L, Wang D, Yao G, Ren Q, Li Z, Mao X, Teng W, Chen Z, Xiang A, Shi S, Sun L | 2025 | Signal Transduction and Targeted Therapy | Immunology | Multiplex IHC, TMA | HALO |
| Dissection of immunotherapeutic predictive versus prognostic transcriptional programs identifies SLC22A5-centric carnitine metabolism-driven resistance to anti-PD-(L)1 treatment in non-small cell lung cancer | Wang Y, Gao N, Lin Z, Wang S, Ai S, Wei Z, Zhang S, Cai J, Yang W, Ma S, Cheng C | 2025 | Drug Resistance Updates | Immuno-oncology | Multiplex IHC | HALO |
| Antibody-gamma/delta T cell receptors targeting GPC2 regress neuroblastoma with low antigen density | Quan A, Huo M, Li D, Hutchins L, Rodriguez C, Oh J, Tsao H, Spetz M, Edmondson E, Ashworth D, Zheng R, Zhou J, Chen J, Liu J, Xiong G, Zhang H, Liu C, Nguyen R, Li N, Ho M | 2025 | Cell Reports Medicine | Immuno-oncology | Multiplex IHC | HALO |
| High Treg and PMN-MDSC densities are a hallmark of tertiary lymphoid structures in fatal cases of cervical cancer | Syding L, Plačková K, Pavelková L, Aquino-Perez C, Santegoets S, Laco J, Grega M, Dundr P, Němejcová K, Hodek M, Bouček J, Zábrodský M, Vošmiková H, Halaška M, Rob L, Čelakovský P, Chrobok V, Iheme M, Práznovec I, Vošmik M, Katina S, Cibula D, Ryška A, van der Burg S, Špíšek R, Fialová A | 2025 | Journal for Immunotherapy of Cancer | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
| Autophagy inhibition improves the efficacy of anlotinib and PD-1 inhibitors in the treatment of NSCLC | Tang H, You T, Ge H, Bai C, Wang Y, Sun Z, Han Q, Zhao RC | 2025 | Journal for Immunotherapy of Cancer | Oncology | Multiplex IHC, Highplex FL | HALO |
| Live biotherapeutic enterococcus lactis MNC-168 promotes the efficacy of immune checkpoint blockade in cancer therapy by activating STING pathway via bacterial membrane vesicles | Xian Y, Chen Z, Zhou L, Zhang C, Sun H, Liu Z, Kong P, Liang Y, Zhao Y, Liu S, Zhou Y, Gan L, Li B, Su X, Huang B, Chen X, Zhu R, Zhao G, Lao C, Lin C, Zhang D, Jiang X | 2025 | Gut Microbes | Immuno-oncology | Multiplex IHC | HALO |
| Gene Signature-Based Drug Screening Reveals Ponatinib Enhances Immunotherapy Efficacy in Triple-Negative Breast Cancer by Reversing MDSC-Mediated Immunosuppressive Tumor Microenvironment | Wang Q, Li S, Wu Y, Yu X, Dai Y, Wang Y, Li L, Yang M, Lin K, Shao W, Wang H, Wang H, Zhang G, Wang D | 2025 | Research | Immuno-oncology | Multiplex IHC | HALO |
| Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial | Verschoor YL, van de Haar J, van den Berg JG, van Sandick JW, Kodach LL, van Dieren JM, Balduzzi S, Grootscholten C, IJsselsteijn ME, Veenhof AAAF, Hartemink KJ, Vollebergh MA, Jurdi A, Sharma S, Spickard E, Owers EC, Bartels-Rutten A, den Hartog P, de Miranda NFCC, van Leerdam ME, Haanen JBAG, Schumacher TN, Voest EE, Chalabi M | 2024 | Nature Medicine | Immuno-oncology | Multiplex IHC | HALO |
| Stromal-derived MAOB promotes prostate cancer growth and progression | Pu T, Wang J, Wei J, Zeng A, Zhang J, Chen J, Yin L, Li J, Lin T, Melamed J, Corey E, Gao A, Wu B | 2024 | Science Advances | Oncology | Multiplex IHC, Highplex FL | HALO |
| HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression | Zhang Y, Wang M, Ye L, Shen S, Zhang Y, Qian X, Zhang T, Yuan M, Ye Z, Cai J, Meng X, Qiu S, Liu S, Liu R, Jia W, Yang X, Zhang H, Zhong X, Gao P | 2024 | Nature Communications | Oncology | Multiplex IHC | HALO |
| IGF2BP3 enhances lipid metabolism in cervical cancer by upregulating the expression of SCD | Han C, Hu C, Liu T, Sun Y, Hu F, He Y, Zhang J, Chen J, Ding J, Fan J, Zhang X, Wang J, Qiao X, Jiang D, Yang K, Yang S | 2024 | Cell Death & Disease | Oncology | Multiplex IHC | HALO |
| Impact of metronomic trabectedin combined with low-dose cyclophosphamide on sarcoma microenvironment and correlation with clinical outcome: results from the TARMIC study | Sun C-M, Toulmonde M, Spalato-Ceruso M, Peyraud F, Bessede A, Kind M, Cousin S, Buy X, Palussiere J, Bougouin A, Sautès-Fridman C, Fridman H W, Pulido M, Italiano A | 2024 | Molecular Cancer | Oncology | Multiplex IHC, Highplex FL | HALO |
| Selective CDK7 inhibition suppresses cell cycle progression and MYC signaling while enhancing apoptosis in therapy-resistant estrogen receptor positive breast cancer | Guarducci C, Nardone A, Russo D, Nagy Z, Heraud C, Grinshpun A, Zhang Q, Freelander A, Leventhal M J, Feit A, Feiglin A, Liu W, Hermida-Prado F, Kesten N, Ma W, De Angelis C, Morlando A, O’Donnell M, Naumenko S, Huang S, Nguyen Q, Huang Y, Malorni L, Bergholz J S, Zhao J J, Fraenkel E, Lim E, Schiff R, Shapiro G I, Jeselsohn R | 2024 | Clinical Cancer Research | Oncology | Multiplex IHC | HALO |
| Nanoparticle mediated photodynamic therapy as a method to ablate oral cavity squamous cell carcinoma in preclinical models | Sahovaler A, Valic M, Townson J, Chan H, Zheng M, Tzelnick S, Mondello T, Pener-Tessler A, Eu D, El-Sayes A, Ding L, Chen J, Douglas C, Weersink R, Muhanna N, Zheng G, Irish J | 2024 | Cancer Research | Oncology | Classifier, Multiplex IHC | HALO |
| Tertiary lymphoid structures predict survival and response to neoadjuvant therapy in locally advanced rectal cancer | Wang Q, Zhong W, Shen X, Hao Z, Wan M, Yang X, An R, Zhu H, Cai H, Li T, Lv Y, Dong X, Chen G, Liu A, Du J | 2024 | Precision Oncology | Oncology | Multiplex IHC | HALO |
| An immune cell map of human lung adenocarcinoma development reveals an anti-tumoral role of the Tfh-dependent tertiary lymphoid structure | Liu W, You W, Lan Z, Ren Y, Gao S, Li S, Chen W, Huang C, Zeng Y, Xiao N, Wang Z, Xie H, Ma H, Chen Y, Wang G, Chen C, Li H | 2024 | Cell Reports Medicine | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
| A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s disease | Tsartsalis S, Sleven H, Fancy N, Wessely F, Smith A M, Willumsen N, Cheung T K D, Rokicki M J, Chau V, Ifie E, Khozoie C, Ansorge O, Yang X, Jenkyns M H, Davey K, McGarry A, Muirhead R C J, Debette S, Jackson J S, Montagne A, Owen D R, Miners J S, Love S, Webber C, Cader M Z, Matthews P M | 2024 | Nature Communications | Neuroscience | Area Quantification, Multiplex IHC | HALO |
| Inhibition of IL-25/IL-17RA improves immune-related adverse events of checkpoint inhibitors and reveals antitumor activity | Hu X, Bukhari SM, Tymm C, Adam K, Lerrer S, Henick BS, Winchester RJ, Mor A | 2024 | Journal for Immunotherapy of Cancer | Immuno-oncology | Multiplex IHC | HALO |
| Oncogenic cell tagging and single-cell transcriptomics reveal cell type-specific and time-resolved responses to Vhl inactivation in the kidney | Kurlekar S, Lima J, Li R, Lombardi O, Masson N, Barros A, Pontecorvi V, Mole D, Pugh C, Adam J, Ratcliffe P | 2024 | Cancer Research | Oncology | Multiplex IHC | HALO, HALO AI |
| Characterisation of premature cell senescence in Alzheimer’s disease using single nuclear transcriptomics | Fancy N, Smith A, Caramello A, Tsartsalis S, Davey K, Muirhead R, McGarry A, Jenkyns M, Schneegans E, Chau V, Thomas M, Boulger S, Cheung T, Adair E, Papageorgopoulou M, Willumsen N, Khozoie C, Gomez-Nicola D, Jackson J S, Matthews P M | 2024 | Acta Neuropathologica | Neuroscience | Multiplex IHC | HALO |
| Preclinical efficacy and pharmacokinetics of an RNA-encoded T cell–engaging bispecific antibody targeting human claudin 6 | Stadler C, Ellinghaus U, Fischer L, Bähr-Mahmud H, Rao M, Lindemann C, Chaturvedi A, Scharf C, Biermann I, Hebich B, Malz A, Beresin G, Falck G, Häcker A, Houben A, Erdeljan M, Wolf K, Kullmann M, Chang P, Türeci Ö, Şahin U | 2024 | Science Translational Medicine | Immuno-oncology | Multiplex IHC | HALO |
| FLI1 promotes IFN-γ-induced kynurenine production to impair anti-tumor immunity | Chen E, Wu J, Huang J, Zhu W, Sun H, Wang X, Lin D, Li X, Shi D, Liu Z, Huang J, Chen M, Xie F, Deng W | 2024 | Nature Communications | Immuno-oncology | Multiplex IHC | HALO |
| Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer | Boufaied N, Chetta P, Hallal T, Cacciatore S, Lalli D, Luthold C, Homsy K, Imada E, Syamala S, Photopoulos C, Di Matteo A, de Polo A, Storaci A, Huang Y, Giunchi F, Sheridan P, Michelotti G, Nguyen Q, Zhao X, Liu Y, Davicioni E, Spratt D, Sabbioneda S, Maga G, Mucci L, Ghigna C, Marchionni L, Butler L, Ellis L, Bordeleau F, Loda M, Vaira V, Labbé D, Zadra G | 2024 | Cancer Research | Oncology | Classifier, Multiplex IHC | HALO |
| The m6A reader HNRNPC promotes glioma progression by enhancing the stability of IRAK1 mRNA through the MAPK pathway | Chen J, Lu T, Wang T, Yan W, Zhong F, Qu X, Gong X, Li J, Tou F, Jiang L, Han X | 2024 | Cell Death & Disease | Oncology | Multiplex IHC | HALO |
| Development of NR0B2 as a therapeutic target for the re-education of tumor associated myeloid cells | Vidana Gamage H E, Albright S T, Smith A J, Farmer R, Shahoei S H, Wang Y, Fink E C, Jacquin E, Weisser E, Bautista R O, Henn M A, Schane C P, Nelczyk A T, Ma L, Das Gupta A, Bendre S V, Nguyen T, Tiwari S, Krawczynska N, He S, Nelson E R | 2024 | Cancer Letters | Oncology | ISH, Multiplex IHC | HALO |
| A High Immune-Related Index with the Suppression of cGAS-STING Pathway is a Key Determinant to Herceptin Resistance in HER2+ Breast Cancer | Cai R, Chen Q, Zhao D, Wang Y, Zhou L, Zhang K, Shan J, Li Z, Chen Y, Zhang H, Feng G, Zhu X, Deng R, Tang J | 2024 | International Journal of Biological Sciences | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
| Single-cell resolution characterization of myeloid-derived cell states with implication in cancer outcome | Rapozo Guimarães G, Resk Maklouf G, Teixeira C, Santos L, Tessarollo N, Toledo N, Serain A, Lanna C, Pretti M, Vieira da Cruz J, Falchetti M, Dimas M, Filgueiras I, Cabral-Marques O, Ramos R, Macedo F, Rodrigues F, Bastos N, Silva J, Rocha E, Chaves C, Melo A, Moraes-Vieira P, Mori M, Boroni M | 2024 | Nature Communications | Immuno-oncology | Multiplex IHC, TMA | HALO |
| Combined inhibition of KRASG12C and mTORC1 kinase is synergistic in non-small cell lung cancer | Kitai H, Choi P H, Yang Y C, Boyer J A, Whaley A, Pancholi P, Thant C, Reiter J, Chen K, Markov V, Taniguchi H, Yamaguchi R, Ebi H, Evans J, Jiang J J, Lee B, Wildes D, Stanchina E, Smith J A M, Singh M, Rosen N | 2024 | Nature Communications | Oncology | Classifier, Area Quantification, Multiplex IHC | HALO |
| MS-20 enhances the gut microbiota-associated antitumor effects of anti-PD1 antibody | Leea P-J, Hung C-M, Yang A-J, Hou C-Y, Chou H-W, Chang Y-C, Chua W-C, Huang W-Y, Kuo W-C, Yang C-C, Lind K-I, Hung K-H, Change L-C, Lee K-Y, Kuo H-P, Liu K-M, Lai H-C, Kuoi M-L, Chen W-J | 2024 | Gut Microbes | Immuno-oncology | Multiplex IHC | HALO |
| Metabolic imaging across scales reveals distinct prostate cancer phenotypes | Sushentsev N, Hamm G, Flint L, Birtles D, Zakirov A, Richings J, Ling S, Tan J Y, McLean M A, Ayyappan V, Menih I H, Brodie C, Miller J L, Mills I G, Gnanapragasam V J, Warren A Y, Barry S T, Goodwin R J A, Barrett T, Gallagher F A | 2024 | Nature Communications | Oncology | Classifier, Area Quantification, FISH, Membrane, Multiplex IHC | HALO, HALO AI |
| PPARα affects hepatic lipid homeostasis by perturbing necroptosis signals in the intestinal epithelium | Na S, Fan Y, Chen H, Li L, Li G, Zhang F, Wang R, Yang Y, Shen Z, Peng Z, Wu Y, Zhu Y, Yang Z, Dong G, Ye Q, Yue J | 2024 | Acta Pharmaceutica Sinica B | Gastroenterology | Multiplex IHC | HALO |
| Citrullination modulation stabilizes HIF-1α to promote tumour progression | Chen R, Lin Z, Shen S, Zhu C, Yan K, Suo C, Liu R, Wei H, Gao L, Fan K, Zhang H, Sun L, Gao P | 2024 | Nature Communications | Oncology | Multiplex IHC | HALO |
| Neoadjuvant immune checkpoint blockade in women with mismatch repair deficient endometrial cancer: a phase I study | Eerkens A L, Brummel K, Vledder A, Paijens S T, Requesens M, Loiero D, van Rooij N, Plat A, Haan F J, Klok P, Yigit R, Roelofsen T, de Lange N M, Klomp R, Church D, ter Elst A, Wardenaar R, Spierings D, Foijer F, Koelzer V H, Bosse T, Bart J, Jalving M, Reyners A K L, de Bruyn M, Nijman H W | 2024 | Nature Communications | Immuno-oncology | Multiplex IHC | HALO, HALO AI |
| YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment | Yang Z, Wang X, Fu Y, Wu W, Hu Z, Lin Q, Peng W, Pan Y, Wang J, Chen J, Hu D, Zhou Z, Xu L, Zhang Y, Hou J, Chen M | 2024 | Molecular Cancer | Immuno-oncology | Multiplex IHC | HALO |
| Angiotensin receptor blocker attacks armored and cold tumors and boosts immune checkpoint blockade | Mei J, Chu J, Yang K, Luo Z, Yang J, Xu J, Li Q, Zhang Y, Zhang Q, Wan M, Xue N, Ding J, Zhu Y, Cai Y, Yin Y | 2024 | Journal for Immunotherapy of Cancer | Immuno-oncology | Area Quantification, Multiplex IHC, Highplex FL | HALO |
| Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial | Nederlof I, Isaeva O. I., de Graaf M, Gielen R. C. A. M., Bakker N. A. M., Rolfes A. L., Garner H, Boeckx B, Traets J. J. H., Mandjes I. A. M., de Maaker M, van Brussel T, Chelushkin M, Champanhet E, Lopez-Yurda M, van de Vijver K, van den Berg J. G., Hofland I, Klioueva N, Mann R. M., Loo C. E., van Duijnhoven F. H., Skinner V, Luykx S, Kerver E, Kalashnikova E, van Dongen M. G. J., Sonke G. S., Linn S. C., Blank C. U., de Visser K. E., Salgado R, Wessels L. F. A. W., Drukker C. A., Schumacher T. N., Horlings H. M., Lambrechts D, Kok M | 2024 | Nature Medicine | Immuno-oncology | Multiplex IHC, Spatial Analysis | HALO, HALO AI |
| Single intravenous administration of oncolytic adenovirus TILT-123 results in systemic tumor transduction and immune response in patients with advanced solid tumors | Jirovec E, Quixabeira D C A, Clubb J H A, Pakola S A, Kudling T, Arias V, Haybout L, Jalkanen K, Alanko T, Monberg T, Khammari A, Dreno B, Svane I M, Block M S, Adamo D A, Mäenpää J, Kistler C, Sorsa S, Hemminki O, Kanerva A, Santos J M, Cervera-Carrascon V, Hemminki A | 2024 | Journal of Experimental & Clinical Cancer Research | Oncology | Multiplex IHC, Highplex FL | HALO |
| Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis | Ghasempour S, Warner N, Guan R, Rodari M M, Ivanochko D, Hawkins R W, Marwaha A, Nowak J K, Liang Y, Mulder D J, Stallard L, Li M, Yu D D, Pluthero F G, Batura V, Zhao M, Siddiqui I, Upton J E M, Hulst J M, Kahr W H A, Mendoza-Londono R, Charbit-Henrion F, Hoefsloot L H, Khiat A, Moreira D, Trindade E, Espinheira M do Céu, Pais I P, Weerts M J A, Douben H, Kotlarz D, Snapper S B, Klein C, Dowling J J, Julien J P, Joosten M, Cerf-Bensussan N, Freeman S A, Parlato M, van Ham T J, Muise A M | 2024 | Journal of Experimental medicine | Other | Multiplex IHC | HALO |
| Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma | Wang T, Liu L, Fang J, Jin H, Natarajan S, Sheppard H, Lu M, Turner G, Confer T, Johnson M, Steinberg J, Ha L, Yadak N, Jain R, Picketts D J, Ma X, Murphy A, Davidoff A M, Glazer E S, Easton J, Chen X, Wang R, Yang J | 2024 | Cancer Research | Oncology, Neuroscience | Multiplex IHC | HALO |
| Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ | Kiourtis C, Terradas-Terradas M, Gee L M, May S, Georgakopoulou A, Collins A L, O’Sullivan E D, Baird D P, Hassan M, Shaw R, Tan E H, Müller M, Engelmann C, Andreola F, Hsieh Y C, Reed L H, Borthwick L A, Nixon C, Clark W, Hanson P S, Sumpton D, Mackay G, Suzuki T, Najumudeen A K, Inman G J, Campbell A, Barry S T, Quaglia A, Morris C M, LeBeau F E N, Sansom O J, Kirschner K, Jalan R, Oakley F, Bird T G | 2024 | Nature Cell Biology | Other | Area Quantification, Multiplex IHC, Highplex FL | HALO |
| Immune microenvironment of Epstein-Barr virus (EBV)-negative compared to EBV-associated gastric cancers: implications for immunotherapy | McMiller TL, Besharati S, Yarchoan M, Zhu Q, Ünsal-Kaçmaz K, Xu K, Lee J, Bhaijee F, Engle LL, Taube JM, Berger AE, Anders RA, Topalian SL | 2024 | Journal for Immunotherapy of Cancer | Immuno-oncology | Multiplex IHC | HALO |
| Inhibition of lung tumorigenesis by transient reprogramming in cancer cells | Pedrosa P, Zhang Z, Nuñez-Quintela V, Macias D, Ge J, Denholm M, Dyas A, Estevez-Souto V, Lado-Fernandez P, Gonzalez P, Gomez M, Martin J E, Da Silva-Alvarez S, Collado M, Muñoz-Espín D | 2024 | Cell Death & Disease | Oncology | Multiplex IHC | HALO |
| SPHK1 promotes HNSCC immune evasion by regulating the MMP1-PD-L1 axis | Fang Q, Chen X, Cao F, Xu P, Zhao Z, Lin R, Wu D, Deng W, Liu X | 2024 | Theranostics | Immunology | Multiplex IHC | HALO |
| Durvalumab and tremelimumab in patients with advanced rare cancer: a multi-centre, non-blinded, open-label phase II basket trial | Gupta A, Tinker A, Jonker D, Jamal R, Hirte H, Winquist E W, Chug Q, Kollmannsberger C, Wong R, Alcindor T, Nielsen T O, Tsao M, Cottrell T R, Provencher D, Hilton J, Krzyżanowska M K, Elser C, Hotte S, Sederias J, Zhang S, Tu W, Dancey J | 2024 | eClinicalMedicine | Immuno-oncology | Multiplex IHC | HALO |
| Intestinal mucosal barrier repair and immune regulation with an AI-developed gut-restricted PHD inhibitor | Fu Y, Ding X, Zhang M, Feng C, Yan Z, Wang F, Xu J, Lin X, Ding X, Wang L, Fan Y, Li T, Yin Y, Liang X, Xu C, Chen S, Pulous F E, Gennert D, Pun F W, Kamya P, Ren F, Aliper A, Zhavoronkov A | 2024 | Nature Biotechnology | Gastroenterology | Multiplex IHC | HALO |
| Dementia with lewy bodies patients with high tau levels display unique proteome profiles | Greally S, Kumar M, Schlaffner C, van der Heijden H, Lawton ES, Biswas D, Berretta S, Steen H, Steen JA | 2024 | Molecular Neurodegeneration | Neuroscience | Area Quantification, Multiplex IHC | HALO, HALO AI |
| TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression | Remy D, Antoine-Bally S, de Toqueville S, Jolly C, Macé A-S, Champenois G, Nemati F, Brito I, Raynal V, Priya A, Berlioz A, Dahmani A, Nicolas A, Meseure D, Marangoni E, Chavrier P | 2024 | Developmental Cell | Oncology | Multiplex IHC | HALO, HALO AI |
| Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer | Wasko U N, Jiang J, Dalton T C, Curiel-Garcia A, Edwards A C, Wang Y, Lee B, Orlen M, Tian S, Stalnecker C A, Drizyte-Miller K, Menard M, Dilly J, Sastra S A, Palermo C F, Hasselluhn M C, Decker-Farrell A R, Chang S, Jiang L, Wei X, Yang Y C, Helland C, Courtney H, Gindin Y, Muonio K, Zhao R, Kemp S B, Clendenin C, Sor R, Vostrejs W P, Hibshman P S, Amparo A M, Hennessey C, Rees M G, Ronan M M, Roth J A, Brodbeck J, Tomassoni L, Bakir B, Socci N D, Herring L E, Barker N K, Wang J, Cleary J M, Wolpin B M, Chabot J A, Kluger M D, Manji G A, Tsai K Y, Sekulic M, Lagana S M, Califano A, Quintana E, Wang Z, Smith J A M, Holderfield M, Wildes D, Lowe S W, Badgley M A, Aguirre A J, Vonderheide R H, Stanger B Z, Baslan T, Der C J, Singh M, Olive K P | 2024 | Nature | Oncology | Multiplex IHC | HALO |
| Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope | Liu X.F, Onda M, Schlomer J, Bassel L, Kozlov S, Tai C.H, Zhou Q, Liu W, Tsao H.E, Hassan R, Ho M, Pastan I | 2024 | Proceedings of the National Academy of Sciences | Immuno-oncology | Multiplex IHC | HALO |
| HER2-Selective and Reversible Tyrosine Kinase Inhibitor Tucatinib Potentiates the Activity of T-DM1 in Preclinical Models of HER2-positive Breast Cancer | Olson D, Taylor J, Willis K, Hensley K, Allred S, Zaval M, Farr L, Thurman R, Jain N, Hein R, Ulrich M, Peterson S, Kulukian A | 2023 | Cancer Research Communications | Oncology | Classifier, Multiplex IHC | HALO |
| Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer | Wang F, Long J, Li L, Wu Z, Da T, Wang X, Huang C, Jiang Y, Yao X, Ma H, Lian Z, Zhao Z, Cao J | 2023 | Science Advances | Oncology | Multiplex IHC, Spatial Analysis, Highplex FL | HALO |
| Cellular mechanisms of heterogeneity in NF2-mutant schwannoma | Chiasson-MacKenzie C, Vitte J, Liu C, Wright E, Flynn E, Stott S, Giovannini M, McClatchey A | 2023 | Nature Communications | Oncology | Classifier, Multiplex IHC, Spatial Analysis, FISH-IF | HALO |
| Prognostic Value of CD8+ Lymphocytes in Hepatocellular Carcinoma and Perineoplastic Parenchyma Assessed by Interface Density Profiles in Liver Resection Samples | Stulpinas R, Zilenaite-Petrulaitiene D, Rasmusson A, Gulla A, Grigonyte A, Strupas K, Laurinavicius A | 2023 | Cancers | Oncology | Multiplex IHC | HALO, HALO AI |
| Dissecting tumor lymphocyte infiltration to predict benefit from immune-checkpoint inhibitors in metastatic colorectal cancer: lessons from the AtezoTRIBE study | Moretto R, Rossini D, Catteau A, Antoniotti C, Giordano M, Boccaccino A, Ugolini C, Proietti A, Conca V, Kassambara A, Pietrantonio F, Salvatore L, Lonardi S, Tamberi S, Tamburini E, Poma A, Fieschi J, Fontanini G, Masi G, Galon J, Cremolini C | 2023 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Multiplex IHC, Spatial Analysis | HALO |
| Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection | Vaca G, Meyer M, Cadete A, Hsiao C, Golding A, Jeon A, Jacquinet E, Azcue E, Guan C, Sanchez-Felix X, Pietzsch C, Mire C, Hyde M, Comeaux M, Williams J, Sung J, Carfi A, Edwards D, Bukreyev A, Bahl K | 2023 | bioRxiv | Infectious Disease | Multiplex IHC | HALO |
| In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma | Taniguchi S, Matsui T, Kimura K, Funaki S, Miyamoto Y, Uchida Y, Sudo T, Kikuta J, Hara T, Motooka D, Liu Y-C, Okuzaki D, Morii E, Emoto N, Shintani Y, Ishii M | 2023 | Nature Communications | Immuno-oncology | Multiplex IHC | HALO |
| Pretreatment with 3-methyladenine ameliorated Pseudomonas aeruginosa-induced acute pneumonia by inhibiting cell death of neutrophils in a mouse infection model | Yue L, Qi J, Yuan J, Wang X, Wang Y, Shan B, Ke H, Li H, Luan N, Liu C | 2023 | International Journal of Medical Microbiology | Infectious Disease | Multiplex IHC | HALO |
| Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors | Chen F, Byrd A, Liu J, Flight R, DuCote T, Naughton K, Song X, Edgin A, Lukyanchuk A, Dixon D, Gosser C, Esoe D-P, Jayswal R, Orkin S, Moseley H, Wang C, Brainson C | 2023 | Nature Communications | Oncology | Multiplex IHC | HALO, HALO AI |
| Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance | Thatikonda V, Lu H, Jurado S, Kostyrko K, Bristow C, Bosch K, Feng N, Gao S, Gerlach D, Gmachi M, Lieb S, Jeschko A, Machado A, Marszalek E, Mahendra M, Jaeger P, Sorokin A, Strauss S, Trapani F, Kopetz S, Vellano C, Petronczki M, Kraut N, Heffernan T, Marszalek J, Pearson M, Waizenegger I, Hofmann M | 2023 | bioRxiv | Oncology | Multiplex IHC | HALO |
| LY6E protects mice from pathogenic effects of murine coronavirus and SARS-CoV-2 | Mar K, Van Dyke M, Lopez A, Eitson J, Fan W, Hanners N, Evers B, Shelton J, Schoggins J | 2023 | bioRxiv | Infectious Disease | Multiplex IHC | HALO |
| APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitors | Zong C, Zhang Z, Gao L, He J, Wang Y, Li Q, Liu X, Yang J, Chen D, Huang R, Zheng G, Jin X, Wei W, Jia R, Shen J | 2023 | Research Square | Oncology | Multiplex IHC | HALO |
| CD8+ Cell Density Gradient across the Tumor Epithelium–Stromal Interface of Non-Muscle Invasive Papillary Urothelial Carcinoma Predicts Recurrence-Free Survival after BCG Immunotherapy | Drachneris J, Rasmusson A, Morkunas M, Fabijonavicius M, Cekauskas A, Jankevicius F, Laurinavicius A | 2023 | Cancers | Immuno-oncology | Multiplex IHC, Spatial Analysis | HALO, HALO AI |
| IL13RA2 downregulation in fibroblast promotes keloid fibrosis via JAK/STAT6 activation | Chao H, Zheng L, Hsu P, He J, Wu R, Xu S, Zeng R, Zhou Y, Ma H, Liu H, Tang Q | 2023 | JCI Insight | Fibrosis | Multiplex IHC | HALO |
| Oncolytic BHV-1 Is Sufficient to Induce Immunogenic Cell Death and Synergizes with Low-Dose Chemotherapy to Dampen Immunosuppressive T Regulatory Cells | Davola M, Cormier O, Vito A, El-Sayes N, Collins S, Salem O, Revill S, Ask K, Wan Y, Mossman K | 2023 | Cancers | Oncology | Multiplex IHC | HALO |
| Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer | Brahim S, Negulescu A, Geneste C, Schott T, Lin S, Morel L, Rama N, Gadot N, Treilleux I, Mehlen P, Meurette O | 2023 | Cell Death & Disease | Oncology | Multiplex IHC | HALO |
| Single-cell analysis reveals changes in BCG vaccine-injected mice modeling tuberculous meningitis brain infection | Zhang X, Zhao Z, Wu Q, Wang L, Li L, Wang M, Ren Y, Pan L, Tang H, Li F | 2023 | Cell Reports | Infectious Disease | Multiplex IHC, Highplex FL | HALO |
| Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion | Jeong Y, Knutsdottir H, Shojaeian F, Lerner M, Wissler M, Henriet E, Ng T, Datta S, Navarro-Serer B, Chianchiano P, Kinny-Koster B, Zimmerman J, Stein-O’Brien G, Gaida M, Eshleman J, Lin M, Fertig E, Ewald A, Bader J, Wood L | 2023 | The Journal of Clinical Investigation | Oncology | Multiplex IHC | HALO |
| Electroacupuncture Zusanli (ST36) Relieves Somatic Pain in Colitis Rats by Inhibiting Dorsal Root Ganglion Sympathetic-Sensory Coupling and Neurogenic Inflammation | Wang Y, Zhu H, Lv X, Ren X, Peng Y, Qu J, Shen X, Sun R, Xiao M, Zhang H, Chen Z, Cong P | 2023 | Neural Plasticity | Neuroscience | Multiplex IHC | HALO |
| Myeloid-specific deletion of activating transcription factor 6 alpha increases CD11b+ macrophage subpopulations and aggravates lung fibrosis | Mekhael O, Revill S, Hayat A, Cass S, MacDonald K, Vierhout M, Ayoub A, Reihani A, Padwal M, Imani J, Ayaub E, Yousof T, Dvorkin-Gheva A, Rullo A, Hirota J, Richards C, Bridgewater D, Stämpfli M, Hambly N, Naqvi A, Kolb M, Ask K | 2023 | Immunology and Cell Biology | Immunology, Fibrosis | Classifier, Area Quantification, FISH, Multiplex IHC | HALO |
| Free fatty acids induce coronary microvascular dysfunction via inhibition of the AMPK/KLF2/eNOS signaling pathway | Zhang Y, Zhao J, Ren C, Hu B, Ding R, He Z, Liang C | 2023 | International Journal of Molecular Medicine | Other | Multiplex IHC | HALO |
| Loss of Peroxiredoxin IV Protects Mice from Azoxymethane/Dextran Sulfate Sodium-Induced Colorectal Cancer Development | Thapa P, Jiang H, Ding N, Hao Y, Alshahrani A, Lee E, Fujii J, Wei Q | 2023 | Antioxidants | Oncology | Multiplex IHC | HALO |
| Immune and pathologic responses in patients with localized prostate cancer who received daratumumab (anti-CD38) or edicotinib (CSF-1R inhibitor) | Siddiqui B, Chapin B, Jindal S, Duan F, Basu S, Yadav S, Gu A, Espejo A, Kinder M, Pettaway C, Ward J, Tidwell R, Troncoso P, Corn P, Logothetis C, Knoblauch R, Hutnick N, Gottardis M, Drake C, Sharma P, Subudhi S | 2023 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Multiplex IHC, Figure Maker | HALO |
| YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cells | Bai Y, Gotz C, Chincarini G, Zhao Z, Slaney C, Boath J, Furic L, Angel C, Jane S, Phillips W, Stacker S, Farah C, Darido C | 2023 | Nature Communications | Oncology | Classifier, Multiplex IHC | HALO |
| HX009, a novel BsAb dual targeting PD1 x CD47, demonstrates potent anti-lymphoma activity in preclinical models | Ke H, Zhang F, Wang J, Xiong L, An X, Tu X, Chen C, Wang Y, Mao B, Guo S, Ju C, He X, Sun R, Zhang L, O’Connor O, Li Q | 2023 | Scientific Reports | Immuno-oncology | Multiplex IHC | HALO |
| Prognostic value of tumor immune microenvironment factors in patients with stage I lung adenocarcinoma | Xue Q, Wang Y, Zheng Q, Chen L, Lin Y, Jin Y, Shen X, Li Y | 2023 | American Journal of Cancer Research | Oncology | Classifier, Multiplex IHC, Highplex FL | HALO |
| Associations of breast cancer etiologic factors with stromal microenvironment of primary invasive breast cancers in the Ghana Breast Health Study | Abubaker M, Aheam T, Duggan M, Lawrence S, Adjei E, Clegg-Lamptey J, Yamey J, Wiafe-Addai B, Awuah B, Wiafe S, Nyarko K, Aitpillah F, Ansong D, Hewitt S, Brinton L, Figueroa J, Garcia-Closas M, Edusei L, Titiloye N | 2023 | Research Square | Oncology | Classifier, Multiplex IHC | HALO |
| Berberine inhibits high fat diet-associated colorectal cancer through modulation of the gut microbiota-mediated lysophosphatidylcholine | Chen H, Ye C, Wu C, Zhang J, Xu L, Wang X, Xu C, Zhang J, Guo Y, Yao Q | 2023 | International Journal of Biological Sciences | Oncology, Metabolism | Multiplex IHC | HALO |
| Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression | Jana S, Brahma S, Arora S, Wladyka C, Hoang P, Blinka S, Hough R, Horn J, Liu Y, Wang L, Depeille P, Smith E, Montgomery R, Lee J, Haffner M, Vakar-Lopez F, Grivas P, Wright J, Lam H, Black P, Roose J, Ryazanov A, Subramaniam A, Henikoff S, and Hsieh A | 2023 | Cancer Cell | Oncology | Multiplex IHC, Highplex FL | HALO |
| Phase I/II sequencing study of azacitidine, epacadostat, and pembrolizumab in advanced solid tumors | Luke J, Fakih M, Schneider C, Chiorean E, Bendell J, Kristeleit R, Kurzrock R, Blagden S, Brana I, Goff L, O’Hayer K, Geschwindt R, Smith M, Zhou F, Naing A | 2023 | British Journal of Cancer | Immuno-oncology | Multiplex IHC | HALO, HALO AI |
| Targeting DRP1 mediated mitochondrial metabolism as a novel treatment strategy for triple negative breast cancer (TNBC) | Wang Y, Harada-Shoji N, Kitamura N, Yamazaki Y, Ebata A, Amari M, Watanabe M, Miyashita M, Tada H, Abe T, Suzuki T, Gonda K, Ishida T | 2023 | Research Square | Oncology | Multiplex IHC | HALO |
| Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis | Conroy L, Clarke H, Allison D, Valenca S, Sun Q, Hawkinson T, Young L, Ferreira J, Hammonds A, Dunne J, McDonald R, Absher K, Dong B, Bruntz R, Markussen K, Juras J, Alilain W, Liu J, Gentry M, Angel P, Waters C, Sun R | 2023 | Nature Communications | Fibrosis | Multiplex IHC, Highplex FL | HALO |
| Induction of cancer neoantigens facilitates development of clinically relevant models for the study of pancreatic cancer immunobiology | Panni U, Chen M, Zhang F, Cullinan D, Li L, James C, Zhang X, Rogers S, Alarcon A, Baer JM, Zhang D, Gao F, Miller CA, Gong Q, Lim KH, DeNardo DG, Goedegebuure SP, Gillanders WE, and Hawkins WG | 2023 | Cancer Immunology, Immunotherapy | Immuno-oncology | Multiplex IHC | HALO |
| Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial | Nassiri F, Patil V, Yefet L, Singh O, Liu J, Dang R, Yamaguchi T, Daras M, Cloughesy T, Colman H, Kumthekar P, Chen C, Aiken R, Groves M, Ong S, Ramakrishna R, Vogelbaum M, Khagi S, Kaley T, Melear J, Peereboom D, Rodriguez A, Yankelevich M, Nair S, Puduvalli V, Aldape K, Gao A, López-Janeiro Á, de Andrea C, Alonso M, Boutros P, Robbins J, Mason W, Sonabend A, Stupp R, Fueyo J, Gomez-Manzano C, Lang F, Zadeh G | 2023 | Nature Medicine | Immuno-oncology | Multiplex IHC | HALO |
| Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E-based Antibody-Drug Conjugate for treatment of Nectin-4-expressing Cancers | Zhou W, Fang P, Yu D, Ren H, You M, Yin L, Mei F, Zhu H, Wang Z, Xu H, Cao Y, Sun X, Xu X, Bi J, Wang J, Ma L, Wang X, Chen L, Zhang Y, Cen X, Zhu X, Lou L, Liu D, Tan X, Yang J, Meng T, Shen J | 2023 | Molecular Cancer Therapeutics | Oncology | Multiplex IHC | HALO |
| Tumor-derived semaphorin 4A improves PD-1–blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation | NAITO Y, KOYAMA S, MASUHIRO K, HIRAI T, UENAMI T, INOUE T, OSA A, MACHIYAMA H, WATANABE G, SAX N, VILLA J, KINUGASA-KATAYAMA Y, NOJIMA S, YAGA M, HOSONO Y, OKUZAKI D, SATOH S, TSUDA T, NAKANISHI Y, SUGA Y, MORITA T, FUKUSHIMA K, NISHIDE M, SHIROYAMA T, MIYAKE K, IWAHORI K, HIRATA H, NAGATOMO I, YANO Y, TAMIYA M, KUMAGAI T, TAKEMOTO N, INOHARA H, YAMASAKI S, YAMASHITA K, AOSHI T, AKBAY E, HOSEN N, SHINTANI Y, TAKAMATSU H, MORI M, TAKEDA Y, KUMANOGOH A | 2023 | Science Advances | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
| Immunoscore immune checkpoint using spatial quantitative analysis of CD8 and PD-L1 markers is predictive of the efficacy of anti- PD1/PD-L1 immunotherapy in non-small cell lung cancer | Ghiringhelli F, Bibeau F, Greillier L, Fumet J, Ilie A, Monville F, Laugé C, Catteau A, Boquet I, Majdi A, Morgand E, Oulkhouir Y, Brandone N, Adam J, Sbarrato T, Kassambara A, Fieschi J, Garcia S, Lepage A, Tomasini P, Galon J | 2023 | EBioMedicine | Immuno-oncology | Multiplex IHC, Spatial Analysis | HALO |
| An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity | Cheng L, Zhu M, Gao Y, Liu W, Yin W, Zhou P, Zhu Z, Niu L, Zeng X, Zhang D, Fang Q, Wang F, Zhao Q, Zhang Y, Shen G | 2023 | Cellular and Molecular Biology Letters | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
| An Immune-Related Gene Expression Signature Predicts Benefit from Adding Atezolizumab to FOLFOXIRI plus Bevacizumab in Metastatic Colorectal Cancer | Antoniotti C, Boccaccino A, Seitz R, Giordano M, Catteau A, Rossini D, Pietrantonio F, Salvatore L, McGregor K, Bergamo F, Conca V, Leonetti S, Morano F, Papiani G, Tamburini E, Bensi M, Murgioni S, Ross D, Passardi A, Boquet I, Nielsen T, Galon J, Varga M, Schweitzer B, and Cremolini C | 2023 | Clinical Cancer Research | Immuno-oncology | Multiplex IHC, Spatial Analysis | HALO |
| Type III interferon inhibits bladder cancer progression by reprogramming macrophage-mediated phagocytosis and orchestrating effective immune responses | Wang B, Zhou B, Chen J, Sun X, Yang W, Yang T, Yu H, Chen P, Chen K, Huang X, Fan X, He W, Huang J, Lin T | 2023 | Research Square | Immuno-oncology | Multiplex IHC | HALO, HALO AI |
| Detection of virus in colorectal cancer and the tumor immune microenvironment in EBV-associated colorectal cancer | Lv D, Zuo Y, Bibi A, Meng T, Xu Y | 2023 | Research Square | Oncology, Infectious Disease | Multiplex IHC | HALO |
| Effects of a long-acting secretin peptide analog alone and in combination with a GLP-1R agonist in a diet-induced obesity mouse model | Loeffler M, Klepac K, Baljuls A, Hamilton B, Mayer-Wrangowski S, Haebel P, Zimmermann T | 2023 | Molecular Metabolism | Metabolism | Multiplex IHC | HALO |
| Endosomal Escape Vehicle Platform Enhances the Delivery of Oligonucleotides in Preclinical Models of Neuromuscular Disorders | Li X, Kheirabadi M, Dougherty P, Kamer K, Shen X, Estrella N, Peddigari S, Pathak A, Blake S, Sizensky E, del Genio C, Gaur A, Dhanabal M, Girgenrath M, Sethuraman N, Qian Z | 2023 | Molecular Therapy: Nucleic Acids | Neuroscience | Multiplex IHC | HALO |
| Endocrine therapy synergizes with SMAC mimetics to potentiate antigen presentation and tumor regression in hormone receptor-positive breast cancer | Hermida-Prado F, Xie Y, Sherman S, Nagy Z, Russo D, Akhshi T, Chu Z, Feit A, Campisi M, Chen M, Nardone A, Guarducci C, Lim K, Font-Tello A, Lee I, García-Pedrero J, Canadas I, Agudo J, Huang Y, Sella T, Jin Q, Tayob N, Mittendorf E, Tolaney S, Qiu X, Long H, Symmans W, Lin J, Santagata S, Bedrosian I, Yardley D, Mayer I, Richardson E, Oliveira G, Wu C, Schuster E, Dowsett M, Welm A, Barbie D, Metzger O, Jeselsohn R | 2023 | Cancer Research | Oncology | Multiplex IHC | HALO |
| Unbiased differential proteomic profiling between cancerassociated fibroblasts and cancer cell lines | Lau R, Yu L, Roumeliotis T, Stewart A, Pickard L, Riisanes R, Gurel B, de Bono J, Choudhary J, Banerji U | 2023 | Journal of Proteomics | Oncology | Multiplex IHC | HALO |
| GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation | Shinzawa K, Matsumoto S, Sada R, Harada A, Saitoh K, Kato K, Ikeda S, Hirayama A, Yokoi K, Tanemura A, Nimura K, Ikawa M, Soga T, Kikuchi A | 2023 | Oncogene | Oncology | Multiplex IHC | HALO |
| Intratumoral Heterogeneity of Ki67 Proliferation Index Outperforms Conventional Prognostic Factors in Hormone Receptor-Positive Breast Cancer | Zilenaite-Petrulaitiene D, Rasmusson A, Besusparis J, Valkiuniene R, Augulis R, Laurinaviciene A, Plancoulaine B, Petkevicius L, Laurinavicius A | 2023 | Research Square | Oncology | Multiplex IHC, Figure Maker | HALO, HALO AI |
| Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer | Quan Y, He J, Zou Q, Zhang L, Sun Q, Huang H, Li W, Xie K, Wie F | 2023 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Classifier, Multiplex IHC, Highplex FL | HALO |
| Neoadjuvant palbociclib plus either giredestrant or anastrozole in oestrogen receptor-positive, HER2-negative, early breast cancer (coopERA Breast Cancer): an open-label, randomised, controlled, phase 2 study | Hurvitz SA, Bardia A, Quiroga V, Park YH, Blancas I, Alonso-Romero JL, Vasiliev A, Adamchuk H, Salgado M, Yardley DA, Berzoy O, Zamora-Auñón P, Chan D, Spera G, Xue C, Ferreira E, Badovinac Crnjevic T, Pérez-Moreno PD, López-Valverde V, Steinseifer J, Fernando TM, Moore HM, Fasching PA, on behalf of the coopERA Breast Cancer study group | 2023 | The Lancet Oncology | Oncology | Multiplex IHC | HALO |
| MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer | Bhin J, Yemelyanenko J, Chao X, Klarenbeek S, Opdam M, Malka Y, Hoekman L, Kruger D, Bleijerveld O, Brambillasca CS, Sprengers J, Siteur B, Annunziato S, van Haren MJ, Martin NI, van de Ven M, Peters D, Agami R, Linn SC, Boven E, Altelaar M, Jonkers J, Zingg D, Wessels LFA | 2023 | Journal of Experimental Medicine | Oncology | Multiplex IHC | HALO |
| Pan-Cancer Analysis Revealed ITM2A as a Predictive Biomarker of Prognosis and Immunotherapy for Kidney Renal Clear Cell Carcinoma | Zhang H, Fang J, Ruan R, Yu J, Wang S | 2023 | Research Square | Oncology | Multiplex IHC | HALO |
| Pathologist-Trained Machine Learning Classifiers Developed to Quantitate Celiac Disease Features Differentiate Endoscopic Biopsies According to Modified Marsh Score and Dietary Intervention Response | Gruver A, Lu H, Zhao X, Fulford A, Soper M, Ballard D, Hanson J, Schade A, His E, Gottlieb K. Credille K | 2023 | Research Square | Gastroenterology | Multiplex IHC | HALO, HALO AI |
| Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area | Kawamura I, Ohe R, Suzuki K, Kabasawa T, Kitoaka T, Takahara D, Kono M, Uchiyama N, Musha H, Futakuchi M, Motoi F | 2023 | Research Square | Immuno-oncology | Multiplex IHC, Spatial Analysis | HALO |
| Evaluation of the efficacy of Abelmoschus manihot (L.) on diabetic nephropathy by analyzing biomarkers in the glomeruli and proximal and distal convoluted tubules of the kidneys | Yu H, Wang M, Yu J, Tang H, Xu Q, Cheng N, Luo X, Wang Y, Ge H, Qiang L, Tang W, Gu H | 2023 | Frontiers in Pharmacology | Gastroenterology | Multiplex IHC | HALO |
| Immune response after pig-to-human kidney xenotransplantation: a multimodal phenotyping study | Loupy A, Goutaudier V, Giarraputo A, Mezine F, Morgand E, Robin B, Khalil K, Mehta S, Keating B, Dandro A, Certain A, Tharaux PL, Narula N, Tissier R, Giraud S, Hauet T, Pass HI, Sannier A, Wu M, Griesemer A, Ayares D, Tatapudi V, Stern J, Lefaucheur C, Bruneval P, Mangiola M, Montgomery RA | 2023 | The Lancet | Immunology | Multiplex IHC | HALO, HALO AI |
| A novel 4-1BB/HER2 bispecific antibody shows potent antitumor activities by increasing and activating tumor-infiltrating T cells | Shen A, Liu W, Wang H, Zeng X, Wang M, Zhang D, Zhao Q, Fang Q, Wang F, Cheng L, Shen G, Li Y | 2023 | American Journal of Cancer Research | Immuno-oncology | Multiplex IHC | HALO |
| Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models | Hopcroft L, Wigmore EM, Williamson SC, Ros S, Eberlein C, Moss JI, Urosevic J, Carnevalli LS, Talbot S, Bradshaw L, Blaker C, Gunda S, Owenson V, Hoffmann S, Sutton D, Jones S, Goodwin RJAG, Willis BS, Rooney C, DeBruin E, Barry ST | 2023 | npj Breast Cancer | Oncology | Multiplex IHC | HALO, HALO AI |
| Macrophage reprogramming—rather than depletion —is efficacious in a specific subset of colorectal tumor models | Mohamed N, Amirkhah R, Lavaud X, Gilroy K, Bartolini R, Mulholland E, Garg A, Pennel K, Jackstadt R, Ridgway R, Nixon C, Hatthakarnku P, Campbell A, Leedham S, Edwards J, Dunne P, Barry S, Graham G, Sansom O | 2023 | Research Square | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
| Early Detection of Genotoxic Hepatocarcinogens in Rats Using γH2AX and Ki-67: Prediction by Machine Learning | Michiba A, Gi M, Yokohira M, Sakurai E, Teramoto A, Kiriyama Y, Yamada S, Wanibuchi H, Tsukamoto T | 2023 | Toxicological Sciences | Oncology | Multiplex IHC, Highplex FL | HALO |
| Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer | Cassier PA, Navaridas R, Bellina M, Rama N, Ducarouge B, Hernandez-Vargas H, Delord JP, Lengrand J, Paradisi A, Fattet L, Garin G, Gheit H, Dalban C, Pastushenko I, Neves D, Jelin R, Gadot N, Braissand N, Léon S, Degletagne C, Matias-Guiu X, Devouassoux-Shisheboran M, Mery-Lamarche EM, Allard J, Zindy E, Decaestecker C, Salmon I, Perol D, Dolcet X, Ray-Coquard I, Blanpain C, Bernet A, Mehlen P | 2023 | Nature | Oncology | Multiplex IHC | HALO |
| Feasibility and Impact of Immunohistochemistry-based Molecular Subtyping for Muscle-invasive Bladder Cancer in Patients Treated with Radiation-based Therapy | Hesswani C, Jackson CL, Marcq G, Hardy C, Kool R, Mansure JJ, Brimo F, Berman DM, Kassouf W | 2023 | European Urology Open Science | Oncology | Multiplex IHC | HALO |
| A TIAM1- TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells | Ginn L, Maltas J, Baker MJ, Chaturvedi A, Wilson L, Guilbert R, Amaral FMR, Priest L, Mole H, Blackhall F, Diamantopoulou Z, Somervaille TCP, Hurlstone A, Mallairi A | 2023 | Proceedings of the National Academy of Sciences | Oncology | Multiplex IHC | HALO |
| Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability | Benabdallah NS, Dalal V, Scott RW, Marcous F, Sotiriou A, Kommoss FKF, Pejkovska A, Gaspar L, Wagner L, Sánchez-Rivera FJ, Ta M, Thornton S, Nielsen TO, Underhill TM, Banito A | 2023 | Nature Structural & Molecular Biology | Oncology | Multiplex IHC, TMA | HALO, HALO AI |
| Effects and Mechanisms of the Subtypes of Apolipoprotein E to the Immune State and Prognosis of hepatocellular carcinoma patients | Gao B, Zhou P, Wang L, Wang Z, Yi Y, Zhou J, Fan J, Qiu S, Xu Y | 2023 | Research Square | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
| Icariside II potentiates the anti-PD-1 antitumor effect by reducing chemotactic infiltration of myeloid-derived suppressor cells into the tumor microenvironment via ROS-mediated inactivation of the SRC/ERK/STAT3 signaling pathways | Kong Q, Ma M, Zhang L, Liu S, He S, Wu J, Liu B, Dong J | 2023 | Phytomedicine | Immuno-oncology | Multiplex IHC | HALO |
| Establishment of reference intervals of endometrial immune cells during the mid-luteal phase | Yu S, Huang C, Lian R, Diao L, Zhang X, Cai S, Wei H, Chen C, Li Y, Zeng Y | 2023 | Journal of Reproductive Immunology | Immunology | Classifier, Multiplex IHC | HALO |
| Anticoagulants Enhance Molecular and Cellular Immunotherapy of Cancer by Improving Tumor Microcirculation Structure and Function and Redistributing Tumor Infiltrates | Wei F, Su Y, Quan Y, Li X, Zou Q, Zhang L, Li S, Jiang M, Lin G, Liang P, He J, Xie K | 2023 | Clinical Cancer Research | Immuno-oncology | Classifier, Multiplex IHC, Spatial Analysis, Highplex FL | HALO |
| Apolipoprotein A-IV of diabetic-foot patients upregulates tumor necrosis factor α expression in microfluidic arterial models | Ji J, Zhao X, Huang J, Wu X, Xie F, Li L, Wang T, Mi S | 2023 | Experimental Biology and Medicine | Other | Multiplex IHC | HALO |
| Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression | Qiu S, Zhong X, Meng X, Li S, Qian X, Lu H, Cai J, Zhang Y, Wang M, Ye Z, Zhang H, Gao P | 2023 | Cell Research | Oncology | Multiplex IHC | HALO |
| Spatial mapping reveals granuloma diversity and histopathological superstructure in human tuberculosis | Sawyer A, Patrick E, Edwards J, Wilmott J, Fielder T, Yang Q, Barber D, Ernst J, Britton W, Palendira U, Chen X, Feng C | 2023 | Journal of Experimental Medicine | Immunology | Multiplex IHC, Spatial Analysis, Highplex FL | HALO |
| Targeting the IL1β Pathway for Cancer Immunotherapy Remodels the Tumor Microenvironment and Enhances Antitumor Immune Responses | Diwanji R, O’Brien N, Choi J, Nguyen B, Laszewski T, Grauel A, Yan Z, Xu X, Wu J, Ruddy D, Piquet M, Pelletier M, Savchenko A, Charette L, Rodrik-Outmezguine V, Baum J, Millholland J, Wong C, Martin A, Dranoff G, Pruteanu-Malinici I, Cremasco V, Sabatos-Peyton C, Jayaraman P | 2023 | Cancer Immunology Research | Immuno-oncology | Multiplex IHC | HALO |
| Spinal Cord Stimulation Increases Chemoefficacy and Prevents Paclitaxel-Induced Pain via CX3CL1 | Sivanesan E, Sanchez K, Zhang C, He S, Linderoth B, Stephens K, Raja S, Guan Y | 2023 | Neuromodulation: Technology at the Neural Interface | Oncology | Multiplex IHC | HALO |
| DNA Damage-Induced, S-Phase Specific Phosphorylation of Orc6 is Critical for the Maintenance of Genome Stability | Lin Y, Liu D, Chakraborty A, Macias V, Brister E, Sonalkar J, Shen L, Mitra J, Ha T, Kajdacsy-Balla A, Prasanth K, Prasanth S | 2023 | Molecular and Cellular Biology | Other | Multiplex IHC | HALO, HALO AI |
| Using artificial intelligence to identify tumor microenvironment heterogeneity in non-small cell lung cancers | DuCote T, Naughton K, Skaggs E, Bocklage T, Allison D, Brainson C | 2023 | Laboratory Investigation | Oncology | Multiplex IHC | HALO, HALO AI |
| Whole-Slide Imaging, Mutual Information Registration for Multiplex Immunohistochemistry and Immunofluorescence | Doyle J, Green B, Eminizer M, Jimenez-Sanchez D, Lu S, Engle E, Xu H, Ogurtsova A, Lai J, Soto-Diaz S, Roskes J, Deutsch J, Taube J, Sunshine J, Szalay A | 2023 | Laboratory Investigation | Other | Multiplex IHC, Registration | HALO |
| Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury | Kayagaki N, Stowe I, Alegre K, Deshpande I, Wu S, Lin Z, Kornfeld O, Lee B, Zhang J, Liu J, Suto E, Lee W, Schneider K, Lin W, Seshasayee D, Bhangale T, Chalouni C, Johnson M, Joshi P, Mossemann J, Zhao S, Ali D, Goldenberg N, Sayed B, Steinberg B, Newton K, Webster J, Kelly R, Dixit V | 2023 | Nature | Other | Multiplex IHC | HALO, HALO AI |
| Nicotinamide N-methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancer | Pinto Couto J, Vulin M, Jehanno C, Coissieux M, Hamelin B, Schmidt A, Ivanek R, Sethi A, Bräutigam K, Frei A, Hager C, Manivannan M, Gómez-Miragaya J, Obradović M, Varga Z, Koelzer V, Mertz K, Bentires-Alj M | 2023 | The EMBO Journal | Oncology | Area Quantification, Multiplex IHC | HALO, HALO AI |
| The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment | Lv J, Wei Y, Yin J, Chen Y, Zhou G, Wei C, Liang X, Zhang Y, Zhang C, He S, He Q, Huang Z, Guan J, Shen J, Li X, Li J, Li W, Tang L, Mao Y, Guo R, Sun R, Zheng Y, Zhou W, Xiong K, Wang S, Jin X, Liu N, Li G, Kuang D, Sun Y, Ma J | 2023 | Nature Medicine | Oncology | Multiplex IHC, Highplex FL | HALO |
| Immune profiling and RNA-seq uncover the cause of partial unexplained recurrent implantation failure | Fan X, Zhao Q, Li Y, Chen Z, Liao J, Chen H, Meng F, Lu G, Lin G, Gong F | 2023 | International Immunopharmacology | Immunology | Classifier, Multiplex IHC | HALO |
| Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression | Macke A, Pachikov A, Divita T, Morris M, LaGrange C, Holzapfel M, Kubyshkin A, Zyablitskaya E, Makalish T, Eremenko S, Qiu H, Riethoven J, Hemstreet G, Petrosyan A | 2023 | Molecular Cancer Research | Oncology | Classifier, Area Quantification, Multiplex IHC, TMA | HALO |
| Comparing the peri-implantation endometrial T-bet/GATA3 ratio between control fertile women and patients with recurrent miscarriage: establishment and application of a reference range Get access Arrow | Yu S, Diao L, Lian R, Chen C, Huang C, Li X, Li Y, Zeng Y | 2023 | Human Reproduction | Other | Classifier, Multiplex IHC | HALO |
| Jing-Fang powder ethyl acetate extracts attenuate atopic dermatitis by modulating T-cell activity | Zhao G, Tong Y, Xu J, Zhu W, Zeng J, Liu R, Luan F, Zeng N | 2023 | Molecular Immunology | Immunology, Dermatology | Multiplex IHC | HALO |
| LY6E is a pan-coronavirus restriction factor in the respiratory tract | Mar K, Wells A, Van Dyke M, Lopez A, Eitson J, Fan W, Hanners N, Evers B, Shelton J, Schoggins J | 2023 | Nature Microbiology | Infectious Disease | Multiplex IHC | HALO |
| Spatial Proximity and Relative Distribution of Tumor-Infiltrating Lymphocytes and Macrophages Predict Survival in Melanoma | De Logu F, Ugolini F, Iannone L F, Simi S, Maio V, de Giorgi V, di Giacomo A M, Miracco C, Cossu A, Palmieri G, Mandalà M, Massi D | 2023 | Laboratory Investigation | Oncology | Multiplex IHC | HALO, HALO Link |
| Deep radiomics-based fusion model for prediction of bevacizumab treatment response and outcome in patients with colorectal cancer liver metastases: a multicentre cohort study | Zhou S, Sun D, Mao W, Liu Y, Cen W, Ye L, Liang F, Xu J, Shi H, Ji Y, Wang L, Chang W | 2023 | eClinicalMedicine | Oncology | Classifier, Multiplex IHC | HALO |
| Inhibition of mitochondrial fission activates glycogen synthesis to support cell survival in colon cancer | Hasani S, Young LEA, Van Nort W, Banerjee M, Rivas DR, Kim J, Xiong X, Sun RC, Gentry MS, Sesaki H, Gao T | 2023 | Cell Death & Disease | Oncology | Multiplex IHC | HALO |
| Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non-small cell lung cancer | Terada Y, Isaka M, Ono A, Kawata T, Serizawa M, Mori K, Muramatsu K, Tone K, Kenmotsu H, Ohshima K, Urakami K, Nagashima T, Kusuhara M, Akiyama Y, Sugino T, Takahashi T, Ohde Y | 2023 | Cancer Reports | Oncology | Multiplex IHC | HALO |
| Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers | Biswas S, Mandal G, Anadon C M, Chaurio R A, Lopez-Bailon L U, Nagy M Z, Mine J A, Hanggi K, Sprenger K B, Innamarato P, Harro C M, Powers J J, Johnson J, Fang B, Eysha M, Nan X, Li R, Perez B A, Curiel T J, Yu X, Rodriguez P C, Conejo-Garcia J R | 2023 | Immunity | Oncology | Multiplex IHC | HALO |
| Histological spatial analysis on the induction of PD-L1+ macrophages by CD8+ T cells at the marginal microenvironment of triple-negative breast cancer | Suzuki K, Ohe R, Kabasawa T, Kitaoka T, Kawai M, Motoi F, Futakuchi M | 2023 | Breast Cancer | Oncology | Multiplex IHC, Spatial Analysis | HALO |
| Positive regulatory loop of platelet-derived growth factor DD-induced STAT3 activation is associated with poor prognosis in advanced urothelial carcinoma | Ando K, Kurashina R, Motoi N, Iizuka T, Inoue M, Maruyama R, Mitani K, Takenobu H, Haruta M, Onuki R, Matsuoka Y, Kamijo T, Kageyama Y | 2023 | Biochemical and Biophysical Research Communications | Oncology | Multiplex IHC, TMA | HALO |
| Effect of microbial muramidase supplementation in diets formulated with different fiber profiles for broiler chickens raised under various coccidiosis management programs | Bortoluzzi C, Perez-Calvo E, Olsen P B, van der Vaart S, van Eerden E, Schmeisser J, Eising I, Segobola P, Sorbara J-O B | 2023 | Poultry Science | Infectious Disease | Multiplex IHC | HALO |
| Comprehensive analysis reveals potential therapeutic targets and an integrated risk stratification model for solitary fibrous tumors | Zhang R, Yang Y, Hu C, Huang M, Cen W, Ling D, Long Y, Yang X-H, Xu B, Peng J, Wang S, Zhu W, Wei M, Yang J, Xu Y, Zhang X, Ma J, Wang F, Zhang H, Ma P, Zhu X, Song G, Sun L-Y, Wang D-S, Wang F-H, Li Y-H, Santagata S, Li Q, Feng Y-F, Du Z | 2023 | Nature Communications | Oncology | Multiplex IHC | HALO |
| Effects of total flavones of Abelmoschus manihot (L.) on the treatment of diabetic nephropathy via the activation of solute carriers in renal tubular epithelial cells | Yu H, Tang H, Wang M, Xu Q, Yu J, Ge H, Qiang L, Tang W, Gu HF | 2023 | Biomedicine & Pharmacotherapy | Other | Multiplex IHC | HALO |
| SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties | Warren M, Matissek S, Rausch M, Panduro M, Hall R, Dulak A, Brennan D, Das Yekkirala S, Koseoglu S, Masia R, Yang Y, Reddy N, Prenovitz R, Strand J, Zaidi T, Devereaux E, Jacoberger Foissac C, Stagg J, Lee B, Holland P, Palombella V, Lake A | 2023 | ImmunoHorizons | Immuno-oncology | Classifier, Area Quantification, Multiplex IHC | HALO |
| GRP78-CAR T cell effector function against solid and brain tumors is controlled by GRP78 expression on T cells | Ibanez J, Hebbar N, Thanekar U, Yi Z, Houke H, Ward M, Nevitt C, Tian L, Mack SC, Sheppard H, Chiang J, Velasquez MP, Krenciute G | 2023 | Cell Reports Medicine | Immuno-oncology | Multiplex IHC | HALO |
| mRNA Vaccine Trafficking and Resulting Protein Expression After Intramuscular Administration | Hassett KJ, Rajilic IL, Bahl K, White R, Cowens K, Jacquinet E, Burke KE | 2023 | Molecular Therapy: Nucleic Acids | Other | ISH, Multiplex IHC | HALO |
| Expression and Correlation of Complement C3 and C4 in Serum and Maternal-Fetal Interface in Patients with Unexplained Recurrent Spontaneous Abortion: A Prospective Cohort Study | Zhou Z, Xie H, Liu M, Li R, Jiang W, Zheng Y, Lv Q | 2023 | Clinical and Experimental Obstetrics & Gynecology | Other | Multiplex IHC | HALO |
| The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer | Taifour T, Attalla SS, Zuo D, Gu Y, Sanguin-Gendreau V, Proud H, Solymoss E, Bui T, Kuasne H, Papavasiliou V, Lee CG, Kamle S, Siegel PM, Elias JA, Park M, Muller WJ | 2023 | Immunity | Immuno-oncology | Multiplex IHC, Spatial Analysis, Highplex FL | HALO |
| Intratumoral aluminum hydroxide–anchored IL-12 drives potent antitumor activity by remodeling the tumor microenvironment | Battula S, Papastoitsis G, Kaufman HL, Wittrup KD, Schmidt MM | 2023 | JCI Insight | Oncology | Multiplex IHC | HALO |
| CD15 Is a Risk Predictor and a Novel Target in Clear Cell Renal Cell Carcinoma | Stenzela PJ, Schindeldeckera MS, Seidmanna L, Herpel E, Hohenfellnere M, Hatiboglue G, Foerscha S, Porubskya S, Macher-Goeppingera S, Rotha W, Tagscherer KE | 2023 | Pathobiology | Oncology | Multiplex IHC, TMA | HALO |
| Fusion-negative rhabdomyosarcoma 3D organoids to predict effective drug combinations: A proof-ofconcept on cell death inducers | Savary C, Luciana L, Huchede´ P, Tourbez A, Coquet C, Broustal M, Gonzalez AL, Deligne C, Diot T, Naret O, Costa M, Meynard N, Barbet V, Muller K, Tonon L, Gadot N, Degletagne C, Attignon V, Le´on S, Vanbelle C, Bomane A, Rochet I, Mournetas V, Oliveira L, Rinaudo P, Bergeron C, Dutour A, Cordier-Bussat M, Roch A, Brandenberg N, El Zein S, Watson S, Orbach D, Delattre O, Dijoud F, Corradini N, Picard C, Maucort-Boulch D, Le Grand M, Pasquier E, Blay JY, Castets M, and Broutier L. | 2023 | Cell Reports Medicine | Oncology | Multiplex IHC | HALO |
| RFX6 facilitates aerobic glycolysis‐mediated growth and metastasis of hepatocellular carcinoma through targeting PGAM1 | Qiu Z, Wang C, Huang P, Yuan Y, Shi Y, Lin Z, Huang Z, Zuo D, Qiu J, He W, Shen J, Niu Y, Yuan Y, Li B | 2023 | Clinical and Translational Medicine | Oncology | Multiplex IHC | HALO |
| Immune microenvironment of basal cell carcinoma and tumor regression following combined PD-1/LAG-3 blockade | Deutsch JS, Lai J, Schenk KM, Soni A, Will EM, Engle LL, Xu H, Ogurtsova A, Madan V, Chong JK, Wang D, Green BF, Nguyen P, Schollenberger MD, Lipson EJ, Taube JM | 2023 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Multiplex IHC | HALO |
| Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma | Sun Y, Wu P, Zhang Z, Wang Z, Zhou K, Song M, Ji Y, Zang F, Lou L, Rao K, Wang P, Gu Y, Gu J, Lu B, Chen L, Pan X, Zhao X, Peng L, Liu D, Chen X, Wu K, Lin P, Wu L, Su Y, Du M, Hou Y, Yang X, Qiu S, Shi Y, Sun H, Zhou J, Huang X, Peng D, Zhang L, Fan J | 2023 | Cancer Cell | Oncology | Classifier, Multiplex IHC, Spatial Analysis, Highplex FL | HALO |
| Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non–small cell lung cancer | Herzog B, Baer J, Borcherding N, Kingston N, Belle J, Knolhoff B, Hogg G, Ahmad F, Kang L, Petrone J, Lin C, Govindan R, Denardo D | 2023 | Science Translational Medicine | Oncology | Classifier, Multiplex IHC | HALO |
| Cholesterol efflux drives the generation of immunosuppressive macrophages to promote the progression of human hepatocellular carcinoma | Li Z, Wang Y, Xing R, Zeng H, Yu X, Zhang Y, Xu J, Zheng L | 2023 | Cancer Immunology Research | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
| Phase 1 Dose Escalation and Expansion Study of Golidocitinib, a Highly Selective JAK1 Inhibitor, in Relapsed or Refractory Peripheral T Cell Lymphomas | Song Y, Yoon D, Yang H, Cao J, Ji D, Koh Y, Jing H, Eom H, Kwak J, Lee W, Lee J, Shin H, Jin J, Wang M, Yang Q, Kim W, Zhu J | 2023 | Annals of Oncology | Immuno-oncology | Multiplex IHC | HALO |
| SMAD4 and KCNQ3 alterations are associated with lymph node metastases in oesophageal adenocarcinoma | Foley K, Shorthouse D, Rahrmann E, Zhuang L, Devonshire G, Gilbertson R, OCCAMS consortium, Fitzgerald R, Hall B | 2023 | Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease | Oncology | Multiplex IHC | HALO |
| Reanalysis of single-cell data reveals macrophage subsets associated with the immunotherapy response and prognosis of patients with endometrial cancer | Wu Q, Jiang G, Sun Y, Li B | 2023 | Experimental Cell Research | Immuno-oncology | Multiplex IHC | HALO |
| Telomere dysfunction in Tert knockout mice delays BrafV600E-induced melanoma development | Zhang J, Zhang F, Porter KI, Dakup PP, Wang S, Robertson GP, Gaddameedhi S, Zhu J | 2023 | International Journal of Cancer | Oncology | Multiplex IHC | HALO |
| Modified Bushen Yiqi formula enhances antitumor immunity by reducing the chemotactic recruitment of M2-TAMs and PMN-MDSCs in Lewis lung cancer-bearing mice | Kong Q, Zhu H, Gong W, Deng X, Liu B, Dong J | 2023 | Journal of Ethnopharmacology | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
| Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC | Baer JM, Zuo C, Kang LI, Alarcon de la Lastra A, Borcherding NC, Knolhoff BL, Bogner SJ, Zhu Y, Yang L, Laurent J, Lewis MA, Zhang N, Kim KW, Fields RC, Yokoyama WM, Mills JC, Ding L, Randolph GJ, DeNardo DG | 2023 | Nature Immunology | Immunology | Multiplex IHC | HALO |
| Tumor microenvironment-mediated immune profiles and efficacy of anti-PD-L1 antibody plus chemotherapy stratified by DLL3 expression in small-cell lung cancer | Shirasawa M, Yoshida T, Shiraishi K, Goto N, Yagishita S, Imabayashi T, Matsumoto Y, Masuda K, Shinno Y, Okuma Y, Goto Y, Horinouchi H, Yotsukura M, Yoshida Y, Nakagawa K, Naoki K, Tsuchida T, Hamamoto R, Yamamoto N, Motoi N, Kohno T, Watanabe SI, Ohe Y | 2023 | British Journal of Cancer | Immuno-oncology | Multiplex IHC | HALO |
| Targeting the metabolic enzyme PGAM2 overcomes enzalutamide resistance in castration-resistant prostate cancer by inhibiting BCL2 signaling | Li Z, Ning K, Zhao D, Zhou Z, Zhao J, Long X, Yang Z, Chen D, Cai X, Hong L, Zhang L, Zhou F, Wang J, Li Y | 2023 | Cancer Research | Oncology | Multiplex IHC | HALO |
| A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury | Zhao X, Zeng W, Xu H, Sun Z, Hu Y, Peng B, McBride JD, Duan J, Deng J, Zhang B, Kim SJ, Zoll B, Saito T, Sasaguri H, Saido TC, Ballatore C, Yao H, Wang Z, Trojanowski JQ, Brunden KR, Lee VMY, He Z | 2023 | Science Translational Medicine | Neuroscience | Area Quantification, Object Colocalization, Multiplex IHC | HALO |
| Enlarged tumour-draining lymph node with immune-activated profile predict favourable survival in non-metastatic colorectal cancer | Guan X, Cheng P, Wei R, Li J, Jiao S, Zhao Z, Chen H, Liu Z, Jiang Z, Zheng Z, Zou S, Wang X | 2023 | British Journal of Cancer | Oncology | Multiplex IHC | HALO |
| Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells | Linder S, Bernasocchi T, Martínez-Pastor B, Sullivan K, Galbraith M, Lewis C, Ferrer C, Boon R, Silveira G, Cho H, Vidoudez C, Shroff S, Oliveira-Costa J, Ross K, Massri R, Matoba Y, Kim E, Rueda B, Stott S, Gottlieb E, Espinosa J, Mostoslavsky R | 2023 | Nature Metabolism | Oncology, Metabolism | Multiplex IHC, Registration | HALO |
| Intrauterine perfusion of dexamethasone improves pregnancy outcomes in recurrent reproductive failure patients with elevated uterine natural killer cells. A retrospective cohort study | Zhang F, Wang Z, Lian R, Diao L, Li Y, Wu Y, Yin T, Huang C | 2023 | American Journal of Reproductive Immunology | Other | Multiplex IHC | HALO |
| Gastric tubular adenocarcinoma with diffuse neutrophils infiltrating: characteristics and probable treatment strategy | Wang B, Zhu Y, Wang S, Li Z, Wang L, Rao W, Cheng N, Chen R, Ying J, Xue L | 2023 | Gastric Cancer | Oncology | Multiplex IHC, Spatial Analysis, Registration | HALO |
| Modified Bushen Yiqi Formula mitigates pulmonary inflammation and airway remodeling by inhibiting neutrophils chemotaxis and IL17 signaling pathway in rats with COPD | Kong Q, Wang B, Zhong Y, Chen W, Sun J, Liu B, Dong J | 2023 | Journal of Ethnopharmacology | Other | Multiplex IHC | HALO |
| Upfront FOLFOXIRI plus bevacizumab with or without atezolizumab in the treatment of patients with metastatic colorectal cancer (AtezoTRIBE): a multicentre, open-label, randomised, controlled, phase 2 trial | Antoniotti C, Rossini D, Pietrantonio F, Catteau A, Salvatore L, Lonardi S, Boquet I, Tamberi S, Marmorino F, Moretto R, Ambrosini M, Tamburini E, Tortora G, Passardi A, Bergamo F, Kassambara A, Sbarrato T, Morano F, Ritorto G, Borelli B, Boccaccino A, Conca V, Giordano M, Ugolini C, Fieschi J, Papadopulos A, Massoue C, Aprile G, Antonyzzo L, Gelsomino F, Martinelli E, Pella N, Masi G, Fontanini G, Boni L, Galon J, Cremolini C | 2022 | The Lancet Oncology | Oncology | Multiplex IHC, Spatial Analysis | HALO |
| Escherichia coli-specific CXCL13-producing TFH are associated with clinical efficacy of neoadjuvant PD-1 blockade against muscle-invasive bladder cancer | Goubet A, Lordello L, Silva C, Peguillet I, Gazzano M, Mbogning-Fonkou M, Thelemaque C, Lebacle C, Thibault C, Audenet F, Pignot G, Gravis G, Helissey C, Campbedel L, Roupret M, Xylinas E, Ouzaid I, Dubuisson A, Mazzenga M, Flament C, Ly P, Marty V, Signolle N, Sauvat A, Sbarrato T, Filahi M, Davin C, Haddad G, Khalil J, Bleriot C, Danlos F, Dunsmore G, Mulder K, Silvin A, Raoult T, Archambaud B, Belhechmi S, Boneca I, Cayet N, Moya-Nilges M, Mallet A, Daillere R, Rouleau E, Radulescu C, Allory Y, Fieschi J, Rouanne M, Ginhoux F, Le Teuff G, Derosa L, Marabelle A, Van Dorp J, Van Dijk N, van der Heijden M, Besse B, Andre F, Merad M, Kroemer G, Scoazec J, Zitvogel L, Loriot Y | 2022 | Cancer Discovery | Oncology | Multiplex IHC, Spatial Analysis | HALO |
| Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation | Wu H, He P, Ren Y, Xiao S, Wang W, Liu Z, Li H, Wang Z, Zhang D, Cai J, Zhou X, Jiang D, Fei X, Zhao L, Zhang H, Liu Z, Chen R, Li W, Wang C, Zhang S, Qin J, Nasan B, Sun C | 2022 | Nature Communications | Infectious Disease | Multiplex IHC | HALO |
| Transcription factor Mesenchyme Homeobox Protein 2 (MEOX2) modulates nociceptor function | Kokotovic T, Lenartowicz E, Langeslag M, Ciotu C, Fell C, Scaramuzza A, Fischer M, Kress M, Penninger J, Nagy V | 2022 | The FEBS Journal | Neuroscience | Multiplex IHC | HALO |
| African-Ancestry Associated Gene Expression Signatures and Pathways in Triple Negative Breast Cancer, a Comparison across Women of African Descent | Martini R, Delpe P, Chu T, Arora K, Lord B, Verma A, Chen Y, Gebregzabher, Oppong J, Adjei E, Jibril A, Awuah B, Bekele M, Abebe E, Kyei I, Aitpillah F, Adinku M, Ankomah K, Osei-Bonsu E, Chitale D, Bensenhaver J, Nathanson S, Jackson L, Jiagge E, Petersen L, Proctor E, Gyan K, Gibbs L, Monojlovic Z, Kittles R, White J, Yates C, Manne U, Gardner K, Mongan N, Cheng E, Ginter P, Hoda S, Elemento O, Robine N, Sboner A, Carpten J, Newman L, Davis M | 2022 | medRxiv | Oncology | Multiplex IHC, Serial Section | HALO |
| An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation | Muik A, Altintas I, Gieseke F, Schoedel K, Burm S, Toker A, Salcedo T, Verzijl, Eisel D, Grunwitz C, Kranz L, Vormehr M, Satijn D, Diken M, Kreiter S, Sasser K, Ahmadi T, Tureci O, Breij E, Jure-Kunkel M, Sahin U | 2022 | OncoImmunology | Immuno-oncology | Area Quantification, Immune, Multiplex IHC | HALO |
| Interspatial Distribution of Tumor and Immune Cells in Correlation with PD-L1 in Molecular Subtypes of Gastric Cancers | Dislich B, Mertz K, Gloor B, Langer R | 2022 | Cancers | Immuno-oncology | Multiplex IHC, Spatial Analysis, Figure Maker | HALO |
| Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques | Aid M, Vidal S, Piedra-Mora C, Ducat S, Chan C, Bondoc S, Colarusso A, Starke C, Nekorchuk M, Busman-Sahay K, Estes J, Martinot A, Barouch D | 2022 | PLOS Pathogens | Infectious Disease | Area Quantification, Multiplex IHC | HALO, HALO AI |
| Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19 | Chait M, Yilmaz M, Shakil S, Ku A, Dogra P, Connors T, Szabo P, Gray J, Wells S, Kubota M, Matsumoto R, Poon M, Snyder M, Baldwin M, Sims P, Saqi A, Farber D, Weisberg S | 2022 | JCI Insight | Infectious Disease | Multiplex IHC | HALO |
| Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection | Lee A, Feng E, Chew M, Balint E, Poznanski S, Giles E, Zhang A, Marzok A, Revill S, Vahedi F, Dubey A, Ayaub E, Jimenez-Saiz R, McGrath J, Ritchie T, Jordana M, Jonigk D, Ackermann M, Ask K, Miller M, Richards C, Ashkar A | 2022 | PLOS Pathogens | Infectious Disease | Area Quantification, Multiplex IHC, TMA | HALO |
| Maternal Western-Style Diet Impairs Bone Marrow Development and Drives a Hyperinflammatory Phenotype in Hematopoietic Stem and Progenitor Cells in Fetal Rhesus Macaques | Sureshchandra S, Chan C, Robino J, Parmelee L, Nash M, Wesolowski S, Pietras E, Friedman J, Takahashi D, Shen W, Hennebold J, Goldman D, Packwood W, Lindner J,Roberts C, Burwitz B, Messaoudi I, Varlamov O | 2022 | bioRxiv | Metabolism | Multiplex IHC | HALO |
| A lncRNA signature associated with tumor immune heterogeneity predicts distant metastasis in locoregionally advanced nasopharyngeal carcinoma | Liang Y, Zhang Y, Tan X, Qiao H, Liu S, Tang L, Mao Y, Chen L, Li W, Zhou G, Zhao Y, Li J, Li Q, Huang S, Gong S, Zheng Z, Li Z, Sun Y, Jiang W, Ma J, Li Y, Liu N | 2022 | Nature Communications | Immuno-oncology | Multiplex IHC, Registration | HALO |
| Prenatal di-(2-ethylhexyl_ phthalate exposure induced myocardial cytotoxicity via the regulation of the NRG1-dependent ErbB2/ErbB4-PI3K/AKT signaling pathway in fetal mice | Yu D, Zhu D, Wang X, Li B, Li J, Lu P, Ji Y, Wang X | 2022 | Ecotoxicology and Environmental Safety | Other | Multiplex IHC | HALO |
| Effects of Extracorporeal Shockwave Therapy on Functional Recovery and Circulating miR-375 and miR-382-5p after Subacute and Chronic Spinal Cord Contusion Injury in Rats | Ashmwe M, Posa K, Ruhrnossl A, Heinzel J, Heimel P, Mock M, Schadl B, Keibl C, Couillard-Despres S, Redl H, Mittermayr R, Hercher D | 2022 | Biomedicines | Neuroscience, Other | Classifier, Multiplex IHC | HALO |
| The combination of gene hyperamplification and PD-L1 expression as a biomarker for the clinical benefit of tislelizumab in gastric/gastroesophageal junction adenocarcinoma | Lu Z, Yang S, Luo X, Shi Y, Lee J, Deva S, Liu T, Chao Y, Zhang Y, Huang R, Xu Y, Shen Z, Shen L | 2022 | Gastric Cancer | Immuno-oncology | Classifier, Multiplex IHC | HALO |
| Spartalizumab or placebo in combination with dabrafenib and trametinib in patients with BRAF V600-mutant melanoma: exploratory biomarker analyses from a randomized phase 3 trial (COMBI-i) | Tawbi H, Robert C, Brase J, Gusenleitner D, Gasal E, Garrett J, Savchenko A, Gorgun G, Flaherty K, Ribas A, Dummer R, Schadendorf D, Long G, Nathan P, Ascierto P | 2022 | Journal for ImmunoTherapy of Cancer | Oncology | Multiplex IHC | HALO |
| Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer | Sushentsev N, McLean M, Warren A, Benjamin A, Brodie C, Frary A, Gill A, Jones J, Kaggie J, Lamb B, Locke M, Miller J, Mills I, Priest A, Robb F, Shah N, Schulte R, Graves M, Gnanapragasam V, Brindle K, Barrett T, Gallacher F | 2022 | Nature Communications | Oncology | ISH/FISH, Membrane, Multiplex IHC | HALO |
| Prostate cancer androgen receptor activity dictates efficacy of Bipolar Androgen Therapy | Sena L, Kumar R, Sanin D, Thompson E, Rosen D, Dalrymple S, Antony L, Yang Y, Comes-Alexandre C, Hicks J, Jones T, Bowers K, Eskra J, Meyers J, Gupta A, Skaist A, Yegnasubramanian S, Luo J, Brennen W, Kachhap S, Antonarakis E, De Marzo A, Isaacs J, Markowski M, Denmeade S | 2022 | medrxiv | Oncology | Classifier, Cytonuclear, Multiplex IHC, Registration | HALO |
| Bright-Field Multiplex Immunohistochemistry Assay for Tumor Microenvironment Evaluation in Melanoma Tissues | Ugolini F, Pasqualini E, Simi S, Baroni G, Massi D | 2022 | Cancers | Other | Multiplex IHC | HALO, HALO Link |
| Knockdown of ZBTB11 impedes R-loop elimination and increases the sensitivity to cisplatin by inhibiting DDX1 transcription in bladder cancer | Chen L, Liu Z, Tang H, Zhou Z, Chen J, Ma Z, Deng M, Li X, Wu Y, Zheng L, Zhou L, Zheng X, Liu Z | 2022 | Cell Proliferation | Oncology | Multiplex IHC | HALO |
| Immune cells in mesothelioma microenvironment simplistic marker of response to nivolumab plus ipilimumab | Disselhorst M, Lubeck Y, van der Noort V, Quispel-Janssen J, Seignette I, Sanders J, Peters D, Hooijberg E, Baas P | 2022 | Lung Cancer | Oncology | Multiplex IHC, Registration | HALO |
| In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues | Young L, Conroy L, Clarke H, Hawkinson T, Bolton K, Sanders W, Chang J, Webb M, Alilain W, Vander Kooi C, Drake R, Andrews D, Badgett T, Wagner L, Allison D, Sun R, Gentry M | 2022 | EMBO Molecular Medicine | Oncology, Metabolism | Multiplex IHC | HALO |
| STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent | Zhang X, Chen Q, He Y, Shi Q, Yin C, Xie Y, Yu H, Bao Y, Tang C, Dong Z | 2022 | Research Square | Oncology | Multiplex IHC | HALO |
| Maternal Undernutrition Model of Two Generations of Rats: Changes in the Aged Retina | Laurinaviciute G, Simkunaite-Rizgeliene R, Zalgeviciene V, Bartuskiene V, Cepuliene R, Jakimaviciene E, Galgauskas S, Petroska D, Besusparis J, Tutkuviene J | 2022 | Histology and Histopathology | Other | Area Quantification, Multiplex IHC | HALO |
| The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers | Tatari N, Khan S, Livingstone J, Zhai K, Mckenna D, Ignatchenko V, Chokshi C, Gwynne W, Singh M, Revill S, Mikolajewicz N, Zhu C, Chan J, Hawkins C, Lu J, Provias J, Ask K, Morrissy S, Brown S, Weiss T, Weller M, Han H, Greenspoon J, Moffat J, Venugopal C, Boutros P | 2022 | Acta Neuropathologica | Oncology | Multiplex IHC, TMA | HALO |
| Integrated pathological analysis to develop a Gal-9 based immune survival stratification to predict the outcome of lung large cell neuroendocrine carcinoma and its usefulness in immunotherapy | Che Y, Luo Z, Cao Y, Wang J, Xue Q, Sun N, He J | 2022 | International Journal of Biological Sciences | Oncology | Classifier, Multiplex IHC | HALO |
| PD-L1 predicts chemotherapy resistance in large-cell neuroendocrine carcinoma | Che Y, Luo Z, Cao Y, Sun N, Xue Q, He J | 2022 | British Journal of Surgery | Oncology | Classifier, Multiplex IHC | HALO |
| Cystatin C is glucocorticoid-responsive, directs recruitment of Trem2+ macrophages and predicts failure of cancer immunotherapy | Kleeman S, Demestichas B, Mourikis N, Loiero D, Ferrer M, Bankier S, Riazat-Kesh Y, Lee H, Chantzichristos D, Regan C, Preall J, Sinha S, Rosin N, Yipp B, de Almeida L, Biernaskie J, Dufour A, Tober-Lau P, Ruusalepp A, Bjorkegren J, Ralser M, Kuth F, Demechev V, Heywood T, Gao Q, Johannsson G, Koelzer V, Walker B, Meyer H, Janowitz T | 2022 | medrxiv | Immuno-oncology | Multiplex IHC | HALO, HALO AI |
| Carbonic anhydrase 14 protects the liver against the cytotoxicity of bile acids in a biliary bicarbonate umbrella-related manner | Qian J, Shen Q, Zhang T, Chen J, Chen L, Dong Y, Yan R, Chen Z | 2022 | Life Sciences | Other | Multiplex IHC | HALO |
| Impact of HPV status on immune responses in head and neck squamous cell carcinoma | Qureshi H, Zhu X, Yang G, Steadele M, Pierce R, Futran N, Lee S, Mendez E, Houghton A | 2022 | Oral Oncology | Oncology | Multiplex IHC, Spatial Analysis, Highplex FL | HALO |
| Evaluating changes in GABAergic and glutamatergic pathways in early life following prenatal stress and postnatal neurosteroid supplementation | Crombie G, Palliser H, Shaw J, Hodgson D, Walkder D, Hirst J | 2022 | Psychoneuroendocrinology | Neuroscience | Multiplex IHC | HALO |
| Presence of Tim3+ and PD-1+ CD8+ T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and distinct clinicopathological features | Klapholz M, Drage M, Srivastava A, Anderson A | 2022 | The Journal of Pathology | Oncology | Multiplex IHC, Highplex FL | HALO |
| Murine fecal microbiota transfer models selectively colonize human microbes and reveal transcriptional programs associated with response to neoadjuvant checkpoint inhibitors | Shaikh F, Gills J, Mohammad F, White J, Stevens C, Ding H, Fu J, Tam A, Blosser R, Domingue J, Larman T, Chaft J, Spicer J, Reuss J, Naidoo J, Forde P, Ganguly S, Housseau F, Pardoll D, Sears C | 2022 | Cancer Immunology, Immunotherapy | Immuno-oncology | Multiplex IHC | HALO |
| Association between mitochondrial and nuclear DNA damages and cellular senescence in the patients with biliary atresia undergoing Kasai portoenterostomy and liver transplantation | Nakajima Y, Yamazaki Y, Gao X, Hashimoto M, Nio M, Wada M, Fujishima F, Sasano H | 2022 | Medical Molecular Morphology | Gastroenterology | Multiplex IHC | HALO |
| NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer | Salome B, Sfakianos J, Ranti D, Daza J, Bieber C, Charap A, Hammer C, Banchereau R, Farkas A, Ruan D, Izadmehr S, Geanon D, Kelly G, Real R, Lee B, Beaumont K, Shroff S, Wang Y, Wang Y, Thin T, Garcia-Barros M, Hegewisch-Solloa E, Mace E, Wang L, O’Donnell T, Chowell D, Fernandez-Rodriguez R, Skobe M, Taylor N, Kim-Schulze S, Sebra R, Palmer D, Clancy-Thompson E, Hammond S, Kamphorst A, Malmberg K, Marcenaro E, Romero P, Brody R, Viard M, Yuki Y, Martin M, Carrington M, Mehrazin R, Wilund P, Mellman I, Mariathasan S, Zhu J, Galsky M, Bhardwaj N, Horowitz A | 2022 | Cancer Cell | Oncology, Immuno-oncology | Classifier, Multiplex IHC | HALO, HALO AI |
| The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma | Zullow H, Sankar A, Ingram D, Guerra D, D’Avino A, Collings C, Lazcano R, Wang W, Liang Y, Qi J, Lazar A, Kadoch C | 2022 | Molecular Cell | Oncology | Multiplex IHC | HALO |
| In vitro cell cultures of Brunner’s glands from male mouse to study GLP-1 receptor function | Voetmann L, Underwood C, Rolin B, Hansen A, Kirk R, Pyke C, Knudsen L, Frederiksen K | 2022 | Methods in Cell Physiology | Gastroenterology | Multiplex IHC | HALO |
| Reduced SARS-CoV-2 disease outcomes in Syrian hamsters receiving immune sera: Quantitative image analysis in pathologic assessments | Pieda-Mora C, Robinson S, Tostanoski L, Dayao D, Chandrashekar A, Bauer K, Wrijil L, Ducat S, Hayes T, Yu J, Bondzie E, McMahan K, Sellers D, Giffin V, Hope D, Nampanya F, Mercado N, Kar S, Andersen H, Tzipori S, Barouch D, Martinot A | 2022 | Veterinary Pathology | Infectious Disease, Other | Classifier, Multiplex IHC | HALO |
| Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer | Xiong X, Hasani S, Young L, Rivas D, Skaggs A, Martinez R, Wang C, Weiss H, Gentry M, Sun R, Gao T | 2022 | Cell Death & Differentiation | Oncology | Multiplex IHC | HALO |
| Aberrant inflammation in rat pregnancy leads to cardiometabolic alterations in their offspring and intrauterine growth restriction in the F2 generation | Ushida T, Cotechini T, Protopapas N, Atallah A, Collyer C, Toews A, Maconald-Goodfellow S, Tse M, Winn L, Pang S, Adams M, Othman M, Kotani T, Kajiyama H, Graham C | 2022 | Journal of Developmental Origins of Health and Disease | Metabolism, Other | Multiplex IHC | HALO |
| High-strength biodegradable zinc alloy implants with antibacterial and osteogenic properties for the treatment of MRSA-induced rat osteomyelitis | Jia B, Zhang Z, Zhuang Y, Yang H, Han Y, Wu Q, Jia X, Yin Y, Qu X, Zheng Y, Dai K | 2022 | Biomaterials | Biomaterials | Multiplex IHC | HALO |
| An In Vivo Model of Human Macrophages in Metastatic Melanoma | Voillet V, Berger T, McKenna K, Paulson K, Tan W, Smythe K, Hunter D, Valente W, Weaver S, Campbell J, Kim T, Byrd D, Bielas J, Pierce R, Chapuis A, Gottardo R, Rongvaux | 2022 | The Journal of Immunology | Oncology, Immuno-oncology | Multiplex IHC | HALO |
| Integrative Analysis of Bioinformatics and Machine Learning Algorithms Identifies a Novel Diagnostic Model Based on Costimulatory Molecule for Predicting Immune Microenvironment Status in Lung Adenocarcinoma | Zhai W, Duan F, Wang Y, Wang J, Zhao Z, Lin Y, Rao B, Chen S, Zheng L, Long H | 2022 | The American Journal of Pathology | Oncology | Multiplex IHC | HALO |
| Ghrelin May Inhibit Inflammatory Response and Apoptosis During Ischemia-Reperfusion Injury | Fukunaga N, Ribeiro R, Bissoondath V, Billia F, Rao V | 2022 | Transplantation Proceedings | Other | Multiplex IHC | HALO |
| Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants | Jardi F, Kelly C, Teague C, Fowler-Williams H, Sevin D, Rodrigues D, Jo H, Ferreira S, Herpers B, Van Heerden M, de Kok T, Pin C, Lynch A, Duckworth C, De Jonghe S, Lammens L, Pritchard D | 2022 | Archives of Toxicology | Toxicology | Multiplex IHC | HALO |
| Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption | Li M, Yang D, Yan H, Tang Z, Jiang D, Zhang J, Chi Z, Nie W, Zhen W, Yu W, Chen S, Wang Z, Yu Q, Zhang X, Yang F, Fan S, Lin X, Wang D | 2022 | Developmental Cell | Other | Area Quantification, Multiplex IHC | HALO |
| Th1-involved immune infiltrates improve neoadjuvant chemoradiotherapy response of esophageal squamous cell carcinoma | Yuan J, Weng Z, Tan Z, Luo K, Zhong J, Xie X, Qu C, Lin X, Yang H, Wen J, Fu J | 2022 | Cancer Letters | Immuno-oncology | Multiplex IHC, Spatial Analysis | HALO |
| Oct4 promoted proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in colon cancer cells by activating the SCF/c-Kit signaling pathway | Bu X, Liu Y, Wang L, Yan Z, Xin G, Su W | 2022 | Cell Cycle | Oncology | Multiplex IHC | HALO |
| Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade | Kaur G, Porter C, Ashenberg O, Lee J, Riesenfeld S, Hofree M, Aggelakopoulou M, Subramanian A, Kuttikkatte S, Attfield K, Desel C, Davies J, Evans H, Avraham-Davidi I, Nguyen L, Dionne D, Neumann A, Jensen L, Barber T, Soilleux E, Carrington M, McVean G, Rozenblatt-Rosen O, Regev A, Fugger L | 2022 | Nature Communications | Other | ISH/FISH, Multiplex IHC | HALO, HALO Link, Pharma Services |
| Defactinib, pembrolizumab, and gemcitabine in patients with advanced treatment refractory pancreatic cancer: A phase I, dose escalation, and expansion study | Wang-Gillam A, Lim K, McWilliams R, Suresh R, Lockhart A, Brown A, Breden M, Belle J, Herndon J, Bogner S, Pedersen K, Tan B, Boice N, Acharya A, Abdiannia M, Gao F, Yoon H, Zhu M, Trikalinos N, Ratner L, Aranha O, Hawkins W, Herzog B, DeNardo D | 2022 | Clinical Cancer Research | Immuno-oncology | Multiplex IHC, Spatial Analysis | HALO |
| A Novel Artificial Intelligence–Powered Method for Prediction of Early Recurrence of Prostate Cancer After Prostatectomy and Cancer Drivers | Huang W, Randhawa R, Jain P, Hubbard S, Eickhoff J, Kummar S, Wilding G, Basu H, Roy R | 2022 | JCO Clinical Cancer Informatics | Oncology | Classifier, Multiplex IHC, Spatial Analysis | HALO |
| CD22-targeted CD28 bispecific antibody enhances antitumor efficacy of odronextamab in refractory diffuse large B cell lymphoma models | Wei J, Montalvo-Ortiz W, Yu L, Krasco A, Olson K, Rizvi S, Fiaschi N, Coetzee S, Wang F, Ullman E, Ahmed H, Herlihy E, Lee K, Havel L, Potocky T, Ebstein S, Frleta D, Khatri A, Godin S, Hamon S, Brouwer-Visser J, Gorenc T, Macdonald D, Hermann A, Chaudhry A, Sirulnik A, Olson W, Lin J, Thurston G, Lowy I, Murphy A, Smith E, Jankovic V, Sleeman M, Skokos D | 2022 | Science Translational Medicine | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
| Liver tumour immune microenvironment subtypes and neutrophil heterogeneity | Xue R, Zhang Q, Cao Q, Kong R, Xiang X, Liu H, Feng M, Wang F, Cheng J, Li Z, Zhan Q, Deng M, Zhu J, Zhang Z, Zhang N | 2022 | Nature | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
| Allogeneic cord blood regulatory T cells can resolve lung inflammation | Lyu M, Huang M, Zeng K, Li L, Khoury J, Nishimoto M, Ma H, Sadeghi T, Mukherjee S, Slutsky A, Flowers C, Parmar S | 2022 | Cytotherapy | Immunology | Multiplex IHC | HALO |
| Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer | Ma Z, Li X, Mao Y, Wei C, Huang Z, Li G, Yin J, Liang X, Liu Z | 2022 | Cancer Cell | Oncology | Multiplex IHC, Highplex FL | HALO |
| LP2, a cyclic angiotensin-(1−7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice | Namsolleck P, de Vries L, Moll G | 2022 | Peptides | Oncology | Multiplex IHC | HALO, HALO AI |
| Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10 | Yang J, Hou C, Wang H, Perez E, Do-Umehara H, Dong H, Arunagiri V, Tong F, Scoyk M, Cho M, Liu X, Ge X, Winn R, Ridge K, Wang X, Chandel N, Liu J | 2022 | Cancer Letters | Oncology | Multiplex IHC | HALO |
| The effect of cyfluthrin on testis inhibin B in rats and the intervention of Lycium barbarum polysaccharide | Guo X, Xie Y-X, Guo C, Wei J-L, Yang H-F | 2021 | Molecular & Cellular Toxicology | Toxicology | Multiplex IHC | HALO |
| Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells | Wanjalla CN, McDonnell WY, Ram R, Chopra A, Gangula R, Leary S, Mashayekhi M, Simmons JD, Warren CM, Bailin S, Gabriel CL, Cuo L, Furch BD, Lima MC, Woodward BO, Hannah L, Pilkinton MA, Fuller DT, Kawai K, Virmani R, Finn AV, Hasty AH, Mallal SA, Kalams SA, Koethe JR | 2021 | Cell Reports Medicine | Immunology, Metabolism | Multiplex IHC | HALO |
| Digital Immunophenotyping Predicts Disease Free and Overall Survival in Early Stage Melanoma Patients | De Logu F, Galli F, Nassini R, Ugolini F, Simi S, Cossa M, Miracco C, Gianatti A, De Giorgi V, Rulli E, Cossu A, Massi D, Mandalà M | 2021 | Cells | Oncology, Immuno-oncology | Multiplex IHC | HALO, HALO Link |
| Activated Regulatory T-Cells, Dysfunctional and SenescentT-Cells Hinder the Immunity in Pancreatic Cancer | Sivakumar S, Abu-Shah E, Ahern DJ, Arbe-Barnes EH, Jainarayanan AK, Mangal N, Reddy S, Rendek A, Easton A, Kurz E, Silva M, Soonawalla Z, Heij LR, Bashford-Rogers R, Middleton MR, DUstin ML | 2021 | cancers | Immuno-oncology | Classifier, Multiplex IHC, Spatial Analysis, Highplex FL | HALO |
| Inhibition of STAT3 augments antitumor efficacy of anti-CTLA-4 treatment against prostate cancer | Witt K, Evans-Axelsson S, Lundqvist A, Johansson M, Bjartell A, Hellsten R | 2021 | Cancer Immunology, Immunotherapy | Immuno-oncology | Area Quantification, Multiplex IHC | HALO |
| Tumor cell PD-L1 expression is a strong predictor of unfavorable prognosis in immune checkpoint therapy-naive clear cell renal cell cancer | Möller K, Fraune C, Blessin NC, Lennartz M, Kluth M, Hube-Magg C, Lindhorst L, Dahlem R, Fisch M, Eichenauer T, Riechardt S, Simon R, Sauter G, Büscheck F, Höppner W, Matthies C, Doh O, Krech T, Marx AH, Zecha H, Rink M, Steurer S, Clauditz TS | 2021 | International Urology and Nephrology | Immuno-oncology | Multiplex IHC, TMA | HALO |
| TNFα secreted by glioma associated macrophages promotes endothelial activation and resistance against anti-angiogenic therapy | Wei Z, Singh O, Ekinci C, Gill J, Li M, Mamatjan Y, Karimi S, Bunda S, Mansouri S, Aldape K, Zadeh G | 2021 | Acta Neuropathologica Communications | Immunology, Neuroscience | Classifier, Multiplex IHC | HALO |
| Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques | Bochart RM, Busman-Sahay K, Bondoc S, Morrow DW, Ortiz AM, Fennessey CM, Fischer MB, Shiel O, Swanson T, Shriver-Munsch CM, Crang HB, Armantrout KM, Barber-Axthelm AM, Langner C, Moats CR, Labriola CS, MacAllister R, Axthelm MK, Brenchley JM, Keele BF, Estes JD, Hansen SG, Smedley JV | 2021 | PLOS Pathogens | Infectious Disease | ISH/FISH, Multiplex IHC | HALO |
| Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes | Ligon JA, Choi W, Cojocaru G, Fu W, Hsiue EH-C, Oke TF, Siegel N, Fong MH, Ladle B, Pratilas CA, Morris CD, Levin A, Rhee DS, Meyer CF, Tam AJ, Blosser R, Thompson ED, Suru A, McConkey D, Housseau F, Anders R, Pardoll DM, Llosa N | 2021 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Multiplex IHC | HALO |
| Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer treated with a combination of the PI3K inhibitor alpelisib (BYL719) and fulvestrant | Jacquemetton J, Kassem L, Poulard C, Dahmani A, De Plater L, Montaudon E, Sourd L, Morisset L, El Botty R, Chateau-Joubert S, Vacher S, Bièche I, Treilleux I, Trédan O, Marangoni E, Le Romancer M | 2021 | Breast Cancer Research | Oncology | Multiplex IHC | HALO |
| Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release | Dang K, Castello G, Clarke S, et al. | 2021 | Journal for Immunotherapy of Cancer | Immuno-oncology | Multiplex IHC | HALO |
| mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation | Jana S, Deo R, Hough R, et al. | 2021 | JCI Insight | Oncology | Multiplex IHC, Highplex FL | HALO |
| Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects | Escuin-Ordinas H, Liu Y, Hufo W, Dimatteo R, Huang R, Krystofinski P, Azhdam A, Lee J, Comin-Anduix B, Cochran A, Lo R, Segura T, Scumpia P, Ribas A | 2021 | PLOS One | Dermatology | Object Colocalization, Multiplex IHC | HALO |
| Extensive Three-Dimensional Intratumor Proteomic Heterogeneity Revealed by Multiregion Sampling in High-Grade Serous Ovarian Tumor Specimens | Hunt A, Bateman N, Barakat W, Makohon-Moore S, Hood B, Conrads K, Zhou M, Calvert V, Pierobon M, Loffredo J, Litzi T, Oliver J, Mitchell D, Gist G, Rojas C, Blanton B, Robinson E, Odunsi K, Sood A, Casablanca Y, Darcy K, Schriver C, Petricoin E, Rao U, Maxwell G, Conrads T | 2021 | iScience | Oncology | Multiplex IHC | HALO |
| TMEM229A suppresses non‑small cell lung cancer progression via inactivating the ERK pathway | Zhang X, He Y, Jiang Y, Bao Y, Chen Q, Xie D, Yu H, Wang X | 2021 | Oncology Reports | Oncology | Multiplex IHC | HALO |
| Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells | Greenstein A, Hunt H | 2021 | Oncotarget | Oncology | Multiplex IHC | HALO |
| A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS CoV-2 | Huang Q, Ji K, Tian S, Wang F, Huang B, Tong Z, Tan S, Hao J, Wang Q, Tan W, Gao G, Yan J | 2021 | Nature Communications | Infectious Disease | Multiplex IHC | HALO |
| ACT1 is required for murine IL-23-induced psoriasiform inflammation potentially independent of E3 ligase activity | Lipovsky A, Slivka PF, Su Z, Wang Y, Paulsboe S, Wetter J, Namovic MT, Gauvin D, Perron D, Gauld S, McGaragughty S, Goedken ER | 2021 | Journal of Investigative Dermatology | Immunology | Multiplex IHC | HALO |
| Pharmacologic modulation of RNA splicing enhances anti-tumor immunity | Lu S, De Neef E, Thomas J, Sabio E, Rousseau B, Gigoux M, Knorr D, Greenbaum B, Elhanti Y, Hogg S, Chow A, Ghosh A, Xie A, Zamarin D, Cui D, Erickson C, Singer M, Cho H, Wang E, Lu B, Durham B, Shah H, Chowell D, Gabel A, Shen Y, Liu J, Jin J, Rhodes M, Taylor R, Molina H, Wolchok J, Merghoub T, Diaz Jr. L, Abdel-Wahab O, Bradley B | 2021 | Cell | Oncology | Multiplex IHC | HALO |
| Multimodal treatment combining cold atmospheric plasma and acidic fibroblast growth factor for multi‐tissue regeneration | Tan F, Rui X, Xiang X, Yu Z, Al-Rubeai M | 2021 | The FASEB Journal | Other | Multiplex IHC | HALO |
| Imaging Tumor-Infiltrating Lymphocytes in Brain Tumors with [64Cu]Cu-NOTA-anti-CD8-Positron Emission Tomography | Nagle V, Henry K, Hertz C, et al. | 2021 | Clinical Cancer Research | Immuno-oncology | Multiplex IHC | HALO |
| Cooperative targeting of immunotherapy-resistant melanoma and lung cancer by an AXL-targeting antibody-drug conjugate and immune checkpoint blockade | Boshuizen J, Pencheva N, Krijgsman O, Altimari DD, Castro PG, de Bruijn B, Ligtenberg MA, den Heuvel EG, Vredevoogd DW, Song J-Y, Visser N, Apriamashvili G, Janmaat ML, Plantinga TS, Franken P, Houtkamp M, Lingnau A, Jure-Kunkel M, Peeper DS | 2021 | Cancer Research | Immuno-oncology | Multiplex IHC | HALO |
| Over-expression of Th2-related molecules in the skin of patients with eosinophilic dermatosis of hematologic malignancy | Maglie R, Ugolini F, De Logu F, Nassini R, Simi S, Nardiello P, Pasqualaini E, Baroini G, Del Bianco E, Massi D, Antiga E | 2021 | Journal of the American Academy of Dermatology | Oncology, Immuno-oncology | Area Quantification, Multiplex IHC | HALO, HALO Link |
| Necroptosis in biliary atresia of the liver | Hashimoto M, Fujishima F, Lomphithak T, Jitkaew S, Nio M, Sasano H | 2021 | Medical Molecular Morphology | Metabolism | Multiplex IHC | HALO |
| Establishing standardized immune phenotyping of metastatic melanoma by digital pathology | Sobottka B, Nowak M, Frei A, Haberecker M, Merki S, Tumor Profiler consortium, Levesque M, Dummer R, Moch H, Koelzer V | 2021 | Laboratory Investigation | Immuno-oncology | Multiplex IHC, Spatial Analysis | HALO, HALO AI |
| Baricitinib Treatment Resolves Lower-Airway Macrophage Inflammation and Neutrophil Recruitment in Sars-Cov-2-Infected Rhesus Macaques | Hoang T, Pino M, Boddapati A, Viox E, Starke C, Upadhyay A, Gumber S, Nekorchuk M, Busman-Sahay K, Strongin Z, Harper J, Tharp G, Pellegrini K, Kirejczyk S, Zandi K, Tao S, Horton T, Beagle E, Mahar E, Lee M, Cohen J, Jean S, Wood J, Connor-Stroud F, Stammen R, Delmas O, Wang S, Cooney K, Sayegh M, Wang L, Filev P, Weiskopf D, Silvestri G, Waggoner J, Piantadosi A, Kasturi S, Al-Shakhshir H, Ribeiro S, Sekaly R, Levit R, Estes J, Vanderfold T, Schinazi R, Bosinger S, Paiardine M | 2021 | Cell | Infectious Disease | Area Quantification, Multiplex IHC | HALO |
| Large-Section Histopathology Can Better Indicate the Immune Microenvironment and Predict the Prognosis of Pancreatic Ductal Adenocarcinoma Than Small-Section Histopathology | Ding G, Guo M, Yang Y, Sun C, Wu S, Liu X, Wang J, Jiang H, Liu Y, Zheng J | 2021 | Frontiers in Oncology | Oncology | Multiplex IHC | HALO |
| Intratumoral Heterogeneity and Immune Response Indicators to Predict Overall Survival in a Retrospective Study of HER2-Borderline (IHC 2+) Breast Cancer Patients | Radziuviene G, Rasmusson A, Augulis R, Grineviciute R, Zilenaite D, Laurinaviciene A, Ostapenko V, Laurinavicius A | 2021 | Frontiers in Oncology | Immuno-oncology | Membrane, Multiplex IHC | HALO, HALO AI |
| The TRPA1 Channel Amplifies the Oxidative Stress Signal in Melanoma | De Logu F, Monteiro de Araujo D, Ugolini F, Iannone L, Vannucchi M, Portelli F, Landini L, Titiz M, De Giorgi V, Geppetti P, Massi D, Nassini R | 2021 | Cells | Oncology | Area Quantification, Multiplex IHC | HALO, HALO AI, HALO Link |
| Investigation of Breast Cancer Microstructure and Microvasculature from Time-Dependent DWI and CEST in Correlation with Histological Biomarkers | Someya Y, Iima M, Imai H, Yoshizawa A, Kataoka M, Isoda H, Le Bihan D, Nakamoto Y | 2021 | Research Square | Oncology | Classifier, Multiplex IHC | HALO |
| Tumor Heterogeneity in VHL Drives Metastasis in Clear Cell Renal Cell Carcinoma | Hu J, Tan P, Ishihara M, Bayley N, Schokrpur S, Reynoso J, Jat P, Van Snick J, Knudsen B, Chin A, Prins R, Graeber T, Xu H, Wu L | 2021 | Research Square | Oncology | Multiplex IHC, Spatial Analysis, Highplex FL | HALO |
| An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer | Voabil P, de Bruijn M, Roelofsen L, Hendriks S, Brokamp S, van den Braber M, Broeks A, Sanders J, Herzig P, Zippelius A, Blank C, Hartemink K, Monkhorst K, Haanen J, Schumacher T, Thommen D | 2021 | Nature Medicine | Immuno-oncology | Classifier, Multiplex IHC | HALO |
| Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice | Kiourtis C, Wilczynska A, Nixon C, Clark W, May S, Bird T | 2021 | Biology Open | Other | Multiplex IHC | HALO |
| Two distinct immunopathological profiles in autopsy lungs of COVID-19 | Nienhold R, Ciani Y, Koelzer V, Tzankov A, Haslbauer J, Menter T, Schwab N, Henkel M, Frank A, Zsikla V, Willi N, Kempf W, Hoyler T, Barbareschi M, Moch H, Tolnay M, Cathomas G, Dernichelis F, Junt T, Mertz K | 2021 | Nature Communications | Infectious Disease | Multiplex IHC | HALO, HALO AI |
| Rejection of benign melanocytic nevi by nevus-resident CD4+ T cells | Schiferle E, Cheon S, Ham S, Son H, Messerschmidt J, Lawrence D, Cohen J, Flaherty K, Moon J, Lian C, Sullivan R, Demehri S | 2021 | Science Advances | Oncology | Multiplex IHC | HALO |
| Age-associated expression of p21 and p53 during human wound healing | Chia CW, Sherman-Baust CA, Larson SA, Pandey R, Withers R, Karikkineth AC, Zukley LM, Campisi J, Egan JM, Sen R, Ferrucci L | 2021 | Aging Cell | Dermatology | Area Quantification, ISH/FISH, Multiplex IHC | HALO |
| Upregulation of C/EBPa Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer | Hashimoto A, Sarker D, Reebye V, Jarvis S, Sodergren M, Kossenkov A, Raulf N, Vasara J, Andrikakou P, Meyer T, Huang K, Plummer R, Chee C, Spalding D, Pai M, Khan S, Pinato D, Sharma R, Basu B, Palmer D, Ma Y, Evans J, Habib R, Martirosyan A, Elasri N Reynaud A, Rossi J, Cobbold M, Habib N, Gabrilovich D | 2021 | Clinical Cancer Research | Oncology, Immuno-oncology | Multiplex IHC | HALO |
| Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology | Smith A, Davey K, Tsartsalis S, Khozoie C, Fancy N, Tang S, Liaptsi E, Weinert M, McGarry A, Muirhead R, Gentleman S, Owen D, Matthews P | 2021 | Acta Neuropathologica | Neuroscience | Area Quantification, Multiplex IHC, Microglia | HALO |
| CD19 and intraglandular CD163-positivity as prognostic indicators of pregnancy outcome in CD138-negative women with a previous fresh-embryo-transfer failure | Fan X, Yang Y, Wen Q, Li Y, Meng F, Liao J, Chen H, Lu G, Gong F | 2021 | Journal of Reproductive Immunology | Other | Multiplex IHC | HALO |
| A clinically applicable integrative molecular classification of meningiomas | Nassiri F, Liu J, Patil V, Mamatjan Y, Wang J, Hugh-White R, Macklin A, Khan S, Singh O, Karimi S, Corona R, Liu L, Chen C, Chakravarthy A, Wei Q, Mehani B, Suppiah S, Gao A, Workewych A, Tabatabai G, Boutros P, Bader G, de Carvalho D, Kislinger T, Aldape K, Zadeh G | 2021 | Nature | Oncology | Multiplex IHC | HALO |
| Selective targeting of MYC mRNA by stabilized antisense oligonucleotides | Gill T, Wang H, Bandaru R, Lawlor M, Lu C, Nieman L, Tao J, Zhang Y, Anderson D, Ting D, Chen X, Bradner J, Ott C | 2021 | Oncogene | Oncology | Multiplex IHC | HALO |
| Radiation Therapy Enhanced by NBTXR3 Nanoparticles Overcomes Anti-PD1 Resistance and Evokes Abscopal Effects | Hu Y, Paris S, Barsoumian H, Abana C, He K, Wasley M, Younes A, Masrorpour F, Chen D, Yang L, Dunn J, Zhang J, Gandhi S, Nguyen Q, Cortez M, Welsh J | 2021 | International Journal of Oncology*Biology*Physics | Immuno-oncology | Multiplex IHC | HALO |
| MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1–cMET signaling | Yin L, Li J, Wang J, Pu T, Wei J, Li Q, Wu B | 2021 | Oncogene | Oncology | Multiplex IHC | HALO |
| Porcine epidemic diarrhea virus infection induces endoplasmic reticulum stress and unfolded protein response in jejunal epithelial cells of weaned pigs | Chen Y, Gabler N, Burrough E | 2021 | Veterinary Pathology | Other | Multiplex IHC | HALO |
| Contribution of NADPH oxidase to the retention of UVR-induced DNA damage by arsenic | Cooper K, Volk L, Dominguez D, Duran A, Liu K, Hudson L | 2021 | Toxicology and Applied Pharmacology | Other | Multiplex IHC | HALO |
| Use of high-rate ventilation results in enhanced recellularization of bio-engineered lung scaffolds | Ahmadipour M, Taniguchi D, Duchesneau P, Aoki F, Phillips G, Sinderby C, Waddell T, Karoubi G | 2021 | Tissue Engineering Part C: Methods | Biomaterials | Classifier, Multiplex IHC | HALO |
| NP-ALT, a Liposomal:Peptide Drug, Blocks p27Kip1 Phosphorylation to Induce Oxidative Stress, Necroptosis, and Regression in Therapy-Resistant Breast Cancer Cells | Jilishitz I, Quinones J, Patel P, Chen G, Pasetsky J, VanInwegen A, Schoninger S, Jogalekar M, Tsiperson V, Yan L, Wu Y, Gottesman S, Somma J, Blain S | 2021 | Molecular Cancer Research | Oncology | Multiplex IHC | HALO |
| Endothelial cell infection and dysfunction, immune activation in severe COVID-19 | Qin Z, Liu F, Blair R, Wang C, Yang H, Mudd J, Currey J, Iwanaga N, He J, Mi R, Han K, Midkiff C, Alam M, Aktas B, Heide R, Veazey R, Piedimonte G, Maness N, Ergün S, Mauvais-Jarvis F, Rappaport J, Kolls J, Qin X | 2021 | Theranostics | Immunology, Infectious Disease | Multiplex IHC, Spatial Analysis | HALO |
| Multiparametric Analyses of Hepatocellular Carcinoma Somatic Mouse Models and Their Associated Tumor Microenvironment | Taranto D, Ramirez C, Vegna S, et al. | 2021 | Current Protocols | Oncology | Multiplex IHC | HALO |
| Integrated functional and spatial profiling of tumor immune responses induced by immunotherapy: the iPROFILER platform | Koelzer V, Herzig P, Zlobec I, Heinzelmann V, Lardinois D, Walseng E, Rader C, Mertz K, Zippelius A, Thommen D | 2021 | Immuno-Oncology and Technology | Immuno-oncology | Cytonuclear, Multiplex IHC | HALO, HALO AI |
| GSTO1‐1 is an upstream suppressor of M2 macrophage skewing and HIF‐1α‐induced eosinophilic airway inflammation | Sokulsky LA, Goggins B, Sherwin S, Eyeers F, Kaiko GE, Board PG, Keely S, Yang M, Foster PS | 2020 | Clinical & Experimental Allergy | Immunology | Multiplex IHC | HALO |
| Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers | Chalabi M, Fanchi LF, Dijkstra KK, Van den Berg JG, Aalbers AG, Sikorska K, Lopez-Yurda M, Grootscholten C, Beets GL, Snaebjornsson P, Maas M, Mertz J, Veninga V, Bounova G, Broeks A, Beets-Tan RG, de Wijkerslooth TR, van Lent AU, Marsman HA, Nuijten E, Kok NF, Kuiper M, Verbeek WH, Kok M, Van Leerdam ME, Schumacher TN, Voest EE, Haanen JB | 2020 | Nature Medicine | Immuno-oncology | Multiplex IHC, Serial Section | HALO |
| Computational image analysis of T-cell infiltrates in resectable gastric cancer: association with survival and molecular subtypes | Challoner BR, von Loga K, Woolston A, Griffiths B, Sivamanoharan N, Semiannikova M, Newey A, Barber LJ, Mansfield D, Hewitt LC, Saito Y, Davarzani N, Starling N, Melcher A, Grabsch HI, Gerlinger M | 2020 | JNCI: Journal of the National Cancer Institute | Immuno-oncology | Multiplex IHC | HALO |
| Assessment of associations between clinical and immune microenvironmental factors and tumor mutation burden in resected nonsmall cell lung cancer by applying machine learning to whole-slide images | Ono A, Terada Y, Kawata T, Serizawa M, Isaka M, Kawabata T, Imai T, Mori K, Muramatsu K, Hayashi I, Kenmotsu H, Oshima K, Urakami K, Nagashima T, Kusuhara M, Akiyama Y, Sugino T, Ohde Y, Yamaguchi K, Takahashi T T | 2020 | Cancer Medicine | Immuno-oncology | Classifier, Multiplex IHC, Serial Section | HALO |
| Immunogradient Indicators for Antitumor Response Assessment by Automated Tumor-Stroma Interface Zone Detection | Rasmusson A, Zilenaite D, Nestarenkaite A, Augulis R, Laurinaviciene A, Ostapenko V, Poskus T, Laurinavicius A | 2020 | The American Journal of Pathology | Immuno-oncology | Multiplex IHC | HALO, HALO AI |
| Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection | Desai N, Neyaz A, Szabolcs A, Shih AR, Chen JH, Thapar V, Nieman LT, Solovyov A, Mehta A, Lieb DJ, Kulkarni AS, Jaicks C, Pinto CJ, Juric D, Chebib I, Colvin RB, Kim AY, Monroe R, Warren SE, Danaher P, Reeves JW, Gong J, Rueckert EH, Greenbaum BD, Hacohen N, Lagana SM, Rivera MN, Sholl LM, Stone JR, Ting DT, Deshpande V | 2020 | medRxiv | Infectious Disease | Multiplex IHC | HALO |
| Two distinct immunopathological profiles in autopsy lungs of COVID-19 | Nienhold R, Ciani Y, Koelzer VH, Tzankov A, Haslbauer JD, Menter T, Schwab N, Henkel M, Frank A, Zsikla V, Willi N, Kempf W, Hoyler T, Barbareschi M, Moch H, Tolnay M, Cathomas G, Demichelis F, Junt T, Mertz KD | 2020 | Nature Communications | Immunology, Infectious Disease | Multiplex IHC | HALO, HALO AI |
| Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters | Tostanoski LH, Wegmann F, Martinot AJ, Loos C, McMahan K, Mercado NB, Yu J, Chan CN, Bondoc S, Starke CE, Nekorchuk M, Busman-Sahay K, Piedra-Mora C, Wrijil LM, Ducat S, Custers J, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Jacob-Dolan C, Lin Z, Mahrokhian SH, Nampanya F, Nityanandam R, Pessaint L, Porto M, ALi V, Benetiene D, Tevi K, Andersen H, Lewis MG, Schmidt AG, Lauffenburger DA, Alter G, Estes JD, Schuitemaker H, Zahn R, Barouch DH | 2020 | Nature Medicine | Infectious Disease | Area Quantification, Multiplex IHC | HALO |
| Linking epigenetic signature and metabolic phenotype in IDH mutant and IDH wildtype diffuse glioma | Buran Y, Filipski K, Bernatz S, Baumgarten P, Roller B, Zinke J, Zeiner PS, Ilina E, Senft C, Ronellenfitsch MW, Plate KH, Bähr O, Hattingen E, Steinbach JP, Mittelbron M, Harter PN | 2020 | Neuropathology and Applied Neurobiology | Neuroscience | Multiplex IHC, TMA | HALO |
| Immuno-Interface Score to Predict Outcome in Colorectal Cancer Independent of Microsatellite Instability Status | Nestarenkaite A, Fadhil W, Ramusson A, Susanti S, Hadjimichael E, Laurinaviciene A, Ilyas M, Laurinavicius A | 2020 | Cancers | Immuno-oncology | Classifier, Multiplex IHC | HALO |
| An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression | Sainson RCA, Thotakura AK, Kosmac M, Borhis G, Parveen N, Kimber R, Carvalho J, Henderson SJ, Pryke KL, Okell T, O’Leary S, Ball S, Van Krinks C, Gamand L, Taggart E, Pring EJ, Ali H, Craig H, Wong VWY, Liang Q, Rowlands RJ, Lecointre M, Campbell J, Kirby I, Melvin D, Germaschewski V, Oelmann E, Quaratino S, McCourt M | 2020 | Cancer Immunology Research | Immuno-oncology | Multiplex IHC | HALO |
| A preclinical trial and molecularly-annotated patient cohort identify predictive biomarkers in homologous recombination deficient pancreatic cancer | Wang Y, Park J, Pacis A, Denroche R, Jang G, Zhang A, Cuggia A, Domecq C, Monlong J, Raitses-Gurevich M, Grant R, Borgida A, Holter S, Stossel C, Bu S, Masoomian M, Lungu I, Bartlett J, Wilson J, Gao Z, Riazalhosseini Y, Asselah J, Bouganim N, Cabrera T, Boucher L, Valenti D, Biagi J, Greenwood C, Polak P, Foulkes W, Golan T, O’Kane G, Fischer S, Knox J, Gallinger S, Zogopoulos G | 2020 | Clinical Cancer Research | Oncology | Classifier, Cytonuclear, Multiplex IHC | HALO |
| Olaparib and durvalumab in patients with germline BRCA-mutated metastatic breast cancer (MEDIOLA): an open-label, multicentre, phase 1/2, basket study | Domchek SM, Postel-Vinay S, Im S-A, Park YH, Delord J-P, Italiano A, Alexandre J, You B, Bastian S, Krebs MG, Wang D, Waqar SN, Lanasa M, Rhee J, Gao H, Rocher-Ros V, Jones EV, Gulati S, Coenen-Stass A, Kozarewa I, Lai Z, Angell HK, Opincar L, Herbolsheimer P, Kaufman B | 2020 | The Lancet Oncology | Oncology | Multiplex IHC | HALO |
| ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response | Nagarajan S, Rao SV, Sutton J, Cheeseman D, Dunn S, Papachristou EK, Prada J-EG, Couturier D-L, Kumar S, Kishore K, Chilamakuri CSR, Glont E, Goode EA, Brodie C, Guppy N, Natrajan R, Bruna A, Caldas C, Russel A, Siersbaek R, Yusa K, Chernukhin I, Carroll JS | 2020 | Nature Genetics | Oncology | Multiplex IHC | HALO |
| Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade | Srivastava S, Furlan SN, Jaeger-Ruckstuhl CA, Sarvothama M, Berger C, Smythe KS, Garrison SM, Specht JM, Lee SM, Amezquita RA, Voillet V, Muhunthan V, Yechan-Gunja S, Pillai SPS, Rader C, Houghton AM, Pierce RH, Gottardo R, Maloney DG, Riddell SR | 2020 | Cancer Cell | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
| IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis | Siersbæk R, Scabia V, Nagarajan S, Chernukhin I, Papachristou EK, Broome R, Johnston SJ, Joosten SEP, Green AR, Kumar S, Jones J, Omarjee S, Alvarez-Fernandez R, Glont S, Aitken SJ, Kishore K, Cheeseman D, Rakha EA, D’Santos C, Zwart W, Ruseel A, Brisken C, Carroll JS | 2020 | Cancer Cell | Oncology | Area Quantification, Multiplex IHC | HALO |
| Genomic analysis of Vascular Invasion in Hepatocellular Carcinoma (HCC) Reveals Molecular Drivers and Predictive Biomarkers | Krishnan MS, Rajan KD A, Park J, Arjunan V, Marques FJG, Bermudez A, Girvan OA, Hoang NS, Yin J, Nguyen MH, Kothary N, Pitteri S, Felsher DW, Dhanasekaran R | 2020 | Hepatology | Oncology | Multiplex IHC, TMA | HALO |
| ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung | Schuijs MJ, Png S, Richard AC, Tsyben A, Hamm G, Stockis J, Garcia C, Panaud S, Nicholls A, Ros XR, Su J, Eldridge MD, Riedel A, Serrao EM, Rodewald H-R, Mack M, Shields JD, Cohen ES, McKenzie ANJ, Goodwin RJA, Brindle KM, Marioni JC, Halim TYF | 2020 | Nature Immunology | Immuno-oncology | Multiplex IHC | HALO |
| STAT3 antisense oligonucleotide remodels the suppressive tumor microenvironment to enhance immune activation in combination with anti-PD-L1 | Proia T, Singh M, Woessner R, Carnevalli LS, Bommakanti G, Magiera L, Srinivasan SS, Grosskurth SE, Collins M, Womack C, Griffin M, Ye M, Cantin S, Russell DL, Xie M, Hughes AM, Deng N, Mele DA, Fawell SE, Barry ST, Reimer C, Barrett JC, McCoon P | 2020 | Clinical Cancer Research | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
| MAOA-mediated reprogramming of stromal fibroblasts promotes prostate tumorigenesis and cancer stemness | Li J, Pu T, Yin L, Li Q, Liao C-P, Wu BJ | 2020 | Oncogene | Oncology | Multiplex IHC | HALO |
| B7-H3 immune checkpoint expression is a poor prognostic factor in colorectal carcinoma | Lu Z, Zhao Z-X, Cheng P, Huang F, Guan X, Zhang M-G, Chen H-P, Liu Z, Jiang Z, Zheng Z-X, Zou S-M, Wang X-S | 2020 | Modern Pathology | Immuno-oncology | Multiplex IHC, TMA | HALO |
| Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice | Goulding DS, Vogel RC, Pandya CD, Shula C, Gensel JC, Mangano FT, Goto J, Miller BA | 2020 | Journal of Neurosurgery | Immunology, Neuroscience | Multiplex IHC, Highplex FL | HALO |
| The RAC1 target NCKAP1 plays a crucial role in progression of BRAF/PTEN -driven melanoma in mice | Swaminathan K, Campbell A, Papalazarou V, Jaber-Hijazi F, Nixon C, McGhee E, Strathdee D, Sansom OJ, Machesky LM | 2020 | Journal of Investigative Dermatology | Oncology, Dermatology | Area Quantification, Multiplex IHC | HALO |
| Intraductal pancreatic cancer is less responsive than cancer in the stroma to neoadjuvant chemotherapy | Fujikura K, Hutchings D, Braxton AM, Zhu Q, Laheru DA, Hruban RH, Thompson ED, Wood LD | 2020 | Modern Pathology | Oncology | Multiplex IHC | HALO |
| Glucagon Receptor Inhibition Reduces Hyperammonemia and Lethality in Male Mice with Urea Cycle Disorder | Cavino K, Sung B, Su Q, Na E, Kim J, Cheng X, Gromada J, Okamoto H | 2020 | Endocrinology | Metabolism | ISH/FISH, Multiplex IHC | HALO |
| Development of a clinically relevant ovarian cancer model incorporating surgical cytoreduction to evaluate treatment of micro-metastatic disease | Morse CB, Voillet V, Bates BM, Chiu EY, Garcia NM, Gottardo R, Greenberg PD, Anderson KG | 2020 | Gynecologic Oncology | Oncology | Multiplex IHC | HALO |
| Discoidin Domain Receptor 1 (DDR1) is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma | Ruggeri JM, Franco-Barraza J, Sohail A, Zhang Y, Long D, di Magliano MP, Cukierman E, Fridman R, Crawford HC | 2020 | The American Journal of Pathology | Oncology, Immunology | Cytonuclear, Multiplex IHC, Highplex FL | HALO |
| Independent Prognostic Value of Intratumoral Heterogeneity and Immune Response Features by Automated Digital Immunohistochemistry Analysis in Early Hormone Receptor-Positive Breast Carcinoma | Zilenaite D, Rasmusson A, Augulis R, Besuparis J, Laurinaviciene A, Plancoulaine B, Ostpenko V, Laurinavicius | 2020 | Frontiers in Oncology | Oncology | Multiplex IHC | HALO, HALO AI |
| Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers | Sun RC, Dukhande VV, Zhou Z, Young LEA, Emanuelle S, Brainson CF, Gentry MS | 2019 | Cell Metabolism | Oncology | Multiplex IHC | HALO |
| Inducing and exploiting vulnerabilities for the treatment of liver cancer | Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, de Oliveira RL, Morris B, Gadiot J, Wang W, du Chatinier A, Wang L, Gao D, Evers B, Jin G, Xue Z, Schepers A, Jochems F, Sanchez AM, Mainardi S, te Riele H, Beijersbergen RL, Qin W, Akkari L, Bernards R | 2019 | Nature | Oncology | Multiplex IHC | HALO |
| The role of WNT10B in normal prostate gland development and prostate cancer | Madueke I, Hu W-Y, Hu D, Swanson SM, Griend DV, Abern M, Prins GS | 2019 | The Prostate | Oncology | Multiplex IHC, TMA | HALO, HALO AI |
| The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis | Oser MG, Sabet AH, Gao W, Chakraborty AA, Schinzel AC, Jennings RB, Fonseca R, Bonal DM, Booker MA, Flaifel A, Novak JS, Christensen VL, Zhang H, Herbert ZT, Tolstorukov MY, Buss EJ, Wong K-K, Bronson RT, Nguyen Q-D, Signoretti S, Kaelin Jr WG | 2019 | Genes & Development | Oncology | Multiplex IHC | HALO |
| Precision immunoprofiling by image analysis and artificial intelligence | Koelzer VH, Sirinukunwattana K, Rittscher J, Mertz KD | 2019 | Vichows Archiv | Review | Classifier, Multiplex IHC, Spatial Analysis | HALO |
| Immune evasion before tumour invasion in early lung squamous carcinogenesis | Mascaux C, Angelova M, Vasaturo A, Beane J, Hijazi K, Anthoine G, Rothe F, Willard-Gallo K, Haller A, Ninane V, Burny A, Sculier J-P, Spira A, Galon J | 2019 | Nature | Oncology, Immuno-oncology | Multiplex IHC | HALO |
| PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN | Flaifel A, Xie W, Braun DA, Ficial M, Bakouny Z, Nassar AH, Jennings RB, Escudier B, George DJ, Motzer RJ, Morris MJ, Powles, Wang E, Huang Y, Freeman GJ, Choueiri TK, Signoretti S | 2019 | Clinical Cancer Research | Immuno-oncology | Multiplex IHC | HALO |
| Multiplexed Immunohistochemistry for Molecular and Immune Profiling in Lung Cancer—Just About Ready for Prime-Time? | Hofman P, Badoual C, Henderson F, Berland L, Hamila M, Long-Mira E, Lassalle S, Roussel H, Hofman V, Tartour E, Ilié M | 2019 | Cancers | Oncology, Immuno-oncology, Review | Classifier, Multiplex IHC | HALO |
| Physiologic serum 1,25 dihydroxyvitamin D is inversely associated with prostatic Ki67 staining in a diverse sample of radical prostatectomy patients | Rosenberg A, NetteY OS, Gogana P, Sheikh U, Virgilia M, Macias V, Kajdacsy-Balla A, R Sharifi R, Kittles RA, Murphy AB | 2019 | Cancer Causes & Control | Oncology | Multiplex IHC | HALO |
| A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade | Thommen DS, Koelzer VH, Herzig P, Roller A, Trefny M, Dimeloe S, Kiialainen A, Hanhart J, Schil C, Hess C, Prince SS, Wiese M, Lardinois D, Ho P-C, Klein C, Karanikas V, Mertz KD, Schumacher TN, Zippelius A | 2018 | Nature Medicine | Oncology, Immuno-oncology | Multiplex IHC | HALO |
| Digital image analysis improves precision of PD‐L1 scoring in cutaneous melanoma | Koelzer VH, Gisler A, Hanhart JC, Griss J, Wagner SN, Willi N, Cathomas G, Sachs M, Kempf W, Thommen DS, Mertz KD | 2018 | Histopathology | Oncology, Immuno-oncology | Classifier, Multiplex IHC | HALO |
| FOXM1 contributes to treatment failure in acute myeloid leukemia | Khan I, Halasi M, Patel A, Schultz R, Kalakota N, Chen Y-H, Aardsma N, Liu L, Crispino JD, Mahmud N, Frankfurt O, Gartel AL | 2018 | JCI Insight | Oncology | Multiplex IHC | HALO |
| A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma | O’Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, MorrissetteJJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot J-M, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV | 2017 | Science Translational Medicine | Oncology, Immuno-oncology | Cytonuclear, Multiplex IHC | HALO |
| Receptor tyrosine kinase expression and phosphorylation in canine nasal carcinoma | Hocker SA, Higginbotham ML, Schermerhorn T, Henningson J | 2017 | Research in Veterinary Science | Oncology | Area Quantification, Multiplex IHC | HALO |
| Bystander effects induced by the interaction between urothelial cancer cells and irradiated adipose tissue-derived stromal cells in urothelial carcinoma | Kawasaki M, Nagase K, Aoki S, Udo K, Tobu S, Rikitake-Yamamoto M, Kubota M, Narita T, Noguchi M | 2022 | Human Cell | Oncology | Multiplex IHC | HALO |
| ICOS-Positive Regulatory T Cells in Hepatocellular Carcinoma: The Perspective from Digital Pathology Analysis | Lu L, Deantonio C, Palu C, Lee Y, Mitchell L, Cowan M, Corser M, Sherry L, Cheng A, Quaratino S, Shao Y, Sainson R, Hsu C | 2022 | Karger | Oncology | Multiplex IHC, Spatial Analysis | HALO |
| CAV1 Impacts the Tumor Immune Microenvironment and Has Potential Value of Predicting Response to Immunotherapy in Esophageal Cancer | Zhang R, Wang H, Xiao J, Lu J, Li M, Zhou Y, Sun H, Liu L, Huang T, Zhao Q | 2023 | DNA and Cell Biology | Immuno-oncology | Multiplex IHC | HALO |
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