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Indica Labs / Metabolism

Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function

Courtney M. Williams et al, The FASEB Journal, 2021
Williams and colleagues at Regeneron Pharmaceuticals perform structure/function relationship studies on Fgf15 and FGF19 using site-directed mutagenesis and downstream functional assays in order to understand their distinct functions in a common pathway. Both molecules are therapeutic targets due to involvement in hepatocellular carcinoma and bile acid production. This publication identifies a single cysteine residue is identified that controls dimerization and hepatocyte proliferation. Understanding these molecular pathways may inform future...

Vacuole Quantification

The Vacuole Quantification module is a multi-purpose tool that can be used for quantifying the number and size of white spaces in tissue such as lipids in brown and white adipose tissue, lipid droplets in liver tissue (steatosis), and alveoli area in lung.  ...

Cytonuclear FL

Cytonuclear FL measures the immunofluorescent positivity of an unlimited number of fluorescent markers in the nucleus or cytoplasm and reports the number of cells that are positive for each marker, the intensity score for each cell (0, 1+, 2+, 3+), and colocalization of different marker combinations. Optionally, the tool can output the complete table of cell data including individual cell sizes and intensity measurements for each dye in each cellular compartment. In the dual stained mouse pancreas shown above, the...