Highplex FL
Quantify expression of an unlimited number of biomarkers in any cellular compartment – membrane, nucleus or cytoplasm.
Highplex FL
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma
Jason Yongsheng Chan,et al, The Journal of Clinical Investigation, 2020.
To molecularly characterize the rare and aggressive tumors known as angiosarcomas, Chan et al utilized a combination of transcriptomic immuno-oncology profiling with multiplex immunohistochemistry and immunofluorescence. HALO image analysis software was used for the quantification of PD-L1, CD68, CD8, FOXP3, CD15, and ERG. From these studies, three phenotypes of patients were identified according to etiology, anatomical origin, signaling pathways, and the tumor inflammation signature. These distinct biological phenotypes provide opportunity for future studies to improve prognosis and treatment of a rare and deadly disease.
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Virtual US User Group Meeting Presentation: A Digital Pathology Repository for COVID, An Evolving Need
8-11 June 2020 | In lieu of our scheduled onsite user group meetings, Indica Labs is pleased to announce our 2020 US Virtual HALO User Group Meeting. To make participation easier for our US audience, we will break down the user groups into four one-hour webinars over three days starting at 9 AM PDT/12 PM EDT.
Brightplex: Combining the power of multiplexing & the ease of chromogenic IHC to assess complex immune phenotypes in the TME
11 June 2019 | In this webinar, Dr Anna Martirosyan and Dr. Emmanuel Prestat will introduce the Brightplex platform, including a description of the MDSC Panel, the workflow and techniques employed. A discussion on how the HALO(R) image analysis platform is integrated as an image processing component of the workflow, and how the technology can be applied to investigate the immune contexture of tumors will follow.